Abstract:
:Artifacts in functional magnetic resonance imaging (fMRI) data, primarily those related to motion and physiological sources, negatively impact the functional signal-to-noise ratio in fMRI studies, even after conventional fMRI preprocessing. Independent component analysis' demonstrated capacity to separate sources of neural signal, structured noise, and random noise into separate components might be utilized in improved procedures to remove artifacts from fMRI data. Such procedures require a method for labeling independent components (ICs) as representing artifacts to be removed or neural signals of interest to be spared. Visual inspection is often considered an accurate method for such labeling as well as a standard to which automated labeling methods are compared. However, detailed descriptions of methods for visual inspection of ICs are lacking in the literature. Here we describe the details of, and the rationale for, an operationalized fMRI data denoising procedure that involves visual inspection of ICs (96% inter-rater agreement). We estimate that dozens of subjects/sessions can be processed within a few hours using the described method of visual inspection. Our hope is that continued scientific discussion of and testing of visual inspection methods will lead to the development of improved, cost-effective fMRI denoising procedures.
journal_name
J Neurosci Methodsjournal_title
Journal of neuroscience methodsauthors
Kelly RE Jr,Alexopoulos GS,Wang Z,Gunning FM,Murphy CF,Morimoto SS,Kanellopoulos D,Jia Z,Lim KO,Hoptman MJdoi
10.1016/j.jneumeth.2010.03.028subject
Has Abstractpub_date
2010-06-15 00:00:00pages
233-45issue
2eissn
0165-0270issn
1872-678Xpii
S0165-0270(10)00162-7journal_volume
189pub_type
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