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An ultra-stable non-coherent light source for optical measurements in neuroscience and cell physiology.

Abstract：

:We demonstrate that high power light-emitting diodes (LED's) exhibit low-frequency noise characteristics that are clearly superior to those of quartz tungsten halogen lamps, the non-coherent light source most commonly employed when freedom from intensity variation is critical. Their extreme stability over tens of seconds (combined with readily selectable wavelength) makes high power LED's ideal light sources for DC recording of optical changes, from living cells and tissues, that last more than a few hundred milliseconds. These optical signals (DeltaI/I(0)) may be intrinsic (light scattering, absorbance or fluorescence) or extrinsic (absorbance or fluorescence from probe molecules) and we show that changes as small as approximately 8 x 10(-5) can be recorded without signal averaging when LED's are used as monochromatic light sources. Here, rapid and slow changes in the intrinsic optical properties of mammalian peptidergic nerve terminals are used to illustrate the advantages of high power LED's compared to filament bulbs.

journal_name

J Neurosci Methods

journal_title

Journal of neuroscience methods

authors

Salzberg BM,Kosterin PV,Muschol M,Obaid AL,Rumyantsev SL,Bilenko Y,Shur MS

doi

10.1016/j.jneumeth.2004.06.009

subject

Has Abstract

pub_date

2005-01-30 00:00:00

pages

165-9

issue

1

eissn

0165-0270

issn

1872-678X

pii

S0165-0270(04)00224-9

journal_volume

141

pub_type

杂志文章

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