Canine plasma alkaline phosphatase polymorphism and its relationship with the canine Tr blood group system.

Abstract:

:A canine blood group antigen, QN, which was detected by a naturally occurring alloantibody in the antiglobulin test, was shown to be antigenically related to the human A and cattle J antigens by absorption experiments. Family studies supported a dominant mode of inheritance with the gene controlling the production of QN being dominant to the gene responsible for its absence. Frequencies of the QN and Tr antigens and serological data strongly suggested that the two antigens are identical. Two canine plasma alkaline phosphatase variants, F and S, were detected by starch gel electrophoresis, pH 8.65. Assuming genetic control of two codominant alleles, ALPF and ALPS, the distributions of types in families differed significantly from expectation. A relationship between the ALP and Tr(QN) systems was demonstrated with Tr-positive animals having a significant deficiency of S alkaline phosphatase types.

journal_name

Anim Genet

journal_title

Animal genetics

authors

Symons M,Bell K

doi

10.1111/j.1365-2052.1992.tb00153.x

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

315-24

issue

4

eissn

0268-9146

issn

1365-2052

journal_volume

23

pub_type

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