Two insertion/deletion variants in the promoter region of the QPCTL gene are significantly associated with body weight and carcass traits in chickens.

Abstract:

:Glutaminyl-peptide cyclotransferase-like (QPCTL) is an isoenzyme of glutaminyl-peptide cyclotransferase (QPCT). QPCTL and QPCT catalyze the formation of N-terminal modified pyroglutamate-fractalkine and the chemokine CCL2. The objective of this study was to investigate the association between insertions/deletions in the chicken QPCTL promoter region with growth traits in chickens. We first detected two insertion/deletion variants of QPCTL via whole-genome resequencing analysis of DNA samples from Xichuan chickens. A total of 1896 individuals from 12 breeds were genotyped for 52- and 224-bp insertions/deletions. We found two novel insertions/deletions in the promoter region of the chicken QPCTL gene and studied their association with chicken body weight and carcass traits. Our findings show that QPCTL can be a molecular marker for chicken genetics and breeding programs.

journal_name

Anim Genet

journal_title

Animal genetics

authors

Ren T,Li W,Liu D,Liang K,Wang X,Li H,Jiang R,Tian Y,Kang X,Li Z

doi

10.1111/age.12741

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

279-282

issue

3

eissn

0268-9146

issn

1365-2052

journal_volume

50

pub_type

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