Abstract:
:Glutaminyl-peptide cyclotransferase-like (QPCTL) is an isoenzyme of glutaminyl-peptide cyclotransferase (QPCT). QPCTL and QPCT catalyze the formation of N-terminal modified pyroglutamate-fractalkine and the chemokine CCL2. The objective of this study was to investigate the association between insertions/deletions in the chicken QPCTL promoter region with growth traits in chickens. We first detected two insertion/deletion variants of QPCTL via whole-genome resequencing analysis of DNA samples from Xichuan chickens. A total of 1896 individuals from 12 breeds were genotyped for 52- and 224-bp insertions/deletions. We found two novel insertions/deletions in the promoter region of the chicken QPCTL gene and studied their association with chicken body weight and carcass traits. Our findings show that QPCTL can be a molecular marker for chicken genetics and breeding programs.
journal_name
Anim Genetjournal_title
Animal geneticsauthors
Ren T,Li W,Liu D,Liang K,Wang X,Li H,Jiang R,Tian Y,Kang X,Li Zdoi
10.1111/age.12741subject
Has Abstractpub_date
2019-06-01 00:00:00pages
279-282issue
3eissn
0268-9146issn
1365-2052journal_volume
50pub_type
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