Linkage disequilibrium pattern and genome-wide association mapping for meat traits in multiple porcine F2 crosses.

Abstract:

:In the present study, data from four F2 crosses were analysed and used to study the linkage disequilibrium (LD) structure within and across the crosses. Genome-wide association analyses (GWASes) for conductivity and dressing out meat traits were conducted using single-marker and Bayesian multi-marker models using the pooled data from all F2 crosses. Porcine F2 crosses generated from the distantly related founder breeds Wild Boar, Piétrain and Meishan, as well as from a porcine F2 cross from the closely related founder breed Piétrain and an F1 Large White × Landrace cross were pooled. A total of 2572 F2 animals were genotyped using a 62K SNP chip. The positions of the SNPs were based on genome assembly Sscrofa11.1. After post-alignment and genotype filtering, approximately 50K SNPs were usable for LD studies and GWASes. The main findings of the present study are that the breakdown of LD was faster in crosses from closely related founder breeds compared to crosses from distantly related founders. The fastest breakdown of LD was observed by pooling the data. Based on the single-marker results and LD structure, clusters and windows were built for 1-Mb intervals. For conductivity and dressing out, 183 and 191 nominal significant associations respectively and six and five clusters respectively were found. Dominance was important for conductivity, and considering dominance in GWASes improved the mapping signals. Most clear signals were found for conductivity on SSC6, 8 and 15 and for dressing out on SSC2 and 7. Considering dominance might contribute to the accuracy of genomic selection and serve as a guide for choosing mating pairs with good combining abilities. However, further research is needed to investigate if dominance is also important in crossbreed pig breeding schemes.

journal_name

Anim Genet

journal_title

Animal genetics

authors

Stratz P,Schmid M,Wellmann R,Preuß S,Blaj I,Tetens J,Thaller G,Bennewitz J

doi

10.1111/age.12684

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

403-412

issue

5

eissn

0268-9146

issn

1365-2052

journal_volume

49

pub_type

杂志文章
  • Genome-wide association study identifies markers associated with carcass and meat quality traits in Italian Large White pigs.

    abstract::A GWAS was performed using the genotypes obtained by PorcineSNP60 v2 BeadChip and 11 phenotypic traits (carcass lean meat percentage; backfat thickness; Longissimus thoracis muscle thickness; lightness; backfat thickness measured with caliper at the midline; meat pH measured at about 1 h post mortem and 24 h post mort...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.13013

    authors: Fabbri MC,Zappaterra M,Davoli R,Zambonelli P

    更新日期:2020-12-01 00:00:00

  • A genome-wide association study reveals a QTL influencing caudal supernumerary teats in Holstein cattle.

    abstract::Supernumerary teats represent a common abnormality of the bovine udder. A genome-wide association study was performed based on the proportion of the occurrence of supernumerary teats in the daughters of 1097 Holstein bulls. The heritability of caudal supernumerary teats without mammary gland in this study was 0.604. T...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12215

    authors: Joerg H,Meili C,Ruprecht O,Bangerter E,Burren A,Bigler A

    更新日期:2014-12-01 00:00:00

  • QTL analysis of body weight and conformation score in commercial broiler chickens using variance component and half-sib analyses.

    abstract::The aim of the study was to investigate quantitative trait loci (QTL) in previously identified regions of chicken chromosomes 1, 4 and 5 relating to 40-day body weights and conformation scores. Half-sib (HS) and variance component analyses were implemented and compared using QTL Express software. Data were from a two-...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2006.01424.x

    authors: Rowe SJ,Windsor D,Haley CS,Burt DW,Hocking PM,Griffin H,Vincent J,De Koning DJ

    更新日期:2006-06-01 00:00:00

  • Sequence analysis of MHC class I alpha 2 domain exon variants in one diploid and two haploid Atlantic salmon pedigrees.

    abstract::Genetic diversity in the second domain exon of Atlantic salmon (Salmo salar) major histocompatibility complex (Mhc) class I was investigated in two dams and nine of their haploid offspring by means of polymerase chain reaction (PCR) and DNA sequence analysis. A similar study was also performed on nine diploid offsprin...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1997.00183.x

    authors: Grimholt U,Olsaker I,Lingaas F,Lie O

    更新日期:1997-12-01 00:00:00

  • No detectable association of the ESR PvuII mutation with sow productivity in a Meishan x Large White F2 population.

    abstract::The polymorphism at the PvuII recognition site in the ESR gene showed no statistically significant association with sow productivity traits in a Meishan x Large White F2 population. Estimates of the effect on litter size were, however, in the opposite direction and statistically different from previously published est...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.2002.00889.x

    authors: Gibson JP,Jiang ZH,Robinson JA,Archibald AL,Haley CS

    更新日期:2002-12-01 00:00:00

  • Phylogenetic relationships of Cheju horses to other horse breeds as determined by mtDNA D-loop sequence polymorphism.

    abstract::Historical records suggest that horses inhabiting the island of Cheju in Korea are descendants of Mongolian horses introduced in 1276. Other studies, however, suggest that horses may have been present on the island prior to the Mongolian introduction. To determine the origin of the Cheju horses we used a phylogenetic ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.1999.00419.x

    authors: Kim KI,Yang YH,Lee SS,Park C,Ma R,Bouzat JL,Lewin HA

    更新日期:1999-04-01 00:00:00

  • The interleukin 4 receptor gene and its role in recurrent airway obstruction in Swiss Warmblood horses.

    abstract::Recurrent airway obstruction (RAO) in horses is the result of an interaction of genetic and environmental factors and shares many characteristics with human asthma. Many studies have suggested that the interleukin-4 receptor gene (IL4R) is associated with this disease, and a QTL region on chromosome 13 containing IL4R...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2011.02277.x

    authors: Klukowska-Rötzler J,Swinburne JE,Drögemüller C,Dolf G,Janda J,Leeb T,Gerber V

    更新日期:2012-08-01 00:00:00

  • From information to understanding: the role of model organism databases in comparative and functional genomics.

    abstract::Data integration is key to functional and comparative genomics because integration allows diverse data types to be evaluated in new contexts. To achieve data integration in a scalable and sensible way, semantic standards are needed, both for naming things (standardized nomenclatures, use of key words) and also for kno...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2006.01475.x

    authors: Bult CJ

    更新日期:2006-08-01 00:00:00

  • Functional genes mapped on the chicken genome.

    abstract::Microsatellite polymorphisms are finding increasing use in genetics. In addition to the random isolation of microsatellite markers, such markers can also be developed from sequences already present in public domain databases. An advantage of public domain databases is that these microsatellites are known to be located...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1995.tb02636.x

    authors: Crooijmans RP,van der Poel JJ,Groenen MA

    更新日期:1995-04-01 00:00:00

  • Single nucleotide polymorphism discovery in albacore and Atlantic bluefin tuna provides insights into worldwide population structure.

    abstract::The optimal management of the commercially important, but mostly over-exploited, pelagic tunas, albacore (Thunnus alalunga Bonn., 1788) and Atlantic bluefin tuna (BFT; Thunnus thynnus L., 1758), requires a better understanding of population structure than has been provided by previous molecular methods. Despite numero...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12051

    authors: Albaina A,Iriondo M,Velado I,Laconcha U,Zarraonaindia I,Arrizabalaga H,Pardo MA,Lutcavage M,Grant WS,Estonba A

    更新日期:2013-12-01 00:00:00

  • Additional studies of sheep haemopexin: genetic control, frequencies and postnatal development.

    abstract::This study presents evidence that sheep haemopexin phenotypes are genetically controlled by three alleles, HpxA, HpxB1 and HpxB2, of a single autosomal locus. Frequencies of two alleles, HpxA and HpxB (HpxB encompasses two isoalleles, HpxB1 and HpxB2), were studied in eight sheep breeds in Czechoslovakia. The frequenc...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1989.tb00856.x

    authors: Stratil A,Bobák P,Margetín M,Glasnák V

    更新日期:1989-01-01 00:00:00

  • Production and characterization of alloantisera specific for bovine class II major histocompatibility complex antigens.

    abstract::Ten alloantisera defining five major histocompatibility complex (MHC) class II specificities of the bovine lymphocyte antigen (BoLA) complex were produced and characterized. Eight antisera defining four of the specificities were generated by immunizing cattle with class I compatible-class II incompatible lymphocytes. ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1991.tb00701.x

    authors: Davies CJ,Antczak DF

    更新日期:1991-01-01 00:00:00

  • Identifying genetic loci controlling neonatal passive transfer of immunity using a hybrid genotyping strategy.

    abstract::Colostrum intake is critical to a piglet's survival and can be measured by precipitating out the γ-immunoglobulins from serum with ammonium sulfate (immunocrit). Genetic analysis of immunocrits on 5312 piglets indicated that the heritabilities (se) for direct and maternal effects were 0.13 (0.06) and 0.53 (0.08) respe...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12131

    authors: Rohrer GA,Rempel LA,Miles JR,Keele JW,Wiedmann RT,Vallet JL

    更新日期:2014-06-01 00:00:00

  • Unequivocal identification of the equine Dcfmqr phenogroup.

    abstract::An alloimmune reagent has been produced that distinguishes the equine factor Df in the D phenogroup, cfmqr, from that occurring in cefmqr and dfklr. Using this reagent it has been possible to correctly genotype Dc, d, f, k, l, m, q and r positive cells without recourse to family data. ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1996.tb00476.x

    authors: Bell K,Colling DT

    更新日期:1996-04-01 00:00:00

  • Mapping economic trait loci for somatic cell score in Holstein cattle using microsatellite markers and selective genotyping.

    abstract::Marker-assisted selection (MAS) uses genetic marker genotypes to predict an animal's production potential and will provide additional selection information for progeny testing. With the discovery of highly polymorphic microsatellite markers, the tools now exist to begin the search for economic trait loci (ETL), which ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1996.tb00484.x

    authors: Ashwell MS,Rexroad CE Jr,Miller RH,VanRaden PM

    更新日期:1996-08-01 00:00:00

  • Identification of candidate genes and mutations in QTL regions for immune responses in chicken.

    abstract::There are two categories of immune responses - innate and adaptive immunity - both having polygenic backgrounds and a significant environmental component. In our study, adaptive immunity was represented by the specific antibody response toward keyhole limpet hemocyanin (KLH); innate immunity was represented by natural...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12280

    authors: Siwek M,Slawinska A,Rydzanicz M,Wesoly J,Fraszczak M,Suchocki T,Skiba J,Skiba K,Szyda J

    更新日期:2015-06-01 00:00:00

  • Genome-wide genetic diversity of 'Nici', the DNA source for the CHORI-260 turkey BAC library and candidate for whole genome sequencing.

    abstract::Vertebrate whole genome sequence assembly can benefit from a priori knowledge of variability in the target genome, with researchers often selecting highly inbred individuals for sequencing. However, for most species highly inbred research lines are lacking, requiring the use of an outbred individual(s). Here we examin...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2008.01845.x

    authors: Chaves LD,Harry DE,Reed KM

    更新日期:2009-06-01 00:00:00

  • Indels within promoter and intron 1 of bovine prion protein gene modulate the gene expression levels in the medulla oblongata of two Japanese cattle breeds.

    abstract::Genetic differences which exist in the prion protein gene (PRNP) have been reported to influence susceptibility of humans, sheep and goats to prion diseases. In cattle, however, none of the known coding polymorphisms has a direct effect on bovine spongiform encephalopathy (BSE). It has been reported that 23-bp inserti...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2009.01983.x

    authors: Msalya G,Shimogiri T,Nishitani K,Okamoto S,Kawabe K,Minesawa M,Maeda Y

    更新日期:2010-04-01 00:00:00

  • Mitochondrial PEPCK: a highly polymorphic gene with alleles co-selected with Marek's disease resistance in chickens.

    abstract::The gene coding for the mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M), a pivotal component in gluconeogenesis from lactate via the Cori cycle, was highly polymorphic in strains of egg-type chickens (White Leghorn) of different origins. Based on MspI restriction fragment polymorphisms a total of seven allel...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.1998.295362.x

    authors: Li S,Zadworny D,Aggrey SE,Kuhnlein U

    更新日期:1998-10-01 00:00:00

  • Single nucleotide polymorphisms in the insulin-like growth factor 1 (IGF1) gene are associated with growth-related traits in farmed Atlantic salmon.

    abstract::Understanding the genetic basis of variation in traits related to growth and fillet quality in Atlantic salmon is of importance to the aquaculture industry. Several growth-related QTL have been identified via the application of genetic markers. The IGF1 gene is considered a highly conserved and crucial growth-regulati...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12202

    authors: Tsai HY,Hamilton A,Guy DR,Houston RD

    更新日期:2014-10-01 00:00:00

  • Breed-specific expression of DROSHA, DICER and AGO2 is regulated by glucocorticoid-mediated miRNAs in the liver of newborn piglets.

    abstract::MicroRNA (miRNA) biogenesis is determined mainly by Drosha, Dicer and Argonaute2 (Ago2). Different breeds of pigs with vast differences in serum cortisol level demonstrate distinct profiles of hepatic miRNA expression. As yet, little is known about whether glucocorticoid contributes to the breed differences in miRNA b...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12232

    authors: Li R,Jia Y,Zou H,Zhao R

    更新日期:2014-12-01 00:00:00

  • Biochemical characterization of the bovine genetic kappa-casein C and E variants.

    abstract::Analysis of elution profiles of enzymatic and CNBr digests of kappa-caseins C and E, and sequencing of most relevant peptides allowed the chemical characterization of both genetic variants. They differ from their B and A allelic counterparts by a single substitution, His97/Arg and Gly155/Ser, respectively. Electrophor...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1993.tb00915.x

    authors: Miranda G,Anglade P,Mahé MF,Erhardt G

    更新日期:1993-02-01 00:00:00

  • Major histocompatibility (B) complex and sex effects on the phytohaemagglutinin wattle response.

    abstract::The influence of the major histocompatibility (B) complex and sex on the phytohaemagglutinin (PHA) wattle response was studied in 136 segregants (B2/B2, B2/B5 and B5/B5) of a fourth generation cross between inbred lines 6(1) and 15(1). At 6 weeks of age, chickens were injected with 100 micrograms purified PHA-P. Wattl...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1987.tb00778.x

    authors: Taylor RL Jr,Cotter PF,Wing TL,Briles WE

    更新日期:1987-01-01 00:00:00

  • Twenty years of artificial directional selection have shaped the genome of the Italian Large White pig breed.

    abstract::In this study, we investigated at the genome-wide level if 20 years of artificial directional selection based on boar genetic evaluation obtained with a classical BLUP animal model shaped the genome of the Italian Large White pig breed. The most influential boars of this breed (n = 192), born from 1992 (the beginning ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12392

    authors: Schiavo G,Galimberti G,Calò DG,Samorè AB,Bertolini F,Russo V,Gallo M,Buttazzoni L,Fontanesi L

    更新日期:2016-04-01 00:00:00

  • A non-coding regulatory variant in the 5'-region of the MITF gene is associated with white-spotted coat in Brown Swiss cattle.

    abstract::Recently, the Swiss breeding association reported an increasing number of white-spotted cattle in the Brown Swiss breed, which is normally solid brown coloured. A total of 60 Brown Swiss cattle with variably sized white abdominal spots, facial markings and depigmented claws were collected for this study. A genome-wide...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12751

    authors: Hofstetter S,Seefried F,Häfliger IM,Jagannathan V,Leeb T,Drögemüller C

    更新日期:2019-02-01 00:00:00

  • Multiple restriction fragment length polymorphisms in the porcine calcium release channel gene (CRC): assignment to the halothane (HAL) linkage group.

    abstract::Two cDNA probes for the porcine calcium release channel gene (CRC) were used in restriction fragment length polymorphism (RFLP) analysis in an attempt to develop genetic markers linked to the malignant hyperthermia (stress susceptibility) gene (HAL). Three TaqI RFLPs, denoted CRC1-CRC3, each composed of two alleles, w...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1992.tb00138.x

    authors: Mariani P,Johansson M,Ellegren H,Harbitz I,Juneja RK,Andersson L

    更新日期:1992-01-01 00:00:00

  • Assessment of DNA fingerprinting for determining genetic diversity in sheep populations.

    abstract::Genomic DNA, prepared from 12 animals from four sheep flocks, was digested with either HaeIII or HinfI and probed with three DNA fingerprinting probes. Mean DNA fingerprint band sharing and band frequency calculated for each flock were used to estimate genetic diversity. Each of the DNA fingerprinting systems showed t...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1993.tb00345.x

    authors: Hermans IF,Morris CA,Chambers GK,Towers NR,Jordan TW

    更新日期:1993-10-01 00:00:00

  • Genomic structure and gene order of swine chromosome 7q1.1-->q1.2.

    abstract::To clarify the structure of the porcine genomic region that contains quantitative trait loci (QTL) related to fat, we constructed a bacterial artificial chromosome (BAC) contig of the region from DST to SRPK1 on porcine chromosome 7 and performed low-redundancy 'skim' shotgun sequencing of the clones that composed a m...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2005.01362.x

    authors: Tanaka M,Suzuki K,Morozumi T,Kobayashi E,Matsumoto T,Domukai M,Eguchi-Ogawa T,Shinkai H,Awata T,Uenishi H

    更新日期:2006-02-01 00:00:00

  • Expression levels of 25 genes in liver and testis located in a QTL region for androstenone on SSC7q1.2.

    abstract::A quantitative trait locus (QTL) for boar fat androstenone levels has been identified near the SSC7 centromere in a Large White × Meishan cross. Backcrosses were produced to isolate the Chinese haplotype in a European genetic background. The expression of 25 genes from the QTL region was studied in the testes and live...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2011.02195.x

    authors: Robic A,Fève K,Larzul C,Billon Y,van Son M,Liaubet L,Sarry J,Milan D,Grindflek E,Bidanel JP,Riquet J

    更新日期:2011-12-01 00:00:00

  • Maternity validation using sire-only BovineSNP50 BeadChip data.

    abstract::Based on pairwise identity-by-state (IBS) distances and whole-genome SNP data, kinship was investigated in the Israeli Holstein population. A total of 789 bulls, including most of the artificial insemination sires in service since 1987, were genotyped by the BovineSNP50 BeadChip. This sample included up to five genera...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12062

    authors: Seroussi E,Glick G,Shirak A,Ezra E,Zeron Y,Ron M,Weller JI

    更新日期:2013-12-01 00:00:00