Abstract:
:Two cDNA probes for the porcine calcium release channel gene (CRC) were used in restriction fragment length polymorphism (RFLP) analysis in an attempt to develop genetic markers linked to the malignant hyperthermia (stress susceptibility) gene (HAL). Three TaqI RFLPs, denoted CRC1-CRC3, each composed of two alleles, were detected. RFLPs were also detected with MspI and PvuII, but the MspI RFLP correlated completely with CRC3 in this material and the PvuII RFLP could not be scored reliably due to a minute size difference between the two allelic fragments. The autosomal codominant inheritance of these RFLP loci was confirmed by family analyses. Significant evidence for genetic linkage between the CRC1/CRC3 loci and the A1BG locus in the HAL linkage group confirmed a previous assignment of the CRC gene to chromosome 6 in the pig.
journal_name
Anim Genetjournal_title
Animal geneticsauthors
Mariani P,Johansson M,Ellegren H,Harbitz I,Juneja RK,Andersson Ldoi
10.1111/j.1365-2052.1992.tb00138.xsubject
Has Abstractpub_date
1992-01-01 00:00:00pages
257-62issue
3eissn
0268-9146issn
1365-2052journal_volume
23pub_type
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