Farm-by-farm analysis of microsatellite, mtDNA and SNP genotype data reveals inbreeding and crossbreeding as threats to the survival of a native Spanish pig breed.

Abstract:

:The Chato Murciano (CM), a pig breed from the Murcia region in the southeastern region of Spain, is a good model for endangered livestock populations. The remaining populations are bred on approximately 15 small farms, and no herdbook exists. To assess the genetic threats to the integrity and survival of the CM breed, and to aid in designing a conservation program, three genetic marker systems - microsatellites, SNPs and mtDNA - were applied across the majority of the total breeding stock. In addition, mtDNA and SNPs were genotyped in breeds that likely contributed genetically to the current CM gene pool. The analyses revealed the levels of genetic diversity within the range of other European local breeds (H(e) = 0.53). However, when the eight farms that rear at least 10 CM pigs were independently analyzed, high levels of inbreeding were found in some. Despite the evidence for recent crossbreeding with commercial breeds on a few farms, the entire breeding stock remains readily identifiable as CM, facilitating the design of traceability assays. The genetic management of the breed is consistent with farm size, farm owner and presence of other pig breeds on the farm, demonstrating the highly ad hoc nature of current CM breeding. The results of genetic diversity and substructure of the entire breed, as well as admixture and crossbreeding obtained in the present study, provide a benchmark to develop future conservation strategies. Furthermore, this study demonstrates that identifying farm-based practices and farm-based breeding stocks can aid in the design of a sustainable breeding program for minority breeds.

journal_name

Anim Genet

journal_title

Animal genetics

authors

Herrero-Medrano JM,Megens HJ,Crooijmans RP,Abellaneda JM,Ramis G

doi

10.1111/age.12001

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

259-66

issue

3

eissn

0268-9146

issn

1365-2052

journal_volume

44

pub_type

杂志文章
  • Three new MHC haplotypes in broiler breeder chickens.

    abstract::Six distinct serotypes of the chicken B blood group system (which encodes the major histocompatibility complex) were identified in a commercial broiler breeder line (Line C). The B serotypes were compared by B-G restriction fragment length polymorphism (RFLP) analysis, allele-specific PCR typing test for B-LBII family...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.2001.00741.x

    authors: Livant EJ,Zheng D,Johnson LW,Shi W,Ewald SJ

    更新日期:2001-06-01 00:00:00

  • Quantitative trait loci affecting eggshell traits in an F(2) population.

    abstract::Good eggshell quality is important for both table egg quality and chicken reproductive performance. Weak eggshells cause economic losses in all production steps. Poor eggshell quality also poses increased risk for Salmonella infections. Eggshell quality has been a difficult trait to improve by traditional breeding, as...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2010.02131.x

    authors: Tuiskula-Haavisto M,Honkatukia M,Preisinger R,Schmutz M,de Koning DJ,Wei WH,Vilkki J

    更新日期:2011-06-01 00:00:00

  • From information to understanding: the role of model organism databases in comparative and functional genomics.

    abstract::Data integration is key to functional and comparative genomics because integration allows diverse data types to be evaluated in new contexts. To achieve data integration in a scalable and sensible way, semantic standards are needed, both for naming things (standardized nomenclatures, use of key words) and also for kno...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2006.01475.x

    authors: Bult CJ

    更新日期:2006-08-01 00:00:00

  • Transcriptome analysis of the endometrium from Chinese Erhualian sows that differ in calcium ion concentration and litter size.

    abstract::Embryonic survival rate, an important factor in the fecundity of sows, is affected by endometrium-secreting histotroph. A higher concentration of calcium ion has been observed in the uterus of highly prolific Erhualian sows (EH) compared with those of less prolific (EL) sows. This suggests that EH sows have better est...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12788

    authors: Ma X,Li P,Zhang Q,He L,Su G,Huang Y,Lu Z,Hu W,Ding H,Huang R

    更新日期:2019-08-01 00:00:00

  • Joint report of the Third International Workshop on Lymphocyte Alloantigens of the Horse, Kennett Square, Pennsylvania, 25-27 April 1984.

    abstract::The Third International Workshop on Lymphocyte Alloantigens of the Horse was held on 25-27 April 1984 in Kennett Square, Pennsylvania. Twelve laboratories from five countries participated. The principal purpose of this Workshop was to determine the phenotypic and gene frequencies of the 10 equine lymphocyte antigens (...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1986.tb00730.x

    authors: Antczak DF,Bailey E,Barger B,Guerin G,Lazary S,McClure J,Mottironi VD,Symons R,Templeton J,Varewyck H

    更新日期:1986-01-01 00:00:00

  • Isolation of microsatellites from a bovine YAC clone harbouring the SOD1 gene.

    abstract::A bovine yeast artificial chromosome (YAC) clone containing the superoxide dismutase 1 (SOD1) gene was used as a template for polymerase chain reaction (PCR) amplification using a conserved short interspersed nuclear element (SINE) primer. Two highly polymorphic microsatellites with nine and eight alleles were isolate...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1997.00158.x

    authors: Band M,Eggen A,Bishop MD,Ron M

    更新日期:1997-10-01 00:00:00

  • Identification of copy number variations in three Chinese horse breeds using 70K single nucleotide polymorphism BeadChip array.

    abstract::Copy number variation (CNV), an essential form of genetic variation, has been increasingly recognized as one promising genetic marker in the analysis of animal genomes. Here, we used the Equine 70K single nucleotide polymorphism genotyping array for the genome-wide detection of CNVs in 96 horses from three diverse Chi...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12451

    authors: Kader A,Liu X,Dong K,Song S,Pan J,Yang M,Chen X,He X,Jiang L,Ma Y

    更新日期:2016-10-01 00:00:00

  • On measures of association among genetic variables.

    abstract::Systems involving many variables are important in population and quantitative genetics, for example, in multi-trait prediction of breeding values and in exploration of multi-locus associations. We studied departures of the joint distribution of sets of genetic variables from independence. New measures of association b...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2012.02326.x

    authors: Gianola D,Manfredi E,Simianer H

    更新日期:2012-07-01 00:00:00

  • Genetic dissection of bull fertility in US Jersey dairy cattle.

    abstract::The service sire has been recognized as an important factor affecting herd fertility in dairy cattle. Recent studies suggest that genetic factors explain part of the difference in fertility among Holstein sires. The main objective of this study was to dissect the genetic architecture of sire fertility in US Jersey cat...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12710

    authors: Rezende FM,Dietsch GO,Peñagaricano F

    更新日期:2018-10-01 00:00:00

  • Genomic regions influencing intramuscular fat in divergently selected rabbit lines.

    abstract::Intramuscular fat (IMF) is one of the main meat quality traits for breeding programmes in livestock species. The main objective of this study was to identify genomic regions associated with IMF content comparing two rabbit populations divergently selected for this trait, and to generate a list of putative candidate ge...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12873

    authors: Sosa-Madrid BS,Hernández P,Blasco A,Haley CS,Fontanesi L,Santacreu MA,Pena RN,Navarro P,Ibáñez-Escriche N

    更新日期:2020-02-01 00:00:00

  • Isolation and genetic characterization of the porcine apolipoprotein E gene.

    abstract::The present report describes the isolation and genetic characterization of the porcine apolipoprotein E (apo-E) gene. A single positive recombinant phage clone containing a 10.7-kb insert was isolated from a porcine genomic library, and a 4.2-kb fragment was subcloned and sequenced. The 4.2-kb fragment contained the e...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.1998.00273.x

    authors: Ramsoondar JJ,Rucker EB,Vasquez JC,Gallagher DS,Grimm DR,Lunney JK,Schook LB,Piedrahita JA

    更新日期:1998-02-01 00:00:00

  • Association analyses of single nucleotide polymorphisms in bovine stearoyl-CoA desaturase and fatty acid synthase genes with fatty acid composition in commercial cross-bred beef steers.

    abstract::Two previously reported non-synonymous coding single nucleotide polymorphisms (SNPs) of bovine stearoyl-CoA desaturase (delta-9-desaturase) (SCD) (c.878C>T) and fatty acid synthase (FASN) (g:17924A>G) were assessed for their associations with 72 individual and 12 groups of fatty acids in brisket adipose tissue of 223 ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2011.02217.x

    authors: Li C,Aldai N,Vinsky M,Dugan ME,McAllister TA

    更新日期:2012-02-01 00:00:00

  • Characterization of Iberian pig genotypes using AFLP markers.

    abstract::The use of the AFLP (amplified fragment length polymorphism) technique for the characterization of highly inbred Iberian pig breed genotypes and the detection of strain-specific polymorphisms is demonstrated. Twelve different primer combinations were used on individual DNA samples from animals belonging to two black h...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.2000.00603.x

    authors: Ovilo C,Cervera MT,Castellanos C,Martínez-Zapater JM

    更新日期:2000-04-01 00:00:00

  • The genetic structure of Spanish Celtic horse breeds inferred from microsatellite data.

    abstract::Partition of the genetic variability, genetic structure and relationships among seven Spanish Celtic horse breeds were studied using PCR amplification of 13 microsatellites on 481 random individuals. In addition, 60 thoroughbred horses were included. The average observed heterozygosity and the mean number of alleles w...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.2000.00591.x

    authors: Cañon J,Checa ML,Carleos C,Vega-Pla JL,Vallejo M,Dunner S

    更新日期:2000-02-01 00:00:00

  • Marker-derived phylogeny of European cattle supports demic expansion of agriculture.

    abstract::Using frequencies of 86 genes from 23 loci of blood group systems, blood and milk proteins, the genetic relationships among 14 cattle breeds including four native Balkan and four synthetic Balkan-Alp breeds were studied. The dendrogram and nonlinear map construction shows a consensus 'Balkan breed cluster', an 'Alp br...

    journal_title:Animal genetics

    pub_type: 历史文章,杂志文章

    doi:10.1111/j.1365-2052.1994.tb00399.x

    authors: Medjugorac I,Kustermann W,Lazar P,Russ I,Pirchner F

    更新日期:1994-06-01 00:00:00

  • Quantitative trait loci for litter size and prenatal loss in a White Duroc x Chinese Erhualian resource population.

    abstract::To detect quantitative trait loci (QTL) for litter size related traits, the total number of born piglets (TNB), the number of born alive piglets (NBA), the number of stillborn piglets (NSB) and the number of mummies (NM) at the first parity were recorded in 299 F(2) sows in a White Duroc x Chinese Erhualian intercross...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2009.01931.x

    authors: Li K,Ren J,Xing Y,Zhang Z,Ma J,Guo Y,Huang L

    更新日期:2009-12-01 00:00:00

  • Extending the chicken-human comparative map by placing 15 genes on the chicken linkage map.

    abstract::To increase the number of type I loci on the chicken linkage map, chicken genes containing microsatellite sequences (TAn, CAn, GAn, An) were selected from the nucleotide sequence database and primers were developed to amplify the repeats. Initially, 40 different microsatellites located within genes were tested on a pa...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.1999.00527.x

    authors: Groenen MA,Crooijmans RP,Dijkhof RJ,Acar R,van der Poel JJ

    更新日期:1999-12-01 00:00:00

  • Restriction fragment length polymorphisms for growth hormone, prolactin, osteonectin, alpha crystallin, gamma crystallin, fibronectin and 21-steroid hydroxylase in cattle.

    abstract::Genomic DNAs from animals representing six breeds of cattle (Angus, Brahman, Hereford, Holstein, Jersey and Texas Longhorn) were screened with cloned gene probes in a search for restriction fragment length polymorphisms (RFLPs). Eleven RFLPs were identified using seven different probes: growth hormone, prolactin, oste...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1989.tb00866.x

    authors: Theilmann JL,Skow LC,Baker JF,Womack JE

    更新日期:1989-01-01 00:00:00

  • Identification of a premature stop codon in the melanocyte-stimulating hormone receptor gene (MC1R) in Labrador and Golden retrievers with yellow coat colour.

    abstract::We have examined whether black/yellow coat colour in Labrador retrievers is controlled by allelic variants at the extension locus. As the gene encoding the melanocyte-stimulating hormone receptor (MC1R) has been shown to correspond to the extension locus in several species, we have determined the genomic MC1R sequence...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.2000.00639.x

    authors: Everts RE,Rothuizen J,van Oost BA

    更新日期:2000-06-01 00:00:00

  • Recombination rates and gene order for some serum alpha-protease inhibitors and immunoglobulin heavy-chain allotypes in pigs.

    abstract::Linkage analysis between the genes coding for immunoglobulin heavy-chain allotypes and variants of some serum alpha-protease inhibitors produced lod scores above the significance limit of 3. The maximum likelihood estimate of the recombination fraction (theta) ranged from 0.15 to 0.20. Since this is the second report ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1987.tb00779.x

    authors: Vögeli P,Kühne R,Wysshaar M,Stranzinger G

    更新日期:1987-01-01 00:00:00

  • Assessing footprints of selection in commercial Atlantic salmon populations using microsatellite data.

    abstract::Relatively large rates of response to traits of economic importance have been observed in different selection experiments in salmon. Several QTL have been mapped in the salmon genome, explaining unprecedented levels of phenotypic variation. Owing to the relatively large selection intensity, individual loci may be indi...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2012.02387.x

    authors: Martinez V,Dettleff P,Lopez P,Fernandez G,Jedlicki A,Yañez JM,Davidson WS

    更新日期:2013-04-01 00:00:00

  • Identification of the myostatin locus (MSTN) as having a major effect on optimum racing distance in the Thoroughbred horse in the USA.

    abstract::One hundred and eighty-nine Thoroughbred horses that had won Graded Stakes races in North America were genotyped with the Illumina Equine SNP50 bead chip. Association tests using PLINK to determine whether any SNPs were associated with optimum racing distance (7 furlongs and under compared to 8-10 furlongs) identified...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2010.02126.x

    authors: Binns MM,Boehler DA,Lambert DH

    更新日期:2010-12-01 00:00:00

  • Equine disease association studies: a clinician's perspective.

    abstract::Diagnostic criteria should be carefully defined and described in disease association studies to allow (1) comparison among studies from different laboratories evaluating the same disease, (2) critical evaluation of selection procedures of patients, and (3) to strengthen genuine associations with any genetic marker sys...

    journal_title:Animal genetics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2052.1988.tb00832.x

    authors: McClure JJ

    更新日期:1988-01-01 00:00:00

  • A proposal for standardization in forensic equine DNA typing: allele nomenclature for 17 equine-specific STR loci.

    abstract::In this study, a proposal is presented for the allele nomenclature of 17 polymorphic STR loci (AHT4, AHT5, ASB2, ASB17, ASB23, CA425, HMS1, HMS2, HMS3, HMS6, HMS7, HTG4, HTG6, HTG7, HTG10, LEX3 and VHL20) for equine genotyping (Equus caballus). The nomenclature is based on sequence data of the polymorphic region of th...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2009.01975.x

    authors: van de Goor LH,Panneman H,van Haeringen WA

    更新日期:2010-04-01 00:00:00

  • Genomic prediction of reproduction traits for Merino sheep.

    abstract::Economically important reproduction traits in sheep, such as number of lambs weaned and litter size, are expressed only in females and later in life after most selection decisions are made, which makes them ideal candidates for genomic selection. Accurate genomic predictions would lead to greater genetic gain for thes...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12541

    authors: Bolormaa S,Brown DJ,Swan AA,van der Werf JHJ,Hayes BJ,Daetwyler HD

    更新日期:2017-06-01 00:00:00

  • Resistance to malignant catarrhal fever in American bison (Bison bison) is associated with MHC class IIa polymorphisms.

    abstract::The Rhadinovirus ovine herpesvirus-2 (OvHV-2) is the most common causative agent of malignant catarrhal fever (MCF) in clinically susceptible ruminants including cattle and bison. American bison (Bison bison) are highly susceptible to clinical MCF. Nevertheless, approximately 20% of bison on ranches or in feedlots bec...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2007.01575.x

    authors: Traul DL,Li H,Dasgupta N,O'Toole D,Eldridge JA,Besser TE,Davies CJ

    更新日期:2007-04-01 00:00:00

  • An integrated comparative map of the porcine X chromosome.

    abstract::The objectives of this study were to assign both microsatellite and gene-based markers on porcine chromosome X to two radiation hybrid (RH) panels and to develop a more extensive integrated map of SSC-X. Thirty-five microsatellite and 20 gene-based markers were assigned to T43RH, and 16 previously unreported microsate...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.2002.00878.x

    authors: McCoard SA,Fahrenkrug SC,Alexander LJ,Freking BA,Rohrer GA,Wise TH,Ford JJ

    更新日期:2002-06-01 00:00:00

  • Genetic variation within and among domesticated Atlantic salmon broodstocks in British Columbia, Canada.

    abstract::Atlantic salmon have been reared in the British Columbia, Canada aquaculture industry since the early 1980s. No breeding programmes spanned the entire production period and pedigree records were not kept for broodstocks prior to or since importation. Of the three recognized industry strains, two are of European ancest...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2004.01220.x

    authors: Withler RE,Supernault KJ,Miller KM

    更新日期:2005-02-01 00:00:00

  • Albinism in the American mink (Neovison vison) is associated with a tyrosinase nonsense mutation.

    abstract::Albino phenotypes are documented in various species including the American mink. In other species the albino phenotypes are associated with tyrosinase (TYR) gene mutations; therefore TYR was considered the candidate gene for albinism in mink. Four microsatellite markers were chosen in the predicted region of the TYR g...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2008.01788.x

    authors: Anistoroaei R,Fredholm M,Christensen K,Leeb T

    更新日期:2008-12-01 00:00:00

  • A new lipoprotein allotype Lpr3 and allele Lpr1,3 in the pig.

    abstract::Specific alloprecipitins were found in blood plasma of pigs, immunized by sera of Lpr1 positive donors. These precipitins detected a new allotype of the lipoprotein Lpr system which was designated Lpr3. Genetic studies confirmed its codominant inheritance and subgroup character. This linear subgroup of allotype Lpr1 i...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1993.tb00361.x

    authors: Hojný J,Janik A,Schröffel J Jr

    更新日期:1993-12-01 00:00:00