Abstract:
:The present report describes the isolation and genetic characterization of the porcine apolipoprotein E (apo-E) gene. A single positive recombinant phage clone containing a 10.7-kb insert was isolated from a porcine genomic library, and a 4.2-kb fragment was subcloned and sequenced. The 4.2-kb fragment contained the entire apo-E gene in addition to upstream and downstream sequences (GenBank accession no. 470240). The porcine apo-E gene is made up of four exons and three introns, and encodes a preapo-E protein comprised of a signal peptide of 18 amino acids and a mature protein of 299 amino acids. The porcine apo-E gene contains a (CG)13 microsatellite marker within intron three. This microsatellite is moderately polymorphic, and at least four alleles were evident at this locus among 10 animals from each of the Yorkshire, Hampshire, Landrace and Duroc breeds. Finally, localization of the porcine apo-E gene to chromosome 6 band q2.1 was determined by fluorescent in situ hybridization and confirmed by genetic linkage analysis.
journal_name
Anim Genetjournal_title
Animal geneticsauthors
Ramsoondar JJ,Rucker EB,Vasquez JC,Gallagher DS,Grimm DR,Lunney JK,Schook LB,Piedrahita JAdoi
10.1046/j.1365-2052.1998.00273.xsubject
Has Abstractpub_date
1998-02-01 00:00:00pages
43-7issue
1eissn
0268-9146issn
1365-2052journal_volume
29pub_type
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