T lymphocyte development and maturation in horses.

Abstract:

:Monoclonal antibodies specific for equine T lymphocyte subpopulations were produced and procedures for the continuous culture of equine lymphocytes were developed. These reagents and procedures were used to analyse the appearance, maturation and functions of T lymphocytes in normal horses and in T lymphocyte deficient horses with severe combined immunodeficiency (SCID). T lymphocytes appeared as early as the 75th day of fetal development and were normally distributed prior to birth of normal foals. Analysis of thymic T lymphocyte differentiation in SCID foals revealed the presence of both prothymocytes and mature thymocytes, but a virtual absence of cortical thymocytes. The data obtained support the hypothesis that two distinct pathways of T lymphocyte differentiation exist within the thymus. Although the gene defect in foals with SCID blocks the production of mature B and T lymphocytes, such foals do possess large granular lymphocytes which are cytotoxic following induction with interleukin 2. This suggests that lymphoid cells with natural killer cell activity are spared by the gene defect resulting in SCID in horses.

journal_name

Anim Genet

journal_title

Animal genetics

authors

Perryman LE,Wyatt CR,Magnuson NS,Mason PH

doi

10.1111/j.1365-2052.1988.tb00825.x

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

343-8

issue

4

eissn

0268-9146

issn

1365-2052

journal_volume

19

pub_type

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