Abstract:
:Extracellular superoxide dismutase (SOD3) is a major antioxidant enzyme that protects organs from damage by reactive oxygen species (ROS). In this study, the SOD3 gene was identified and characterized from the freshwater mussel Hyriopsis cumingii (Hc-SOD3). The cDNA sequence consists of 763 bp, encoding a protein of 208 amino acids. The amino acid sequence possesses two CuZnSOD signature sequences, and amino acids required for binding of Cu (His-93, -95, -110 and -169) and Zn (His-110, -118, -129 and Asp-132) were conserved in Hc-SOD3. The Hc-SOD3 genomic sequence was 9165 bp in length, containing four exons and three introns. Eighteen single nucleotide polymorphisms were detected in the Hc-SOD3 gene from resistant stock (RS) and susceptible stock (SS) of H. cumingii to Aeromonas hydrophila. The genotype and allele distribution were examined in resistant and susceptible stocks. Among them, a C/G substitution at the g.7994C>G locus and G/C substitution at the g.8087G>C locus were significantly associated with resistance/susceptibility of H. cumingii to A. hydrophila, both in genotype (P = 0.017, P = 0.004 respectively) and allele frequency (P = 0.021, P = 0.006 respectively). Linkage disequilibrium analysis revealed that g.7994C>G, g.8001A>G, g.8035G>A, g.8087G>C and g.8191T>A were in linkage disequilibrium. The results suggest that the two polymorphic loci, g.7994C>G and g.8087G>C, could be potential genetic markers for future molecular selection of strains that are resistant to diseases.
journal_name
Anim Genetjournal_title
Animal geneticsauthors
Wang GL,Li XL,Li JLdoi
10.1111/age.12059subject
Has Abstractpub_date
2013-12-01 00:00:00pages
693-702issue
6eissn
0268-9146issn
1365-2052journal_volume
44pub_type
杂志文章相关文献
ANIMAL GENETICS文献大全abstract::Animals were identified from two sire lines as being homozygous for the class I bovine lymphocyte antigen (BoLA-A) w23. These animals were also shown to be homozygous for class II antigens (BoLA-D) which, however, differed between the two sire lines. Lymphocytes from these animals were then used either as stimulator c...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1990.tb03218.x
更新日期:1990-01-01 00:00:00
abstract::There are two categories of immune responses - innate and adaptive immunity - both having polygenic backgrounds and a significant environmental component. In our study, adaptive immunity was represented by the specific antibody response toward keyhole limpet hemocyanin (KLH); innate immunity was represented by natural...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12280
更新日期:2015-06-01 00:00:00
abstract::A genetic disease observed in certain Quarter horses is hyperkalaemic periodic paralysis (HYPP). This disease causes attacks of paralysis which can be induced by ingestion of potassium. Recent studies have shown that HYPP in humans is due to single base changes within the adult skeletal muscle sodium channel gene. A l...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1992.tb00136.x
更新日期:1992-01-01 00:00:00
abstract::Atlantic salmon have been reared in the British Columbia, Canada aquaculture industry since the early 1980s. No breeding programmes spanned the entire production period and pedigree records were not kept for broodstocks prior to or since importation. Of the three recognized industry strains, two are of European ancest...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2004.01220.x
更新日期:2005-02-01 00:00:00
abstract::The role of the porcine GH gene was investigated in 292 F2 animals of mating Wild Boar x Piétrain and in 310 F2 animals of mating Meishan x Piétrain. Forty-three traits of fattening, carcass composition, meat quality and stress resistance were recorded. For the analysis of associations between GH gene variants and qua...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1997.00093.x
更新日期:1997-04-01 00:00:00
abstract::The genetic differentiation and phylogenetic relationships of 18 indigenous goat populations from seven East Asian countries were analysed based on data obtained from 26 microsatellite DNA markers. The mean number of alleles (MNA) per population ranged from 2.5 to 7.6, with an average of 5.8. Genetic variability estim...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2012.02334.x
更新日期:2012-12-01 00:00:00
abstract::Insulin-like growth factor 2 (IGF2) is an imprinted gene expressed in most tissues affecting lean muscle content in mice, pigs and cattle. We previously identified the bovine IGF2 c.-292C>T SNP in the non-translated exon 2. Using this SNP, we demonstrated biallelic expression of IGF2 after birth. Seven alternatively s...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2007.01576.x
更新日期:2007-04-01 00:00:00
abstract::Presented herein is an updated sheep cytogenetic map that contains 452 loci (291 type I and 161 type II) assigned to specific chromosome bands or regions on standard R-banded ideograms. This map, which significantly extends our knowledge of the physical organization of the ovine genome, includes new assignments for 88...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2007.01598.x
更新日期:2007-06-01 00:00:00
abstract::Toll-like receptor 3 (TLR3) has an important protective function against viral infection. The ability of an individual to respond properly to TLR ligands may be impaired by variants located in the TLR genes. By directly PCR sequencing four exons and their flanking sequence of chicken TLR3, a total of 50 nucleotide var...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2011.02244.x
更新日期:2012-06-01 00:00:00
abstract::Although there are differences in performance between genetic groups of channel catfish, identification and management of these groups is difficult because catfish strains look alike and individuals cannot be tagged efficiently. Thus, US catfish producers have not been able to objectively identify fish from different ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2007.01586.x
更新日期:2007-04-01 00:00:00
abstract::Cryptorchidism is the most common disorder of sex development in dogs and testosterone plays a crucial role in the inguinal phase of the testes descending into the scrotum. The molecular background of impaired testosterone synthesis in the testes of cryptorchid dogs is poorly elucidated. In this study, we analyzed the...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12977
更新日期:2020-10-01 00:00:00
abstract::A bovine yeast artificial chromosome (YAC) clone containing the superoxide dismutase 1 (SOD1) gene was used as a template for polymerase chain reaction (PCR) amplification using a conserved short interspersed nuclear element (SINE) primer. Two highly polymorphic microsatellites with nine and eight alleles were isolate...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1997.00158.x
更新日期:1997-10-01 00:00:00
abstract::Quantitative trait loci (QTL) mapping for susceptibility to a Salmonella Abortusovis vaccinal strain was performed using an experimental design involving 30 Romane sheep sire families (1216 progenies). Nine QTL corresponding to bacterial load, weight variations and antibody response criteria were mapped on eight chrom...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2011.02291.x
更新日期:2012-10-01 00:00:00
abstract::Positive selection not only increases beneficial allele frequency but also causes augmentation of allele frequencies of sequence variants in close proximity. Signals for positive selection were detected by the statistical differences in subsequent allele frequencies. To identify selection signatures in Korean cattle, ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12209
更新日期:2014-12-01 00:00:00
abstract::Israeli Holstein-Friesian dairy bulls were screened for restriction fragment length polymorphisms by hybridizing cloned DNA probes for bovine growth hormone, for chymosin, and for rat muscle beta-actin to restriction endonuclease-digested DNA immobilized on nitrocellulose filters. The population proved to be polymorph...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1986.tb03185.x
更新日期:1986-01-01 00:00:00
abstract::The mitochondrial hypervariable region 1 (HVR1) sequence of 67 goats belonging to the Girgentana, Maltese and Derivata di Siria breeds was partially sequenced in order to present the first phylogenetic characterization of Sicilian goat breeds. These sequences were compared with published sequences of Indian and Pakist...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2006.01451.x
更新日期:2006-08-01 00:00:00
abstract::The expression of haemoglobin (Hb) has been studied in 260 Norwegian Dairy goats by the Immobiline technique at pH ranges 6.7-7.7, 6.9-7.6 and 6.9-7.5. The majority of goats exhibited two- or four-band patterns. In two-band types the average ratio between the anodal and cathodal band was 74:26. PAGE with 8M urea disti...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1987.tb00762.x
更新日期:1987-01-01 00:00:00
abstract::We have examined whether black/yellow coat colour in Labrador retrievers is controlled by allelic variants at the extension locus. As the gene encoding the melanocyte-stimulating hormone receptor (MC1R) has been shown to correspond to the extension locus in several species, we have determined the genomic MC1R sequence...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1046/j.1365-2052.2000.00639.x
更新日期:2000-06-01 00:00:00
abstract::To increase the number of type I loci on the chicken linkage map, chicken genes containing microsatellite sequences (TAn, CAn, GAn, An) were selected from the nucleotide sequence database and primers were developed to amplify the repeats. Initially, 40 different microsatellites located within genes were tested on a pa...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1046/j.1365-2052.1999.00527.x
更新日期:1999-12-01 00:00:00
abstract::We describe a polymorphism in the bovine gene PTHG which can be readily typed by PCR assay. The polymorphism is codominantly inherited and the allele frequencies appear characteristic of Bo indicus and B. taurus cattle. ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1993.tb00323.x
更新日期:1993-08-01 00:00:00
abstract::Campylobacter jejuni is one of the most common causes of human bacterial enteritis worldwide. The molecular mechanisms of the host responses of chickens to C. jejuni colonization are not well understood. We have previously found differences in C. jejuni colonization at 7-days post-inoculation (pi) between two genetic ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2010.02168.x
更新日期:2011-10-01 00:00:00
abstract::We present herein a bovine chromosome 24 (BTA24) radiation hybrid (RH) map using 40 markers scored on a panel of 90 RHs. Of these markers, 29 loci were ordered with odds of at least 1000:1 in a framework map. An average retention frequency of 17.4% was observed, with relatively higher frequencies near the centromere. ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1046/j.1365-2052.2003.00996.x
更新日期:2003-06-01 00:00:00
abstract::One hundred and eighty-nine Thoroughbred horses that had won Graded Stakes races in North America were genotyped with the Illumina Equine SNP50 bead chip. Association tests using PLINK to determine whether any SNPs were associated with optimum racing distance (7 furlongs and under compared to 8-10 furlongs) identified...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2010.02126.x
更新日期:2010-12-01 00:00:00
abstract::Relatively large rates of response to traits of economic importance have been observed in different selection experiments in salmon. Several QTL have been mapped in the salmon genome, explaining unprecedented levels of phenotypic variation. Owing to the relatively large selection intensity, individual loci may be indi...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2012.02387.x
更新日期:2013-04-01 00:00:00
abstract::Ovine hereditary chondrodysplasia, or spider lamb syndrome (SLS), is a genetic disorder that is characterized by severe skeletal abnormalities and has resulted in substantial economic losses for sheep producers. Here we demonstrate that a non-synonymous T>A transversion in the highly conserved tyrosine kinase II domai...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2005.01398.x
更新日期:2006-02-01 00:00:00
abstract::Genomic imprinting is a mammalian developmental process that uses epigenetic mechanisms to induce monoallelic and parental-specific expression of particular autosomal genes. A crucial epigenetic event consists of DNA methylation of CpG-islands, which become differentially methylated regions (DMRs) on the maternal and ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2009.01939.x
更新日期:2009-12-01 00:00:00
abstract::The crest in chicken consists of elongated and upraised feathers, as seen in various breeds such as the Silkie chicken. Recently, the still unknown causative mutation for the crest phenotype was assigned to chromosome 33 and an ectopic expression of HOXC8 was shown. The aim this study was to evaluate whether the crest...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12674
更新日期:2018-08-01 00:00:00
abstract::Nucleotide-Binding Oligomerization Domain 2 (NOD2) has been reported to be a candidate gene for Mycobacterium avium subsp. paratuberculosis (MAP) infection in a Bos taurus × Bos indicus mixed breed based on a genetic association with the c.2197T>C single nucleotide polymorphism (SNP). Nevertheless, this SNP has also b...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2010.02055.x
更新日期:2010-12-01 00:00:00
abstract::Understanding the genetic basis of variation in traits related to growth and fillet quality in Atlantic salmon is of importance to the aquaculture industry. Several growth-related QTL have been identified via the application of genetic markers. The IGF1 gene is considered a highly conserved and crucial growth-regulati...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12202
更新日期:2014-10-01 00:00:00
abstract::We present the first radiation hybrid (RH) map of river buffalo (Bubalus bubalis) chromosome 6 (BBU6) developed with a recently constructed river buffalo whole-genome RH panel (BBURH(5000)). The preliminary map contains 33 cattle-derived markers, including 12 microsatellites, 19 coding genes and two ESTs, distributed ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2007.01612.x
更新日期:2007-08-01 00:00:00