Extending the chicken-human comparative map by placing 15 genes on the chicken linkage map.

Abstract:

:To increase the number of type I loci on the chicken linkage map, chicken genes containing microsatellite sequences (TAn, CAn, GAn, An) were selected from the nucleotide sequence database and primers were developed to amplify the repeats. Initially, 40 different microsatellites located within genes were tested on a panel of animals from diverse breeds, and identified 17 polymorphic microsatellites. These polymorphisms allowed us to add 15 new genes to the chicken linkage map. In addition, two genes were added to the chicken map by fluorescent in situ hybridization. As the map position of the human homologues of 13 of these genes is known, these markers extend the comparative map between chicken and man. Our results confirm and refine conserved regions between chicken and man on chicken chromosomes 2 and 7 and on linkage group E29C09W09. Furthermore, an additional conserved region is identified on chromosome 7.

journal_name

Anim Genet

journal_title

Animal genetics

authors

Groenen MA,Crooijmans RP,Dijkhof RJ,Acar R,van der Poel JJ

doi

10.1046/j.1365-2052.1999.00527.x

subject

Has Abstract

pub_date

1999-12-01 00:00:00

pages

418-22

issue

6

eissn

0268-9146

issn

1365-2052

journal_volume

30

pub_type

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