Mapping and characterization of the DQ subregion of the ovine MHC.

Abstract:

:A map of the ovine MHC class II DQ subregion has been constructed from overlapping cosmid clones. This region consists of two loci linked on a linear tract of 130 kb DNA. Each locus consists of a DQA and a DQB gene in a tail-to-tail orientation. The genes in each locus are transcribed but only those designated DQ1 express class II molecules at the surface of mouse L cells following DNA-mediated gene transfection. The DQA1 and DQB1 genes are separated by 11 kb while the DQA2 and B2 genes are 25 kb apart. The loci are separated by 22 kb.

journal_name

Anim Genet

journal_title

Animal genetics

authors

Wright H,Ballingall KT

doi

10.1111/j.1365-2052.1994.tb00200.x

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

243-9

issue

4

eissn

0268-9146

issn

1365-2052

journal_volume

25

pub_type

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