Breed-specific expression of DROSHA, DICER and AGO2 is regulated by glucocorticoid-mediated miRNAs in the liver of newborn piglets.

Abstract:

:MicroRNA (miRNA) biogenesis is determined mainly by Drosha, Dicer and Argonaute2 (Ago2). Different breeds of pigs with vast differences in serum cortisol level demonstrate distinct profiles of hepatic miRNA expression. As yet, little is known about whether glucocorticoid contributes to the breed differences in miRNA biogenesis. Here, we used newborn Large White (LW) and Erhualian (EHL) piglets to investigate the role of glucocorticoid in breed-specific hepatic miRNA biogenesis. Erhualian piglets showing significantly higher serum cortisol level, as compared to LW, demonstrated higher hepatic expression of Drosha, Dicer and Ago2 at the protein level, but not at the mRNA level. At the post-transcriptional level, miRNAs that are predicted to target these proteins may be involved in the regulation. Hepatic expression of miR-15b and miR-222 was significantly lower in EHL piglets and was associated with higher glucocorticoid receptor binding to the respective promoter regions of miR-15b and miR-222 genes. The inhibitory effect of glucocorticoid on miR-15b and miR-222 expression was further verified in HepG2 cells, in which dexamethasone significantly downregulated the expression of primary transcripts of miR-15b and miR-222 genes. In conclusion, the higher protein content of Drosha, Dicer and Ago2 in the liver of EHL piglets is post-transcriptionally regulated, at least in part, by glucocorticoid-mediated repression of miR-15b and miR-222.

journal_name

Anim Genet

journal_title

Animal genetics

authors

Li R,Jia Y,Zou H,Zhao R

doi

10.1111/age.12232

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

817-26

issue

6

eissn

0268-9146

issn

1365-2052

journal_volume

45

pub_type

杂志文章
  • Bovine monoclonal alloantibodies to blood group antigens prepared by murine x bovine or (murine x bovine) x bovine interspecies fusions.

    abstract::In order to obtain monoclonal alloantibodies against bovine blood group antigens, lymph node cells from calves immunized with bovine red blood cells (RBC) were fused with either murine NSO/1 myeloma cells or a HAT sensitive murine x bovine heterohybridoma cell line. Both fusion partners resulted in heterohybridoma cel...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:

    authors: Hønberg LS,Larsen B

    更新日期:1992-01-01 00:00:00

  • A first-generation microsatellite linkage map of the Japanese quail.

    abstract::A linkage map of the Japanese quail (Coturnix japonica) genome was constructed based upon segregation analysis of 72 microsatellite loci in 433 F(2) progeny of 10 half-sib families obtained from a cross between two quail lines of different genetic origins. One line was selected for long duration of tonic immobility, a...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2004.01135.x

    authors: Kayang BB,Vignal A,Inoue-Murayama M,Miwa M,Monvoisin JL,Ito S,Minvielle F

    更新日期:2004-06-01 00:00:00

  • Effects of DGAT1 and GHR on milk yield and milk composition in the Chinese dairy population.

    abstract::Previous studies have demonstrated that the p.Lys232Ala substitution in the acylCoA: diacylglycerol acyltransferase (DGAT1) gene and the p.Phe279Tyr mutation in the growth hormone receptor (GHR) gene are the causative quantitative trait loci underlying milk yield and composition on BTA14 and BTA20 respectively. To exa...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2009.01945.x

    authors: Sun D,Jia J,Ma Y,Zhang Y,Wang Y,Yu Y,Zhang Y

    更新日期:2009-12-01 00:00:00

  • Biochemical characterization of the bovine genetic kappa-casein C and E variants.

    abstract::Analysis of elution profiles of enzymatic and CNBr digests of kappa-caseins C and E, and sequencing of most relevant peptides allowed the chemical characterization of both genetic variants. They differ from their B and A allelic counterparts by a single substitution, His97/Arg and Gly155/Ser, respectively. Electrophor...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1993.tb00915.x

    authors: Miranda G,Anglade P,Mahé MF,Erhardt G

    更新日期:1993-02-01 00:00:00

  • Three new MHC haplotypes in broiler breeder chickens.

    abstract::Six distinct serotypes of the chicken B blood group system (which encodes the major histocompatibility complex) were identified in a commercial broiler breeder line (Line C). The B serotypes were compared by B-G restriction fragment length polymorphism (RFLP) analysis, allele-specific PCR typing test for B-LBII family...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.2001.00741.x

    authors: Livant EJ,Zheng D,Johnson LW,Shi W,Ewald SJ

    更新日期:2001-06-01 00:00:00

  • Evaluation of HOXC8 in crested Swiss chicken.

    abstract::The crest in chicken consists of elongated and upraised feathers, as seen in various breeds such as the Silkie chicken. Recently, the still unknown causative mutation for the crest phenotype was assigned to chromosome 33 and an ectopic expression of HOXC8 was shown. The aim this study was to evaluate whether the crest...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12674

    authors: Joller S,Ammann P,Flury C,Drögemüller C

    更新日期:2018-08-01 00:00:00

  • Compound heterozygosity for TNXB genetic variants in a mixed-breed dog with Ehlers-Danlos syndrome.

    abstract::The Ehlers-Danlos syndromes (EDSs) are a heterogeneous group of inherited connective tissue disorders characterized by skin hyperextensibility, joint hypermobility and tissue fragility. Inherited disorders similar to human EDS have been reported in different mammalian species. In the present study, we investigated a f...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12830

    authors: Bauer A,de Lucia M,Leuthard F,Jagannathan V,Leeb T

    更新日期:2019-10-01 00:00:00

  • Chromosomal assignment of porcine microsatellites by use of a somatic cell hybrid mapping panel.

    abstract::A well-established and characterized somatic cell hybrid panel was used to map three polymorphic microsatellites. Microsatellite S0072, representing the linkage group S0007-S0072, was assigned to porcine chromosome 14. Microsatellite S0009, representing the unassigned linkage group EAM-S0009-S0071, was assigned tentat...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1994.tb00369.x

    authors: Rettenberger G,Fredholm M,Fries R

    更新日期:1994-10-01 00:00:00

  • Ligneous membranitis in Scottish Terriers is associated with a single nucleotide polymorphism in the plasminogen (PLG) gene.

    abstract::Ligneous membranitis (LM) is a rare chronic inflammatory condition of the mucous membranes associated with plasminogen (encoded by PLG) deficiency in affected humans and dogs. In human, the condition is genetic in nature with numerous mutations and polymorphisms in PLG identified in affected individuals and related fa...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12339

    authors: Ainsworth S,Carter S,Fisher C,Dawson J,Makrides L,Nuttall T,Mason SL

    更新日期:2015-12-01 00:00:00

  • Genetic variation within and among domesticated Atlantic salmon broodstocks in British Columbia, Canada.

    abstract::Atlantic salmon have been reared in the British Columbia, Canada aquaculture industry since the early 1980s. No breeding programmes spanned the entire production period and pedigree records were not kept for broodstocks prior to or since importation. Of the three recognized industry strains, two are of European ancest...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2004.01220.x

    authors: Withler RE,Supernault KJ,Miller KM

    更新日期:2005-02-01 00:00:00

  • Analysis of ROH patterns in the Noriker horse breed reveals signatures of selection for coat color and body size.

    abstract::Overlapping runs of homozygosity (ROH islands) shared by the majority of a population are hypothesized to be the result of selection around a target locus. In this study we investigated the impact of selection for coat color within the Noriker horse on autozygosity and ROH patterns. We analyzed overlapping homozygous ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12797

    authors: Grilz-Seger G,Druml T,Neuditschko M,Mesarič M,Cotman M,Brem G

    更新日期:2019-08-01 00:00:00

  • A post-GWAS confirming the SCD gene associated with milk medium- and long-chain unsaturated fatty acids in Chinese Holstein population.

    abstract::The stearoyl-CoA desaturase (delta-9-desaturase) gene encodes a key enzyme in the cellular biosynthesis of monounsaturated fatty acids. In our initial genome-wide association study (GWAS) of Chinese Holstein cows, 19 SNPs fell in a 1.8-Mb region (20.3-22.1 Mb) on chromosome 26 underlying the SCD gene and were highly s...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12432

    authors: Li C,Sun D,Zhang S,Liu L,Alim MA,Zhang Q

    更新日期:2016-08-01 00:00:00

  • Definition of the USDA103 strain of channel catfish (Ictalurus punctatus).

    abstract::Although there are differences in performance between genetic groups of channel catfish, identification and management of these groups is difficult because catfish strains look alike and individuals cannot be tagged efficiently. Thus, US catfish producers have not been able to objectively identify fish from different ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2007.01586.x

    authors: Waldbieser GC,Wolters WR

    更新日期:2007-04-01 00:00:00

  • Melanocortin-4 receptor (MC4R) genotypes have no major effect on fatness in a Large White x Wild Boar intercross.

    abstract::The melanocortin-4 receptor (MC4R), a G-protein coupled receptor, is implicated in mediating the effect of leptin on food intake and energy balance. A previous candidate gene study reported an association between an MC4R missense mutation (Asp298Asn) and fatness, growth and feed intake in pigs. To assess this associat...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.2002.00824.x

    authors: Park HB,Carlborg O,Marklund S,Andersson L

    更新日期:2002-04-01 00:00:00

  • Genome-wide association study identifies markers associated with carcass and meat quality traits in Italian Large White pigs.

    abstract::A GWAS was performed using the genotypes obtained by PorcineSNP60 v2 BeadChip and 11 phenotypic traits (carcass lean meat percentage; backfat thickness; Longissimus thoracis muscle thickness; lightness; backfat thickness measured with caliper at the midline; meat pH measured at about 1 h post mortem and 24 h post mort...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.13013

    authors: Fabbri MC,Zappaterra M,Davoli R,Zambonelli P

    更新日期:2020-12-01 00:00:00

  • Mutation in the melanocortin 1 receptor is associated with amber colour in the Norwegian Forest Cat.

    abstract::Amber (previously called X-Colour) is a yellow recessive coat colour observed in the Norwegian Forest Cat (NFC) population and apparently absent in other cat breeds. Until now, there has never been any scientific evidence of yellow recessive mutation (e) reported in the extension gene in Felidae. We sequenced the comp...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2009.01864.x

    authors: Peterschmitt M,Grain F,Arnaud B,Deléage G,Lambert V

    更新日期:2009-08-01 00:00:00

  • Genetic association between bovine NOD2 polymorphisms and infection by Mycobacterium avium subsp. paratuberculosis in Holstein-Friesian cattle.

    abstract::Nucleotide-Binding Oligomerization Domain 2 (NOD2) has been reported to be a candidate gene for Mycobacterium avium subsp. paratuberculosis (MAP) infection in a Bos taurus × Bos indicus mixed breed based on a genetic association with the c.2197T>C single nucleotide polymorphism (SNP). Nevertheless, this SNP has also b...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2010.02055.x

    authors: Ruiz-Larrañaga O,Garrido JM,Iriondo M,Manzano C,Molina E,Koets AP,Rutten VP,Juste RA,Estonba A

    更新日期:2010-12-01 00:00:00

  • Comparison of joining and constant κ-light chain regions in different cattle breeds.

    abstract::A comparative transcription analysis of Ig κ-light chains (IGK) of the cattle breeds Holstein Friesian (HF), German Black Pied (GBP), German Simmental (GS) and Aubrac (A) revealed three alleles coding for two putative allotypic variants of IGKC. The amino acid residues p.Asp100Asn and p.Thr116Ala were located at the o...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2012.02324.x

    authors: Stein SK,Diesterbeck US,Aboelhassan DM,Czerny CP

    更新日期:2012-12-01 00:00:00

  • Extending the chicken-human comparative map by placing 15 genes on the chicken linkage map.

    abstract::To increase the number of type I loci on the chicken linkage map, chicken genes containing microsatellite sequences (TAn, CAn, GAn, An) were selected from the nucleotide sequence database and primers were developed to amplify the repeats. Initially, 40 different microsatellites located within genes were tested on a pa...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.1999.00527.x

    authors: Groenen MA,Crooijmans RP,Dijkhof RJ,Acar R,van der Poel JJ

    更新日期:1999-12-01 00:00:00

  • Restriction fragment length polymorphism among Israeli Holstein-Friesian dairy bulls.

    abstract::Israeli Holstein-Friesian dairy bulls were screened for restriction fragment length polymorphisms by hybridizing cloned DNA probes for bovine growth hormone, for chymosin, and for rat muscle beta-actin to restriction endonuclease-digested DNA immobilized on nitrocellulose filters. The population proved to be polymorph...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1986.tb03185.x

    authors: Beckmann JS,Kashi Y,Hallerman EM,Nave A,Soller M

    更新日期:1986-01-01 00:00:00

  • Assessing footprints of selection in commercial Atlantic salmon populations using microsatellite data.

    abstract::Relatively large rates of response to traits of economic importance have been observed in different selection experiments in salmon. Several QTL have been mapped in the salmon genome, explaining unprecedented levels of phenotypic variation. Owing to the relatively large selection intensity, individual loci may be indi...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2012.02387.x

    authors: Martinez V,Dettleff P,Lopez P,Fernandez G,Jedlicki A,Yañez JM,Davidson WS

    更新日期:2013-04-01 00:00:00

  • Parentage testing of dogs using variants of blood proteins: description of five new plasma protein polymorphisms.

    abstract::Plasma samples of 1126 dogs belonging to 21 different European breeds were analysed by two-dimensional agarose gel (pH 5.4 or pH 8.6)--horizontal polyacrylamide gel (pH 9.0) electrophoresis, followed by general-protein staining of gels. Genetic polymorphism was detected for five as yet unidentified proteins designated...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1987.tb00773.x

    authors: Juneja RK,Arnold IC,Gahne B,Bouw J

    更新日期:1987-01-01 00:00:00

  • Genetic polymorphism of the sixth component of complement (C6) in dogs.

    abstract::Using agarose gel isoelectric focusing and immunoblotting with rabbit anti-rabbit C6, a genetic polymorphism was found in the sixth component of complement (C6) in 18 Asian native breeds or populations and three European breeds of dog. The C6 locus was highly polymorphic. The phenotype distribution data indicated that...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1995.tb02641.x

    authors: Shibata T,Abe T,Tanabe Y

    更新日期:1995-04-01 00:00:00

  • Detection of copy number variants in the horse genome and examination of their association with recurrent laryngeal neuropathy.

    abstract::We used the data from a recently performed genome-wide association study using the Illumina Equine SNP50 beadchip for the detection of copy number variants (CNVs) and examined their association with recurrent laryngeal neuropathy (RLN), an important equine upper airway disease compromising performance. A total of 2797...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2012.02373.x

    authors: Dupuis MC,Zhang Z,Durkin K,Charlier C,Lekeux P,Georges M

    更新日期:2013-04-01 00:00:00

  • Identification of a short interspersed repetitive element insertion polymorphism in the porcine MX1 promoter associated with resistance to porcine reproductive and respiratory syndrome virus infection.

    abstract::The myxovirus resistance (Mx) proteins belong to the dynamin superfamily and are important for innate host defence against RNA viruses. In this study, we demonstrate that positive elements are present in the two promoter regions of -2713 to -2565 and -688 to -431 in the porcine MX1 gene. Sequencing and alignment of th...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12316

    authors: Li Y,Liang S,Liu H,Sun Y,Kang L,Jiang Y

    更新日期:2015-08-01 00:00:00

  • Major histocompatibility (B) complex and sex effects on the phytohaemagglutinin wattle response.

    abstract::The influence of the major histocompatibility (B) complex and sex on the phytohaemagglutinin (PHA) wattle response was studied in 136 segregants (B2/B2, B2/B5 and B5/B5) of a fourth generation cross between inbred lines 6(1) and 15(1). At 6 weeks of age, chickens were injected with 100 micrograms purified PHA-P. Wattl...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1987.tb00778.x

    authors: Taylor RL Jr,Cotter PF,Wing TL,Briles WE

    更新日期:1987-01-01 00:00:00

  • Isolation and sequencing of porcine lipoprotein lipase cDNA and its use in multiallelic restriction fragment length polymorphism detection.

    abstract::Porcine lipoprotein lipase (LPL) cDNA has been cloned and sequenced. The deduced amino acid sequence shows a high degree of identity to LPL from other species, and contains the Ser/His/Asp triade characteristic of serine proteases and esterases. A repetitive element is present in the 3'-untranslated region of the cDNA...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1992.tb00170.x

    authors: Harbitz I,Kristensen T,Kran S,Davies W

    更新日期:1992-01-01 00:00:00

  • Functional genes mapped on the chicken genome.

    abstract::Microsatellite polymorphisms are finding increasing use in genetics. In addition to the random isolation of microsatellite markers, such markers can also be developed from sequences already present in public domain databases. An advantage of public domain databases is that these microsatellites are known to be located...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1995.tb02636.x

    authors: Crooijmans RP,van der Poel JJ,Groenen MA

    更新日期:1995-04-01 00:00:00

  • Solexa sequencing and custom microRNA chip reveal repertoire of microRNAs in mammary gland of bovine suffering from natural infectious mastitis.

    abstract::Identification of microRNAs (miRNAs), target genes and regulatory networks associated with innate immune and inflammatory responses and tissue damage is essential to elucidate the molecular and genetic mechanisms for resistance to mastitis. In this study, a combination of Solexa sequencing and custom miRNA chip approa...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12628

    authors: Ju Z,Jiang Q,Liu G,Wang X,Luo G,Zhang Y,Zhang J,Zhong J,Huang J

    更新日期:2018-02-01 00:00:00

  • FTO gene variants are associated with growth and carcass traits in cattle.

    abstract::An important aim in animal breeding is the improvement of growth and meat quality traits. Previous studies have demonstrated that genetic variants in the fat mass and obesity associated (FTO) gene have a relatively large effect on human obesity as well as on body composition in rodents and, more recently, in livestock...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12403

    authors: Jevsinek Skok D,Kunej T,Kovac M,Malovrh S,Potocnik K,Petric N,Zgur S,Dovc P,Horvat S

    更新日期:2016-04-01 00:00:00