Tyrosinase mutations associated with Siamese and Burmese patterns in the domestic cat (Felis catus).

Abstract:

:The Siamese cat has a highly recognized coat colour phenotype that expresses pigment at the extremities of the body, such as the ears, tail and paws. This temperature-sensitive colouration causes a 'mask' on the face and the phenotype is commonly referred to as 'pointed'. Burmese is an allelic variant that is less temperature-sensitive, producing more pigment throughout the torso than Siamese. Tyrosinase (TYR) mutations have been suspected to cause these phenotypes because mutations in TYR are associated with similar phenotypes in other species. Linkage and synteny mapping in the cat has indirectly supported TYR as the causative gene for these feline phenotypes. TYR mutations associated with Siamese and Burmese phenotypes are described herein. Over 200 cats were analysed, representing 12 breeds as well as randomly bred cats. The SNP associated with the Siamese phenotype is an exon 2 G > A transition changing glycine to arginine (G302R). The SNP associated with the Burmese phenotype is an exon 1 G > T transversion changing glycine to tryptophan (G227W). The G302R mutation segregated concordantly within a pedigree of Himalayan (pointed) Persians. All cats that had 'pointed' or the Burmese coat colour phenotype were homozygous for the corresponding mutations, respectively, suggesting that these phenotypes are a result of the identified mutations or unidentified mutations that are in linkage disequilibrium. Because the same mutations were identified in different breeds with similar phenotypes, the mutations are likely to be identical by descent rather than multiple mutation events occurring at the same site.

journal_name

Anim Genet

journal_title

Animal genetics

authors

Lyons LA,Imes DL,Rah HC,Grahn RA

doi

10.1111/j.1365-2052.2005.01253.x

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

119-26

issue

2

eissn

0268-9146

issn

1365-2052

pii

AGE1253

journal_volume

36

pub_type

杂志文章
  • Mapping of expressed sequence tags from a porcine early embryonic cDNA library.

    abstract::The goal of this study was to identify and map genes expressed during the elongation phase of embryogenesis in swine. Expressed sequence tags were analysed from a previously described porcine cDNA library prepared from elongating swine embryos. Average insert length of randomly selected clones was approximately 600 bp...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.2001.00739.x

    authors: Smith TP,Fahrenkrug SC,Rohrer GA,Simmen FA,Rexroad CE,Keele JW

    更新日期:2001-04-01 00:00:00

  • Physical mapping of the brain and ovarian aromatase genes in the Nile Tilapia, Oreochromis niloticus, by fluorescence in situ hybridization.

    abstract::Cytochrome P450-aromatase enzyme (CYP19), which catalyses the conversion of androgens to oestrogens, is critical in ovarian differentiation and hence in the sex differentiation pathways of non-mammalian vertebrates. As in other fish species, distinct ovarian and brain aromatase genes have been identified in the Nile T...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.2003.00941.x

    authors: Harvey SC,Kwon JY,Penman DJ

    更新日期:2003-02-01 00:00:00

  • Analysis of genetic relatedness among Indian cattle (Bos indicus) using genotyping-by-sequencing markers.

    abstract::Genetic relatedness of 24 animals belonging to seven Indian cattle breeds was studied using high throughput genotyping-by-sequencing (GBS) markers. GBS produced 93.6 million reads with an average of about 3.9 million reads per animal. A total of 107 488 SNPs were identified in these individuals. When only one SNP per ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12650

    authors: Malik AA,Sharma R,Ahlawat S,Deb R,Negi MS,Tripathi SB

    更新日期:2018-06-01 00:00:00

  • Mapping and characterization of the DQ subregion of the ovine MHC.

    abstract::A map of the ovine MHC class II DQ subregion has been constructed from overlapping cosmid clones. This region consists of two loci linked on a linear tract of 130 kb DNA. Each locus consists of a DQA and a DQB gene in a tail-to-tail orientation. The genes in each locus are transcribed but only those designated DQ1 exp...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1994.tb00200.x

    authors: Wright H,Ballingall KT

    更新日期:1994-08-01 00:00:00

  • The European sea bass: a key marine fish model in the wild and in aquaculture.

    abstract::The European sea bass (Dicentrarchus labrax L.) is a marine fish of key economic and cultural importance in Europe. It is now more an aquaculture than a fisheries species (>96% of the production in 2016), although modern rearing techniques date back only from the late 1980s. It also has high interest for evolutionary ...

    journal_title:Animal genetics

    pub_type: 杂志文章,评审

    doi:10.1111/age.12779

    authors: Vandeputte M,Gagnaire PA,Allal F

    更新日期:2019-06-01 00:00:00

  • Genetic diversity of Hungarian indigenous chicken breeds based on microsatellite markers.

    abstract::Six local chicken breeds are registered in Hungary and are regarded as Hungarian national treasures: Hungarian White, Yellow and Speckled, and Transylvanian Naked Neck White, Black and Speckled. Three Hungarian academic institutes have maintained these genetic resources for more than 30 years. The Hungarian Yellow, th...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2009.01876.x

    authors: Bodzsar N,Eding H,Revay T,Hidas A,Weigend S

    更新日期:2009-08-01 00:00:00

  • Transcriptomic analysis reveals differentially expressed genes associated with wool length in rabbit.

    abstract::Rabbit fur characteristics are primarily genetically determined traits. We used Illumina high-throughput sequencing technology to assess gene expression in the skin tissues of rabbits derived from a cross between Wanxi Angora rabbits and Rex rabbits, which exhibit differential characteristics of short and long wool re...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12701

    authors: Zhao B,Chen Y,Hao Y,Yang N,Wang M,Mei M,Wang J,Qiu X,Wu X

    更新日期:2018-10-01 00:00:00

  • Single nucleotide polymorphisms in the insulin-like growth factor 1 (IGF1) gene are associated with growth-related traits in farmed Atlantic salmon.

    abstract::Understanding the genetic basis of variation in traits related to growth and fillet quality in Atlantic salmon is of importance to the aquaculture industry. Several growth-related QTL have been identified via the application of genetic markers. The IGF1 gene is considered a highly conserved and crucial growth-regulati...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12202

    authors: Tsai HY,Hamilton A,Guy DR,Houston RD

    更新日期:2014-10-01 00:00:00

  • Preliminary radiation hybrid map for river buffalo chromosome 6 and comparison to bovine chromosome 3.

    abstract::We present the first radiation hybrid (RH) map of river buffalo (Bubalus bubalis) chromosome 6 (BBU6) developed with a recently constructed river buffalo whole-genome RH panel (BBURH(5000)). The preliminary map contains 33 cattle-derived markers, including 12 microsatellites, 19 coding genes and two ESTs, distributed ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2007.01612.x

    authors: Stafuzza NB,Ianella P,Miziara MN,Agarwala R,Schäffer AA,Riggs PK,Womack JE,Amaral ME

    更新日期:2007-08-01 00:00:00

  • Polymorphisms in eggshell organic matrix genes are associated with eggshell quality measurements in pedigree Rhode Island Red hens.

    abstract::Novel and traditional eggshell quality measurements were made from up to 2000 commercial pedigree hens for a candidate gene association analysis with organic eggshell matrix genes: ovocleidin-116, osteopontin (SPP1), ovocalyxin-32 (RARRES1), ovotransferrin (LTF), ovalbumin and ovocalyxin-36, as well as key genes in th...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2008.01794.x

    authors: Dunn IC,Joseph NT,Bain M,Edmond A,Wilson PW,Milona P,Nys Y,Gautron J,Schmutz M,Preisinger R,Waddington D

    更新日期:2009-02-01 00:00:00

  • Genetic diversity of donkey populations from the putative centers of domestication.

    abstract::Donkey domestication drastically changed ancient transport systems in Africa and Asia, enabling overland circulation of people and goods and influencing the organization of early cities and pastoral societies. Genetic studies based on mtDNA have pointed to the African wild ass as the most probable ancestor of the dome...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12256

    authors: Rosenbom S,Costa V,Al-Araimi N,Kefena E,Abdel-Moneim AS,Abdalla MA,Bakhiet A,Beja-Pereira A

    更新日期:2015-02-01 00:00:00

  • A genome-wide scan for tying-up syndrome in Japanese Thoroughbreds.

    abstract::Tying-up syndrome, also known as recurrent exertional rhabdomyolysis in Thoroughbreds, is a common muscle disorder for racehorses. In this study, we performed a multipoint linkage analysis using LOKI based on the Bayesian Markov chain Monte Carlo method using 5 half-sib families (51 affected and 277 nonaffected horses...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2010.02112.x

    authors: Tozaki T,Hirota K,Sugita S,Ishida N,Miyake T,Oki H,Hasegawa T

    更新日期:2010-12-01 00:00:00

  • Effects of DGAT1 and GHR on milk yield and milk composition in the Chinese dairy population.

    abstract::Previous studies have demonstrated that the p.Lys232Ala substitution in the acylCoA: diacylglycerol acyltransferase (DGAT1) gene and the p.Phe279Tyr mutation in the growth hormone receptor (GHR) gene are the causative quantitative trait loci underlying milk yield and composition on BTA14 and BTA20 respectively. To exa...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2009.01945.x

    authors: Sun D,Jia J,Ma Y,Zhang Y,Wang Y,Yu Y,Zhang Y

    更新日期:2009-12-01 00:00:00

  • Evaluation of the genetic diversity and population structure of Chinese indigenous horse breeds using 27 microsatellite markers.

    abstract::We determined the genetic diversity and evolutionary relationships among 26 Chinese indigenous horse breeds and two introduced horse breeds by genotyping these animals for 27 microsatellite loci. The 26 Chinese horse breeds come from 12 different provinces. Two introduced horse breeds were the Mongolia B Horse from Mo...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2010.02067.x

    authors: Ling YH,Ma YH,Guan WJ,Cheng YJ,Wang YP,Han JL,Mang L,Zhao QJ,He XH,Pu YB,Fu BL

    更新日期:2011-02-01 00:00:00

  • Studies on the bovine major histocompatibility class I and class II antigens using homozygous typing cells and antigen-specific BoT4+ blast cells.

    abstract::Animals were identified from two sire lines as being homozygous for the class I bovine lymphocyte antigen (BoLA-A) w23. These animals were also shown to be homozygous for class II antigens (BoLA-D) which, however, differed between the two sire lines. Lymphocytes from these animals were then used either as stimulator c...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1990.tb03218.x

    authors: Rothel JS,Dufty JH,Wood PR

    更新日期:1990-01-01 00:00:00

  • Linkage of the grey coat colour locus to microsatellites on horse chromosome 25.

    abstract::The progressive loss of colour in the hair of grey horses is controlled by a dominantly inherited allele at the Grey locus (GG). In this study, two paternal Quarter Horse (QH) families segregating for the GG allele were genotyped with a set of 101 microsatellite markers spanning the 31 autosomes and the X chromosome. ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.2002.00885.x

    authors: Locke MM,Penedo MC,Bricker SJ,Millon LV,Murray JD

    更新日期:2002-10-01 00:00:00

  • Ligneous membranitis in Scottish Terriers is associated with a single nucleotide polymorphism in the plasminogen (PLG) gene.

    abstract::Ligneous membranitis (LM) is a rare chronic inflammatory condition of the mucous membranes associated with plasminogen (encoded by PLG) deficiency in affected humans and dogs. In human, the condition is genetic in nature with numerous mutations and polymorphisms in PLG identified in affected individuals and related fa...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12339

    authors: Ainsworth S,Carter S,Fisher C,Dawson J,Makrides L,Nuttall T,Mason SL

    更新日期:2015-12-01 00:00:00

  • Quantitative trait loci for chemical body composition traits in pigs and their positional associations with body tissues, growth and feed intake.

    abstract::In this study, quantitative trait loci (QTL) for chemical and physical body composition, growth and feed intake in pigs were identified in a three-generation full-sib population, developed by crossing Pietrain sires with a commercial dam line. Phenotypic data from 315 F(2) animals were available for protein and lipid ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2007.01689.x

    authors: Duthie C,Simm G,Doeschl-Wilson A,Kalm E,Knap PW,Roehe R

    更新日期:2008-04-01 00:00:00

  • Polymorphism of erythrocyte malic enzyme in the goat.

    abstract::Three electrophoretic variants of erythrocyte malic enzyme (ME) in goats were reported. Inheritance data indicate that they are controlled by codominant alleles. The allele frequencies in four Mediterranean populations are given. ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1995.tb03255.x

    authors: Di Stasio L,Rasero R,Fiandra P,Giaccone P

    更新日期:1995-08-01 00:00:00

  • Large-scale potential RNA editing profiling in different adult chicken tissues.

    abstract::RNA editing is a post-transcription maturation process that diversifies genomically encoded information and can lead to transcriptome diversity. Thanks to next-generation sequencing technologies, a large number of editing sites have been identified in different species. Although this mechanism is well described in mam...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12818

    authors: Shafiei H,Bakhtiarizadeh MR,Salehi A

    更新日期:2019-10-01 00:00:00

  • Characterization of the methylation status of five imprinted genes in sheep gametes.

    abstract::Genomic imprinting is a mammalian developmental process that uses epigenetic mechanisms to induce monoallelic and parental-specific expression of particular autosomal genes. A crucial epigenetic event consists of DNA methylation of CpG-islands, which become differentially methylated regions (DMRs) on the maternal and ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2009.01939.x

    authors: Colosimo A,Di Rocco G,Curini V,Russo V,Capacchietti G,Berardinelli P,Mattioli M,Barboni B

    更新日期:2009-12-01 00:00:00

  • The influence of extracellular matrix and prolactin on global gene expression profiles of primary bovine mammary epithelial cells in vitro.

    abstract::An in vitro bovine mammosphere model was characterized for use in lactational biology studies using a functional genomics approach. Primary bovine mammary epithelial cells cultured on a basement membrane, Matrigel, formed three-dimensional alveoli-like structures or mammospheres. Gene expression profiling during mammo...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2009.01964.x

    authors: Riley LG,Gardiner-Garden M,Thomson PC,Wynn PC,Williamson P,Raadsma HW,Sheehy PA

    更新日期:2010-02-01 00:00:00

  • Associations of GH gene variants with performance traits in F2 generations of European wild boar, Piétrain and Meishan pigs.

    abstract::The role of the porcine GH gene was investigated in 292 F2 animals of mating Wild Boar x Piétrain and in 310 F2 animals of mating Meishan x Piétrain. Forty-three traits of fattening, carcass composition, meat quality and stress resistance were recorded. For the analysis of associations between GH gene variants and qua...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1997.00093.x

    authors: Knorr C,Moser G,Müller E,Geldermann H

    更新日期:1997-04-01 00:00:00

  • Differential expression of the GTL2 gene within the callipyge region of ovine chromosome 18.

    abstract::The inheritance pattern of the skeletal muscle hypertrophy phenotype caused by the callipyge gene has been characterized as polar overdominance. We hypothesized that this trait may be caused by a gain or loss of gene expression because of the reversible nature of the phenotype in paternal vs. maternal inheritance. Sup...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.2001.00776.x

    authors: Bidwell CA,Shay TL,Georges M,Beever JE,Berghmans S,Cockett NE

    更新日期:2001-10-01 00:00:00

  • Chromosomal assignment of porcine microsatellites by use of a somatic cell hybrid mapping panel.

    abstract::A well-established and characterized somatic cell hybrid panel was used to map three polymorphic microsatellites. Microsatellite S0072, representing the linkage group S0007-S0072, was assigned to porcine chromosome 14. Microsatellite S0009, representing the unassigned linkage group EAM-S0009-S0071, was assigned tentat...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1994.tb00369.x

    authors: Rettenberger G,Fredholm M,Fries R

    更新日期:1994-10-01 00:00:00

  • Identification of an FBN1 mutation in bovine Marfan syndrome-like disease.

    abstract::Mutations in the gene encoding fibrillin-1 (FBN1), a component of the extracellular microfibril, cause Marfan syndrome (MFS). Frequent observation of cattle with a normal withers height, but lower body weight than age-matched normal cattle, was recently reported among cattle sired by phenotypically normal Bull A, in J...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2011.02209.x

    authors: Hirano T,Matsuhashi T,Kobayashi N,Watanabe T,Sugimoto Y

    更新日期:2012-02-01 00:00:00

  • Association analysis between canine behavioural traits and genetic polymorphisms in the Shiba Inu breed.

    abstract::The relationships between behavioural trait data and the genotype of 15 polymorphisms in eight neurotransmitter-related genes were analysed in 77 dogs of the Shiba Inu breed, an indigenous Japanese dog. The data were obtained from a 26-item questionnaire on the dog's behaviour, distributed to the dog's owners, through...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2009.01888.x

    authors: Takeuchi Y,Kaneko F,Hashizume C,Masuda K,Ogata N,Maki T,Inoue-Murayama M,Hart BL,Mori Y

    更新日期:2009-10-01 00:00:00

  • Channel catfish BAC-end sequences for marker development and assessment of syntenic conservation with other fish species.

    abstract::In the present study, 25 195 BAC ends for channel catfish (Ictalurus punctatus) were sequenced, generating 20 366 clean BAC-end sequences (BES), with an average read length of 557 bp after trimming. A total of 11 414 601 bp were generated, representing approximately 1.2% of the catfish genome. Based on this survey, th...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2006.01453.x

    authors: Xu P,Wang S,Liu L,Peatman E,Somridhivej B,Thimmapuram J,Gong G,Liu Z

    更新日期:2006-08-01 00:00:00

  • Selection signature analysis reveals genes associated with tail type in Chinese indigenous sheep.

    abstract::Fat-tailed sheep have commercial value because consumers prefer high-protein and low-fat food and producers care about feed conversion rate. However, fat-tailed sheep still have some scientific significance, as the fat tail is commonly regarded as a characteristic of environmental adaptability. Finding the candidate g...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12477

    authors: Yuan Z,Liu E,Liu Z,Kijas JW,Zhu C,Hu S,Ma X,Zhang L,Du L,Wang H,Wei C

    更新日期:2017-02-01 00:00:00

  • Genome-wide association study confirms that the chromosome Z harbours a region responsible for rumplessness in Hongshan chickens.

    abstract::Rumplessness in Hongshan chickens has been reported as a novel sex-linked characteristic. Re-sequencing data suggest that a pseudogene on the Z chromosome, LOC431648, is affiliated with this phenotype. In this study, we chose 23 rumpless and 25 normal Hongshan chickens to localize the potential variation by means of a...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12664

    authors: Wang Q,Pi J,Shen J,Pan A,Qu L

    更新日期:2018-08-01 00:00:00