IGF2 gene characterization and association with rib eye area in beef cattle.

Abstract:

:Insulin-like growth factor 2 (IGF2) is an imprinted gene expressed in most tissues affecting lean muscle content in mice, pigs and cattle. We previously identified the bovine IGF2 c.-292C>T SNP in the non-translated exon 2. Using this SNP, we demonstrated biallelic expression of IGF2 after birth. Seven alternatively spliced mRNA transcripts of IGF2 were expressed among 15 tissues. An IGF2 pseudogene (psiIGF2) was identified with sequence identical to at least IGF2 exons 2 and 3 without the intervening intron. The biallelic expression of this c.-292C>T SNP was associated with an increase in rib eye area (REA) in two populations of cattle, with the C.-292C allele associated with a 10% increase. A significant association with per cent fat was found in one of the populations.

journal_name

Anim Genet

journal_title

Animal genetics

authors

Goodall JJ,Schmutz SM

doi

10.1111/j.1365-2052.2007.01576.x

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

154-61

issue

2

eissn

0268-9146

issn

1365-2052

pii

AGE1576

journal_volume

38

pub_type

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