Abstract:
:Insulin-like growth factor 2 (IGF2) is an imprinted gene expressed in most tissues affecting lean muscle content in mice, pigs and cattle. We previously identified the bovine IGF2 c.-292C>T SNP in the non-translated exon 2. Using this SNP, we demonstrated biallelic expression of IGF2 after birth. Seven alternatively spliced mRNA transcripts of IGF2 were expressed among 15 tissues. An IGF2 pseudogene (psiIGF2) was identified with sequence identical to at least IGF2 exons 2 and 3 without the intervening intron. The biallelic expression of this c.-292C>T SNP was associated with an increase in rib eye area (REA) in two populations of cattle, with the C.-292C allele associated with a 10% increase. A significant association with per cent fat was found in one of the populations.
journal_name
Anim Genetjournal_title
Animal geneticsauthors
Goodall JJ,Schmutz SMdoi
10.1111/j.1365-2052.2007.01576.xsubject
Has Abstractpub_date
2007-04-01 00:00:00pages
154-61issue
2eissn
0268-9146issn
1365-2052pii
AGE1576journal_volume
38pub_type
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