Abstract:
:In cattle (Bos taurus), there is evidence of more than 50 alleles of BoLA-DQB (bovine lymphocyte antigen DQB) that are distributed across at least five DQB loci, making this region one of the most complex in the BoLA gene family. In this study, DQB alleles were analysed for the water buffalo (Bubalus bubalis), another economically important bovine species. Twelve alleles for Bubu-DQB (Bubalis bubalis DQB) were determined by nucleotide sequence analysis. A phylogenetic analysis revealed numerous trans-species polymorphisms, with alleles from water buffalo assigned to at least three different loci (BoLA-DQB1, BoLA-DQB3 and BoLA-DQB4) that are also found in cattle. These presumptive loci were analysed for patterns of synonymous (d(S)) and non-synonymous (d(N)) substitution. Like BoLA-DQB1, Bubu-DQB1 was observed to be under strong positive selection for polymorphism. We conclude that water buffalo and cattle share the current arrangement of their DQB region because of their common ancestry.
journal_name
Anim Genetjournal_title
Animal geneticsauthors
Sena L,Schneider MP,Brenig BB,Honeycutt RL,Honeycutt DA,Womack JE,Skow LCdoi
10.1111/j.1365-2052.2010.02157.xsubject
Has Abstractpub_date
2011-08-01 00:00:00pages
378-85issue
4eissn
0268-9146issn
1365-2052journal_volume
42pub_type
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