Abstract:
:Bilateral convergent strabismus with exophthalmus (BCSE) is a widespread inherited eye defect in several cattle populations. Its progressive condition often leads to blindness in affected cattle and decreases their usability. Furthermore, the German animal welfare laws prevent breeding with animals whose progeny are expected to be affected by genetic defects. Identifying genes involved in the heredity of BCSE should lead to insights into the molecular pathogenesis of this eye disease and permit the establishment of a genetic test for this disease. A whole-genome scan for 10 families containing a total of 159 genotyped individuals identified two BCSE loci. One BCSE locus mapped to the centromeric region on bovine chromosome (BTA) 5 and the other BCSE locus mapped to the telomeric region of BTA18. Thus, it is possible that two genes are involved in the development of BCSE. Alternatively, one of these loci could be the cause for the development of BCSE and the other locus could affect the progression and severity of the defect.
journal_name
Anim Genetjournal_title
Animal geneticsauthors
Mömke S,Fink S,Wöhlke A,Drögemüller C,Distl Odoi
10.1111/j.1365-2052.2008.01771.xsubject
Has Abstractpub_date
2008-10-01 00:00:00pages
544-9issue
5eissn
0268-9146issn
1365-2052pii
AGE1771journal_volume
39pub_type
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