Polymorphism at the ovine major histocompatibility complex class II loci.

Abstract:

:Southern hybridization analysis of the ovine major histocompatibility complex (MHC) (MhcOvar) class II region, using sheep-specific probes for the DQA1, DQA2, DQB and DRA loci, has revealed extensive polymorphism. DQA1 and DQA2 had eight and 16 alleles respectively, DQB had six and DRA had three alleles. Little information was derived from the DRB locus owing to extensive cross-hybridization between the DRB probe and the DQB locus. Differences in allele frequency between breeds were revealed. At the DQA1 locus a null allele (DQA1-N) was observed with a frequency of between 27% and 45%, making this the most common DQA1 allele in all breeds examined. The frequency of DQA1-N homozygotes was between 11% and 18%, raising questions as to the functional significance of the DQA1 gene. Linkage analysis between the DQA1, DQA2, DQB and DRA loci did not reveal any recombination.

journal_name

Anim Genet

journal_title

Animal genetics

authors

Escayg AP,Hickford JG,Montgomery GW,Dodds KG,Bullock DW

doi

10.1111/j.1365-2052.1996.tb00974.x

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

305-12

issue

5

eissn

0268-9146

issn

1365-2052

journal_volume

27

pub_type

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