Characterization of the porcine acyl-CoA synthetase long-chain 4 gene and its association with growth and meat quality traits.


:Summary Long-chain acyl-CoA synthetase (ACSL) catalyses the formation of long-chain acyl-CoA from fatty acid, ATP and CoA, activating fatty acids for subsequent reactions. Long-chain acyl-CoA synthetase thus plays an essential role in both lipid biosynthesis and fatty acid degradation. The ACSL4 gene was evaluated as a positional candidate gene for the quantitative trait loci (QTL) located between SW2456 and SW1943 on chromosome X. We have sequenced 4906 bp of the pig ACSL4 mRNA. Sequence analysis allowed us to identify 10 polymorphisms located in the 3'-UTR region and to elucidate two ACSL4 haplotypes. Furthermore, a QTL and an association study between polymorphisms of the ACSL4 gene and traits of interest were carried out in an Iberian x Landrace cross. We report QTL that have not been previously identified, and we describe an association of the ACSL4 polymorphisms with growth and percentage of oleic fatty acid. Finally, we have determined allelic frequencies in 140 pigs belonging to the Iberian, Landrace, Large White, Meishan, Pietrain, Duroc, Vietnamese, Peccary and Babirusa populations.


Anim Genet


Animal genetics


Mercadé A,Estellé J,Pérez-Enciso M,Varona L,Silió L,Noguera JL,Sánchez A,Folch JM




Has Abstract


2006-06-01 00:00:00














  • Breed-specific expression of DROSHA, DICER and AGO2 is regulated by glucocorticoid-mediated miRNAs in the liver of newborn piglets.

    abstract::MicroRNA (miRNA) biogenesis is determined mainly by Drosha, Dicer and Argonaute2 (Ago2). Different breeds of pigs with vast differences in serum cortisol level demonstrate distinct profiles of hepatic miRNA expression. As yet, little is known about whether glucocorticoid contributes to the breed differences in miRNA b...

    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Li R,Jia Y,Zou H,Zhao R

    更新日期:2014-12-01 00:00:00

  • Parentage testing of dogs using variants of blood proteins: description of five new plasma protein polymorphisms.

    abstract::Plasma samples of 1126 dogs belonging to 21 different European breeds were analysed by two-dimensional agarose gel (pH 5.4 or pH 8.6)--horizontal polyacrylamide gel (pH 9.0) electrophoresis, followed by general-protein staining of gels. Genetic polymorphism was detected for five as yet unidentified proteins designated...

    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Juneja RK,Arnold IC,Gahne B,Bouw J

    更新日期:1987-01-01 00:00:00

  • Phylogenetic analysis of Sicilian goats reveals a new mtDNA lineage.

    abstract::The mitochondrial hypervariable region 1 (HVR1) sequence of 67 goats belonging to the Girgentana, Maltese and Derivata di Siria breeds was partially sequenced in order to present the first phylogenetic characterization of Sicilian goat breeds. These sequences were compared with published sequences of Indian and Pakist...

    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Sardina MT,Ballester M,Marmi J,Finocchiaro R,van Kaam JB,Portolano B,Folch JM

    更新日期:2006-08-01 00:00:00

  • Sequence analysis of MHC class I alpha 2 domain exon variants in one diploid and two haploid Atlantic salmon pedigrees.

    abstract::Genetic diversity in the second domain exon of Atlantic salmon (Salmo salar) major histocompatibility complex (Mhc) class I was investigated in two dams and nine of their haploid offspring by means of polymerase chain reaction (PCR) and DNA sequence analysis. A similar study was also performed on nine diploid offsprin...

    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Grimholt U,Olsaker I,Lingaas F,Lie O

    更新日期:1997-12-01 00:00:00

  • Microphthalmia-associated transcription factor mutations are associated with white-spotted coat color in swamp buffalo.

    abstract::A candidate gene analysis of the microphthalmia-associated transcription factor (MITF) gene was used in an attempt to identify the genetic basis for a white-spotted coat color phenotype in the Asian swamp buffalo (Bubalus bubalis carabanensis). Ninety-three buffaloes-32 solid, 38 spotted and 23 white individuals-were ...

    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Yusnizar Y,Wilbe M,Herlino AO,Sumantri C,Noor RR,Boediono A,Andersson L,Andersson G

    更新日期:2015-12-01 00:00:00

  • Evaluation of the genetic diversity and population structure of Chinese indigenous horse breeds using 27 microsatellite markers.

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    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Ling YH,Ma YH,Guan WJ,Cheng YJ,Wang YP,Han JL,Mang L,Zhao QJ,He XH,Pu YB,Fu BL

    更新日期:2011-02-01 00:00:00

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    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Bigi D,Perrotta G,Zambonelli P

    更新日期:2014-08-01 00:00:00

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    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Andersson-Eklund L,Rendel J

    更新日期:1993-04-01 00:00:00

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    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Tozaki T,Hirota K,Sugita S,Ishida N,Miyake T,Oki H,Hasegawa T

    更新日期:2010-12-01 00:00:00

  • Definition of the USDA103 strain of channel catfish (Ictalurus punctatus).

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    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Waldbieser GC,Wolters WR

    更新日期:2007-04-01 00:00:00

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    abstract::Comparative anchor tagged sequence (CATS) consensus primers from loci mapped to human chromosomes 9, 10, 20, and 22 have been used to amplify homologous loci in pigs. Of 53, CATS primers tested in pigs, only 23 yielded products homologous to the human locus (42% success). Ten loci were physically mapped (43% success r...

    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Lee JH,Zhang W,Moran C

    更新日期:2001-10-01 00:00:00

  • Genomic prediction of reproduction traits for Merino sheep.

    abstract::Economically important reproduction traits in sheep, such as number of lambs weaned and litter size, are expressed only in females and later in life after most selection decisions are made, which makes them ideal candidates for genomic selection. Accurate genomic predictions would lead to greater genetic gain for thes...

    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Bolormaa S,Brown DJ,Swan AA,van der Werf JHJ,Hayes BJ,Daetwyler HD

    更新日期:2017-06-01 00:00:00

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    abstract::A quantitative trait locus (QTL) for boar fat androstenone levels has been identified near the SSC7 centromere in a Large White × Meishan cross. Backcrosses were produced to isolate the Chinese haplotype in a European genetic background. The expression of 25 genes from the QTL region was studied in the testes and live...

    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Robic A,Fève K,Larzul C,Billon Y,van Son M,Liaubet L,Sarry J,Milan D,Grindflek E,Bidanel JP,Riquet J

    更新日期:2011-12-01 00:00:00

  • Identification of a premature stop codon in the melanocyte-stimulating hormone receptor gene (MC1R) in Labrador and Golden retrievers with yellow coat colour.

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    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Everts RE,Rothuizen J,van Oost BA

    更新日期:2000-06-01 00:00:00

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    abstract::Nucleotide sequence analysis of polymerase chain reaction products confirmed that ev21 integrated into one of two large homologous elements on the Z chromosome of late-feathering (LF) White Leghorn chickens. Southern blots of NotI-, NaeI-, KspI- and BamHI-digested DNA from early-feathering (EF) and LF White Leghorns, ...

    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Iraqi F,Smith EJ

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    abstract::The stearoyl-CoA desaturase (delta-9-desaturase; SCD) gene is a candidate gene for fatty acid composition. It is located on pig SSC14 in a region where quantitative trait loci (QTL) for fatty acid composition were previously detected in a Duroc purebred population. The objective of the present study was to fine map th...

    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Uemoto Y,Nakano H,Kikuchi T,Sato S,Ishida M,Shibata T,Kadowaki H,Kobayashi E,Suzuki K

    更新日期:2012-04-01 00:00:00

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    abstract::A well-established and characterized somatic cell hybrid panel was used to map three polymorphic microsatellites. Microsatellite S0072, representing the linkage group S0007-S0072, was assigned to porcine chromosome 14. Microsatellite S0009, representing the unassigned linkage group EAM-S0009-S0071, was assigned tentat...

    journal_title:Animal genetics

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    authors: Rettenberger G,Fredholm M,Fries R

    更新日期:1994-10-01 00:00:00

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    abstract::The aim of the study was to investigate quantitative trait loci (QTL) in previously identified regions of chicken chromosomes 1, 4 and 5 relating to 40-day body weights and conformation scores. Half-sib (HS) and variance component analyses were implemented and compared using QTL Express software. Data were from a two-...

    journal_title:Animal genetics

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    authors: Rowe SJ,Windsor D,Haley CS,Burt DW,Hocking PM,Griffin H,Vincent J,De Koning DJ

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  • Single nucleotide polymorphism discovery in albacore and Atlantic bluefin tuna provides insights into worldwide population structure.

    abstract::The optimal management of the commercially important, but mostly over-exploited, pelagic tunas, albacore (Thunnus alalunga Bonn., 1788) and Atlantic bluefin tuna (BFT; Thunnus thynnus L., 1758), requires a better understanding of population structure than has been provided by previous molecular methods. Despite numero...

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    authors: Albaina A,Iriondo M,Velado I,Laconcha U,Zarraonaindia I,Arrizabalaga H,Pardo MA,Lutcavage M,Grant WS,Estonba A

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  • Genetic signature of hybridization between Chinese spot-billed ducks and domesticated ducks.

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    journal_title:Animal genetics

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    authors: Guo X,Wang ZC,Wang S,Li HF,Suwannapoom C,Wang JX,Zhang C,Shao Y,Wang MS,Jiang RS

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  • Sequence of porcine beta-lactoglobulin cDNA.

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    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Alexander LJ,Beattie CW

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  • Solexa sequencing and custom microRNA chip reveal repertoire of microRNAs in mammary gland of bovine suffering from natural infectious mastitis.

    abstract::Identification of microRNAs (miRNAs), target genes and regulatory networks associated with innate immune and inflammatory responses and tissue damage is essential to elucidate the molecular and genetic mechanisms for resistance to mastitis. In this study, a combination of Solexa sequencing and custom miRNA chip approa...

    journal_title:Animal genetics

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    authors: Ju Z,Jiang Q,Liu G,Wang X,Luo G,Zhang Y,Zhang J,Zhong J,Huang J

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  • Development of microsatellite markers and comparative mapping for bovine chromosome 19.

    abstract::Previous research has mapped an ovulation rate quantitative trait locus (QTL) to bovine chromosome 19. In an effort to enhance comparative mapping information and develop additional markers for refined QTL mapping, microsatellite markers were developed in a targeted approach. A bovine bacterial artificial chromosome (...

    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Kirkpatrick BW,Byla B,Kurar E,Warren WC

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  • Preparation of chromosome-specific paints and complete assignment of chromosomes in the pig flow karyotype.

    abstract::Sorted chromosomes from each of the 20 clusters of the male porcine bivariate flow karyotype were amplified and biotinylated using DOP-PCR. The chromosomes comprising each cluster were identified by fluorescence in situ hybridization (FISH) of the 20 probes to R-banded male pig metaphase spreads. A standard flow karyo...

    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Langford CF,Telenius H,Miller NG,Thomsen PD,Tucker EM

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    abstract::As part of a whole genome scan undertaken to detect quantitative trait loci (QTL) affecting milk yield and composition, we have genotyped a granddaughter design comprising 1152 sons for six microsatellite markers spanning bovine chromosome 20. An analysis performed across families provided strong evidence (experiment-...

    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Arranz JJ,Coppieters W,Berzi P,Cambisano N,Grisart B,Karim L,Marcq F,Moreau L,Mezer C,Riquet J,Simon P,Vanmanshoven P,Wagenaar D,Georges M

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  • Effects of DGAT1 and GHR on milk yield and milk composition in the Chinese dairy population.

    abstract::Previous studies have demonstrated that the p.Lys232Ala substitution in the acylCoA: diacylglycerol acyltransferase (DGAT1) gene and the p.Phe279Tyr mutation in the growth hormone receptor (GHR) gene are the causative quantitative trait loci underlying milk yield and composition on BTA14 and BTA20 respectively. To exa...

    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Sun D,Jia J,Ma Y,Zhang Y,Wang Y,Yu Y,Zhang Y

    更新日期:2009-12-01 00:00:00

  • The albinism of the feral Asinara white donkeys (Equus asinus) is determined by a missense mutation in a highly conserved position of the tyrosinase (TYR) gene deduced protein.

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    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Utzeri VJ,Bertolini F,Ribani A,Schiavo G,Dall'Olio S,Fontanesi L

    更新日期:2016-02-01 00:00:00

  • Intrageneric amplification of horse microsatellite markers with emphasis on the Przewalski's horse (E. przewalskii).

    abstract::Primer sequences flanking 13 microsatellite loci isolated from the domestic horse (E. caballus) were successfully used to amplify homologous loci in the Przewalski's horse (E. przewalskii). The results demonstrate that the level of polymorphism at all 13 loci in the Przewalski's horse was comparable to that in the dom...

    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Breen M,Downs P,Irvin Z,Bell K

    更新日期:1994-12-01 00:00:00

  • Physical mapping of the brain and ovarian aromatase genes in the Nile Tilapia, Oreochromis niloticus, by fluorescence in situ hybridization.

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    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Harvey SC,Kwon JY,Penman DJ

    更新日期:2003-02-01 00:00:00

  • Genetic diversity within chicken populations from different continents and management histories.

    abstract::Intra-population variation was assessed in 1970 chickens from 64 populations using 29 autosomal microsatellites. On average, 95% of the loci were polymorphic across populations. In 1456 (c. 83%) of the 1763 combinations of populations and polymorphic loci, no departure from Hardy-Weinberg equilibrium was observed. On ...

    journal_title:Animal genetics

    pub_type: 杂志文章


    authors: Granevitze Z,Hillel J,Chen GH,Cuc NT,Feldman M,Eding H,Weigend S

    更新日期:2007-12-01 00:00:00