Abstract:
:The distribution of biochemical genetic variants was examined among eight inbred strains of mice, which served as contributors to a heterogeneous stock of mice (HS), and in short-sleep (SS) and long-sleep (LS) mice, selectively bred from the HS stock for differential ethanol sensitivity. Fifteen loci for enzymes of alcohol and aldehyde metabolism, as well as 12 other biochemical loci, were investigated. Thirteen of these loci exhibited allelic variation between strains, of which six were separately fixed in the SS and LS mice. Comparisons of genetic similarity coefficients, based upon the distributions of allelic variants for the loci examined, with behavioural sensitivities (sleep-time) to an acute dose of ethanol for the inbred and selected strains of mice, indicated no correlations between these data. This suggests that this collective group of loci are not useful indicators of the genes selectively bred in the SS and LS strains, which are responsible for the differential sensitivities to acute doses of ethanol.
journal_name
Anim Genetjournal_title
Animal geneticsauthors
Holmes RS,Petersen DR,Deitrich RAdoi
10.1111/j.1365-2052.1986.tb03195.xsubject
Has Abstractpub_date
1986-01-01 00:00:00pages
235-44issue
3eissn
0268-9146issn
1365-2052journal_volume
17pub_type
杂志文章相关文献
ANIMAL GENETICS文献大全abstract::Colostrum intake is critical to a piglet's survival and can be measured by precipitating out the γ-immunoglobulins from serum with ammonium sulfate (immunocrit). Genetic analysis of immunocrits on 5312 piglets indicated that the heritabilities (se) for direct and maternal effects were 0.13 (0.06) and 0.53 (0.08) respe...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12131
更新日期:2014-06-01 00:00:00
abstract::To understand the origin and genetic diversity of Italian horses, mitochondrial DNA D-loop sequences were generated for 163 horses from seven breeds. Sequence analysis of a 480-bp segment revealed a total of 84 haplotypes with 57 polymorphic sites, indicating multiple maternal origins and high genetic diversity. Compa...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12156
更新日期:2014-08-01 00:00:00
abstract::A pioneering study showed that the glycosphingolipid biosynthesis-globo series pathway genes (FUT1, FUT2, ST3GAL1, HEXA, HEXB, B3GALNT1 and NAGA) may play an important regulatory role in resistance to Escherichia coli F18 in piglets. Therefore, we analysed differential gene expression in 11 tissues of two populations ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12428
更新日期:2016-08-01 00:00:00
abstract::Specific alloprecipitins were found in blood plasma of pigs, immunized by sera of Lpr1 positive donors. These precipitins detected a new allotype of the lipoprotein Lpr system which was designated Lpr3. Genetic studies confirmed its codominant inheritance and subgroup character. This linear subgroup of allotype Lpr1 i...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1993.tb00361.x
更新日期:1993-12-01 00:00:00
abstract::In cattle (Bos taurus), there is evidence of more than 50 alleles of BoLA-DQB (bovine lymphocyte antigen DQB) that are distributed across at least five DQB loci, making this region one of the most complex in the BoLA gene family. In this study, DQB alleles were analysed for the water buffalo (Bubalus bubalis), another...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2010.02157.x
更新日期:2011-08-01 00:00:00
abstract::The goal of this study was to identify and map genes expressed during the elongation phase of embryogenesis in swine. Expressed sequence tags were analysed from a previously described porcine cDNA library prepared from elongating swine embryos. Average insert length of randomly selected clones was approximately 600 bp...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1046/j.1365-2052.2001.00739.x
更新日期:2001-04-01 00:00:00
abstract::Understanding the genetic basis of variation in traits related to growth and fillet quality in Atlantic salmon is of importance to the aquaculture industry. Several growth-related QTL have been identified via the application of genetic markers. The IGF1 gene is considered a highly conserved and crucial growth-regulati...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12202
更新日期:2014-10-01 00:00:00
abstract::The myxovirus resistance (Mx) proteins belong to the dynamin superfamily and are important for innate host defence against RNA viruses. In this study, we demonstrate that positive elements are present in the two promoter regions of -2713 to -2565 and -688 to -431 in the porcine MX1 gene. Sequencing and alignment of th...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12316
更新日期:2015-08-01 00:00:00
abstract::The progressive loss of colour in the hair of grey horses is controlled by a dominantly inherited allele at the Grey locus (GG). In this study, two paternal Quarter Horse (QH) families segregating for the GG allele were genotyped with a set of 101 microsatellite markers spanning the 31 autosomes and the X chromosome. ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1046/j.1365-2052.2002.00885.x
更新日期:2002-10-01 00:00:00
abstract::We have for the first time assessed the ability of the Sleeping Beauty (SB) transposon system to enhance transgenesis in chicken and turkey cells. The efficiency of transgenesis with a transposon encoding an antibiotic resistance gene was dramatically enhanced 15- to 35-fold when transposase was supplied by co-transfe...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2008.01702.x
更新日期:2008-04-01 00:00:00
abstract::Ten alloantisera defining five major histocompatibility complex (MHC) class II specificities of the bovine lymphocyte antigen (BoLA) complex were produced and characterized. Eight antisera defining four of the specificities were generated by immunizing cattle with class I compatible-class II incompatible lymphocytes. ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1991.tb00701.x
更新日期:1991-01-01 00:00:00
abstract::Milk production is one of the most important characteristics of dairy sheep, and the identification of genes affecting milk production traits is critical to understanding the genetics and improve milk production in future generations. Three statistical techniques, namely GWAS, ridge-regression BLUP and BayesC ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12956
更新日期:2020-08-01 00:00:00
abstract::We measured and compared the transcripts of adipose tissue from Korean native pig (KNP) and Yorkshire (YS) breeds to investigate breed-specific transcription changes. We employed both the Affymetrix porcine genome array and quantitative reverse transcription-polymerase chain reaction (qRT-PCR). We found eight genes sh...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2008.01798.x
更新日期:2009-02-01 00:00:00
abstract::An MspI polymorphism was identified in intron 13 of the equine homologue of proto-oncogene c-kit (KIT) by comparing DNA sequences from horses with solid coat colour and horses homozygous for the tobiano spotting (To) gene. The allele associated with solid coat colour was designated KM0, while the allele associated wit...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1046/j.1365-2052.2002.00854.x
更新日期:2002-08-01 00:00:00
abstract::As part of a whole genome scan undertaken to detect quantitative trait loci (QTL) affecting milk yield and composition, we have genotyped a granddaughter design comprising 1152 sons for six microsatellite markers spanning bovine chromosome 20. An analysis performed across families provided strong evidence (experiment-...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1046/j.1365-2052.1998.00307.x
更新日期:1998-04-01 00:00:00
abstract::The history of domestic sheep (Ovis aries) in Africa remains largely unknown. After being first introduced from the Near East, sheep gradually spread through the African continent with pastoral societies. The eastern part of Africa was important either for the first diffusion of sheep southward or for putative seconda...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12412
更新日期:2016-06-01 00:00:00
abstract::The Icelandic horse is a breed known mainly for its ability to perform the ambling four-beat gait 'tölt' and the lateral two-beat gait pace. The natural ability of the breed to perform these alternative gaits is highly desired by breeders. Therefore, the discovery that a nonsense mutation (C>A) in the DMRT3 gene was t...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12610
更新日期:2017-12-01 00:00:00
abstract::Almost half of all US households own a dog (Canis familiaris). Though these household pets can attack humans and other animals, they are also frequently victims of cruelty, neglect and theft. In human-oriented investigations, the tendency of domestic dogs to leave behind physical traces (such as hair) can serve as val...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12758
更新日期:2019-02-01 00:00:00
abstract::Genomic imprinting is a mammalian developmental process that uses epigenetic mechanisms to induce monoallelic and parental-specific expression of particular autosomal genes. A crucial epigenetic event consists of DNA methylation of CpG-islands, which become differentially methylated regions (DMRs) on the maternal and ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2009.01939.x
更新日期:2009-12-01 00:00:00
abstract::Relatively large rates of response to traits of economic importance have been observed in different selection experiments in salmon. Several QTL have been mapped in the salmon genome, explaining unprecedented levels of phenotypic variation. Owing to the relatively large selection intensity, individual loci may be indi...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2012.02387.x
更新日期:2013-04-01 00:00:00
abstract::In domestic goats, the polled intersex syndrome (PIS) refers to XX female-to-male sex reversal associated with the absence of horn growth (polled). The causal variant was previously reported as a 11.7 kb deletion at approximately 129 Mb on chromosome 1 that affects the transcription of both FOXL2 and several long non-...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12918
更新日期:2020-06-01 00:00:00
abstract::This study presents evidence that sheep haemopexin phenotypes are genetically controlled by three alleles, HpxA, HpxB1 and HpxB2, of a single autosomal locus. Frequencies of two alleles, HpxA and HpxB (HpxB encompasses two isoalleles, HpxB1 and HpxB2), were studied in eight sheep breeds in Czechoslovakia. The frequenc...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1989.tb00856.x
更新日期:1989-01-01 00:00:00
abstract::Three genomic clones were isolated from a size-selected pig DNA library by hybridization with a DNA-fingerprint probe. Analysis at the sequence level revealed that all three clones contain interrupted stretches of triplet repeats mainly composed of CAC and CAT triplets. Evaluation of the corresponding loci for polymor...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1995.tb02667.x
更新日期:1995-10-01 00:00:00
abstract::Acetyl-coenzyme A carboxylase alpha (ACACA) catalyses the first committed step in the biosynthesis of long-chain fatty acids (FA) by converting acetyl-CoA into malonyl-CoA. In pigs, the ACACA gene maps to a chromosome 12 QTL with important effects on FA composition. In the present study, we have sequenced the coding r...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2009.01854.x
更新日期:2009-08-01 00:00:00
abstract::Ovine hereditary chondrodysplasia, or spider lamb syndrome (SLS), is a genetic disorder that is characterized by severe skeletal abnormalities and has resulted in substantial economic losses for sheep producers. Here we demonstrate that a non-synonymous T>A transversion in the highly conserved tyrosine kinase II domai...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2005.01398.x
更新日期:2006-02-01 00:00:00
abstract::Linkage between the amylase-1 (Am-1) locus and a quantitative trait locus influencing fat content in milk was studied in offspring from heterozygous sires of the Swedish Red and White dairy breed. The effect on bull breeding values for fat content was estimated as interactions between sire and paternal Am-1 allele usi...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1993.tb00248.x
更新日期:1993-04-01 00:00:00
abstract::Recently, linkage of a DNA microsatellite marker to inherited copper toxicosis has been reported in American Bedlington terrier families. Due to the fact that there is little exchange of breeding stock between the USA and Europe, it remains to be investigated whether in Europe the marker is informative and is linked w...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1046/j.1365-2052.1999.00451.x
更新日期:1999-06-01 00:00:00
abstract::Modern commercial chickens have been bred for one of two specific purposes: meat production (broilers) or egg production (layers). This has led to large phenotypic changes, so that the genomic signatures of selection may be detectable using statistical techniques. Genetic differentiation between nine distinct broiler ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12252
更新日期:2015-02-01 00:00:00
abstract::Previous research has mapped an ovulation rate quantitative trait locus (QTL) to bovine chromosome 19. In an effort to enhance comparative mapping information and develop additional markers for refined QTL mapping, microsatellite markers were developed in a targeted approach. A bovine bacterial artificial chromosome (...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1046/j.1365-2052.2002.00808.x
更新日期:2002-02-01 00:00:00
abstract::In this study, we have characterized the mitochondrial diversity of 81 swine from Uganda. Median-joining network analysis of D-loop sequences from these individuals and others characterized in previous studies allowed us to determine that Ugandan pigs cluster with populations from the West (Europe/North Africa), Far E...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12305
更新日期:2015-08-01 00:00:00