Abstract:
:The Icelandic horse is a breed known mainly for its ability to perform the ambling four-beat gait 'tölt' and the lateral two-beat gait pace. The natural ability of the breed to perform these alternative gaits is highly desired by breeders. Therefore, the discovery that a nonsense mutation (C>A) in the DMRT3 gene was the main genetic factor for horses' ability to perform gaits in addition to walk, trot and canter was of great interest. Although several studies have demonstrated that homozygosity for the DMRT3 mutation is important for the ability to pace, only about 70% of the homozygous mutant (AA) Icelandic horses are reported to pace. The aim of the study was to genetically compare four- and five-gaited (i.e. horses with and without the ability to pace) AA Icelandic horses by performing a genome-wide association (GWA) analysis. All horses (n = 55) were genotyped on the 670K Axiom Equine Genotyping Array, and a GWA analysis was performed using the genabel package in r. No SNP demonstrated genome-wide significance, implying that the ability to pace goes beyond the presence of a single gene variant. Despite its limitations, the current study provides additional information regarding the genetic complexity of pacing ability in horses. However, to fully understand the genetic differences between four- and five-gaited AA horses, additional studies with larger sample materials and consistent phenotyping are needed.
journal_name
Anim Genetjournal_title
Animal geneticsauthors
Jäderkvist Fegraeus K,Hirschberg I,Árnason T,Andersson L,Velie BD,Andersson LS,Lindgren Gdoi
10.1111/age.12610subject
Has Abstractpub_date
2017-12-01 00:00:00pages
694-697issue
6eissn
0268-9146issn
1365-2052journal_volume
48pub_type
杂志文章相关文献
ANIMAL GENETICS文献大全abstract::Two previously reported non-synonymous coding single nucleotide polymorphisms (SNPs) of bovine stearoyl-CoA desaturase (delta-9-desaturase) (SCD) (c.878C>T) and fatty acid synthase (FASN) (g:17924A>G) were assessed for their associations with 72 individual and 12 groups of fatty acids in brisket adipose tissue of 223 ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2011.02217.x
更新日期:2012-02-01 00:00:00
abstract::A cDNA library for porcine skeletal muscle was established in the vector pBR322. The library was screened with an oligonucleotide probe coding for a hexapeptide from glucosephosphate isomerase (Gpi). A positive clone with an insert of about 450 bp and restriction sites for PstI, BamHI and PvuII was isolated. A 362-bp ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1987.tb00763.x
更新日期:1987-01-01 00:00:00
abstract::Two new alleles (A and E) of the bovine MUC locus which encodes PAS-1 protein, a glycoprotein of the milk fat globule membrane, are reported. The A allele was found in Italian Brown while E was present in the Jersey and the Piedmont breeds. ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1995.tb03163.x
更新日期:1995-06-01 00:00:00
abstract::The C3 polymorphism of equine serum or plasma revealed by agarose gel electrophoresis can be diagnosed with protein stain following acid protein fixation. In addition to the three alleles previously described (C31, C32, C33), a fourth allele (C34) was found. Population data for 25 domestic breeds and Equus przewalskii...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1990.tb03210.x
更新日期:1990-01-01 00:00:00
abstract::The objective of this study was to identify twinning rate quantitative trait loci (QTL) by typing pooled samples in a preliminary screening followed by interval mapping to test QTL effects. Four elite North American Holstein half-sib sire families with high twinning rate predicted transmitting abilities (PTA) were use...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2005.01299.x
更新日期:2005-08-01 00:00:00
abstract::Intra-population variation was assessed in 1970 chickens from 64 populations using 29 autosomal microsatellites. On average, 95% of the loci were polymorphic across populations. In 1456 (c. 83%) of the 1763 combinations of populations and polymorphic loci, no departure from Hardy-Weinberg equilibrium was observed. On ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2007.01650.x
更新日期:2007-12-01 00:00:00
abstract::Recurrent airway obstruction (RAO) in horses is the result of an interaction of genetic and environmental factors and shares many characteristics with human asthma. Many studies have suggested that the interleukin-4 receptor gene (IL4R) is associated with this disease, and a QTL region on chromosome 13 containing IL4R...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2011.02277.x
更新日期:2012-08-01 00:00:00
abstract::MicroRNA (miRNA) is a class of single-stranded small (19-24nt) regulatory RNA that silences gene expression post-transcriptionally. miRNAs regulate a wide range of biological processes through the recognition of complementary sequences between miRNAs and their target genes. Profiling studies in livestock have revealed...
journal_title:Animal genetics
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2052.2009.01995.x
更新日期:2010-06-01 00:00:00
abstract::We determined the genetic diversity and evolutionary relationships among 26 Chinese indigenous horse breeds and two introduced horse breeds by genotyping these animals for 27 microsatellite loci. The 26 Chinese horse breeds come from 12 different provinces. Two introduced horse breeds were the Mongolia B Horse from Mo...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2010.02067.x
更新日期:2011-02-01 00:00:00
abstract::Porcine lipoprotein lipase (LPL) cDNA has been cloned and sequenced. The deduced amino acid sequence shows a high degree of identity to LPL from other species, and contains the Ser/His/Asp triade characteristic of serine proteases and esterases. A repetitive element is present in the 3'-untranslated region of the cDNA...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1992.tb00170.x
更新日期:1992-01-01 00:00:00
abstract::Ligneous membranitis (LM) is a rare chronic inflammatory condition of the mucous membranes associated with plasminogen (encoded by PLG) deficiency in affected humans and dogs. In human, the condition is genetic in nature with numerous mutations and polymorphisms in PLG identified in affected individuals and related fa...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12339
更新日期:2015-12-01 00:00:00
abstract::The optimal management of the commercially important, but mostly over-exploited, pelagic tunas, albacore (Thunnus alalunga Bonn., 1788) and Atlantic bluefin tuna (BFT; Thunnus thynnus L., 1758), requires a better understanding of population structure than has been provided by previous molecular methods. Despite numero...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12051
更新日期:2013-12-01 00:00:00
abstract::Three electrophoretic variants of erythrocyte malic enzyme (ME) in goats were reported. Inheritance data indicate that they are controlled by codominant alleles. The allele frequencies in four Mediterranean populations are given. ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1995.tb03255.x
更新日期:1995-08-01 00:00:00
abstract::A synthetic oligodeoxyribonucleotide probe (OAT36) comprising nine repeats of 5'GACA 3' and several enzymes were used to analyse cow, (Bos taurus) and buffalo (Bubalus bubalis) genomes and a number of monomorphic loci were detected in both the species. Different animals from the same species showed an almost 'similar'...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1993.tb00288.x
更新日期:1993-06-01 00:00:00
abstract::The recent extension of genetic tools to the domestic cat, together with the serendipitous consequences of selective breeding, have been essential to the study of the genetic diseases that affect them. Cats are increasingly presented for veterinary surveillance and share many of human's heritable diseases, allowing th...
journal_title:Animal genetics
pub_type: 杂志文章,评审
doi:10.1111/age.12799
更新日期:2019-08-01 00:00:00
abstract::There is evidence that NR6A1 is a strong candidate for being a causal gene underlying vertebral number in pigs. The Licha Black is one of the leanest Chinese indigenous pig breeds, having an average vertebral number of 21.5. The introgression of Western germplasm into Licha Black, resulting in increased vertebral numb...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2008.01820.x
更新日期:2009-04-01 00:00:00
abstract::In domestic goats, the polled intersex syndrome (PIS) refers to XX female-to-male sex reversal associated with the absence of horn growth (polled). The causal variant was previously reported as a 11.7 kb deletion at approximately 129 Mb on chromosome 1 that affects the transcription of both FOXL2 and several long non-...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12918
更新日期:2020-06-01 00:00:00
abstract::Swine genomic DNA segments containing repetitive sequences were isolated from a porcine genomic library using genomic DNA as a probe. Three fragments containing the repetitive sequences from two of the primary phage clones were subcloned for sequence analysis, which revealed six new PRE-1 repetitive families other tha...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1992.tb02164.x
更新日期:1992-01-01 00:00:00
abstract::In the present study, 25 195 BAC ends for channel catfish (Ictalurus punctatus) were sequenced, generating 20 366 clean BAC-end sequences (BES), with an average read length of 557 bp after trimming. A total of 11 414 601 bp were generated, representing approximately 1.2% of the catfish genome. Based on this survey, th...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2006.01453.x
更新日期:2006-08-01 00:00:00
abstract::The progressive loss of colour in the hair of grey horses is controlled by a dominantly inherited allele at the Grey locus (GG). In this study, two paternal Quarter Horse (QH) families segregating for the GG allele were genotyped with a set of 101 microsatellite markers spanning the 31 autosomes and the X chromosome. ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1046/j.1365-2052.2002.00885.x
更新日期:2002-10-01 00:00:00
abstract::Drip loss, one of the most important meat quality traits, is characterized by low heritability. To date, the genetic factors affecting the drip loss trait have not been clearly elucidated. The objective of this study was to identify critical candidate genes affecting drip loss. First, we generated a Pietrain × Duroc ×...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12401
更新日期:2016-04-01 00:00:00
abstract::Nucleotide-Binding Oligomerization Domain 2 (NOD2) has been reported to be a candidate gene for Mycobacterium avium subsp. paratuberculosis (MAP) infection in a Bos taurus × Bos indicus mixed breed based on a genetic association with the c.2197T>C single nucleotide polymorphism (SNP). Nevertheless, this SNP has also b...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2010.02055.x
更新日期:2010-12-01 00:00:00
abstract::Genomic DNAs from animals representing six breeds of cattle (Angus, Brahman, Hereford, Holstein, Jersey and Texas Longhorn) were screened with cloned gene probes in a search for restriction fragment length polymorphisms (RFLPs). Eleven RFLPs were identified using seven different probes: growth hormone, prolactin, oste...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1989.tb00866.x
更新日期:1989-01-01 00:00:00
abstract::The mitochondrial hypervariable region 1 (HVR1) sequence of 67 goats belonging to the Girgentana, Maltese and Derivata di Siria breeds was partially sequenced in order to present the first phylogenetic characterization of Sicilian goat breeds. These sequences were compared with published sequences of Indian and Pakist...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2006.01451.x
更新日期:2006-08-01 00:00:00
abstract::In this study, we performed a sequence characterization of the duck melanocortin 1 receptor (alpha-melanocyte stimulating hormone receptor) (MC1R) gene to analyze the relationship between MC1R polymorphism and the extended black variant in domestic ducks based on the extended black (E) and non-extended black (e(+) ) a...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2012.02377.x
更新日期:2013-04-01 00:00:00
abstract::Mutations in the gene encoding fibrillin-1 (FBN1), a component of the extracellular microfibril, cause Marfan syndrome (MFS). Frequent observation of cattle with a normal withers height, but lower body weight than age-matched normal cattle, was recently reported among cattle sired by phenotypically normal Bull A, in J...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2011.02209.x
更新日期:2012-02-01 00:00:00
abstract::The influence of the major histocompatibility (B) complex and sex on the phytohaemagglutinin (PHA) wattle response was studied in 136 segregants (B2/B2, B2/B5 and B5/B5) of a fourth generation cross between inbred lines 6(1) and 15(1). At 6 weeks of age, chickens were injected with 100 micrograms purified PHA-P. Wattl...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1987.tb00778.x
更新日期:1987-01-01 00:00:00
abstract::Bilateral convergent strabismus with exophthalmus (BCSE) is a widespread inherited eye defect in several cattle populations. Its progressive condition often leads to blindness in affected cattle and decreases their usability. Furthermore, the German animal welfare laws prevent breeding with animals whose progeny are e...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2008.01771.x
更新日期:2008-10-01 00:00:00
abstract::Plasma samples of 1126 dogs belonging to 21 different European breeds were analysed by two-dimensional agarose gel (pH 5.4 or pH 8.6)--horizontal polyacrylamide gel (pH 9.0) electrophoresis, followed by general-protein staining of gels. Genetic polymorphism was detected for five as yet unidentified proteins designated...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1987.tb00773.x
更新日期:1987-01-01 00:00:00
abstract::The mitochondrial DNA sequence of cytochrome b gene in a Thoroughbred horse was determined. By comparing DNA sequences between the Thoroughbred and published sequence data (two horses and one Grevyi zebra), polymerase chain reaction (PCR) primers were designed for amplification of a 590 bp DNA fragment in the cytochro...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1996.tb00979.x
更新日期:1996-10-01 00:00:00