The interleukin 4 receptor gene and its role in recurrent airway obstruction in Swiss Warmblood horses.

Abstract:

:Recurrent airway obstruction (RAO) in horses is the result of an interaction of genetic and environmental factors and shares many characteristics with human asthma. Many studies have suggested that the interleukin-4 receptor gene (IL4R) is associated with this disease, and a QTL region on chromosome 13 containing IL4R was previously detected in one of the two Swiss Warmblood families. We sequenced the entire IL4R gene in this family and detected 93 variants including five non-synonymous protein-coding variants. The allele distribution at these SNPs supported the previously detected QTL signal. Subsequently, we investigated IL4R mRNA expression in bronchoalveolar lavage fluid cells. During exacerbation, IL4R expression was increased in RAO-affected offspring in the implicated family, but not in the other family. These findings support that IL4R plays a role in some cases of RAO.

journal_name

Anim Genet

journal_title

Animal genetics

authors

Klukowska-Rötzler J,Swinburne JE,Drögemüller C,Dolf G,Janda J,Leeb T,Gerber V

doi

10.1111/j.1365-2052.2011.02277.x

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

450-3

issue

4

eissn

0268-9146

issn

1365-2052

journal_volume

43

pub_type

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