Polymorphisms in MHC-DRA and -DRB alleles of water buffalo (Bubalus bubalis) reveal different features from cattle DR alleles.

Abstract:

:Seventy-five individuals of Bubalus bubalis belonging to four different breeds, three of river buffalo and one of swamp buffalo, were studied for polymorphism in MHC DRB (Bubu-DRB) and DRA (Bubu-DRA) loci. Eight alleles of Bubu-DRB were found, and all alleles in the swamp type were shared with the three river breeds. All alleles sampled from the breed of European origin (Mediterranean) were present in breeds sampled in Brazil, thus variability of this locus may have been preserved to a great extent in the more recently founded Brazilian population. Bubu-DRB alleles contained higher proportions of synonymous vs. non-synonymous substitutions in the non-peptide-binding sites (PBS) region, in contrast to the pattern of variation found in BoLA-DRB3, the orthologous locus in cattle. This indicated that either the first domain exon (exon 2) of Bubu-DRB has not undergone as much recombination and/or gene conversion as in cattle alleles, or Bubu-DRB may be more ancient than BoLA-DRB3 alleles. Phylogenetic analysis of DRB alleles from Bubalus, Syncerus c. caffer, the Cape buffalo, and domestic cattle demonstrated transspecies polymorphism. Water buffalo contained two alleles of DRA that differed from each other in two amino acid positions, including one in the PBS (alpha22) that was also shared with Anoa depressicornis, the anoa. Discovery of variation in DRA was surprising as the first domain of DRA is a highly conserved polypeptide in mammals in general and especially in ruminants, where no other substitution in PBS was seen.

journal_name

Anim Genet

journal_title

Animal genetics

authors

Sena L,Schneider MP,Brenig B,Honeycutt RL,Womack JE,Skow LC

doi

10.1046/j.1365-2052.2003.00920.x

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

1-10

issue

1

eissn

0268-9146

issn

1365-2052

pii

920

journal_volume

34

pub_type

杂志文章
  • Maternity validation using sire-only BovineSNP50 BeadChip data.

    abstract::Based on pairwise identity-by-state (IBS) distances and whole-genome SNP data, kinship was investigated in the Israeli Holstein population. A total of 789 bulls, including most of the artificial insemination sires in service since 1987, were genotyped by the BovineSNP50 BeadChip. This sample included up to five genera...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12062

    authors: Seroussi E,Glick G,Shirak A,Ezra E,Zeron Y,Ron M,Weller JI

    更新日期:2013-12-01 00:00:00

  • Mutation in the melanocortin 1 receptor is associated with amber colour in the Norwegian Forest Cat.

    abstract::Amber (previously called X-Colour) is a yellow recessive coat colour observed in the Norwegian Forest Cat (NFC) population and apparently absent in other cat breeds. Until now, there has never been any scientific evidence of yellow recessive mutation (e) reported in the extension gene in Felidae. We sequenced the comp...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2009.01864.x

    authors: Peterschmitt M,Grain F,Arnaud B,Deléage G,Lambert V

    更新日期:2009-08-01 00:00:00

  • Identification of a short interspersed repetitive element insertion polymorphism in the porcine MX1 promoter associated with resistance to porcine reproductive and respiratory syndrome virus infection.

    abstract::The myxovirus resistance (Mx) proteins belong to the dynamin superfamily and are important for innate host defence against RNA viruses. In this study, we demonstrate that positive elements are present in the two promoter regions of -2713 to -2565 and -688 to -431 in the porcine MX1 gene. Sequencing and alignment of th...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12316

    authors: Li Y,Liang S,Liu H,Sun Y,Kang L,Jiang Y

    更新日期:2015-08-01 00:00:00

  • A QTL affecting milk yield and composition maps to bovine chromosome 20: a confirmation.

    abstract::As part of a whole genome scan undertaken to detect quantitative trait loci (QTL) affecting milk yield and composition, we have genotyped a granddaughter design comprising 1152 sons for six microsatellite markers spanning bovine chromosome 20. An analysis performed across families provided strong evidence (experiment-...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.1998.00307.x

    authors: Arranz JJ,Coppieters W,Berzi P,Cambisano N,Grisart B,Karim L,Marcq F,Moreau L,Mezer C,Riquet J,Simon P,Vanmanshoven P,Wagenaar D,Georges M

    更新日期:1998-04-01 00:00:00

  • Toward the most ideal case-control design with related and unrelated dogs in whole-exome sequencing studies.

    abstract::With the recent development of whole-exome sequencing enrichment designs for the dog, a novel tool for disease-association studies became available. The aim of disease-association studies is to identify one or a very limited number of putative causal variants or genes from the large pool of genetic variation. To maxim...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12400

    authors: Broeckx BJ,Coopman F,Verhoeven GE,De Keulenaer S,De Meester E,Bavegems V,Smets P,Van Ryssen B,Van Nieuwerburgh F,Deforce D

    更新日期:2016-04-01 00:00:00

  • Phenotyping of pig alpha 1B-glycoprotein (PO2) and haemopexin by 1D polyacrylamide gel electrophoresis and immunoblotting.

    abstract::Described is an alternative procedure for the phenotyping of pig alpha 1B-glycoprotein (PO2) and haemopexin. The procedure is based on the separation of serum samples by horizontal polyacrylamide gel electrophoresis, passive blotting onto a nitrocellulose (NC) sheet, and immunochemical detection using a mixture of a p...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1989.tb00870.x

    authors: Kaláb P,Stratil A

    更新日期:1989-01-01 00:00:00

  • Genome-wide methylation study of diploid and triploid brown trout (Salmo trutta L.).

    abstract::The induction of triploidization in fish is a very common practice in aquaculture. Although triploidization has been applied successfully in many salmonid species, little is known about the epigenetic mechanisms implicated in the maintenance of the normal functions of the new polyploid genome. By means of methylation-...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12287

    authors: Covelo-Soto L,Leunda PM,Pérez-Figueroa A,Morán P

    更新日期:2015-06-01 00:00:00

  • Direct sequencing and bidirectional allele specific polymerase chain reaction of the bovine beta-casein B variant.

    abstract::We have used the polymerase chain reaction (PCR) to amplify exon VII of the bovine beta-casein gene. The mutations responsible for the B variant were identified by direct sequencing of the amplification products. A bidirectional allele-specific PCR method (BAS-PCR) has been developed using oligonucleotides overlapping...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1992.tb00180.x

    authors: Damiani G,Pilla F,Leone P,Cacciò S

    更新日期:1992-01-01 00:00:00

  • Definition of the USDA103 strain of channel catfish (Ictalurus punctatus).

    abstract::Although there are differences in performance between genetic groups of channel catfish, identification and management of these groups is difficult because catfish strains look alike and individuals cannot be tagged efficiently. Thus, US catfish producers have not been able to objectively identify fish from different ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2007.01586.x

    authors: Waldbieser GC,Wolters WR

    更新日期:2007-04-01 00:00:00

  • Detecting selection signatures in three Iranian sheep breeds.

    abstract::The objective of genome mapping is to achieve valuable insight into the connection between gene variants (genotype) and observed traits (phenotype). Part of that objective is to understand the selective forces that have operated on a population. Finding links between genotype-phenotype changes makes it possible to ide...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12772

    authors: Manzari Z,Mehrabani-Yeganeh H,Nejati-Javaremi A,Moradi MH,Gholizadeh M

    更新日期:2019-06-01 00:00:00

  • Biochemical genetic variants in mice selectively bred for sensitivity or resistance to ethanol-induced sedation.

    abstract::The distribution of biochemical genetic variants was examined among eight inbred strains of mice, which served as contributors to a heterogeneous stock of mice (HS), and in short-sleep (SS) and long-sleep (LS) mice, selectively bred from the HS stock for differential ethanol sensitivity. Fifteen loci for enzymes of al...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1986.tb03195.x

    authors: Holmes RS,Petersen DR,Deitrich RA

    更新日期:1986-01-01 00:00:00

  • Genome-wide association study identifies markers associated with carcass and meat quality traits in Italian Large White pigs.

    abstract::A GWAS was performed using the genotypes obtained by PorcineSNP60 v2 BeadChip and 11 phenotypic traits (carcass lean meat percentage; backfat thickness; Longissimus thoracis muscle thickness; lightness; backfat thickness measured with caliper at the midline; meat pH measured at about 1 h post mortem and 24 h post mort...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.13013

    authors: Fabbri MC,Zappaterra M,Davoli R,Zambonelli P

    更新日期:2020-12-01 00:00:00

  • Comparative porcine gene mapping relative to human chromosomes 9, 10, 20 and 22.

    abstract::Comparative anchor tagged sequence (CATS) consensus primers from loci mapped to human chromosomes 9, 10, 20, and 22 have been used to amplify homologous loci in pigs. Of 53, CATS primers tested in pigs, only 23 yielded products homologous to the human locus (42% success). Ten loci were physically mapped (43% success r...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.2001.00787.x

    authors: Lee JH,Zhang W,Moran C

    更新日期:2001-10-01 00:00:00

  • Linkage of hyperkalaemic periodic paralysis in quarter horses to the horse adult skeletal muscle sodium channel gene.

    abstract::A genetic disease observed in certain Quarter horses is hyperkalaemic periodic paralysis (HYPP). This disease causes attacks of paralysis which can be induced by ingestion of potassium. Recent studies have shown that HYPP in humans is due to single base changes within the adult skeletal muscle sodium channel gene. A l...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1992.tb00136.x

    authors: Rudolph JA,Spier SJ,Byrns G,Hoffman EP

    更新日期:1992-01-01 00:00:00

  • A PCR-RFLP for KIT associated with tobiano spotting pattern in horses.

    abstract::An MspI polymorphism was identified in intron 13 of the equine homologue of proto-oncogene c-kit (KIT) by comparing DNA sequences from horses with solid coat colour and horses homozygous for the tobiano spotting (To) gene. The allele associated with solid coat colour was designated KM0, while the allele associated wit...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.2002.00854.x

    authors: Brooks SA,Terry RB,Bailey E

    更新日期:2002-08-01 00:00:00

  • Physical mapping of the brain and ovarian aromatase genes in the Nile Tilapia, Oreochromis niloticus, by fluorescence in situ hybridization.

    abstract::Cytochrome P450-aromatase enzyme (CYP19), which catalyses the conversion of androgens to oestrogens, is critical in ovarian differentiation and hence in the sex differentiation pathways of non-mammalian vertebrates. As in other fish species, distinct ovarian and brain aromatase genes have been identified in the Nile T...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.2003.00941.x

    authors: Harvey SC,Kwon JY,Penman DJ

    更新日期:2003-02-01 00:00:00

  • Four new alleles at the mannose-6-phosphate isomerase locus in rabbit.

    abstract::Four new alleles at the rabbit (Oryctolagus cuniculus) mannose-6-phosphate isomerase (E.C. 5.3.1.8, MPI) locus are proposed to account for phenotypes observed after starch gel electrophoresis and enzymatic staining of red cell lysates and tissues. Population data from various wild and domestic rabbit populations are p...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1995.tb02617.x

    authors: Vieira J,Ferrand N

    更新日期:1995-02-01 00:00:00

  • APOB-associated cholesterol deficiency in Holstein cattle is not a simple recessive disease.

    abstract::In 2015, cholesterol deficiency (CD) was reported for the first time as a new recessive defect in Holstein cattle. After GWAS mapping and identification of a disease-associated haplotype, a causative loss-of-function variant in APOB was identified. CD-clinically affected APOB homozygotes showed poor development, inter...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12801

    authors: Häfliger IM,Hofstetter S,Mock T,Stettler MH,Meylan M,Mehinagic K,Stokar-Regenscheit N,Drögemüller C

    更新日期:2019-08-01 00:00:00

  • Farm-by-farm analysis of microsatellite, mtDNA and SNP genotype data reveals inbreeding and crossbreeding as threats to the survival of a native Spanish pig breed.

    abstract::The Chato Murciano (CM), a pig breed from the Murcia region in the southeastern region of Spain, is a good model for endangered livestock populations. The remaining populations are bred on approximately 15 small farms, and no herdbook exists. To assess the genetic threats to the integrity and survival of the CM breed,...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12001

    authors: Herrero-Medrano JM,Megens HJ,Crooijmans RP,Abellaneda JM,Ramis G

    更新日期:2013-06-01 00:00:00

  • Validation of microsatellite markers for routine horse parentage testing.

    abstract::A parallel testing of 4803 routine Quarter Horse parentage cases, using 15 loci of blood group and protein polymorphisms (blood typing) and 11 loci of dinucleotide repeat microsatellites (DNA typing), validated DNA markers for horse pedigree verification. For the 26 loci, taken together, the theoretical effectiveness ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1997.00123.x

    authors: Bowling AT,Eggleston-Stott ML,Byrns G,Clark RS,Dileanis S,Wictum E

    更新日期:1997-08-01 00:00:00

  • Phylogenetic analysis of Sicilian goats reveals a new mtDNA lineage.

    abstract::The mitochondrial hypervariable region 1 (HVR1) sequence of 67 goats belonging to the Girgentana, Maltese and Derivata di Siria breeds was partially sequenced in order to present the first phylogenetic characterization of Sicilian goat breeds. These sequences were compared with published sequences of Indian and Pakist...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2006.01451.x

    authors: Sardina MT,Ballester M,Marmi J,Finocchiaro R,van Kaam JB,Portolano B,Folch JM

    更新日期:2006-08-01 00:00:00

  • Identification and SNP association analysis of a novel gene in chicken.

    abstract::A novel gene that was predicted to encode a long noncoding RNA (lncRNA) transcript was identified in a previous study that aimed to detect candidate genes related to growth rate differences between Chinese local breed Gushi chickens and Anka broilers. To characterise the biological function of the lncRNA, we cloned an...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12387

    authors: Mei X,Kang X,Liu X,Jia L,Li H,Li Z,Jiang R

    更新日期:2016-02-01 00:00:00

  • Identification of candidate genes and mutations in QTL regions for immune responses in chicken.

    abstract::There are two categories of immune responses - innate and adaptive immunity - both having polygenic backgrounds and a significant environmental component. In our study, adaptive immunity was represented by the specific antibody response toward keyhole limpet hemocyanin (KLH); innate immunity was represented by natural...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12280

    authors: Siwek M,Slawinska A,Rydzanicz M,Wesoly J,Fraszczak M,Suchocki T,Skiba J,Skiba K,Szyda J

    更新日期:2015-06-01 00:00:00

  • Channel catfish BAC-end sequences for marker development and assessment of syntenic conservation with other fish species.

    abstract::In the present study, 25 195 BAC ends for channel catfish (Ictalurus punctatus) were sequenced, generating 20 366 clean BAC-end sequences (BES), with an average read length of 557 bp after trimming. A total of 11 414 601 bp were generated, representing approximately 1.2% of the catfish genome. Based on this survey, th...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2006.01453.x

    authors: Xu P,Wang S,Liu L,Peatman E,Somridhivej B,Thimmapuram J,Gong G,Liu Z

    更新日期:2006-08-01 00:00:00

  • Restriction site heteroplasmy in the mitochondrial DNA of the marine fish Sciaenops ocellatus (L.).

    abstract::Restriction site heteroplasmy involving the enzymes NcoI and XbaI was detected in the mitochondrial DNAs of two individuals of the marine fish Sciaenops ocellatus. This represents only the sixth documented example of mitochondrial DNA restriction site heteroplasmy in animals. Two heteroplasmic individuals were found i...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1990.tb03241.x

    authors: Gold JR,Richardson LR

    更新日期:1990-01-01 00:00:00

  • Ligneous membranitis in Scottish Terriers is associated with a single nucleotide polymorphism in the plasminogen (PLG) gene.

    abstract::Ligneous membranitis (LM) is a rare chronic inflammatory condition of the mucous membranes associated with plasminogen (encoded by PLG) deficiency in affected humans and dogs. In human, the condition is genetic in nature with numerous mutations and polymorphisms in PLG identified in affected individuals and related fa...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12339

    authors: Ainsworth S,Carter S,Fisher C,Dawson J,Makrides L,Nuttall T,Mason SL

    更新日期:2015-12-01 00:00:00

  • Bovine monoclonal alloantibodies to blood group antigens prepared by murine x bovine or (murine x bovine) x bovine interspecies fusions.

    abstract::In order to obtain monoclonal alloantibodies against bovine blood group antigens, lymph node cells from calves immunized with bovine red blood cells (RBC) were fused with either murine NSO/1 myeloma cells or a HAT sensitive murine x bovine heterohybridoma cell line. Both fusion partners resulted in heterohybridoma cel...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:

    authors: Hønberg LS,Larsen B

    更新日期:1992-01-01 00:00:00

  • Unveiling introgression in bumblebee (Bombus terrestris) populations through mitogenome-based markers.

    abstract::The bumblebee, Bombus terrestris, is an important pollinator commercially used on a global scale. The exported subspecies B. t. terrestris has colonised diverse environments, in some cases displacing wild pollinators to the verge of local extinction. In this sense, the native Iberian subspecies B. t. lusitanicus may b...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12874

    authors: Cejas D,López-López A,Muñoz I,Ornosa C,De la Rúa P

    更新日期:2020-02-01 00:00:00

  • Intrageneric amplification of horse microsatellite markers with emphasis on the Przewalski's horse (E. przewalskii).

    abstract::Primer sequences flanking 13 microsatellite loci isolated from the domestic horse (E. caballus) were successfully used to amplify homologous loci in the Przewalski's horse (E. przewalskii). The results demonstrate that the level of polymorphism at all 13 loci in the Przewalski's horse was comparable to that in the dom...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1994.tb00530.x

    authors: Breen M,Downs P,Irvin Z,Bell K

    更新日期:1994-12-01 00:00:00

  • IGF2 gene characterization and association with rib eye area in beef cattle.

    abstract::Insulin-like growth factor 2 (IGF2) is an imprinted gene expressed in most tissues affecting lean muscle content in mice, pigs and cattle. We previously identified the bovine IGF2 c.-292C>T SNP in the non-translated exon 2. Using this SNP, we demonstrated biallelic expression of IGF2 after birth. Seven alternatively s...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2007.01576.x

    authors: Goodall JJ,Schmutz SM

    更新日期:2007-04-01 00:00:00