Novel alternative splicing by exon skipping in KIT associated with whole-body roan in an intercrossed population of Landrace and Korean Native pigs.

Abstract:

:The KIT locus has been suggested to be a strong candidate region linked with whole-body roan in the F(2) population produced by intercrosses between Landrace and Korean Native pigs. In this manuscript, we report the finding of a novel alternative splicing event in the porcine KIT gene that results in the skipping of exon 5 in the I(Rn) allele. KIT mRNAs that lack exon 5 were identified in the large intestine and skin, suggesting that the mechanism responsible for the skipping of exon 5 may be tissue specific. A U(26) repeat in intron 5 showed complete linkage (LOD = 11.8) with the roan phenotype and absolute association with the black phenotype of the Korean Native pig (KNP) population samples, inferring that the repeat pattern may alter the complementary base-pairing-mediated looping-out of introns 4 and 5, which may mediate the exon 5-skipping event. Although the sample size in our study was relatively small, we speculate that the R3 allele containing the U(26) repeat is a causative element for the roan phenotype via alternative control of the exon skipping in our roan pedigree.

journal_name

Anim Genet

journal_title

Animal genetics

authors

Lim HT,Zhong T,Cho IC,Seo BY,Kim JH,Lee SS,Ko MS,Park HB,Kim BW,Lee JH,Jeon JT

doi

10.1111/j.1365-2052.2011.02225.x

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

451-5

issue

4

eissn

0268-9146

issn

1365-2052

journal_volume

42

pub_type

杂志文章
  • Tracing genetic differentiation of Chinese Mongolian sheep using microsatellites.

    abstract::The genetic consequences of population differentiation and isolation have been the subject of conservation biology. In this study, we analysed the genetic diversity and structure of Mongolian sheep in China. These animals belong to a traditional local breed with high production, extensive adaption, early maturity and ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2011.02181.x

    authors: Zhong T,Han JL,Guo J,Zhao QJ,Fu BL,Pu YB,He XH,Jeon JT,Guan WJ,Ma YH

    更新日期:2011-10-01 00:00:00

  • Mapping and SNP analysis of bovine candidate genes for meat and carcass quality.

    abstract::The chromosomal localization of 13 bovine genes was determined using radiation hybrid (RH) mapping. The RH mapping data were in agreement with published data using either linkage, somatic cell hybrids or in situ hybridization. Mutation analysis using single-stranded conformational polymorphism, restriction fragment le...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.2003.01008.x

    authors: Haegeman A,Williams JL,Law A,Van Zeveren A,Peelman LJ

    更新日期:2003-10-01 00:00:00

  • Farm-by-farm analysis of microsatellite, mtDNA and SNP genotype data reveals inbreeding and crossbreeding as threats to the survival of a native Spanish pig breed.

    abstract::The Chato Murciano (CM), a pig breed from the Murcia region in the southeastern region of Spain, is a good model for endangered livestock populations. The remaining populations are bred on approximately 15 small farms, and no herdbook exists. To assess the genetic threats to the integrity and survival of the CM breed,...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12001

    authors: Herrero-Medrano JM,Megens HJ,Crooijmans RP,Abellaneda JM,Ramis G

    更新日期:2013-06-01 00:00:00

  • Characterization of swine short interspersed repetitive sequences.

    abstract::Swine genomic DNA segments containing repetitive sequences were isolated from a porcine genomic library using genomic DNA as a probe. Three fragments containing the repetitive sequences from two of the primary phage clones were subcloned for sequence analysis, which revealed six new PRE-1 repetitive families other tha...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1992.tb02164.x

    authors: Takahashi H,Awata T,Yasue H

    更新日期:1992-01-01 00:00:00

  • Isolation and sequencing of porcine lipoprotein lipase cDNA and its use in multiallelic restriction fragment length polymorphism detection.

    abstract::Porcine lipoprotein lipase (LPL) cDNA has been cloned and sequenced. The deduced amino acid sequence shows a high degree of identity to LPL from other species, and contains the Ser/His/Asp triade characteristic of serine proteases and esterases. A repetitive element is present in the 3'-untranslated region of the cDNA...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1992.tb00170.x

    authors: Harbitz I,Kristensen T,Kran S,Davies W

    更新日期:1992-01-01 00:00:00

  • Current knowledge of microRNA characterization in agricultural animals.

    abstract::MicroRNA (miRNA) is a class of single-stranded small (19-24nt) regulatory RNA that silences gene expression post-transcriptionally. miRNAs regulate a wide range of biological processes through the recognition of complementary sequences between miRNAs and their target genes. Profiling studies in livestock have revealed...

    journal_title:Animal genetics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2052.2009.01995.x

    authors: Liu HC,Hicks JA,Trakooljul N,Zhao SH

    更新日期:2010-06-01 00:00:00

  • Genome-wide methylation study of diploid and triploid brown trout (Salmo trutta L.).

    abstract::The induction of triploidization in fish is a very common practice in aquaculture. Although triploidization has been applied successfully in many salmonid species, little is known about the epigenetic mechanisms implicated in the maintenance of the normal functions of the new polyploid genome. By means of methylation-...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12287

    authors: Covelo-Soto L,Leunda PM,Pérez-Figueroa A,Morán P

    更新日期:2015-06-01 00:00:00

  • Tropically adapted cattle of Africa: perspectives on potential role of copy number variations.

    abstract::Africa is host to diverse and locally adapted cattle breeds that are expected to survive the harsh and extreme tropical environments associated with diseases and parasite infections, heat stress and episodes of feed and water scarcity. Genomic copy number variations (CNVs) are considered to be primary role players in ...

    journal_title:Animal genetics

    pub_type: 杂志文章,评审

    doi:10.1111/age.12391

    authors: Wang MD,Dzama K,Rees DJ,Muchadeyi FC

    更新日期:2016-04-01 00:00:00

  • Restriction fragment length polymorphism among Israeli Holstein-Friesian dairy bulls.

    abstract::Israeli Holstein-Friesian dairy bulls were screened for restriction fragment length polymorphisms by hybridizing cloned DNA probes for bovine growth hormone, for chymosin, and for rat muscle beta-actin to restriction endonuclease-digested DNA immobilized on nitrocellulose filters. The population proved to be polymorph...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1986.tb03185.x

    authors: Beckmann JS,Kashi Y,Hallerman EM,Nave A,Soller M

    更新日期:1986-01-01 00:00:00

  • Evaluation of the genetic diversity and population structure of Chinese indigenous horse breeds using 27 microsatellite markers.

    abstract::We determined the genetic diversity and evolutionary relationships among 26 Chinese indigenous horse breeds and two introduced horse breeds by genotyping these animals for 27 microsatellite loci. The 26 Chinese horse breeds come from 12 different provinces. Two introduced horse breeds were the Mongolia B Horse from Mo...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2010.02067.x

    authors: Ling YH,Ma YH,Guan WJ,Cheng YJ,Wang YP,Han JL,Mang L,Zhao QJ,He XH,Pu YB,Fu BL

    更新日期:2011-02-01 00:00:00

  • The interleukin 4 receptor gene and its role in recurrent airway obstruction in Swiss Warmblood horses.

    abstract::Recurrent airway obstruction (RAO) in horses is the result of an interaction of genetic and environmental factors and shares many characteristics with human asthma. Many studies have suggested that the interleukin-4 receptor gene (IL4R) is associated with this disease, and a QTL region on chromosome 13 containing IL4R...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2011.02277.x

    authors: Klukowska-Rötzler J,Swinburne JE,Drögemüller C,Dolf G,Janda J,Leeb T,Gerber V

    更新日期:2012-08-01 00:00:00

  • Validation of microsatellite markers for routine horse parentage testing.

    abstract::A parallel testing of 4803 routine Quarter Horse parentage cases, using 15 loci of blood group and protein polymorphisms (blood typing) and 11 loci of dinucleotide repeat microsatellites (DNA typing), validated DNA markers for horse pedigree verification. For the 26 loci, taken together, the theoretical effectiveness ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1997.00123.x

    authors: Bowling AT,Eggleston-Stott ML,Byrns G,Clark RS,Dileanis S,Wictum E

    更新日期:1997-08-01 00:00:00

  • A high-resolution radiation hybrid map of porcine chromosome 6.

    abstract::A high-resolution comprehensive map was constructed for porcine chromosome (SSC) 6, where quantitative trait loci (QTL) for reproduction and meat quality traits have been reported to exist. A radiation hybrid (RH) map containing 105 gene-based markers and 15 microsatellite markers was constructed for this chromosome u...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2004.01161.x

    authors: Cao H,Robinson JA,Jiang Z,Melville JS,Golovan SP,Jones MW,Verrinder Gibbins AM

    更新日期:2004-10-01 00:00:00

  • Sequence analysis of MHC class I alpha 2 domain exon variants in one diploid and two haploid Atlantic salmon pedigrees.

    abstract::Genetic diversity in the second domain exon of Atlantic salmon (Salmo salar) major histocompatibility complex (Mhc) class I was investigated in two dams and nine of their haploid offspring by means of polymerase chain reaction (PCR) and DNA sequence analysis. A similar study was also performed on nine diploid offsprin...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1997.00183.x

    authors: Grimholt U,Olsaker I,Lingaas F,Lie O

    更新日期:1997-12-01 00:00:00

  • Canine plasma alkaline phosphatase polymorphism and its relationship with the canine Tr blood group system.

    abstract::A canine blood group antigen, QN, which was detected by a naturally occurring alloantibody in the antiglobulin test, was shown to be antigenically related to the human A and cattle J antigens by absorption experiments. Family studies supported a dominant mode of inheritance with the gene controlling the production of ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1992.tb00153.x

    authors: Symons M,Bell K

    更新日期:1992-01-01 00:00:00

  • A genetic analysis of the London strain of rainbow trout.

    abstract::The London strain of rainbow trout (Oncorhynchus mykiss) was created by interbreeding three other strains of rainbow trout and therefore was expected to have higher levels of genetic variation than other strains of rainbow trout. We examined 129 London strain rainbow trout from Indiana by allozyme electrophoresis to a...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.2001.00766.x

    authors: Gregg RE,Rhodes OE,Armstrong G

    更新日期:2001-08-01 00:00:00

  • Effects of DGAT1 and GHR on milk yield and milk composition in the Chinese dairy population.

    abstract::Previous studies have demonstrated that the p.Lys232Ala substitution in the acylCoA: diacylglycerol acyltransferase (DGAT1) gene and the p.Phe279Tyr mutation in the growth hormone receptor (GHR) gene are the causative quantitative trait loci underlying milk yield and composition on BTA14 and BTA20 respectively. To exa...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2009.01945.x

    authors: Sun D,Jia J,Ma Y,Zhang Y,Wang Y,Yu Y,Zhang Y

    更新日期:2009-12-01 00:00:00

  • Detecting signatures of selection in nine distinct lines of broiler chickens.

    abstract::Modern commercial chickens have been bred for one of two specific purposes: meat production (broilers) or egg production (layers). This has led to large phenotypic changes, so that the genomic signatures of selection may be detectable using statistical techniques. Genetic differentiation between nine distinct broiler ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12252

    authors: Stainton JJ,Haley CS,Charlesworth B,Kranis A,Watson K,Wiener P

    更新日期:2015-02-01 00:00:00

  • Additional studies of sheep haemopexin: genetic control, frequencies and postnatal development.

    abstract::This study presents evidence that sheep haemopexin phenotypes are genetically controlled by three alleles, HpxA, HpxB1 and HpxB2, of a single autosomal locus. Frequencies of two alleles, HpxA and HpxB (HpxB encompasses two isoalleles, HpxB1 and HpxB2), were studied in eight sheep breeds in Czechoslovakia. The frequenc...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1989.tb00856.x

    authors: Stratil A,Bobák P,Margetín M,Glasnák V

    更新日期:1989-01-01 00:00:00

  • Quantitative trait loci for resistance to infection in sheep using a live Salmonella Abortusovis vaccine.

    abstract::Quantitative trait loci (QTL) mapping for susceptibility to a Salmonella Abortusovis vaccinal strain was performed using an experimental design involving 30 Romane sheep sire families (1216 progenies). Nine QTL corresponding to bacterial load, weight variations and antibody response criteria were mapped on eight chrom...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2011.02291.x

    authors: Lantier I,Moreno CR,Berthon P,Sallé G,Pitel F,Schibler L,Gautier-Bouchardon AV,Boivin R,Weisbecker JL,François D,Bouix J,Cribiu EP,Elsen JM,Lantier F

    更新日期:2012-10-01 00:00:00

  • Chromosomal assignment of chicken clone contigs by extending the consensus linkage map.

    abstract::The bacterial artificial clone-based physical map for chicken plays an important role in the integration of the consensus linkage map and the whole-genome shotgun sequence. It also provides a valuable resource for clone selection within applications such as fluorescent in situ hybridization and positional cloning. How...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2005.01289.x

    authors: Aerts JA,Veenendaal T,van der Poel JJ,Crooijmans RP,Groenen MA

    更新日期:2005-06-01 00:00:00

  • A third variant of glucose phosphate isomerase in pigs.

    abstract::A new variant of glucose phosphate isomerase (GPI), also known as phosphohexose isomerase (PHI), was detected in a primitive pig population. ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1988.tb00790.x

    authors: Van de Weghe A,Yablanski T,Van Zeveren A,Bouquet Y

    更新日期:1988-01-01 00:00:00

  • Heritability of racing performance in the Australian Thoroughbred racing population.

    abstract::Performance data for 164,046 Thoroughbreds entered in a race or official barrier trial in Australia were provided by Racing Information Services Australia. Analyses estimating the heritability for a range of racing performance traits using a single-trait animal model were performed using ASREML-R. Log of cumulative ea...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12234

    authors: Velie BD,Hamilton NA,Wade CM

    更新日期:2015-02-01 00:00:00

  • Significant association between SNPs in the superoxide dismutase 3, extracellular (SOD3) gene and resistance to Aeromonas hydrophila in the freshwater mussel Hyriopsis cumingii.

    abstract::Extracellular superoxide dismutase (SOD3) is a major antioxidant enzyme that protects organs from damage by reactive oxygen species (ROS). In this study, the SOD3 gene was identified and characterized from the freshwater mussel Hyriopsis cumingii (Hc-SOD3). The cDNA sequence consists of 763 bp, encoding a protein of 2...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12059

    authors: Wang GL,Li XL,Li JL

    更新日期:2013-12-01 00:00:00

  • RNA-seq analysis reveals new candidate genes for drip loss in a Pietrain × Duroc × Landrace × Yorkshire population.

    abstract::Drip loss, one of the most important meat quality traits, is characterized by low heritability. To date, the genetic factors affecting the drip loss trait have not been clearly elucidated. The objective of this study was to identify critical candidate genes affecting drip loss. First, we generated a Pietrain × Duroc ×...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12401

    authors: Li B,Liu K,Weng Q,Li P,Wei W,Li Q,Chen J,Huang R,Wu W,Liu H

    更新日期:2016-04-01 00:00:00

  • Polymorphism and gene organization of water buffalo MHC-DQB genes show homology to the BoLA DQB region.

    abstract::In cattle (Bos taurus), there is evidence of more than 50 alleles of BoLA-DQB (bovine lymphocyte antigen DQB) that are distributed across at least five DQB loci, making this region one of the most complex in the BoLA gene family. In this study, DQB alleles were analysed for the water buffalo (Bubalus bubalis), another...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2010.02157.x

    authors: Sena L,Schneider MP,Brenig BB,Honeycutt RL,Honeycutt DA,Womack JE,Skow LC

    更新日期:2011-08-01 00:00:00

  • Identification of the myostatin locus (MSTN) as having a major effect on optimum racing distance in the Thoroughbred horse in the USA.

    abstract::One hundred and eighty-nine Thoroughbred horses that had won Graded Stakes races in North America were genotyped with the Illumina Equine SNP50 bead chip. Association tests using PLINK to determine whether any SNPs were associated with optimum racing distance (7 furlongs and under compared to 8-10 furlongs) identified...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2010.02126.x

    authors: Binns MM,Boehler DA,Lambert DH

    更新日期:2010-12-01 00:00:00

  • Linkage disequilibrium and historical effective population size in the Thoroughbred horse.

    abstract::Many genomic methodologies rely on the presence and extent of linkage disequilibrium (LD) between markers and genetic variants underlying traits of interest, but the extent of LD in the horse has yet to be comprehensively characterized. In this study, we evaluate the extent and decay of LD in a sample of 817 Thoroughb...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2010.02092.x

    authors: Corbin LJ,Blott SC,Swinburne JE,Vaudin M,Bishop SC,Woolliams JA

    更新日期:2010-12-01 00:00:00

  • On measures of association among genetic variables.

    abstract::Systems involving many variables are important in population and quantitative genetics, for example, in multi-trait prediction of breeding values and in exploration of multi-locus associations. We studied departures of the joint distribution of sets of genetic variables from independence. New measures of association b...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2012.02326.x

    authors: Gianola D,Manfredi E,Simianer H

    更新日期:2012-07-01 00:00:00

  • A PCR-RFLP for KIT associated with tobiano spotting pattern in horses.

    abstract::An MspI polymorphism was identified in intron 13 of the equine homologue of proto-oncogene c-kit (KIT) by comparing DNA sequences from horses with solid coat colour and horses homozygous for the tobiano spotting (To) gene. The allele associated with solid coat colour was designated KM0, while the allele associated wit...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.2002.00854.x

    authors: Brooks SA,Terry RB,Bailey E

    更新日期:2002-08-01 00:00:00