An integrated comparative map of the porcine X chromosome.

Abstract:

:The objectives of this study were to assign both microsatellite and gene-based markers on porcine chromosome X to two radiation hybrid (RH) panels and to develop a more extensive integrated map of SSC-X. Thirty-five microsatellite and 20 gene-based markers were assigned to T43RH, and 16 previously unreported microsatellite and 15 gene-based markers were added to IMpRH map. Of these, 30 microsatellite and 12 gene-based markers were common to both RH maps. Twenty-two gene-based markers were submitted to BLASTN analysis for identification of orthologues of genes on HSA-X. Single nucleotide polymorphisms (SNPs) were detected for 12 gene-based markers, and nine of these were placed on the genetic map. A total of 92 known loci are present on at least one porcine chromosome X map. Thirty-seven loci are present on all three maps; 31 loci are found on only one map. Location of 33 gene-based markers on the comprehensive map translates into an integrated comparative map that supports conservation of gene order between SSC-X and HSA-X. This integrated map will be valuable for selection of candidate genes for porcine quantitative trait loci (QTLs) that map to SSC-X.

journal_name

Anim Genet

journal_title

Animal genetics

authors

McCoard SA,Fahrenkrug SC,Alexander LJ,Freking BA,Rohrer GA,Wise TH,Ford JJ

doi

10.1046/j.1365-2052.2002.00878.x

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

178-85

issue

3

eissn

0268-9146

issn

1365-2052

pii

878

journal_volume

33

pub_type

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