Abstract:
:The gene coding for the mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M), a pivotal component in gluconeogenesis from lactate via the Cori cycle, was highly polymorphic in strains of egg-type chickens (White Leghorn) of different origins. Based on MspI restriction fragment polymorphisms a total of seven alleles could be distinguished. The allele frequencies were determined in six pairs of strains derived from different genetic base populations. Each pair consisted of two strains which differed in their susceptibility to Marek's disease (MD), a virus-induced neoplastic disease. The frequency of the most common haplotype (M2) was consistently higher in the susceptible strains than in the corresponding resistant strains (P < 0.05, Wilcoxon signed-ranks test), indicating that the observed differences were not due to random genetic drift. This result suggests that PEPCK-M may be a candidate gene which contains genetic variants affecting MD susceptibility. Variations in gluconeogenesis may affect the interplay between proliferation of neoplasia and host metabolism.
journal_name
Anim Genetjournal_title
Animal geneticsauthors
Li S,Zadworny D,Aggrey SE,Kuhnlein Udoi
10.1046/j.1365-2052.1998.295362.xsubject
Has Abstractpub_date
1998-10-01 00:00:00pages
395-7issue
5eissn
0268-9146issn
1365-2052journal_volume
29pub_type
杂志文章相关文献
ANIMAL GENETICS文献大全abstract::The goal of this study was to identify and map genes expressed during the elongation phase of embryogenesis in swine. Expressed sequence tags were analysed from a previously described porcine cDNA library prepared from elongating swine embryos. Average insert length of randomly selected clones was approximately 600 bp...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1046/j.1365-2052.2001.00739.x
更新日期:2001-04-01 00:00:00
abstract::Abdominal fat content is an economically important trait in commercially bred chickens. Although many quantitative trait loci (QTL) related to fat deposition have been detected, the resolution for these regions is low and functional variants are still unknown. The current study was conducted aiming at increasing resol...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12263
更新日期:2015-04-01 00:00:00
abstract::Colostrum intake is critical to a piglet's survival and can be measured by precipitating out the γ-immunoglobulins from serum with ammonium sulfate (immunocrit). Genetic analysis of immunocrits on 5312 piglets indicated that the heritabilities (se) for direct and maternal effects were 0.13 (0.06) and 0.53 (0.08) respe...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12131
更新日期:2014-06-01 00:00:00
abstract::Acetyl-coenzyme A carboxylase alpha (ACACA) catalyses the first committed step in the biosynthesis of long-chain fatty acids (FA) by converting acetyl-CoA into malonyl-CoA. In pigs, the ACACA gene maps to a chromosome 12 QTL with important effects on FA composition. In the present study, we have sequenced the coding r...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2009.01854.x
更新日期:2009-08-01 00:00:00
abstract::Ten alloantisera defining five major histocompatibility complex (MHC) class II specificities of the bovine lymphocyte antigen (BoLA) complex were produced and characterized. Eight antisera defining four of the specificities were generated by immunizing cattle with class I compatible-class II incompatible lymphocytes. ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1991.tb00701.x
更新日期:1991-01-01 00:00:00
abstract::The objectives of this study were to assign both microsatellite and gene-based markers on porcine chromosome X to two radiation hybrid (RH) panels and to develop a more extensive integrated map of SSC-X. Thirty-five microsatellite and 20 gene-based markers were assigned to T43RH, and 16 previously unreported microsate...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1046/j.1365-2052.2002.00878.x
更新日期:2002-06-01 00:00:00
abstract::Loss-of-function variants in the MC1R gene cause recessive red or yellow coat-colour phenotypes in many species. The canine MC1R:c.916C>T (p.Arg306Ter) variant is widespread and found in a homozygous state in many uniformly yellow- or red-coloured dogs. We investigated cream-coloured Australian Cattle Dogs whose coat ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12660
更新日期:2018-08-01 00:00:00
abstract::Linkage analysis between the genes coding for immunoglobulin heavy-chain allotypes and variants of some serum alpha-protease inhibitors produced lod scores above the significance limit of 3. The maximum likelihood estimate of the recombination fraction (theta) ranged from 0.15 to 0.20. Since this is the second report ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1987.tb00779.x
更新日期:1987-01-01 00:00:00
abstract::Novel and traditional eggshell quality measurements were made from up to 2000 commercial pedigree hens for a candidate gene association analysis with organic eggshell matrix genes: ovocleidin-116, osteopontin (SPP1), ovocalyxin-32 (RARRES1), ovotransferrin (LTF), ovalbumin and ovocalyxin-36, as well as key genes in th...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2008.01794.x
更新日期:2009-02-01 00:00:00
abstract::Clinical-chemical traits are diagnostic parameters essential for characterization of health and disease in veterinary practice. The traits show significant variability and are under genetic control, but little is known about the fundamental genetic architecture of this variability, especially in swine. We have identif...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2008.01804.x
更新日期:2009-02-01 00:00:00
abstract::Recently, linkage of a DNA microsatellite marker to inherited copper toxicosis has been reported in American Bedlington terrier families. Due to the fact that there is little exchange of breeding stock between the USA and Europe, it remains to be investigated whether in Europe the marker is informative and is linked w...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1046/j.1365-2052.1999.00451.x
更新日期:1999-06-01 00:00:00
abstract::A new variant of glucose phosphate isomerase (GPI), also known as phosphohexose isomerase (PHI), was detected in a primitive pig population. ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1988.tb00790.x
更新日期:1988-01-01 00:00:00
abstract::cDNAs encoding porcine beta-lactoglobulin were isolated and sequenced. The porcine beta-lactoglobulin cDNA is 768bp in length and encodes a pre-protein of 178 amino acids. One additional cDNA clone was found to encode an additional amino acid (lysine) in the mature protein. ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1992.tb00139.x
更新日期:1992-01-01 00:00:00
abstract::Monoclonal antibodies specific for equine T lymphocyte subpopulations were produced and procedures for the continuous culture of equine lymphocytes were developed. These reagents and procedures were used to analyse the appearance, maturation and functions of T lymphocytes in normal horses and in T lymphocyte deficient...
journal_title:Animal genetics
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2052.1988.tb00825.x
更新日期:1988-01-01 00:00:00
abstract::Taste perception in animals affects feed intake and may influence production traits. In particular, bitter is sensed by receptors encoded by the family of TAS2R genes. In this research, using a DNA pool-seq approach coupled with next generation semiconductor based target resequencing, we analysed nine porcine TAS2R ge...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12472
更新日期:2017-02-01 00:00:00
abstract::In the European rabbit (Oryctolagus cuniculus), a polytocous livestock species, the number of teats indirectly impacts the doe reproduction efficiency and, in turn, the sustainable production of rabbit meat. In this study, we carried out a genome-wide association study (GWAS) for the total number of teats in 247 Itali...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.13036
更新日期:2021-01-11 00:00:00
abstract::Polymorphic bands were detected within the DQB and DRB regions of the ovine major histocompatibility complex by probing TaqI digested DNA from three large sheep half-sib families derived from a highly resistant ram. All animals were phenotypically assessed for Haemonchus contortus resistance by faecal egg counts and a...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1993.tb00311.x
更新日期:1993-08-01 00:00:00
abstract::We have used the polymerase chain reaction (PCR) to amplify exon VII of the bovine beta-casein gene. The mutations responsible for the B variant were identified by direct sequencing of the amplification products. A bidirectional allele-specific PCR method (BAS-PCR) has been developed using oligonucleotides overlapping...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1992.tb00180.x
更新日期:1992-01-01 00:00:00
abstract::The objective of genome mapping is to achieve valuable insight into the connection between gene variants (genotype) and observed traits (phenotype). Part of that objective is to understand the selective forces that have operated on a population. Finding links between genotype-phenotype changes makes it possible to ide...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12772
更新日期:2019-06-01 00:00:00
abstract::Using frequencies of 86 genes from 23 loci of blood group systems, blood and milk proteins, the genetic relationships among 14 cattle breeds including four native Balkan and four synthetic Balkan-Alp breeds were studied. The dendrogram and nonlinear map construction shows a consensus 'Balkan breed cluster', an 'Alp br...
journal_title:Animal genetics
pub_type: 历史文章,杂志文章
doi:10.1111/j.1365-2052.1994.tb00399.x
更新日期:1994-06-01 00:00:00
abstract::The influence of the major histocompatibility (B) complex and sex on the phytohaemagglutinin (PHA) wattle response was studied in 136 segregants (B2/B2, B2/B5 and B5/B5) of a fourth generation cross between inbred lines 6(1) and 15(1). At 6 weeks of age, chickens were injected with 100 micrograms purified PHA-P. Wattl...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1987.tb00778.x
更新日期:1987-01-01 00:00:00
abstract::Nineteen cattle bones from the Viking 10th and early 11th century levels in Dublin were assessed for presence of reliable genotypes from three autosomal markers. Due to the good preservational condition of the samples, it was possible to amplify and type at least two out of three of the microsatellite markers (CSRM60,...
journal_title:Animal genetics
pub_type: 历史文章,杂志文章
doi:10.1046/j.0268-9146.2003.01043.x
更新日期:2003-12-01 00:00:00
abstract::The recent extension of genetic tools to the domestic cat, together with the serendipitous consequences of selective breeding, have been essential to the study of the genetic diseases that affect them. Cats are increasingly presented for veterinary surveillance and share many of human's heritable diseases, allowing th...
journal_title:Animal genetics
pub_type: 杂志文章,评审
doi:10.1111/age.12799
更新日期:2019-08-01 00:00:00
abstract::Genotype imputation facilitates the identification of missing genotypes on a high-density array using low-density arrays and has great potential for reducing genotyping costs for cattle populations. However, the imputation quality varies across breeds, which have different effective population sizes. Therefore, the ac...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12314
更新日期:2015-08-01 00:00:00
abstract::A genetic disease observed in certain Quarter horses is hyperkalaemic periodic paralysis (HYPP). This disease causes attacks of paralysis which can be induced by ingestion of potassium. Recent studies have shown that HYPP in humans is due to single base changes within the adult skeletal muscle sodium channel gene. A l...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.1992.tb00136.x
更新日期:1992-01-01 00:00:00
abstract::The crest in chicken consists of elongated and upraised feathers, as seen in various breeds such as the Silkie chicken. Recently, the still unknown causative mutation for the crest phenotype was assigned to chromosome 33 and an ectopic expression of HOXC8 was shown. The aim this study was to evaluate whether the crest...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12674
更新日期:2018-08-01 00:00:00
abstract::Insulin-like growth factor 2 (IGF2) is an imprinted gene expressed in most tissues affecting lean muscle content in mice, pigs and cattle. We previously identified the bovine IGF2 c.-292C>T SNP in the non-translated exon 2. Using this SNP, we demonstrated biallelic expression of IGF2 after birth. Seven alternatively s...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2007.01576.x
更新日期:2007-04-01 00:00:00
abstract::The stearoyl-CoA desaturase (delta-9-desaturase; SCD) gene is a candidate gene for fatty acid composition. It is located on pig SSC14 in a region where quantitative trait loci (QTL) for fatty acid composition were previously detected in a Duroc purebred population. The objective of the present study was to fine map th...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2011.02236.x
更新日期:2012-04-01 00:00:00
abstract::Albino phenotypes are documented in various species including the American mink. In other species the albino phenotypes are associated with tyrosinase (TYR) gene mutations; therefore TYR was considered the candidate gene for albinism in mink. Four microsatellite markers were chosen in the predicted region of the TYR g...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2008.01788.x
更新日期:2008-12-01 00:00:00
abstract::Single nucleotide polymorphisms (SNPs) in the calpain 1 (CAPN1) and calpastatin (CAST) genes were studied to determine their effects on meat tenderness in Bos taurus cattle. Strip loins (M. longissimus dorsi) were removed from cattle in four resource populations after slaughter (n = 1042), aged under controlled condit...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/j.1365-2052.2006.01483.x
更新日期:2006-08-01 00:00:00