Abstract：
:The filoviruses, Ebola and Marburg, are two of the most pathogenic viruses, causing lethal hemorrhagic fever in humans. Recent discoveries suggest that filoviruses, along with other phylogenetically or functionally related viruses, utilize a complex mechanism of replication exploiting multiple cellular components including lipid rafts, endocytic compartments, and vacuolar protein sorting machinery. In this review, we summarize these recent findings and discuss the implications for vaccine and therapeutics development.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Aman MJ,Bosio CM,Panchal RG,Burnett JC,Schmaljohn A,Bavari Sdoi
10.1016/s1286-4579(03)00095-9subject
Has Abstractpub_date
2003-06-01 00:00:00pages
639-49issue
7eissn
1286-4579issn
1769-714Xpii
S1286457903000959journal_volume
5pub_type
杂志文章,评审abstract：:To identify immunodominant antigens and MHC-restricted antibody responses, seven different strains of mice were intravaginally infected with Chlamydia muridarum and compared for antibody responses to 257 C. muridarum proteins. The 7 strains of mice recognized a total of 109 proteins as antigens, of which, 5 antigens (...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2012.02.005
更新日期：2012-07-01 00:00:00
abstract：:Despite high vaccination coverage, pertussis remains an important respiratory infectious disease and the least-controlled vaccine-preventable infectious disease in children. Natural infection with Bordetella pertussis is known to induce strong and long-lasting immunity that wanes later than vaccine-mediated immunity. ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2013.10.002
更新日期：2014-01-01 00:00:00
abstract：:Campylobacter jejuni is one of the most common causes of bacterial gastroenteritis and chronic sequelae, such as reactive arthritis and Guillain-Barré syndrome (GBS), are known to follow uncomplicated infections. While little is known about reactive arthritis following Campylobacter infection, our knowledge on the pat...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(02)01553-8
更新日期：2002-04-01 00:00:00
abstract：:Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase which plays pivotal roles in stress and immune responses. This review is focused on three major subjects on ASK1: the regulatory mechanisms of the kinase activity, the pathophysiological roles in stress response and innate ...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2005.12.001
更新日期：2006-04-01 00:00:00
abstract：:Staphylococcus aureus is a major cause of hospital-acquired infections. The ability to survive on abiotic surfaces is an important characteristic that facilitates transmission between human hosts. We found that S. aureus survivors of dry surface incubation are resistant to subsequent dry stress exposure. Survivors als...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2015.02.004
更新日期：2015-06-01 00:00:00
abstract：:Theiler's murine encephalomyelitis virus (TMEV) infects macrophages and causes demyelinating disease (DD) in certain mouse strains. IL-23 p19/p40 and IFN-beta, which are both expressed by macrophages in response to TMEV, could contribute to or prevent DD. Because TMEV may induce macrophages' cytokines through TLR3 and...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2007.07.001
更新日期：2007-09-01 00:00:00
abstract：:The identification of Brachyspira hyodysenteriae outer membrane proteins (OMPs) that may stimulate immunity to swine dysentery is important for vaccine development. We report here the analysis of a novel locus, blpGFEA, encoding four tandem paralogous proteins of approximately 30 kDa from B. hyodysenteriae. The four p...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(03)00027-3
更新日期：2003-04-01 00:00:00
abstract：:Although Pneumocystis carinii pneumonia is one of the leading causes of morbidity and mortality among patients with the acquired immunodeficiency syndrome, many questions about its epidemiology and transmission remain unanswered. Whereas traditional theory postulates that the disease results from reactivation of laten...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(01)01514-3
更新日期：2002-01-01 00:00:00
abstract：:Two candidate DNA vaccines based on the proteins CFP10 and CFP21 encoded by regions of difference (RDs) of Mycobacterium tuberculosis were evaluated individually and in multivalent combination with the immunodominant protein Ag85B for induction of protective immune responses against experimental tuberculosis. Experime...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.04.025
更新日期：2006-08-01 00:00:00
abstract：:Measles and pertussis are ubiquitous vaccine-preventable diseases, which remain an important public health problem in developing countries. Hence, developing a deep understanding of their transmission dynamics remains imperative. To achieve this, we compared the impact of vaccination at both individual and population ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2004.12.018
更新日期：2005-04-01 00:00:00
abstract：:CCR5-tropic (R5) immunodeficiency virus type 1 (HIV-1) strains are highly transmissible during the early stage of infection in humans, whereas CXCR4-tropic (X4) strains are less transmissible. This study aimed to explore the basis for early phase R5 and X4 HIV-1 infection in vivo by using humanized mice dually challen...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2015.02.002
更新日期：2015-05-01 00:00:00
abstract：:Toxoplasma gondii can activate the nucleotide-binding domain and leucine-rich repeat-containing proteins NLRP1/3 inflammasomes, which mediate host resistance to the infection. Here we showed that deletion of mitogen-activated protein kinases MAPK1 and MAPK2 of type I parasite decreases acute virulence in mice, charact...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2016.07.004
更新日期：2016-11-01 00:00:00
abstract：:The differentiation and survival of developing alpha beta thymocytes depends on effective T-cell receptor (TCR) signaling upon recognition of self peptide/major histocompatibility complex (MHC) molecule ligands. Although this concept is uniformly accepted with regard to immature thymocytes, there are conflicting repor...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(02)01571-x
更新日期：2002-04-01 00:00:00
abstract：:Toxin B, an exotoxin produced by the anaerobic Gram-positive bacteria Clostridium difficile, is responsible for pseudomembranous colitis in humans. It deeply modifies morphology of cultured cells and enhances their membrane surface area, which suggests a possible alteration of membrane receptor distribution. Since tox...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(99)00247-6
更新日期：1999-12-01 00:00:00
abstract：:Most pandemic influenza virus strains undergo adaptation or reassortment before they acquire the ability to cause fatal infections in a new host species. The pathologic changes and tissue tropism during virus adaptation are not fully understood. Here we investigated pathologic changes and tissue tropism by serial lung...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2008.09.013
更新日期：2009-01-01 00:00:00
abstract：:In vitro cell culture models used to study how Salmonella initiates disease at the intestinal epithelium would benefit from the recognition that organs and tissues function in a three-dimensional (3-D) environment and that this spatial context is necessary for development of cultures that more realistically resemble i...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.02.020
更新日期：2006-06-01 00:00:00
abstract：:A psittacosis epidemic linked to fulmar hunting occurred on the Faroe Islands in the 1930s. This study investigates a plausible explanation to the 20% human mortality in this outbreak. Phylogenetic analysis showed that Chlamydia psittaci isolated from fulmars were closely related to the highly virulent 6BC strains fro...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2020.02.007
更新日期：2020-09-01 00:00:00
abstract：:Helicobacter pylori infection induces chronic inflammation in the gastric mucosa with a marked increase in the number of lymphoid follicles consisting of infiltrating B and T cells, neutrophils, dendritic cells (DC) and macrophages. It has been suggested that an accumulation of mature DC in the tissue, resulting from ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2005.10.007
更新日期：2006-03-01 00:00:00
abstract：:Tissue Factor (TF) is the initiator of coagulation and Tissue Factor Inhibitor (TFPI) is the physiological inhibitor of the TF/FVIIa complex. Circulating levels of TF and TFPI were quantified in dengue patients and the relationships with disease severity and infecting serotype analysed. A significant decrease in TF an...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2016.08.005
更新日期：2017-01-01 00:00:00
abstract：:Major advances have recently been achieved in the area of microbial recognition by the innate immune system. In this Forum, we discuss important issues related to innate recognition of bacteria and protozoan parasites. In particular, we highlight the structural characterization of pathogen-associated molecular pattern...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(02)01625-8
更新日期：2002-07-01 00:00:00
abstract：:Filifactor alocis, a previously unrecognized Gram-positive anaerobic rod, is now considered a new emerging pathogen that may play a significant role in periodontal disease. F. alocis' unique characteristics and variations at the molecular level that may be responsible for the functional changes required to mediate the...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2015.03.011
更新日期：2015-07-01 00:00:00
abstract：:Recent studies have shown that infection with Porphyromonas gingivalis, a major periodontal pathogen, hastens the progression of non-alcoholic fatty liver disease (NAFLD). However, the intracellular fate of P. gingivalis in hepatocytes remains unknown. Here, using oleic-acid-induced HepG2 cells as an in vitro model fo...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2016.05.004
更新日期：2016-09-01 00:00:00
abstract：:The establishment of infection by Brucella ovis and Brucella canis in J774.A1 macrophages was found to be dependent upon cholesterol and ganglioside GM(1), two components of lipid rafts. This process also required a class A scavenger receptor of macrophages, and was not inhibited by smooth and rough lipopolysaccharide...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2009.12.008
更新日期：2010-03-01 00:00:00
abstract：:Gliotoxin is a mycotoxin having a considerable number of immuno-suppressive actions and is produced by several moulds such as Aspergillus fumigatus. In this study, we investigated its toxic effects on human neutrophils at concentrations corresponding to those found in the blood of patients with invasive aspergillosis....
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.10.009
更新日期：2007-01-01 00:00:00
abstract：:Infectious diseases are major causes, with malignancies, of morbidity and mortality in the elderly. Increased susceptibility to infections may result from underlying dysfunction of an aged immune system; moreover, inappropriate immunologic functions associated with aging can determine an insufficient response to vacci...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(01)01443-5
更新日期：2001-08-01 00:00:00
abstract：:We tested the hypothesis that host resistance to Campylobacter jejuni is Nramp1 dependent. Following intraperitoneal (IP) inoculation of Nramp1+/+ and isogenic Nramp1-deficient (Nramp1-/-) mice C. jejuni primarily associated with mac1-positive cells in liver tissue. A significant reduction of C. jejuni was observed in...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2008.05.001
更新日期：2008-07-01 00:00:00
abstract：:A number of inbred lines of chickens have been shown to be resistant or susceptible to systemic salmonellosis caused by Salmonella enterica serovar Gallinarum in adult birds, or by S. enterica serovar Enteritidis and S. enterica serovar Typhimurium in young chicks. Resistant lines show only moderate pathology and low ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(02)01635-0
更新日期：2002-09-01 00:00:00
abstract：:Within the brain, glial cells are target cells for human cytomegalovirus (HCMV) and HIV. We infected cultures of unstimulated human microglial cells and astrocytes of embryonic origin and of monocyte-derived macrophages (MDM) with HCMV strain AD169 and observed down-regulation of the plasma membrane expression of CCR5...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(02)00022-9
更新日期：2002-11-01 00:00:00
abstract：:Erythritol is a four-carbon sugar preferentially utilized by Brucella spp. The presence of erythritol in the placentas of goats, cows, and pigs has been used to explain the localization of Brucella to these sites and the subsequent accumulation of large amounts of bacteria, eventually leading to abortion. Here we show...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2013.02.002
更新日期：2013-06-01 00:00:00
abstract：:The Mycobacterium abscessus complex can cause fatal pulmonary disease, especially in cystic fibrosis patients. Diagnosing M. abscessus complex pulmonary disease is challenging. Immunologic assays specific for M. abscessus are not available. In this study seven clinical M. abscessus complex strains and the M. abscessus...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2018.10.006
更新日期：2019-01-01 00:00:00
