A prospective and retrospective analysis of the nephrotoxicity and efficacy of lipid-based amphotericin B formulations.

abstract：:Cefepime is a new extended-spectrum cephalosporin with gram-positive and gram-negative coverage including Staphylococcus aureus and Pseudomonas aeruginosa. We evaluated the drug's plasma, peritoneal fluid, and appendix tissue concentrations in patients with a postoperative diagnosis of perforated or gangrenous appendi...

journal_title：Pharmacotherapy

authors： Okamoto MP,Chin A,Gill MA,Yellin AE,Berne TV,Heseltine PN,Appleman MD,Knupp CA,Sclar DA

更新日期：1991-01-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the level of agreement between two sets of criteria, the Thrombolysis in Myocardial Infarction (TIMI) criteria and investigator-developed criteria, for identifying bleeding events in patients who had undergone a percutaneous coronary intervention (PCI) and to measure length of hospital stay ...

journal_title：Pharmacotherapy

authors： McCollum M,Stringer KA,Wittkowsky AK,Young S,Spinler SA

更新日期：2007-01-01 00:00:00

abstract：:The U.S. population continues to experience an alarmingly high rate of unintended pregnancies that have an impact on individual families and society alike. Lack of effective contraception accounts for most unintended pregnancies, along with incorrect use of contraceptives. The most common reversible contraceptive meth...

journal_title：Pharmacotherapy

authors： Rafie S,McIntosh J,Shealy KM,Borgelt LM,Forinash A,Shrader SP,Koepf ER,McClendon KS,Griffin BL,Horlen C,Karaoui LR,Rowe EL,Lodise NM,Wigle PR

更新日期：2014-09-01 00:00:00

abstract：:Torsades de pointes is a polymorphic ventricular tachycardia characterized by marked QT prolongation on the electrocardiogram. It can be induced by both antiarrhythmic and nonantiarrhythmic drugs, such as quinidine and erythromycin. No extensive literature documents an interaction between quinidine and erythromycin wh...

journal_title：Pharmacotherapy

authors： Lin JC,Quasny HA

更新日期：1997-05-01 00:00:00

abstract：STUDY OBJECTIVE:To describe the population pharmacokinetics and pharmacodynamic target attainment of ampicillin in neonates with hypoxic-ischemic encephalopathy (HIE) undergoing controlled hypothermia (CH). DESIGN:Prospective, open-label pharmacokinetic study. SETTING:A 189-bed, freestanding children's tertiary care ...

journal_title：Pharmacotherapy

authors： Cies JJ,Fugarolas KN,Moore WS 2nd,Mason RW,Menkiti OR

更新日期：2017-04-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effect of fluoxetine on the pharmacokinetics and cardiovascular safety of cisapride at steady state in healthy men. DESIGN:Open-label, three-phase, sequential study. SETTING:Clinical research center. SUBJECTS:Twelve healthy male volunteers. INTERVENTIONS:Each subject was treated acco...

journal_title：Pharmacotherapy

authors： Zhao Q,Wojcik MA,Parier JL,Pesco-Koplowitz L

更新日期：2001-02-01 00:00:00

abstract：:The frequency of type 2 diabetes mellitus is increasing at an alarming rate. Prediabetes, also referred to as impaired glucose tolerance (IGT) and/or impaired fasting glucose, is a major risk factor for development of type 2 diabetes mellitus. In addition, IGT has been associated with an increased risk of cardiovascul...

journal_title：Pharmacotherapy

authors： Irons BK,Mazzolini TA,Greene RS

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVE:To review the current pharmacotherapy for idiopathic pulmonary arterial hypertension (IPAH). METHODS:A search of the primary literature was conducted by using MEDLINE, the National Institutes of Health medical research Web site (www.clinicaltrials.gov), and the United States Food and Drug Administration's Ce...

journal_title：Pharmacotherapy

authors： Hackman AM,Lackner TE

更新日期：2006-01-01 00:00:00

abstract：:A new transdermal drug-delivery system that administers the synthetic opioid fentanyl through intact skin was evaluated for 24 hours postoperatively in eight patients who had undergone orthopedic surgery. Plasma samples were obtained over a 72-hour period for pharmacokinetic analysis in five patients. The patients wer...

journal_title：Pharmacotherapy

authors： Plezia PM,Kramer TH,Linford J,Hameroff SR

更新日期：1989-01-01 00:00:00

abstract：:Genotype-guided warfarin dosing algorithms are a rational approach to optimize warfarin dosing and potentially reduce adverse drug events. Diverse populations, such as African Americans and Latinos, have greater variability in warfarin dose requirements and are at greater risk for experiencing warfarin-related adverse...

journal_title：Pharmacotherapy

authors： Kaye JB,Schultz LE,Steiner HE,Kittles RA,Cavallari LH,Karnes JH

更新日期：2017-09-01 00:00:00

abstract：:Although heparin-dependent antibodies (HDAs) typically manifest with thrombocytopenia as in heparin-induced thrombocytopenia (HIT), they may also manifest with preserved platelet counts. We describe a 35-year-old woman who developed severe thrombotic complications due to heparinization and unrecognized HDAs. She had r...

journal_title：Pharmacotherapy

authors： Bream-Rouwenhorst HR,Hobbs RA

更新日期：2008-11-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the activity of CYP2D6, N-acetylation, and xanthine oxidase, three drug-metabolizing enzyme systems, in patients with cystic fibrosis and compare the findings with those in individuals without the disease. DESIGN:Prospective cohort study. SETTING:General pediatrics service. PATIENTS:Fift...

journal_title：Pharmacotherapy

authors： Bosso JA,Liu Q,Evans WE,Relling MV

更新日期：1996-09-01 00:00:00

abstract：:The pharmacokinetics of methylprednisolone sodium succinate (MPHS) and methylprednisolone (MP) were determined in six patients undergoing open heart surgery with cardiopulmonary bypass. Plasma concentrations of both compounds were measured by high-performance liquid chromatography after doses of MPHS of 1.7-2.4 g. The...

journal_title：Pharmacotherapy

authors： Kong AN,Jungbluth GL,Pasko MT,Beam TR,Jusko WJ

更新日期：1990-01-01 00:00:00

abstract：:Certain enteric ailments are particularly common among homosexual men. They are primarily infectious diseases and include not only such common venereal diseases as gonorrhea and syphilis but also infections not usually regarded as being sexually transmitted. Among the latter are shigellosis, salmonellosis, giardiasis,...

journal_title：Pharmacotherapy

authors： Baker RW,Peppercorn MA

更新日期：1982-01-01 00:00:00

abstract：:A 58-year-old woman who had been taking digoxin 0.25 mg/day for more than 35 years for heart palpitations after mitral valve repair was prescribed a 5-day course of telithromycin for acute bronchitis. On the sixth day of therapy, she came to the emergency department complaining of general malaise and having experience...

journal_title：Pharmacotherapy

authors： Nenciu LM,Laberge P,Thirion DJ

更新日期：2006-06-01 00:00:00

abstract：:A 58-year-old man went to his physician with complaints of midepigastric pain, flatulence, belching, and shortness of breath. During a physical examination, the patient was in no acute distress. The patient underwent an ultrasound examination, which revealed cholelithiasis, a laparoscopic cholecystectomy, which reveal...

journal_title：Pharmacotherapy

authors： Baker EL,Baker WL,Cloney DJ

更新日期：2007-02-01 00:00:00

abstract：:A 12-year-old girl with cystic fibrosis was diagnosed with a high-grade glioma after radiographic and biopsy results confirmed the primary intracranial lesion. She was treated with single-agent erlotinib during and after daily localized radiation therapy. Pharmacokinetic studies were conducted to assess the effect of ...

journal_title：Pharmacotherapy

authors： Christiansen SR,Broniscer A,Panetta JC,Stewart CF

更新日期：2009-07-01 00:00:00

abstract：:The death rate from coronary heart disease (CHD) declined by 25% in the United States during 1987-1997, but the actual number of deaths fell by only 9%. Modifiable risk factors for CHD include hypertension, elevated low-density lipoprotein cholesterol, reduced high-density lipoprotein cholesterol, cigarette smoking, a...

journal_title：Pharmacotherapy

authors： Pieper JA

更新日期：2001-09-01 00:00:00

abstract：STUDY OBJECTIVE:To investigate the adverse drug reactions (ADRs) from peginterferon alfa-2b plus ribavirin in patients infected with the hepatitis C virus (HCV). DESIGN:Prospective, observational, pharmacovigilance study. SETTING:Gastroenterology department of a French university hospital. PATIENTS:A cohort of conse...

journal_title：Pharmacotherapy

authors： Bagheri H,Fouladi A,Barange K,Lapeyre-Mestre M,Payen JL,Montastruc JL,Vinel JP

更新日期：2004-11-01 00:00:00

abstract：:Cephalosporins are often administered to prevent infections that can follow total joint replacements (TJR) and other arthroplastic procedures. However, recommendations contained within published guidelines and review articles vary greatly from those given by the manufacturer in product information circulars. Similarly...

journal_title：Pharmacotherapy

authors： Heath AF

更新日期：1991-01-01 00:00:00

abstract：:Diurnal variation in plasma norepinephrine (PNE) levels is well documented in healthy individuals but not in patients with heart failure. Therefore, we attempted to determine variations in PNE levels over 24 hours, measured hourly, in six patients with an ejection fraction below 40% and a history of heart failure of l...

journal_title：Pharmacotherapy

authors： Bleske BE,Chung HS,DiMagno M,Nicklas JM

更新日期：1999-08-01 00:00:00

abstract：:Olanzapine has been associated with insulin resistance and new-onset diabetes mellitus. A 27-year-old African-American man developed new-onset severe hyperglycemia-glucose 1240 mg/dl, with ketonuria and acidosis, but no weight gain-2 years after starting olanzapine. Although his diabetes was stabilized with insulin, h...

journal_title：Pharmacotherapy

authors： Seaburg HL,McLendon BM,Doraiswamy PM

更新日期：2001-11-01 00:00:00

abstract：:Beta-blockers are an important cardiovascular drug class, recommended as first-line treatment of numerous diseases such as heart failure, hypertension, and angina, as well as treatment after myocardial infarction. However, responses to a beta-blocker are variable among patients. Results of numerous studies now suggest...

journal_title：Pharmacotherapy

authors： Shin J,Johnson JA

更新日期：2007-06-01 00:00:00

abstract：:We reviewed the spectrum of activity, pharmacokinetics, clinical efficacy, adverse effects, and relative advantages of piperacillin-tazobactam, a new beta-lactam-beta-lactamase inhibitor. Piperacillin-tazobactam has a wide spectrum of activity that includes gram-positive organisms such as staphylococci and streptococc...

journal_title：Pharmacotherapy

authors： Daniel KP,Krop LC

更新日期：1996-03-01 00:00:00

abstract：:Cyclosporine can be given intravenously or orally, as a solution or soft gelatin capsule. Because of the drug's poor water solubility, ethoxylated plant fats and ethanol are added to the commercially available dosage forms. ...

journal_title：Pharmacotherapy

authors： Yee GC

更新日期：1991-01-01 00:00:00

abstract：:A 69-year-old woman was admitted for control of intractable rectal pain caused by a 4-cm malignant mass. She was treated successfully with EMLA (eutectic mixture of local anesthetics) cream applied every 8 hours and covered with a Xeroform dressing. Despite an increase in tumor size to 6 cm, her pain control was maint...

journal_title：Pharmacotherapy

authors： Stegman MB,Stoukides CA

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVES:To compare the efficacy of a single dose of basiliximab with two doses in preventing acute rejection in selected low-risk renal transplant recipients. METHODS:This observational study of 760 kidney transplant recipients considered to be at low immunologic risk (peak panel reactive antibody less than 10%) co...

journal_title：Pharmacotherapy

authors： Cunningham KC,Hager DR,Fischer J,D'Alessandro AM,Leverson GE,Kaufman DB,Djamali A

更新日期：2016-07-01 00:00:00

abstract：:The complexities of oral anticoagulation with warfarin have led to the search for more practical alternative agents. Novel direct factor IIa inhibitors and direct factor Xa inhibitors currently in development can be administered at a fixed dose and do not require routine coagulation monitoring and ongoing dosage adjus...

journal_title：Pharmacotherapy

authors： Wittkowsky AK

更新日期：2011-12-01 00:00:00

abstract：:Limitations of traditional anticoagulants have led to the need for structured services to provide anticoagulation monitoring. Anticoagulation management services have historically filled this role. Novel antithrombotic agents currently in development have the potential to improve on the limitations of vitamin K antago...

journal_title：Pharmacotherapy

authors： Nutescu EA,Spinler SA,Dager WE,Bussey HI

更新日期：2004-10-01 00:00:00

abstract：STUDY OBJECTIVE:To compare the efficacy of amlodipine and valsartan in African-American patients with hypertension using ambulatory blood pressure monitoring (ABPM). DESIGN:Prospective, randomized, double-blind, crossover comparison study. SETTING:University-affiliated cardiac center clinic. PATIENTS:Twenty African-...

journal_title：Pharmacotherapy

authors： Maciejewski S,Mohiuddin SM,Packard KA,Mooss AN,Reyes AP,Aryana A,Hilleman DE

更新日期：2006-07-01 00:00:00