Abstract:
STUDY OBJECTIVE:To determine the activity of CYP2D6, N-acetylation, and xanthine oxidase, three drug-metabolizing enzyme systems, in patients with cystic fibrosis and compare the findings with those in individuals without the disease. DESIGN:Prospective cohort study. SETTING:General pediatrics service. PATIENTS:Fifty-nine patients with cystic fibrosis and 480 healthy Caucasian volunteers. INTERVENTIONS:Enzyme activity was determined based on urinary molar metabolite ratios of caffeine and dextromethorphan probes. MEASUREMENTS AND MAIN RESULTS:The percentage of poor metabolizers of CYP2D6 in patients with cystic fibrosis was not different from that in the control group (p = 0.45). N-Acetylation activity was significantly lower in the patients (p = 0.007), but no statistically significant difference was found in xanthine oxidase activity (p = 0.12). CONCLUSION:The activity of these drug-metabolic pathways does not appear to be increased in cystic fibrosis. Whether the activity of other pathways is increased, thus providing a partial explanation for the generally increased drug clearance in this disease, remains to be determined.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Bosso JA,Liu Q,Evans WE,Relling MVsubject
Has Abstractpub_date
1996-09-01 00:00:00pages
749-53issue
5eissn
0277-0008issn
1875-9114journal_volume
16pub_type
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