Acetaminophen-related acute renal failure without fulminant liver failure.

abstract：:A 32-year-old woman with a history of deep vein thrombosis (DVT), steroid-dependent ulcerative colitis, and osteoporosis was prescribed azathioprine for a steroid-sparing effect. Stable, therapeutic international normalized ratios (INRs) were obtained with warfarin 35 mg/week during a 6-week postpartum course to treat...

journal_title：Pharmacotherapy

authors： Havrda DE,Rathbun S,Scheid D

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVE:To review the current pharmacotherapy for idiopathic pulmonary arterial hypertension (IPAH). METHODS:A search of the primary literature was conducted by using MEDLINE, the National Institutes of Health medical research Web site (www.clinicaltrials.gov), and the United States Food and Drug Administration's Ce...

journal_title：Pharmacotherapy

authors： Hackman AM,Lackner TE

更新日期：2006-01-01 00:00:00

abstract：STUDY OBJECTIVES:To determine if low-dose lovastatin in combination with niacin causes a greater percentage reduction in low-density lipoprotein (LDL) cholesterol than lovastatin alone, and to determine if the combination increases the risk of serious adverse effects. design. Prospective, randomized, open-label, clinic...

journal_title：Pharmacotherapy

authors： Gardner SF,Schneider EF,Granberry MC,Carter IR

更新日期：1996-05-01 00:00:00

abstract：:Infections caused by yeasts and molds continue to be associated with high rates of morbidity and mortality in both immunocompromised and immunocompetent patients. Many antifungal drugs have been developed over the past 15 years to aid in the management of these infections. However, treatment is still not optimal, as t...

journal_title：Pharmacotherapy

authors： Mohr J,Johnson M,Cooper T,Lewis JS,Ostrosky-Zeichner L

更新日期：2008-05-01 00:00:00

abstract：:Although heparin-dependent antibodies (HDAs) typically manifest with thrombocytopenia as in heparin-induced thrombocytopenia (HIT), they may also manifest with preserved platelet counts. We describe a 35-year-old woman who developed severe thrombotic complications due to heparinization and unrecognized HDAs. She had r...

journal_title：Pharmacotherapy

authors： Bream-Rouwenhorst HR,Hobbs RA

更新日期：2008-11-01 00:00:00

abstract：:Acute graft-versus-host disease (GVHD) remains the major obstacle for successful allogeneic bone marrow transplantation (BMT). The frequency of grade II or higher acute GVHD ranges from 30-50% in human leukocyte antigen (HLA)-matched sibling transplants and 50-80% in HLA-matched unrelated transplants. The mortality an...

journal_title：Pharmacotherapy

authors： Tse JC,Moore TB

更新日期：1998-09-01 00:00:00

abstract：:Recombinant human erythropoietin reverses the severe anemia associated with end-stage renal disease. Mean half-life values after a single intravenous bolus dose range from 4-13 hours. Renal clearance is not a significant route of elimination. Dosing schedules in chronic renal failure involve a single intravenous bolus...

journal_title：Pharmacotherapy

authors： Flaharty KK

更新日期：1990-03-01 00:00:00

abstract：:3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are a frequently prescribed class of drugs that are generally well tolerated by most patients. A rare, yet serious side effect associated with these drugs is rhabdomyolysis. Although all HMG-CoA reductase inhibitors can cause this adverse effect, pre...

journal_title：Pharmacotherapy

authors： Ravnan SL,Locke C,Yee WP,Haase K

更新日期：2002-04-01 00:00:00

abstract：:Thrombin, a serine protease, is the keystone of the twin processes of hemostasis and thrombosis. Through procoagulant, anticoagulant, and antifibrinolytic mechanisms, thrombin helps maintain vascular integrity in the face of hemorrhage. These same mechanisms, however, allow for the pathologic formation of thrombi in r...

journal_title：Pharmacotherapy

authors： Nappi J

更新日期：2002-06-01 00:00:00

abstract：:Hormonal emergency contraceptives have been used to prevent unwanted pregnancy for more than 3 decades. The mechanisms of action of the regimen containing a combination of estrogen and progestin, known as the Yuzpe regimen, and those of the levonorgestrel regimen continue to be controversial, especially over the possi...

journal_title：Pharmacotherapy

authors： Leung VW,Levine M,Soon JA

更新日期：2010-02-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the pharmacokinetics and use of intravenous human cytomegalovirus immune globulin (CytoGam) in allogeneic bone marrow transplantation (BMT). DESIGN:Prospective, nonrandomized, nonblinded, single-center study. SETTING:University teaching hospital. PATIENTS:Five consecutive patients with he...

journal_title：Pharmacotherapy

authors： DeRienzo SY,Chiang KY,O'Neal WM,Godder K,Abhyankar S,Christiansen NP,Bridges KD,Henslee-Downey PJ

更新日期：2000-10-01 00:00:00

abstract：:Acute graft-versus-host disease remains a devastating complication following hematopoietic cell transplantation, resulting in increased morbidity and mortality. Vast research efforts continue to refine or develop new means of prediction, assessment, prevention, and treatment of this syndrome. Recent updates in acute g...

journal_title：Pharmacotherapy

authors： DiMaggio E

更新日期：2020-08-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the pharmacokinetics and dose-proportionality of four dose strengths (5, 10, 20, and 40 mg) of oxymorphone extended release (ER) under both single-dose and steady-state conditions. DESIGN:Randomized, three-period, four-sequence, crossover study. SETTING:Bioavailability clinic. SUBJECTS:Tw...

journal_title：Pharmacotherapy

authors： Adams MP,Ahdieh H

更新日期：2004-04-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the disposition of pentoxifylline and its metabolite, lisofylline, in New Zealand rabbits after two alternative routes of administration, intranasal and intratracheal. DESIGN:Pharmacokinetics study in an animal model. SETTING:University-affiliated animal care facility. SUBJECTS:Twenty New...

journal_title：Pharmacotherapy

authors： Adcock KG,Kyle PB,Deaton JS,Olivier JH,Hogan SM

更新日期：2007-02-01 00:00:00

abstract：:Struvite calculi result from urinary tract infections secondary to urease-producing bacteria. To prevent recurrent infection and stone formation complete removal of struvite calculi is recommended. Two illustrative reports of patients with renal struvite calculi are presented in which 10% hemiacidrin (Renacidin) irrig...

journal_title：Pharmacotherapy

authors： Massaro FJ,Weiner B,Sant GR,Meares EM Jr

更新日期：1983-11-01 00:00:00

abstract：:Use of oral N-acetylcysteine for preventing radiographic contrast material-induced nephropathy (RCIN) has become widespread, despite conflicting results from clinical trials and meta-analyses. The variability in study results may reflect differences in baseline risks in study patients, hydration regimens, choice of co...

journal_title：Pharmacotherapy

authors： Shalansky SJ,Vu T,Pate GE,Levin A,Humphries KH,Webb JG

更新日期：2005-08-01 00:00:00

abstract：STUDY OBJECTIVE:To investigate the relationship between two widely used, generic health-related quality of life (HRQOL) measures, Short Form-12 (SF-12) and EuroQol's EQ-5D, and potentially inappropriate drug use in an elderly cohort. DESIGN:Longitudinal retrospective cohort study. DATA SOURCE:Medical Expenditure Pane...

journal_title：Pharmacotherapy

authors： Franic DM,Jiang JZ

更新日期：2006-06-01 00:00:00

abstract：STUDY OBJECTIVE:To determine clinical and microbiologic success in patients receiving adjunctive aerosolized antibiotics for the treatment of ventilator-associated pneumonia (VAP). DESIGN:Retrospective medical record review. SETTING:Level I trauma intensive care unit of a large academic medical center. PATIENTS:Fort...

journal_title：Pharmacotherapy

authors： Czosnowski QA,Wood GC,Magnotti LJ,Croce MA,Swanson JM,Boucher BA,Fabian TC

更新日期：2009-09-01 00:00:00

abstract：STUDY OBJECTIVE:To assess the effects of food on the bioavailability of testosterone undecanoate, testosterone, and 5alpha-dihydrotestosterone (DHT) after administration of a new oral testosterone undecanoate formulation, Andriol Testocaps. DESIGN:Randomized, open-label, crossover study with a 1-week washout period. ...

journal_title：Pharmacotherapy

authors： Bagchus WM,Hust R,Maris F,Schnabel PG,Houwing NS

更新日期：2003-03-01 00:00:00

abstract：:A 12-year-old girl with cystic fibrosis was diagnosed with a high-grade glioma after radiographic and biopsy results confirmed the primary intracranial lesion. She was treated with single-agent erlotinib during and after daily localized radiation therapy. Pharmacokinetic studies were conducted to assess the effect of ...

journal_title：Pharmacotherapy

authors： Christiansen SR,Broniscer A,Panetta JC,Stewart CF

更新日期：2009-07-01 00:00:00

abstract：:Daptomycin is a lipopeptide antibiotic active against multidrug-resistant gram-positive organisms. Our search of the literature found no published pediatric pharmacokinetic data. We report the use of pharmacokinetic analysis of daptomycin in a 13-year-old boy with vancomycin-resistant Enterococcus faecium endocarditis...

journal_title：Pharmacotherapy

authors： Akins RL,Haase MR,Levy EN

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:As tenofovir disoproxil fumarate substantially increases plasma concentrations of didanosine in patients with human immunodeficiency virus-1 infection, we sought to determine whether tenofovir and didanosine showed a similar intracellular interaction in human peripheral blood mononuclear cells (PBMCs). DESIG...

journal_title：Pharmacotherapy

authors： Robbins BL,Wilcox CK,Fridland A,Rodman JH

更新日期：2003-06-01 00:00:00

abstract：:The traditional role of theophylline as a bronchodilator has been expanded by recent findings that suggest this drug has more than smooth muscle relaxant properties. Several investigators indicate that theophylline has an inotropic effect on respiratory muscle, causing enhanced muscular contraction and prevention of m...

journal_title：Pharmacotherapy

authors： Landsberg KF,Vaughan LM,Heffner JE

更新日期：1990-01-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) has become the most prevalent cause of acute hematogenous osteomyelitis (AHO) in pediatric patients. This increase in MRSA is due to the rise in community-acquired MRSA. Therefore, it is important that clinicians are aware of the various and upcoming therapies that co...

journal_title：Pharmacotherapy

authors： DeRonde KJ,Girotto JE,Nicolau DP

更新日期：2018-10-01 00:00:00

abstract：:Acute myeloid leukemia (AML), a clonal hematologic malignancy that results in bone marrow failure, is the most common acute leukemia in adults (median age of diagnosis 67 yrs), and treatment options, especially in the elderly population, are limited. Induction chemotherapy with 7 + 3, the combination of continuous-inf...

journal_title：Pharmacotherapy

authors： Stansfield LC,Pollyea DA

更新日期：2017-12-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the relationship between impaired renal function and antifactor Xa activity in patients receiving dalteparin. DESIGN:Open-label prospective study. SETTING:Inpatient and outpatient units of a large teaching hospital. SUBJECTS:Eleven patients with renal impairment and 11 control subjects wi...

journal_title：Pharmacotherapy

authors： Shprecher AR,Cheng-Lai A,Madsen EM,Cohen HW,Sinnett MJ,Wong ST,Billett HH

更新日期：2005-06-01 00:00:00

abstract：:Telavancin is a once-daily lipoglycopeptide antibiotic structurally derived from vancomycin. It has broad-spectrum activity against gram-positive bacteria, including strains with reduced susceptibility to vancomycin. Telavancin's multifunctional mechanism of action, including inhibition of peptidoglycan synthesis and ...

journal_title：Pharmacotherapy

authors： Leonard SN,Rybak MJ

更新日期：2008-04-01 00:00:00

abstract：:The role of the formulary system for effective cost containment is becoming increasingly important. With antimicrobial agents taking up a large proportion of most pharmaceutical budgets, this group of agents is an obvious target for cost reduction. The responsible interchange of selected antimicrobial agents offers a ...

journal_title：Pharmacotherapy

authors： Wright DB

更新日期：1991-01-01 00:00:00

abstract：:A 58-year-old woman who had been taking digoxin 0.25 mg/day for more than 35 years for heart palpitations after mitral valve repair was prescribed a 5-day course of telithromycin for acute bronchitis. On the sixth day of therapy, she came to the emergency department complaining of general malaise and having experience...

journal_title：Pharmacotherapy

authors： Nenciu LM,Laberge P,Thirion DJ

更新日期：2006-06-01 00:00:00

abstract：STUDY OBJECTIVES:To examine potential threats to internal and external study validity caused by differential patient withdrawal from a randomized controlled trial evaluating pharmacist management of hypertension, to compare the characteristics of patients who withdrew with those of patients who completed the study, and...

journal_title：Pharmacotherapy

authors： Rozenfeld Y,Hunt JS

更新日期：2006-11-01 00:00:00