Adjunctive aerosolized antibiotics for treatment of ventilator-associated pneumonia.

abstract：STUDY OBJECTIVE:To quantify Asian and Asian-American college students' knowledge of osteoporosis and preventive health behaviors. DESIGN:Sixty-four-question survey SETTING:University of Minnesota. SUBJECTS:One hundred sixty-eight male and female Asian and Asian-American students, mean age 21 +/- 3.4 years. MAIN RES...

journal_title：Pharmacotherapy

authors： Nguyen DN,O'Connell MB

更新日期：2002-08-01 00:00:00

abstract：STUDY OBJECTIVES:To determine the odds of antiepileptic drug substitution among patients who had an epileptic event requiring acute care-ambulance service, emergency department visit, or hospitalization-relative to patients who did not have an event, and to compare these results with those from a recent study involving...

journal_title：Pharmacotherapy

authors： Rascati KL,Richards KM,Johnsrud MT,Mann TA

更新日期：2009-07-01 00:00:00

abstract：:In critically ill patients with acute renal failure, continuous arteriovenous hemodiafiltration (CAVHD) has become an increasing popular supportive technique. An adult with acute renal failure during CAVHD therapy received fluconazole. Drug clearance by the hemodiafilter system and its total body clearance during the ...

journal_title：Pharmacotherapy

authors： Nicolau DP,Crowe H,Nightingale CH,Quintiliani R

更新日期：1994-07-01 00:00:00

abstract：:The clinical and economic impacts of bacterial resistance are substantial. The development of bacterial resistance during a course of therapy often leads to clinical failure, prolonged hospitalization, increased morbidity, mortality, and increased health care costs. Resistance has been reported to occur most frequentl...

journal_title：Pharmacotherapy

authors： Barriere SL

更新日期：1992-01-01 00:00:00

abstract：:We conducted an extensive literature review to evaluate the appropriate use, route, and dose of vitamin K to reverse excessive anticoagulation. Issues such as sample size, study design, different patient populations, and various study end points confounded results. Of 18 studies published, 8 enrolled 229 patients to e...

journal_title：Pharmacotherapy

authors： Taylor CT,Chester EA,Byrd DC,Stephens MA

更新日期：1999-12-01 00:00:00

abstract：:Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a rare, complex, idiosyncratic drug reaction that can be fatal. Systemic symptoms include lymphadenopathy, hepatic failure, and possibly renal failure. The syndrome has been primarily associated with anticonvulsants, whereas antimicrobials are less ...

journal_title：Pharmacotherapy

authors： Miller Quidley A,Bookstaver PB,Gainey AB,Gainey MD

更新日期：2012-12-01 00:00:00

abstract：:High-performance capillary electrophoresis (HPCE) is a new separation technique that is applied in the pharmaceutical sciences. Separations by HPCE occur in a narrow-bore capillary under the influence of an applied electrical field. Components of the sample matrix are separated and migrate at different rates based on ...

journal_title：Pharmacotherapy

authors： Brunner LJ,DiPiro JT,Feldman S

更新日期：1995-01-01 00:00:00

abstract：:We investigated the effect of endotoxemia on alpha1-adrenergic receptor-mediated smooth muscle contraction as measured by mean arterial pressure (MAP) in response to incremental doses of a vasopressor. Twelve male Sprague-Dawley rats were randomized to receive parenteral nutrition alone (PN) or in combination with a c...

journal_title：Pharmacotherapy

authors： Dickerson RN,Lima JJ,Kuhl DA,Brown RO,Hak LJ

更新日期：1998-01-01 00:00:00

abstract：:Clinical pharmacists must often interpret and use data derived from observational studies when making clinical decisions and recommendations, answering drug information questions, and educating patients about drug therapy. This is the third article in a three-part series intended to enhance clinical pharmacists' under...

journal_title：Pharmacotherapy

authors： Shields KM,DiPietro NA,Kier KL

更新日期：2011-02-01 00:00:00

abstract：:We attempted to determine if an association exists between vancomycin serum concentrations resulting from traditional dosing regimens, and efficacy and toxicity outcomes. We reviewed the medical charts of 273 consecutive patients prescribed 273 courses of vancomycin therapy for documented, gram-positive bacteremia. Of...

journal_title：Pharmacotherapy

authors： Zimmermann AE,Katona BG,Plaisance KI

更新日期：1995-01-01 00:00:00

abstract：STUDY OBJECTIVE:To describe the population pharmacokinetics and pharmacodynamic target attainment of ampicillin in neonates with hypoxic-ischemic encephalopathy (HIE) undergoing controlled hypothermia (CH). DESIGN:Prospective, open-label pharmacokinetic study. SETTING:A 189-bed, freestanding children's tertiary care ...

journal_title：Pharmacotherapy

authors： Cies JJ,Fugarolas KN,Moore WS 2nd,Mason RW,Menkiti OR

更新日期：2017-04-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the effects of mild-to-moderate induced hypothermia-a neuroprotectant and/or therapeutic strategy for the management of intracranial hypertension in neurologically injured patients-on the pharmacokinetics of aminoglycoside therapy. DESIGN:Pharmacokinetic analysis. SETTING:Critical care un...

journal_title：Pharmacotherapy

authors： Mercer JM,Neyens RR

更新日期：2010-07-01 00:00:00

abstract：:We compared total costs and adherence to the regimen of older versus newer angiotensin-converting enzyme (ACE) inhibitors for the treatment of elderly patients with hypertension. A computer search using the data base of a health care insurer identified 6176 subjects age 65 years or older who had ICD-9 coding for hyper...

journal_title：Pharmacotherapy

authors： Small RE,Freeman-Arnold SB,Goode JV,Pyles MA

更新日期：1997-09-01 00:00:00

abstract：:Serious gram-positive infections present an increasingly common therapeutic dilemma. Combination antimicrobial regimens (e.g., linezolid with rifampin) aimed at improving bacterial eradication and preventing resistance are often used; however, most data supporting this treatment strategy are not from randomized contro...

journal_title：Pharmacotherapy

authors： Gebhart BC,Barker BC,Markewitz BA

更新日期：2007-03-01 00:00:00

abstract：:Ceftazidime, a beta-lactamase-stable, third-generation cephalosporin, is widely used for the treatment of serious gram-negative infections. Neurotoxicity has rarely been associated with the drug; however, two of our patients developed ceftazidime-induced neurotoxicity that produced confusion, disorientation, agitation...

journal_title：Pharmacotherapy

authors： Slaker RA,Danielson B

更新日期：1991-01-01 00:00:00

abstract：:We sought to summarize and assess original evaluations of the economic impact of clinical pharmacy services published from 1996-2000, and to provide recommendations and methodologic considerations for future research. A systematic literature search was conducted to identify articles that were then blinded and randomly...

journal_title：Pharmacotherapy

authors： Schumock GT,Butler MG,Meek PD,Vermeulen LC,Arondekar BV,Bauman JL,2002 Task Force on Economic Evaluation of Clinical Pharmacy Services of the American College of Clinical Pharmacy.

更新日期：2003-01-01 00:00:00

abstract：STUDY OBJECTIVES:To assess the effectiveness of pretreatment with ibuprofen or acetaminophen compared with no pretreatment in decreasing adverse events in children and adolescents receiving the first and second series of pamidronate therapy; and to compare the effectiveness of ibuprofen versus acetaminophen for prevent...

journal_title：Pharmacotherapy

authors： Robinson RE,Nahata MC,Hayes JR,Batisky DL,Bates CM,Mahan JD

更新日期：2004-02-01 00:00:00

abstract：:Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a rare neurodegenerative disease caused by the decreased ability of cells to produce sufficient energy in the form of adenosine 5'-triphosphate. Although it is one of the most common maternally inherited mitochondrial...

journal_title：Pharmacotherapy

authors： Santa KM

更新日期：2010-11-01 00:00:00

abstract：:Nausea and vomiting are common complaints in the postoperative period and contribute to patient distress and delay of discharge for outpatient surgical procedures. Laparoscopic procedures are associated with a high incidence of postoperative nausea and vomiting (PONV) episodes. Parenteral use of metoclopramide prevent...

journal_title：Pharmacotherapy

authors： Wagner BK,Berman SL,Devitt PA,Halvorsen MB,O'Hara DA

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVES:To compare the usage and cost of antibiotics in the United States and United Kingdom in children younger than 10 years. METHODS:A follow up of some 160,000 young children enrolled in U.S. private health insurance companies and an equal number in general practices in the United Kingdom in 2009, based on two ...

journal_title：Pharmacotherapy

authors： Jick H,Wilson A,Chamberlin D

更新日期：2014-01-01 00:00:00

abstract：STUDY OBJECTIVE:To determine if development of acneiform rash is a predictor of objective response rate with lapatinib. DESIGN:Subanalysis of data from a prospective, phase II study. SETTING:Academic breast care clinic. PATIENTS:Forty-nine treatment-naïve patients with human epidermal growth factor receptor-2 (HER2)...

journal_title：Pharmacotherapy

authors： Parma J,Pavlick A,Schiff R,Osborne CK,Chang JC,Rimawi M,Trivedi MV

更新日期：2013-10-01 00:00:00

abstract：:The objective of this study was to describe the postinduction clearance of carbamazepine (CBZ) in adult psychiatric patients by population pharmacokinetic analysis using the NONMEM program. Specifically, an estimate of CBZ clearance and insight into the effect of common patient characteristics on clearance were sought...

journal_title：Pharmacotherapy

authors： Martin ES 3rd,Crismon ML,Godley PJ

更新日期：1991-01-01 00:00:00

abstract：:The National Kidney Foundation developed and oversees the Kidney Disease Outcomes Quality Initiative, a process that develops clinical practice guidelines in nephrology. Recent guidelines address the evaluation, classification, and stratification of chronic kidney disease (CKD). These guidelines provide, for the first...

journal_title：Pharmacotherapy

authors： Bailie GR,Uhlig K,Levey AS

更新日期：2005-04-01 00:00:00

abstract：:Resistance of nosocomial and community-acquired pathogens to antimicrobial agents is a serious problem with significant clinical consequences. Microbiologic surveillance data, such as those provided by the National Nosocomial Infections Surveillance System, supply information on current nosocomial pathogens in the Uni...

journal_title：Pharmacotherapy

authors： Thornsberry C

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:To describe the legal, professional, and consumer status of prescribers dispensing legend and over-the-counter drugs in the United States. METHODS:Legal and academic databases were searched to identify those states that permit prescribers to dispense medications to patients and any limitations on such practi...

journal_title：Pharmacotherapy

authors： Munger MA,Ruble JH,Nelson SD,Ranker L,Petty RC,Silverstein S,Barton E,Feehan M

更新日期：2014-10-01 00:00:00

abstract：:The development of an intravenous form of nitroglycerin has further enhanced the role of nitrates in the therapy of cardiovascular disorders. This new preparation permits prompt initiation of therapy and rapid attainment of high systemic levels; because of its short half-life, rapid dose titration is both feasible and...

journal_title：Pharmacotherapy

authors： Jaffe AS,Roberts R

更新日期：1982-09-01 00:00:00

abstract：:Cytochrome P450 3A5 (CYP3A5) and cytochrome P450 3A4 (CYP3A4) are the predominate enzymes responsible for tacrolimus metabolism. The presence of CYP3A4 and CYP3A5 genetic variants significantly affects tacrolimus clearance and dose requirements. CYP3A5*3 is a loss-of-function variant resulting in no CYP3A5 enzyme prod...

journal_title：Pharmacotherapy

authors： Scheibner A,Remmel R,Schladt D,Oetting WS,Guan W,Wu B,Dorr C,Israni A,Jacobson PA

更新日期：2018-07-01 00:00:00

abstract：:Thirty-six indigent patients hospitalized within 6 months of study initiation and who met criteria were enrolled in a 6-month assistance program to determine if provision of both medical care and prescription drugs at no cost would be associated with a change in overall health care charges secondary to a change in the...

journal_title：Pharmacotherapy

authors： Nykamp D,Ruggles D

更新日期：2000-02-01 00:00:00

abstract：:Antimicrobial susceptibility testing for the polymyxins-colistin and polymyxin B-is fraught with technical challenges. Key among these is the propensity of the polymyxins to adsorb to polystyrene, a material often used for in vitro minimum inhibitory concentration testing devices. This effect may be mitigated by the a...

journal_title：Pharmacotherapy

authors： Humphries RM

更新日期：2015-01-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the disposition of pentoxifylline and its metabolite, lisofylline, in New Zealand rabbits after two alternative routes of administration, intranasal and intratracheal. DESIGN:Pharmacokinetics study in an animal model. SETTING:University-affiliated animal care facility. SUBJECTS:Twenty New...

journal_title：Pharmacotherapy

authors： Adcock KG,Kyle PB,Deaton JS,Olivier JH,Hogan SM

更新日期：2007-02-01 00:00:00