Telithromycin-induced digoxin toxicity and electrocardiographic changes.


:A 58-year-old woman who had been taking digoxin 0.25 mg/day for more than 35 years for heart palpitations after mitral valve repair was prescribed a 5-day course of telithromycin for acute bronchitis. On the sixth day of therapy, she came to the emergency department complaining of general malaise and having experienced three episodes of syncope over the previous 2 days. Laboratory analysis revealed elevated digoxin plasma levels, and electrocardiography showed several nonspecific repolarization anomalies. Telithromycin is known to increase digoxin plasma levels; however, the clinical significance of this interaction is not known. To our knowledge, this is the first report of elevated plasma digoxin levels associated with signs and symptoms of toxicity. This drug interaction-determined as probable according to the Naranjo adverse drug reaction probability scale-may be mediated by P-glycoprotein. By inhibiting the transport of digoxin by P-glycoprotein, telithromycin may have decreased digoxin elimination in the intestinal lumen and its renal tubular excretion, resulting in elevated plasma levels and drug toxicity. Clinicians should be aware of possible digoxin toxicity after concomitant administration with telithromycin, especially in patients who are at risk, such as those with electrolyte abnormalities and decreased renal function.






Nenciu LM,Laberge P,Thirion DJ




Has Abstract


2006-06-01 00:00:00












  • Pharmacokinetics of intranasal and intratracheal pentoxifylline in rabbits.

    abstract:STUDY OBJECTIVE:To evaluate the disposition of pentoxifylline and its metabolite, lisofylline, in New Zealand rabbits after two alternative routes of administration, intranasal and intratracheal. DESIGN:Pharmacokinetics study in an animal model. SETTING:University-affiliated animal care facility. SUBJECTS:Twenty New...


    pub_type: 杂志文章


    authors: Adcock KG,Kyle PB,Deaton JS,Olivier JH,Hogan SM

    更新日期:2007-02-01 00:00:00

  • Oxandrolone treatment in adults with severe thermal injury.

    abstract::Severe thermal injury is associated with hypermetabolism and hypercatabolism, leading to skeletal muscle breakdown, lean body mass loss, weight loss, and negative nitrogen balance. Muscle protein catabolism in patients with severe thermal injury is the result of stress-induced increased release of cytokines and counte...


    pub_type: 杂志文章,评审


    authors: Miller JT,Btaiche IF

    更新日期:2009-02-01 00:00:00

  • Adjunctive aerosolized antibiotics for treatment of ventilator-associated pneumonia.

    abstract:STUDY OBJECTIVE:To determine clinical and microbiologic success in patients receiving adjunctive aerosolized antibiotics for the treatment of ventilator-associated pneumonia (VAP). DESIGN:Retrospective medical record review. SETTING:Level I trauma intensive care unit of a large academic medical center. PATIENTS:Fort...


    pub_type: 杂志文章


    authors: Czosnowski QA,Wood GC,Magnotti LJ,Croce MA,Swanson JM,Boucher BA,Fabian TC

    更新日期:2009-09-01 00:00:00

  • The impact of first-line antihypertensive drugs on erectile dysfunction.

    abstract::Erectile dysfunction, a problem estimated to affect up to 30 million American men, is associated with a number of systemic illnesses and drugs. Age is not thought to be an independent risk factor for the disorder, but accompanying illnesses and their treatments may contribute to its onset. Newer classes of antihyperte...


    pub_type: 杂志文章,评审


    authors: Barksdale JD,Gardner SF

    更新日期:1999-05-01 00:00:00

  • Heart failure caused by molecularly targeted therapies for cancer.

    abstract::Cancer therapeutics is undergoing a revolution with the advent of new drugs that can selectively target molecules responsible for carcinogenesis and tumor growth. The type and mechanism of these targeting drugs vary. Some are small molecules that specifically target a binding site on a receptor or signal transduction ...


    pub_type: 杂志文章,评审


    authors: Jarkowski A 3rd,Glode AE,Spangenthal EJ,Wong MK

    更新日期:2011-01-01 00:00:00

  • Last-observation-carried-forward imputation method in clinical efficacy trials: review of 352 antidepressant studies.

    abstract:STUDY OBJECTIVE:To determine the prevalence, over 40 years, of using the last-observation-carried-forward (LOCF) imputation method in clinical trials, the association between use of LOCF and how the trials were conducted, and the extent of information about attrition and LOCF use in published reports. DESIGN:Retrospec...


    pub_type: 杂志文章,评审


    authors: Woolley SB,Cardoni AA,Goethe JW

    更新日期:2009-12-01 00:00:00

  • Microbiologic surrogate end points in clinical trials of infectious diseases: example of acute otitis media trials.

    abstract::Clinical outcomes that measure how patients feel, function, or survive are the most important and relevant outcomes of therapy in clinical trials and in clinical practice. Surrogate end points, which do not directly measure clinical benefit to the patient, may function as substitutes for clinical end points in clinica...


    pub_type: 杂志文章,评审


    authors: Powers JH

    更新日期:2005-12-01 00:00:00

  • Glucagon for Relief of Acute Esophageal Foreign Bodies and Food Impactions: A Systematic Review and Meta-Analysis.

    abstract::Glucagon is frequently used for the relief of esophageal impactions. This systematic review and meta-analysis were performed to evaluate the efficacy and safety of glucagon for acute esophageal foreign body and food impactions. PubMed, CINAHL, Latin American and Caribbean Health Sciences Literature (LILACS), Scopus, C...


    pub_type: 杂志文章,meta分析


    authors: Peksa GD,DeMott JM,Slocum GW,Burkins J,Gottlieb M

    更新日期:2019-04-01 00:00:00

  • Impact of an antimicrobial allergy label in the medical record on clinical outcomes in hospitalized patients.

    abstract:STUDY OBJECTIVE:To determine the impact of having an antimicrobial allergy label in the medical record on clinical outcomes in hospitalized patients. DESIGN:Retrospective cohort study. SETTING:Urban academic teaching hospital. PATIENTS:A total of 11,872 adults admitted to nonsurgical patient care wards who received ...


    pub_type: 杂志文章


    authors: Charneski L,Deshpande G,Smith SW

    更新日期:2011-08-01 00:00:00

  • Comparison of bivalirudin and argatroban for the management of heparin-induced thrombocytopenia.

    abstract:STUDY OBJECTIVES:To compare the effectiveness of bivalirudin and argatroban in achieving anticoagulation goals and to compare clinical outcomes assessing the safety and efficacy in patients with known or suspected heparin-induced thrombocytopenia (HIT). DESIGN:Single-center, retrospective analysis. SETTING:Large tert...


    pub_type: 杂志文章


    authors: Skrupky LP,Smith JR,Deal EN,Arnold H,Hollands JM,Martinez EJ,Micek ST

    更新日期:2010-12-01 00:00:00

  • Antimicrobial prophylaxis for arthroplasty and total joint replacement: discussion and review of published clinical trials.

    abstract::Cephalosporins are often administered to prevent infections that can follow total joint replacements (TJR) and other arthroplastic procedures. However, recommendations contained within published guidelines and review articles vary greatly from those given by the manufacturer in product information circulars. Similarly...


    pub_type: 杂志文章,评审


    authors: Heath AF

    更新日期:1991-01-01 00:00:00

  • Zidovudine pharmacokinetics in five HIV seronegative patients undergoing continuous ambulatory peritoneal dialysis.

    abstract::A few reports in the literature describe zidovudine (AZT) pharmacokinetics in patients undergoing hemodialysis; however, the effect of continuous ambulatory peritoneal dialysis (CAPD) on the drug's disposition has not been studied. The pharmacokinetics of AZT were evaluated in five patients, age 37-62 years, who were ...


    pub_type: 杂志文章


    authors: Kremer D,Munar MY,Kohlhepp SJ,Swan SK,Stinnett EA,Gilbert DN,Young EW,Bennett WM

    更新日期:1992-01-01 00:00:00

  • Tacrolimus toxicity associated with concomitant metoclopramide therapy.

    abstract::Subtherapeutic tacrolimus trough concentrations were noted in a 52-year-old woman who had undergone liver transplantation. Her tacrolimus dosage was increased from 7 to 28 mg twice/day, and ketoconazole therapy was added; however, her tacrolimus concentration remained undetectable. Metoclopramide 10 mg 4 times/day was...


    pub_type: 杂志文章


    authors: Prescott WA Jr,Callahan BL,Park JM

    更新日期:2004-04-01 00:00:00

  • Olanzapine-associated severe hyperglycemia, ketonuria, and acidosis: case report and review of literature.

    abstract::Olanzapine has been associated with insulin resistance and new-onset diabetes mellitus. A 27-year-old African-American man developed new-onset severe hyperglycemia-glucose 1240 mg/dl, with ketonuria and acidosis, but no weight gain-2 years after starting olanzapine. Although his diabetes was stabilized with insulin, h...


    pub_type: 杂志文章,评审


    authors: Seaburg HL,McLendon BM,Doraiswamy PM

    更新日期:2001-11-01 00:00:00

  • Vancomycin assay performance in patients with end-stage renal disease receiving hemodialysis.

    abstract:STUDY OBJECTIVE:To compare the performance of polyclonal fluorescence polarization immunoassay (pFPIA) with that of enzyme-multiplied immunoassay technique (EMIT) in patients receiving vancomycin and hemodialysis. SETTING:Outpatient hemodialysis center. PATIENTS:Seven subjects with end-stage renal disease treated wit...


    pub_type: 杂志文章


    authors: Kingery JR,Sowinski KM,Kraus MA,Klaunig JE,Mueller BA

    更新日期:2000-06-01 00:00:00

  • Vigabatrin for infantile spasms.

    abstract::Infantile spasms describe a pediatric epilepsy syndrome characterized by frequent clusters of brief symmetric muscle contractions; the condition is often associated with developmental delay. When infantile spasms are accompanied by hypsarrhythmia on electroencephalogram, the condition is labeled West syndrome. The mai...


    pub_type: 杂志文章,评审


    authors: Pesaturo KA,Spooner LM,Belliveau P

    更新日期:2011-03-01 00:00:00

  • Cerivastatin-induced rhabdomyolysis: 11 case reports.

    abstract::3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are a frequently prescribed class of drugs that are generally well tolerated by most patients. A rare, yet serious side effect associated with these drugs is rhabdomyolysis. Although all HMG-CoA reductase inhibitors can cause this adverse effect, pre...


    pub_type: 杂志文章,评审


    authors: Ravnan SL,Locke C,Yee WP,Haase K

    更新日期:2002-04-01 00:00:00

  • Salary survey of ambulatory care clinical pharmacists.

    abstract::To determine salary and selected fringe benefits of members of the Ambulatory Care Practice and Research Network of the American College of Clinical Pharmacy, we developed a self-administered questionnaire that surveyed demographic information, schooling and training, academic appointments, yearly salary (as of Februa...


    pub_type: 杂志文章


    authors: Anastasio GD,Shaughnessy AF

    更新日期:1997-05-01 00:00:00

  • Systemic preexposure prophylaxis for human immunodeficiency virus infection.

    abstract::Antiretroviral therapy has significantly improved the typical course of human immunodeficiency virus (HIV) infection in industrialized nations, and life expectancies associated with the infection have increased. However, infection rates have generally remained unchanged, with increases noted among certain subpopulatio...


    pub_type: 杂志文章,评审


    authors: Romanelli F,Murphy B

    更新日期:2010-10-01 00:00:00

  • Insights into mechanisms of cisplatin resistance and potential for its clinical reversal.

    abstract::Cisplatin in combination with other cytotoxic agents is the backbone for a potential cure of testicular germ cell neoplasms and is a critical factor in the substantial activity observed in the treatment of small cell lung cancer, bladder cancer, and ovarian germ cell tumors. Resistance to cisplatin at the onset of tre...


    pub_type: 杂志文章,评审


    authors: Gosland M,Lum B,Schimmelpfennig J,Baker J,Doukas M

    更新日期:1996-01-01 00:00:00

  • Efficacy of topical atorvastatin for the treatment of pressure ulcers: a randomized clinical trial.

    abstract:STUDY OBJECTIVE:To evaluate the effects of topical atorvastatin on the healing process of pressure ulcers in critically ill patients. DESIGN:Randomized, double-blind, placebo-controlled clinical trial. SETTING:Medical-surgical intensive care unit of a university-affiliated teaching hospital in Tehran, Iran. PATIENTS...


    pub_type: 杂志文章,随机对照试验


    authors: Farsaei S,Khalili H,Farboud ES,Karimzadeh I,Beigmohammadi MT

    更新日期:2014-01-01 00:00:00

  • Theophylline--an alternative therapy for bradyarrhythmia in the elderly.

    abstract::Treating elderly debilitated patients with symptomatic bradyarrhythmia may be difficult. Traditional therapy includes use of limited resources (intensive care unit monitoring) and expensive interventions (permanent pacemaker insertion). When a pacemaker is not ideal or appropriate, yet intervention is desired to impro...


    pub_type: 杂志文章,评审


    authors: Kragie L,Sekovski B

    更新日期:1992-01-01 00:00:00

  • Barriers to patient self-testing of prothrombin time: national survey of anticoagulation practitioners.

    abstract::Oral anticoagulation with warfarin requires routine monitoring of prothrombin time, expressed as the international normalized ratio (INR). Patient self-testing for INR is common in Europe but not in the United States. In order to determine the frequency of INR self-testing among patients whose anticoagulant therapy is...


    pub_type: 杂志文章


    authors: Wittkowsky AK,Sekreta CM,Nutescu EA,Ansell J

    更新日期:2005-02-01 00:00:00

  • Ziconotide infusion for severe chronic pain: case series of patients with neuropathic pain.

    abstract::Ziconotide intrathecal infusion was recently approved by the United States Food and Drug Administration for the treatment of intractable severe chronic pain. Patients with neuropathic pain make up a significant population among those who experience chronic pain for which there are less than optimal pharmacotherapeutic...


    pub_type: 临床试验,杂志文章


    authors: Wermeling DP,Berger JR

    更新日期:2006-03-01 00:00:00

  • Serum sickness associated with 6-mercaptopurine in a patient with Crohn's disease.

    abstract::A 43-year-old man with a 19-year history of Crohn's disease experienced serum sickness with acute lobular panniculitis and vasculitis within 2 weeks of initiating 6-mercaptopurine therapy. He had no history of extraintestinal manifestations of Crohn's disease or drug allergy. Symptoms included disabling joint pain, pr...


    pub_type: 杂志文章


    authors: Andersen JM,Tiede JJ

    更新日期:1997-01-01 00:00:00

  • Verapamil hydrochloride: pharmacological properties and role in cardiovascular therapeutics.

    abstract::Verapamil hydrochloride, a prototype calcium antagonist, is now marketed in the United States for the acute treatment of supraventricular tachyarrhythmias and for chronic management of vasospastic and chronic stable angina. It inhibits the slow inward channel in in the heart and blocks calcium influx in smooth muscle....


    pub_type: 杂志文章,评审


    authors: Baky SH,Singh BN

    更新日期:1982-11-01 00:00:00

  • Loss of glycemic control in patients with type 2 diabetes mellitus who were receiving initial metformin, sulfonylurea, or thiazolidinedione monotherapy.

    abstract:STUDY OBJECTIVES:To examine glycosylated hemoglobin (A1C) values longitudinally in patients who newly started metformin, sulfonylurea, or thiazolidinedione monotherapy; in a subset of patients whose A1C values were 7% or greater before starting therapy (baseline) and who achieved A1C goal (A1C < 7%) during therapy, rat...


    pub_type: 杂志文章


    authors: Riedel AA,Heien H,Wogen J,Plauschinat CA

    更新日期:2007-08-01 00:00:00

  • Respiratory tract penetration of quinolone antimicrobials: a case in study.

    abstract::Antimicrobial lung penetration is thought to be predictive of efficacy in the treatment of lower respiratory tract infections. Lung penetration studies are commonly conducted with new antimicrobial agents to elucidate their potential utility in treating such infections. Although some very useful information may emerge...


    pub_type: 杂志文章,评审


    authors: Ritrovato CA,Deeter RG

    更新日期:1991-01-01 00:00:00

  • Tobacco interventions delivered by pharmacists: a summary and systematic review.

    abstract:BACKGROUND:As one of the most accessible health care professionals, pharmacists are in an ideal position to provide tobacco-cessation and prevention services. Although there is growing interest in expanding the pharmacist's role in tobacco treatment, few published studies have assessed the efficacy or effectiveness of ...


    pub_type: 杂志文章,评审


    authors: Dent LA,Harris KJ,Noonan CW

    更新日期:2007-07-01 00:00:00

  • Clinical and economic outcomes of rabbit antithymocyte globulin induction in adults who received kidney transplants from living unrelated donors and received cyclosporine-based immunosuppression.

    abstract:STUDY OBJECTIVE:To evaluate the efficacy, safety, and costs of rabbit antithymocyte globulin (TMG) induction in patients who received kidney transplants from living unrelated donors. DESIGN:Retrospective cohort study. SETTING:Large academic medical center. PATIENTS:Eighty-seven patients who received kidney transplan...


    pub_type: 杂志文章


    authors: Miller JT,Collins CD,Stuckey LJ,Luan FL,Englesbe MJ,Magee JC,Park JM

    更新日期:2009-10-01 00:00:00