Important effect of food on the bioavailability of oral testosterone undecanoate.

abstract：:An area of unidirectional conduction block is one requirement for reentrant arrhythmias to occur. Functional block caused by dispersion of repolarization and refractoriness is the most probable mechanism of drug-induced unidirectional conduction block. We assessed the effects of lidocaine on spatial dispersion of myoc...

journal_title：Pharmacotherapy

authors： Sims JJ,Winecoff AP,Ujhelyi MR

更新日期：1997-11-01 00:00:00

abstract：:Since the discovery of penicillin 80 years ago, gram-negative bacteria have become proficient at evading the lethal activity of β-lactam antibiotics, principally through the production of β-lactamases. The rapid emergence of penicillinases in both gram-positive and gram-negative bacteria led to the development of ceph...

journal_title：Pharmacotherapy

authors： Rapp RP,Urban C

更新日期：2012-05-01 00:00:00

abstract：:In 2006, the American College of Clinical Pharmacy (ACCP) charged the Task Force on Residency Equivalency to define the professional experience expected of a clinically mature practitioner that would meet or exceed the knowledge and skills of an accredited postgraduate year one residency-trained pharmacist. In this co...

journal_title：Pharmacotherapy

authors： American College of Clinical Pharmacy.,Jordan CJ,Wall GC,Lobo B,Wilkinson J,Creekmore FM,Sorrells K,Hartis C,Miller S,Uchal L

更新日期：2009-12-01 00:00:00

abstract：:Apixaban, a direct factor Xa inhibitor, is a novel oral anticoagulant (NOAC) indicated for prevention of embolic events in patients with nonvalvular atrial fibrillation. The agent is associated with a lower risk of bleeding compared with vitamin K antagonists such as warfarin. Hemopericardium is a life-threatening ble...

journal_title：Pharmacotherapy

authors： Sigawy C,Apter S,Vine J,Grossman E

更新日期：2015-07-01 00:00:00

abstract：:Antithrombin deficiency is a hypercoagulable state that can increase the risk for thrombosis, especially in the presence of other procoagulant triggers. Unfractionated heparin and low-molecular-weight heparins may not provide effective anticoagulation since they require antithrombin for activity. Direct thrombin inhib...

journal_title：Pharmacotherapy

authors： Dager WE,Gosselin RC,Owings JT

更新日期：2004-05-01 00:00:00

abstract：:Highly active antiretroviral therapy (HAART) for human immunodeficiency virus (HIV) has resulted in significant morbidity and mortality reductions. Lifelong antiretroviral therapy must be incorporated into each patient's medical regimen. Patients with HIV may also have simultaneous chronic medical conditions, resultin...

journal_title：Pharmacotherapy

authors： Fulco PP,Zingone MM,Higginson RT

更新日期：2008-07-01 00:00:00

abstract：:Warfarin and unfractionated heparin have been in clinical use for more than 50 years. Both are effective anticoagulants, but their use is associated with a number of impediments, including the need for intensive coagulation monitoring, wide variation in dose-response relationships, multiple drug interactions (in the c...

journal_title：Pharmacotherapy

authors： Hawkins D

更新日期：2004-07-01 00:00:00

abstract：STUDY OBJECTIVES:To determine the incidence of Clostridium difficile infection (CDI) at one community hospital by identifying patients with stool samples positive for C. difficile toxin A or B, and to compare the incidence with a 2008 national estimate; and to determine which patient characteristics and concomitant ant...

journal_title：Pharmacotherapy

authors： King RN,Lager SL

更新日期：2011-07-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effectiveness, safety, and costs associated with a formulary conversion from amlodipine to alternative calcium channel blockers. DESIGN:Retrospective study. SETTING:Veterans Affairs Medical Center. PATIENTS:One hundred patients with hypertension who were receiving amlodipine. INTERVE...

journal_title：Pharmacotherapy

authors： Parra D,Beckey NP,Korman L

更新日期：2000-09-01 00:00:00

abstract：STUDY OBJECTIVE:To assess the relationship of the 33 single nucleotide polymorphisms (SNPs) previously associated with fasting glucose in Caucasians in genome-wide association studies (GWAS) with glucose response to antihypertensive drugs shown to increase risk for hyperglycemia and diabetes. DESIGN:Randomized, multic...

journal_title：Pharmacotherapy

authors： Gong Y,McDonough CW,Beitelshees AL,Karnes JH,O'Connell JR,Turner ST,Chapman AB,Gums JG,Bailey KR,Boerwinkle E,Johnson JA,Cooper-DeHoff RM

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Anticoagulation monitoring during transition from direct oral anticoagulants (DOAC) to heparin infusions is a significant challenge. Factor Xa inhibitors influence the heparin calibrated antifactor Xa assay. The University of Virginia (UVA) Medical Center utilized a corrected antifactor Xa assay (c-AXA) duri...

journal_title：Pharmacotherapy

authors： Plum MD,Hedrick JN,Hockman R,Bazydlo L,Palkimas S

更新日期：2020-09-01 00:00:00

abstract：:Warfarin is a commonly used oral anticoagulant that is usually initiated after the definitive diagnosis of a certain thromboembolic disorder or disease. Warfarin therapy will usually be prescribed for 6-12 weeks or more, and some patients may continue therapy throughout life, depending on the type of thromboembolic di...

journal_title：Pharmacotherapy

authors： Yamreudeewong W,Johnson JV,Cassidy TG,Berg JT

更新日期：1996-11-01 00:00:00

abstract：:Although heparin-dependent antibodies (HDAs) typically manifest with thrombocytopenia as in heparin-induced thrombocytopenia (HIT), they may also manifest with preserved platelet counts. We describe a 35-year-old woman who developed severe thrombotic complications due to heparinization and unrecognized HDAs. She had r...

journal_title：Pharmacotherapy

authors： Bream-Rouwenhorst HR,Hobbs RA

更新日期：2008-11-01 00:00:00

abstract：STUDY OBJECTIVE:To assess the level of agreement between one subjective definition of major bleeding (criteria A) and two objective definitions: the International Society on Thrombosis and Haemostasis ([ISTH] criteria B) and the Italian Study of Complications of Anticoagulant Therapy ([ISCOAT] criteria C). DESIGN:Retr...

journal_title：Pharmacotherapy

authors： Seto AC,Kenyon K,Wittkowsky AK

更新日期：2008-09-01 00:00:00

abstract：:Certain demographic, practice, staffing, and pharmacist satisfaction variables may contribute to dispensing errors. A survey was randomly mailed to 7298 (50%) Texas pharmacists, of which 2862 were returned (39% response rate). Responders were 2437 pharmacists who indicated that they were in practice. Of these, 535 (23...

journal_title：Pharmacotherapy

authors： Bond CA,Raehl CL

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:To review the current pharmacotherapy for idiopathic pulmonary arterial hypertension (IPAH). METHODS:A search of the primary literature was conducted by using MEDLINE, the National Institutes of Health medical research Web site (www.clinicaltrials.gov), and the United States Food and Drug Administration's Ce...

journal_title：Pharmacotherapy

authors： Hackman AM,Lackner TE

更新日期：2006-01-01 00:00:00

abstract：:Pseudomonas aeruginosa is one of the leading gram-negative organisms associated with nosocomial infections. The increasing frequency of multi-drug-resistant Pseudomonas aeruginosa (MDRPA) strains is concerning as efficacious antimicrobial options are severely limited. By searching MEDLINE from January 1966-February 20...

journal_title：Pharmacotherapy

authors： Obritsch MD,Fish DN,MacLaren R,Jung R

更新日期：2005-10-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effect of fluoxetine on the pharmacokinetics and cardiovascular safety of cisapride at steady state in healthy men. DESIGN:Open-label, three-phase, sequential study. SETTING:Clinical research center. SUBJECTS:Twelve healthy male volunteers. INTERVENTIONS:Each subject was treated acco...

journal_title：Pharmacotherapy

authors： Zhao Q,Wojcik MA,Parier JL,Pesco-Koplowitz L

更新日期：2001-02-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the accuracy of four equations based on serum creatinine concentration-the original Schwartz equation and the Leger, Bedside Chronic Kidney Disease in Children (CKiD), and Counahan-Barratt equations-for determining glomerular filtration rate (GFR) in pediatric patients with chronic kidney di...

journal_title：Pharmacotherapy

authors： Lee CK,Swinford RD,Cerda RD,Portman RJ,Hwang W,Furth SL

更新日期：2012-07-01 00:00:00

abstract：:Cytochrome P450 3A5 (CYP3A5) and cytochrome P450 3A4 (CYP3A4) are the predominate enzymes responsible for tacrolimus metabolism. The presence of CYP3A4 and CYP3A5 genetic variants significantly affects tacrolimus clearance and dose requirements. CYP3A5*3 is a loss-of-function variant resulting in no CYP3A5 enzyme prod...

journal_title：Pharmacotherapy

authors： Scheibner A,Remmel R,Schladt D,Oetting WS,Guan W,Wu B,Dorr C,Israni A,Jacobson PA

更新日期：2018-07-01 00:00:00

abstract：:Calcium channel blockers, nitrates, and beta blockers are the primary agents used for the treatment of angina. Calcium has a central role in excitation-contraction, action potential generation, and ischemic cell death. The three currently available calcium antagonists are nifedipine, verapamil, and diltiazem. Second-g...

journal_title：Pharmacotherapy

authors： Angaran D

更新日期：1987-01-01 00:00:00

abstract：:Gram-negative septicemia due to central venous catheter-related infection is a leading cause of mortality and morbidity among patients who undergo hemodialysis. Antibiotic-heparin locks are valuable for preserving access sites and lowering the cost and inconvenience associated with central venous catheter replacement ...

journal_title：Pharmacotherapy

authors： Saxena AK,Panhotra BR,Naguib M

更新日期：2002-01-01 00:00:00

abstract：:The clinical significance of rifampin's induction of warfarin metabolism is well documented, but no published studies or case reports have quantified this interaction with respect to the international normalized ratio (INR). A patient receiving concomitant rifampin and warfarin to treat a mycobacterial infection and i...

journal_title：Pharmacotherapy

authors： Lee CR,Thrasher KA

更新日期：2001-10-01 00:00:00

abstract：:The statins are widely used to treat dyslipidemias. They are generally associated with mild adverse effects, but rarely, more serious reactions may occur. A 51-year-old man experienced delayed-onset, progressive memory loss while receiving simvastatin for hypercholesterolemia. His therapy was switched to pravastatin, ...

journal_title：Pharmacotherapy

authors： Orsi A,Sherman O,Woldeselassie Z

更新日期：2001-06-01 00:00:00

abstract：:The traditional role of theophylline as a bronchodilator has been expanded by recent findings that suggest this drug has more than smooth muscle relaxant properties. Several investigators indicate that theophylline has an inotropic effect on respiratory muscle, causing enhanced muscular contraction and prevention of m...

journal_title：Pharmacotherapy

authors： Landsberg KF,Vaughan LM,Heffner JE

更新日期：1990-01-01 00:00:00

abstract：:A 43-year-old man with a 19-year history of Crohn's disease experienced serum sickness with acute lobular panniculitis and vasculitis within 2 weeks of initiating 6-mercaptopurine therapy. He had no history of extraintestinal manifestations of Crohn's disease or drug allergy. Symptoms included disabling joint pain, pr...

journal_title：Pharmacotherapy

authors： Andersen JM,Tiede JJ

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:As tenofovir disoproxil fumarate substantially increases plasma concentrations of didanosine in patients with human immunodeficiency virus-1 infection, we sought to determine whether tenofovir and didanosine showed a similar intracellular interaction in human peripheral blood mononuclear cells (PBMCs). DESIG...

journal_title：Pharmacotherapy

authors： Robbins BL,Wilcox CK,Fridland A,Rodman JH

更新日期：2003-06-01 00:00:00

abstract：:Use of the Molecular Adsorbent Recirculating System (MARS) as a liver support device continues to grow worldwide. Various components of the MARS circuit remove both protein-bound and water-soluble molecules. Little is known about the extent of the enhanced clearance mechanisms used in MARS therapy on drug elimination....

journal_title：Pharmacotherapy

authors： Personett HA,Larson SL,Frazee EN,Nyberg SL,El-Zoghby ZM

更新日期：2015-08-01 00:00:00

abstract：:Although various manifestations of pentamidine-induced cardiotoxicity have been reported, to our knowledge, second-degree heart block associated with this agent has not been described. In addition, cardiac adverse effects usually develop after at least 6 days of therapy. We describe a 54-year-old, human immunodeficien...

journal_title：Pharmacotherapy

authors： Antoniou T,Gough KA

更新日期：2005-06-01 00:00:00

abstract：:Acute graft-versus-host disease remains a devastating complication following hematopoietic cell transplantation, resulting in increased morbidity and mortality. Vast research efforts continue to refine or develop new means of prediction, assessment, prevention, and treatment of this syndrome. Recent updates in acute g...

journal_title：Pharmacotherapy

authors： DiMaggio E

更新日期：2020-08-01 00:00:00