听力与言语-语言病理学

行为科学

医学伦理学

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  • Predictors of a Response to Dexmedetomidine in Intubated, Critically Ill Adult Patients.

    abstract:BACKGROUND:Dexmedetomidine is a centrally acting α-2 receptor agonist used to maintain light analgosedation in mechanically ventilated adults. This study was conducted to determine factors predictive of successful maintenance of light sedation (Richmond Agitation-Sedation Scale (RASS) 0 to -2) for ≥60% of the first 48 ...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.2501

    authors: DiCesare MA,Rech MA,DeMott JM

    更新日期:2021-01-09 00:00:00

  • Drug-Induced Ototoxicity: A Comprehensive Review and Reference Guide.

    abstract:OBJECTIVE:In an era of increasing polypharmacy, adverse drug effects such as ototoxicity have significant public health implications. Despite the availability of evidence, many health care professionals may not know the risk of ototoxicity in common medications. Therefore, the aim of this review is to provide a compreh...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.2478

    authors: Rizk HG,Lee JA,Liu YF,Endriukaitis L,Isaac JL,Bullington WM

    更新日期:2020-12-01 00:00:00

  • Advances in Personalized Medicine and Non-Invasive Diagnostics in Solid Organ Transplantation.

    abstract::Personalized medicine has been a mainstay and in practice in transplant pharmacotherapy since the advent of the field. Decisions pertaining to the diagnosis, selection, and monitoring of transplant pharmacotherapy are aimed toward the individual, the allograft, and the overall immunologic needs of the patient. Recent ...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.2484

    authors: Maldonado AQ,West-Thielke P,Joyal K,Marks CR

    更新日期:2020-11-06 00:00:00

  • Complementary Use of U.S. FDA's Adverse Event Reporting System and Sentinel System to Characterize Direct Oral Anticoagulants-Associated Cutaneous Small Vessel Vasculitis.

    abstract:BACKGROUND:Cutaneous small vessel vasculitis (CSVV) has been reported after exposure to direct oral anticoagulants (DOACs), such as dabigatran, rivaroxaban, apixaban, and edoxaban. OBJECTIVE:We used the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) to describe clinical characteristics associ...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.2468

    authors: Mohamoud M,Horgan C,Eworuke E,Dee E,Bohn J,Shapira O,Munoz MA,Stojanovic D,Sansing-Foster V,Ajao A,La Grenade L

    更新日期:2020-11-01 00:00:00

  • Potentially Inappropriate Medication Combination with Opioids among Older Dental Patients: A Retrospective Review of Insurance Claims Data.

    abstract:BACKGROUND:Opioid prescribing by dentists for older patients receiving medications with potential contraindications and the subsequent impact on acute care outcomes is not well described. OBJECTIVES:Our objective of this paper was to evaluate the use of potentially inappropriate medication combinations (PIMCs) involvi...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.2452

    authors: Zhou J,Calip GS,Rowan S,McGregor JC,Perez RI,Evans CT,Gellad WF,Suda KJ

    更新日期:2020-10-01 00:00:00

  • An Overview of the Treatment of Less Common Non-Lactose-Fermenting Gram-Negative Bacteria.

    abstract::Stenotrophomonas maltophilia, Burkholderia cepacia complex, Elizabethkingia spp., Chryseobacterium spp., Achromobacter spp., and Alcaligenes spp. are less-common non-lactose-fermenting bacteria that have emerged as important opportunistic pathogens. Patients at the highest risk for these infections include the immunoc...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1002/phar.2447

    authors: Spencer HK,Spitznogle SL,Borjan J,Aitken SL

    更新日期:2020-09-01 00:00:00

  • The Relationship between the Initial Anti-factor Xa Measurement and the Duration of Direct Oral Anticoagulant Influence in Patients Transitioning to Heparin.

    abstract:BACKGROUND:Anticoagulation monitoring during transition from direct oral anticoagulants (DOAC) to heparin infusions is a significant challenge. Factor Xa inhibitors influence the heparin calibrated antifactor Xa assay. The University of Virginia (UVA) Medical Center utilized a corrected antifactor Xa assay (c-AXA) duri...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.2444

    authors: Plum MD,Hedrick JN,Hockman R,Bazydlo L,Palkimas S

    更新日期:2020-09-01 00:00:00

  • Acute Graft-versus-Host Disease: Emerging Insights and Updates into Detection, Prevention, and Treatment.

    abstract::Acute graft-versus-host disease remains a devastating complication following hematopoietic cell transplantation, resulting in increased morbidity and mortality. Vast research efforts continue to refine or develop new means of prediction, assessment, prevention, and treatment of this syndrome. Recent updates in acute g...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1002/phar.2436

    authors: DiMaggio E

    更新日期:2020-08-01 00:00:00

  • Association of GGH Promoter Methylation Levels with Methotrexate Concentrations in Chinese Children with Acute Lymphoblastic Leukemia.

    abstract:BACKGROUND:It is known that γ-glutamyl hydrolase (GGH) is involved in the disposition of methotrexate (MTX), and GGH activity is regulated by DNA methylation in acute lymphoblastic leukemia (ALL) cells. The present study explores the methylation status of the GGH promoter in peripheral blood and its association with MT...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.2430

    authors: Wang SM,Kong XY,Li M,Sun LL,Yan D

    更新日期:2020-07-01 00:00:00

  • Predicting Interactions between Rifampin and Antihypertensive Drugs Using the Biopharmaceutics Drug Disposition Classification System.

    abstract:STUDY OBJECTIVE:Lack of blood pressure control is often seen in hypertensive patients concomitantly taking antituberculosis medications due to the complex drug-drug interactions between rifampin and antihypertensive drugs. Therefore, it is of clinical importance to understand the underlying mechanisms of these interact...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.2380

    authors: Liu W,Yan T,Chen K,Yang L,Benet LZ,Zhai S

    更新日期:2020-04-01 00:00:00

  • Insulin Glargine in Critically ill Patients: Once/Day versus Twice/Day Dosing.

    abstract:OBJECTIVE:Twice/day dosing of insulin glargine has been used to treat hyperglycemia in clinical practice; however, data supporting its use in the critically ill population are lacking. This study was designed to evaluate the safety and efficacy of twice/day insulin glargine in critically ill patients. METHODS:A retros...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.2373

    authors: Fox MA,Perry MC,Liu-DeRyke X

    更新日期:2020-03-01 00:00:00

  • Timing of Initiation of Oral Anticoagulation after Acute Ischemic Stroke in Patients with Atrial Fibrillation.

    abstract::Patients with atrial fibrillation (AF) who suffer an acute ischemic stroke are at risk for both hemorrhagic transformation and recurrent ischemic stroke in the acute post-stroke period. Oral anticoagulants are recommended for secondary stroke prevention in patients with AF. The optimal time to initiate anticoagulant t...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1002/phar.2345

    authors: Smythe MA,Parker D,Garwood CL,Cuker A,Messé SR

    更新日期:2020-01-01 00:00:00

  • Bevacizumab Use and the Risk of Arterial and Venous Thromboembolism in Patients with High-Grade Gliomas: A Nested Case-Control Study.

    abstract:STUDY OBJECTIVE:Bevacizumab is used in the treatment of recurrent glioblastoma, but evidence is limited on the incidence of thromboembolic complications regarding the use of this drug in real-world settings. We evaluated the risk of arterial thromboembolism (ATE) and venous thromboembolism (VTE) associated with the use...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.2310

    authors: Lee I,Adimadhyam S,Nutescu EA,Zhou J,Asfaw AA,Sweiss KI,Patel PR,Calip GS

    更新日期:2019-09-01 00:00:00

  • Efficacy and Safety of the Use of Pulmonary Arterial Hypertension Pharmacotherapy in Patients with Pulmonary Hypertension Secondary to Left Heart Disease: A Systematic Review.

    abstract::Pulmonary hypertension (PH) is often caused by left heart disease (LHD) such as heart failure (HF) or valvular heart disease. Historically, few randomized controlled trials have evaluated the off-label use of medications for treating pulmonary arterial hypertension (PAH) in patients with PH-LHD. However, multiple rand...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.2314

    authors: Kido K,Coons JC

    更新日期:2019-09-01 00:00:00

  • Impact of Central Nervous System Stimulant Medication Use on Growth in Pediatric Populations with Attention-Deficit/Hyperactivity Disorder: A Review.

    abstract::Central nervous system stimulants are a commonly used first-line treatment option for attention-deficit/hyperactivity disorder (ADHD). Stimulants are generally well tolerated, with anorexia and insomnia the most common adverse effects. However, there are some concerns with long-term use of stimulants, such as potentia...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1002/phar.2192

    authors: Troksa K,Kovacich N,Moro M,Chavez B

    更新日期:2019-06-01 00:00:00

  • Association Between Time-in-Therapeutic Tacrolimus Range and Early Rejection After Heart Transplant.

    abstract:BACKGROUND:Historically, there is perceived pressure to achieve therapeutic levels of tacrolimus quickly after heart transplant (HT). We evaluated the association between time within therapeutic tacrolimus range and time to therapeutic trough and rejection in the 30 days following HT. METHODS:This is a single-center r...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.2262

    authors: Baker WL,Steiger S,Martin S,Patel N,Radojevic J,Darsaklis K,O'Bara L,Kutzler H,Dougherty J,Feingold A,Hammond J,Fusco D,Gluck JA

    更新日期:2019-05-01 00:00:00

  • Integrase Inhibitors: After 10 Years of Experience, Is the Best Yet to Come?

    abstract::The era of the integrase strand transfer inhibitors (INSTIs) for the treatment of human immunodeficiency virus (HIV) infection began with raltegravir in 2007. Since that time, several other INSTIs have been introduced including elvitegravir, dolutegravir, and, most recently, bictegravir, that have shown great utility ...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1002/phar.2246

    authors: Brooks KM,Sherman EM,Egelund EF,Brotherton A,Durham S,Badowski ME,Cluck DB

    更新日期:2019-05-01 00:00:00

  • Review of Real-World Implementation Data on Emtricitabine-Tenofovir Disoproxil Fumarate as HIV Pre-exposure Prophylaxis in the United States.

    abstract::The antiretroviral combination of emtricitabine-tenofovir disoproxil fumarate (FTC/TDF) was approved by the U.S. Food and Drug Administration for use as pre-exposure prophylaxis (PrEP) in individuals at high risk for acquiring human immunodeficiency virus (HIV) in July 2012. Since then, Centers for Disease Control and...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1002/phar.2240

    authors: Adams JL,Shelley K,Nicol MR

    更新日期:2019-04-01 00:00:00

  • Glucagon for Relief of Acute Esophageal Foreign Bodies and Food Impactions: A Systematic Review and Meta-Analysis.

    abstract::Glucagon is frequently used for the relief of esophageal impactions. This systematic review and meta-analysis were performed to evaluate the efficacy and safety of glucagon for acute esophageal foreign body and food impactions. PubMed, CINAHL, Latin American and Caribbean Health Sciences Literature (LILACS), Scopus, C...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,meta分析

    doi:10.1002/phar.2236

    authors: Peksa GD,DeMott JM,Slocum GW,Burkins J,Gottlieb M

    更新日期:2019-04-01 00:00:00

  • Prevention of Clostridium difficile Infection in Critically Ill Adults.

    abstract::The incidence and severity of Clostridium difficile infection (CDI) remain high across intensive care units in the United States despite national efforts to decrease this escalating health care burden. Most published literature and guidelines address treatment rather than prevention, yet this approach may be too downs...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1002/phar.2200

    authors: Leedahl DD,Personett HA,Nagpal A,Barreto EF

    更新日期:2019-03-01 00:00:00

  • Use of Newer Anticonvulsants for the Treatment of Status Epilepticus.

    abstract::Status epilepticus (SE) has a high mortality rate and is one of the most common neurologic emergencies. Fast progression of this neurologic emergency and lack of response to traditional antiepileptic drugs (AEDs) in most cases has challenged clinicians to use new agents. This article evaluates the efficacy and safety ...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1002/phar.2229

    authors: Farrokh S,Bon J,Erdman M,Tesoro E

    更新日期:2019-03-01 00:00:00

  • Effect of Neuromuscular Blocking Agents on Sedation Requirements in Trauma Patients with an Open Abdomen.

    abstract::The appropriate level of sedation in patients with an open abdomen following damage control laparotomy (DCL) is debated. Chemical paralysis with neuromuscular blocking agents (NMBAs) has been used to decrease time to abdominal closure. We sought to evaluate the effect of NMBA use on sedation requirements in patients w...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.2225

    authors: Smith SE,Hamblin SE,Dennis BM

    更新日期:2019-03-01 00:00:00

  • TLR9 rs352139 Genetic Variant Promotes Tacrolimus Elimination in Chinese Liver Transplant Patients During the Early Posttransplantation Period.

    abstract:BACKGROUND:There are limited markers that could facilitate individualized tacrolimus treatment in the early posttransplantation period. Genetic factors have been found to play critical roles in determining tacrolimus pharmacokinetics. OBJECTIVE:We aimed to examine the association of donor and recipient Toll-like recep...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.2204

    authors: Ou B,Liu Y,Zhang T,Sun Y,Chen J,Peng Z

    更新日期:2019-01-01 00:00:00

  • Adjunctive Use of Cidofovir and Intravenous Immunoglobulin to Treat Invasive Adenoviral Disease in Solid Organ Transplant Recipients.

    abstract:BACKGROUND:Infections with adenoviruses (ADVs) can result in considerable mortality and morbidity in solid organ transplant (SOT) recipients. Standard therapy for ADV infections in transplant recipients is not established. At our institution, intravenous cidofovir and immunoglobulin have been used to treat disseminated...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.2194

    authors: Permpalung N,Mahoney MV,Alonso CD

    更新日期:2018-12-01 00:00:00

  • Incidence of Acute Kidney Injury Among Patients Receiving the Combination of Vancomycin with Piperacillin-Tazobactam or Meropenem.

    abstract:INTRODUCTION:Vancomycin (VAN) is associated with an increased risk of acute kidney injury (AKI). Evidence is conflicting regarding the risk of AKI when VAN is combined with an antipseudomonal β-lactam. OBJECTIVES:To determine the comparative incidence of AKI when VAN is combined with piperacillin-tazobactam (PTZ) or m...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.2179

    authors: Robertson AD,Li C,Hammond DA,Dickey TA

    更新日期:2018-12-01 00:00:00

  • Omadacycline Enters the Ring: A New Antimicrobial Contender.

    abstract::Omadacycline is a novel aminomethylcycline approved for the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections. This article reviews existing data pertaining to the biochemistry, mechanism of action, pharmacokinetics/pharmacodynamics, in vitro activity, and curre...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1002/phar.2185

    authors: Barber KE,Bell AM,Wingler MJB,Wagner JL,Stover KR

    更新日期:2018-12-01 00:00:00

  • Pharmacokinetics of the Meropenem Component of Meropenem-Vaborbactam in the Treatment of KPC-Producing Klebsiella pneumoniae Bloodstream Infection in a Pediatric Patient.

    abstract::Meropenem-vaborbactam is a new β-lactam/β-lactamase inhibitor combination designed to target Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae. Meropenem-vaborbactam was United States Food and Drug Administration-approved for complicated urinary tract infections in patients 18 years of age or olde...

    journal_title:Pharmacotherapy

    pub_type:

    doi:10.1002/phar.2187

    authors: Hanretty AM,Kaur I,Evangelista AT,Moore WS 2nd,Enache A,Chopra A,Cies JJ

    更新日期:2018-12-01 00:00:00

  • Management of Pediatric Acute Hematogenous Osteomyelitis, Part II: A Focus on Methicillin-Resistant Staphylococcus aureus, Current and Emerging Therapies.

    abstract::Methicillin-resistant Staphylococcus aureus (MRSA) has become the most prevalent cause of acute hematogenous osteomyelitis (AHO) in pediatric patients. This increase in MRSA is due to the rise in community-acquired MRSA. Therefore, it is important that clinicians are aware of the various and upcoming therapies that co...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1002/phar.2164

    authors: DeRonde KJ,Girotto JE,Nicolau DP

    更新日期:2018-10-01 00:00:00

  • A Randomized Pharmacokinetic and Pharmacodynamic Evaluation of Every 8-Hour and 12-Hour Dosing Strategies of Vancomycin and Cefepime in Neurocritically ill Patients.

    abstract:PURPOSE:Neurocritically ill patients have clinically significant alterations in pharmacokinetic parameters of renally eliminated medications that may result in subtherapeutic plasma and cerebrospinal fluid antibiotic concentrations. METHODS:We conducted a prospective randomized open-label study of adult neurocriticall...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/phar.2156

    authors: Kassel LE,Van Matre ET,Foster CJ,Fish DN,Mueller SW,Sherman DS,Wempe MF,MacLaren R,Neumann RT,Kiser TH

    更新日期:2018-09-01 00:00:00

  • Expanding Opportunities in the Postacute Long-Term Care Setting: Bringing Medication Safety to the Next Level.

    abstract::Skilled nursing facilities and nursing homes are care settings that offer increasing opportunities for pharmacists to take the lead when addressing the new updated Centers for Medicare and Medicaid Services (CMS) requirements coupled with enhanced quality measures reporting. In addition, the complexity of the medicati...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1002/phar.2155

    authors: Brandt NJ,Worz C,Clackum SF

    更新日期:2018-08-01 00:00:00

  • Clinical Outcomes with Penicillin Versus Alternative β-Lactams in the Treatment of Penicillin-Susceptible Staphylococcus aureus Bacteremia.

    abstract:OBJECTIVES:To identify the impact of penicillin versus alternative β-lactams on clinical outcomes in patients with penicillin-susceptible Staphylococcus aureus (PSSA) bacteremia. DESIGN:Retrospective cohort study. SETTING:Academic medical center. PATIENTS:Adult patients with PSSA bacteremia treated with a β-lactam a...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.2124

    authors: Shah MD,Wardlow LC,Stevenson KB,Coe KE,Reed EE

    更新日期:2018-07-01 00:00:00

  • Impact of High-Dose Acyclovir Cytomegalovirus Prophylaxis Failure in Abdominal Solid Organ Transplant Recipients.

    abstract:STUDY OBJECTIVE:To evaluate the clinical course and long-term impact of high-dose acyclovir (HD-A, 800 mg 4 times/day) cytomegalovirus (CMV) prophylaxis failure in a CMV-seropositive abdominal solid organ transplant population. DESIGN:Retrospective cohort study. SETTING:Tertiary academic medical center. PATIENTS:A t...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.2126

    authors: Siodlak M,Jorgenson MR,Descourouez JL,Leverson GE,Mandelbrot DA,Smith JA,Redfield RR

    更新日期:2018-07-01 00:00:00

  • Tacrolimus Elimination in Four Patients With a CYP3A5*3/*3 CYP3A4*22/*22 Genotype Combination.

    abstract::Cytochrome P450 3A5 (CYP3A5) and cytochrome P450 3A4 (CYP3A4) are the predominate enzymes responsible for tacrolimus metabolism. The presence of CYP3A4 and CYP3A5 genetic variants significantly affects tacrolimus clearance and dose requirements. CYP3A5*3 is a loss-of-function variant resulting in no CYP3A5 enzyme prod...

    journal_title:Pharmacotherapy

    pub_type:

    doi:10.1002/phar.2131

    authors: Scheibner A,Remmel R,Schladt D,Oetting WS,Guan W,Wu B,Dorr C,Israni A,Jacobson PA

    更新日期:2018-07-01 00:00:00

  • Cannabis for Chronic Pain: Challenges and Considerations.

    abstract::The National Academies of Sciences, Engineering, and Medicine has found substantial evidence that cannabis (plant) is effective for the treatment of chronic pain in adults, and moderate evidence that oromucosal cannabinoids (extracts, especially nabiximols) improve short-term sleep disturbances in chronic pain. The pa...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1002/phar.2115

    authors: Romero-Sandoval EA,Fincham JE,Kolano AL,Sharpe BN,Alvarado-Vázquez PA

    更新日期:2018-06-01 00:00:00

  • Glycemic Management in the Bariatric Surgery Population: A Review of the Literature.

    abstract::Obesity is a worldwide epidemic often complicated by multiple comorbidities, including type 2 diabetes mellitus (T2DM). Bariatric surgery is an increasingly common and effective weight-loss strategy for obese patients that may result in resolution of metabolic-related disease states, such as T2DM. Although bariatric s...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1002/phar.2120

    authors: Howard ML,Steuber TD,Nisly SA

    更新日期:2018-06-01 00:00:00

  • Do Electronic Cigarettes Have a Role in Tobacco Cessation?

    abstract::Tobacco use continues to be a major cause of morbidity and mortality. Even with behavioral and pharmacologic treatment, long-term tobacco cessation rates are low. Electronic nicotine delivery systems, commonly referred to as electronic cigarettes or e-cigarettes, are increasingly used for tobacco cessation. Because e-...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1002/phar.2103

    authors: Franks AS,Sando K,McBane S

    更新日期:2018-05-01 00:00:00

  • Antipsychotics, Delirium, and Acute Respiratory Distress Syndrome: What Is the Link?

    abstract::Acute respiratory distress syndrome (ARDS) is an acute inflammatory process that impairs the ability of the lungs to oxygenate and ultimately leads to respiratory failure. Patients who develop ARDS often have prolonged and complicated hospital courses putting them at risk for intensive care unit (ICU) delirium. Patien...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1002/phar.2093

    authors: Torbic H,Duggal A

    更新日期:2018-04-01 00:00:00

  • Guideline-Directed Medical Therapy and Survival Following Hospitalization in Patients with Heart Failure.

    abstract:BACKGROUND:Modification of guideline-directed medical therapy (GDMT) in hospitalized patients with heart failure (HF) has not been extensively evaluated. METHODS:The community surveillance arm of the Atherosclerosis Risk in Communities Study identified 6959 HF hospitalizations from 2005-2011. Predictors of GDMT modifi...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,多中心研究

    doi:10.1002/phar.2091

    authors: Tran RH,Aldemerdash A,Chang P,Sueta CA,Kaufman B,Asafu-Adjei J,Vardeny O,Daubert E,Alburikan KA,Kucharska-Newton AM,Stearns SC,Rodgers JE

    更新日期:2018-04-01 00:00:00

  • Cabozantinib: A Multitargeted Oral Tyrosine Kinase Inhibitor.

    abstract::Cabozantinib is an oral small-molecule multitargeted tyrosine kinase inhibitor (TKI) that may confer an advantage over other TKIs that target a single receptor. It was approved by the U.S. Food and Drug Administration for the treatment of both advanced renal cell carcinoma and progressive metastatic medullary thyroid ...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1002/phar.2076

    authors: Markowitz JN,Fancher KM

    更新日期:2018-03-01 00:00:00

  • Facilitators and Barriers to the Adoption of Pharmacogenetic Testing in an Inner-City Population.

    abstract:OBJECTIVES:To examine the knowledge, attitudes, and interest of an inner-city population toward pharmacogenetic testing, with the primary objective of identifying facilitators and barriers toward pharmacogenetic testing; and secondary objectives of determining predictors of patient interest in pharmacogenetic testing a...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.2077

    authors: Lee YM,Manzoor BS,Cavallari LH,Nutescu EA

    更新日期:2018-02-01 00:00:00

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