解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Dexmedetomidine is a centrally acting α-2 receptor agonist used to maintain light analgosedation in mechanically ventilated adults. This study was conducted to determine factors predictive of successful maintenance of light sedation (Richmond Agitation-Sedation Scale (RASS) 0 to -2) for ≥60% of the first 48 ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2501
更新日期:2021-01-09 00:00:00
abstract:OBJECTIVE:In an era of increasing polypharmacy, adverse drug effects such as ototoxicity have significant public health implications. Despite the availability of evidence, many health care professionals may not know the risk of ototoxicity in common medications. Therefore, the aim of this review is to provide a compreh...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2478
更新日期:2020-12-01 00:00:00
abstract::Personalized medicine has been a mainstay and in practice in transplant pharmacotherapy since the advent of the field. Decisions pertaining to the diagnosis, selection, and monitoring of transplant pharmacotherapy are aimed toward the individual, the allograft, and the overall immunologic needs of the patient. Recent ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2484
更新日期:2020-11-06 00:00:00
abstract:BACKGROUND:Cutaneous small vessel vasculitis (CSVV) has been reported after exposure to direct oral anticoagulants (DOACs), such as dabigatran, rivaroxaban, apixaban, and edoxaban. OBJECTIVE:We used the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) to describe clinical characteristics associ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2468
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Opioid prescribing by dentists for older patients receiving medications with potential contraindications and the subsequent impact on acute care outcomes is not well described. OBJECTIVES:Our objective of this paper was to evaluate the use of potentially inappropriate medication combinations (PIMCs) involvi...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2452
更新日期:2020-10-01 00:00:00
abstract::Stenotrophomonas maltophilia, Burkholderia cepacia complex, Elizabethkingia spp., Chryseobacterium spp., Achromobacter spp., and Alcaligenes spp. are less-common non-lactose-fermenting bacteria that have emerged as important opportunistic pathogens. Patients at the highest risk for these infections include the immunoc...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2447
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Anticoagulation monitoring during transition from direct oral anticoagulants (DOAC) to heparin infusions is a significant challenge. Factor Xa inhibitors influence the heparin calibrated antifactor Xa assay. The University of Virginia (UVA) Medical Center utilized a corrected antifactor Xa assay (c-AXA) duri...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2444
更新日期:2020-09-01 00:00:00
abstract::Acute graft-versus-host disease remains a devastating complication following hematopoietic cell transplantation, resulting in increased morbidity and mortality. Vast research efforts continue to refine or develop new means of prediction, assessment, prevention, and treatment of this syndrome. Recent updates in acute g...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2436
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:It is known that γ-glutamyl hydrolase (GGH) is involved in the disposition of methotrexate (MTX), and GGH activity is regulated by DNA methylation in acute lymphoblastic leukemia (ALL) cells. The present study explores the methylation status of the GGH promoter in peripheral blood and its association with MT...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2430
更新日期:2020-07-01 00:00:00
abstract:STUDY OBJECTIVE:Lack of blood pressure control is often seen in hypertensive patients concomitantly taking antituberculosis medications due to the complex drug-drug interactions between rifampin and antihypertensive drugs. Therefore, it is of clinical importance to understand the underlying mechanisms of these interact...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2380
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:Twice/day dosing of insulin glargine has been used to treat hyperglycemia in clinical practice; however, data supporting its use in the critically ill population are lacking. This study was designed to evaluate the safety and efficacy of twice/day insulin glargine in critically ill patients. METHODS:A retros...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2373
更新日期:2020-03-01 00:00:00
abstract::Patients with atrial fibrillation (AF) who suffer an acute ischemic stroke are at risk for both hemorrhagic transformation and recurrent ischemic stroke in the acute post-stroke period. Oral anticoagulants are recommended for secondary stroke prevention in patients with AF. The optimal time to initiate anticoagulant t...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2345
更新日期:2020-01-01 00:00:00
abstract:STUDY OBJECTIVE:Bevacizumab is used in the treatment of recurrent glioblastoma, but evidence is limited on the incidence of thromboembolic complications regarding the use of this drug in real-world settings. We evaluated the risk of arterial thromboembolism (ATE) and venous thromboembolism (VTE) associated with the use...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2310
更新日期:2019-09-01 00:00:00
abstract::Pulmonary hypertension (PH) is often caused by left heart disease (LHD) such as heart failure (HF) or valvular heart disease. Historically, few randomized controlled trials have evaluated the off-label use of medications for treating pulmonary arterial hypertension (PAH) in patients with PH-LHD. However, multiple rand...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2314
更新日期:2019-09-01 00:00:00
abstract::Central nervous system stimulants are a commonly used first-line treatment option for attention-deficit/hyperactivity disorder (ADHD). Stimulants are generally well tolerated, with anorexia and insomnia the most common adverse effects. However, there are some concerns with long-term use of stimulants, such as potentia...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2192
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Historically, there is perceived pressure to achieve therapeutic levels of tacrolimus quickly after heart transplant (HT). We evaluated the association between time within therapeutic tacrolimus range and time to therapeutic trough and rejection in the 30 days following HT. METHODS:This is a single-center r...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2262
更新日期:2019-05-01 00:00:00
abstract::The era of the integrase strand transfer inhibitors (INSTIs) for the treatment of human immunodeficiency virus (HIV) infection began with raltegravir in 2007. Since that time, several other INSTIs have been introduced including elvitegravir, dolutegravir, and, most recently, bictegravir, that have shown great utility ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2246
更新日期:2019-05-01 00:00:00
abstract::The antiretroviral combination of emtricitabine-tenofovir disoproxil fumarate (FTC/TDF) was approved by the U.S. Food and Drug Administration for use as pre-exposure prophylaxis (PrEP) in individuals at high risk for acquiring human immunodeficiency virus (HIV) in July 2012. Since then, Centers for Disease Control and...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2240
更新日期:2019-04-01 00:00:00
abstract::Glucagon is frequently used for the relief of esophageal impactions. This systematic review and meta-analysis were performed to evaluate the efficacy and safety of glucagon for acute esophageal foreign body and food impactions. PubMed, CINAHL, Latin American and Caribbean Health Sciences Literature (LILACS), Scopus, C...
journal_title:Pharmacotherapy
pub_type: 杂志文章,meta分析
doi:10.1002/phar.2236
更新日期:2019-04-01 00:00:00
abstract::The incidence and severity of Clostridium difficile infection (CDI) remain high across intensive care units in the United States despite national efforts to decrease this escalating health care burden. Most published literature and guidelines address treatment rather than prevention, yet this approach may be too downs...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2200
更新日期:2019-03-01 00:00:00
abstract::Status epilepticus (SE) has a high mortality rate and is one of the most common neurologic emergencies. Fast progression of this neurologic emergency and lack of response to traditional antiepileptic drugs (AEDs) in most cases has challenged clinicians to use new agents. This article evaluates the efficacy and safety ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2229
更新日期:2019-03-01 00:00:00
abstract::The appropriate level of sedation in patients with an open abdomen following damage control laparotomy (DCL) is debated. Chemical paralysis with neuromuscular blocking agents (NMBAs) has been used to decrease time to abdominal closure. We sought to evaluate the effect of NMBA use on sedation requirements in patients w...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2225
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:There are limited markers that could facilitate individualized tacrolimus treatment in the early posttransplantation period. Genetic factors have been found to play critical roles in determining tacrolimus pharmacokinetics. OBJECTIVE:We aimed to examine the association of donor and recipient Toll-like recep...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2204
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Infections with adenoviruses (ADVs) can result in considerable mortality and morbidity in solid organ transplant (SOT) recipients. Standard therapy for ADV infections in transplant recipients is not established. At our institution, intravenous cidofovir and immunoglobulin have been used to treat disseminated...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2194
更新日期:2018-12-01 00:00:00
abstract:INTRODUCTION:Vancomycin (VAN) is associated with an increased risk of acute kidney injury (AKI). Evidence is conflicting regarding the risk of AKI when VAN is combined with an antipseudomonal β-lactam. OBJECTIVES:To determine the comparative incidence of AKI when VAN is combined with piperacillin-tazobactam (PTZ) or m...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2179
更新日期:2018-12-01 00:00:00
abstract::Omadacycline is a novel aminomethylcycline approved for the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections. This article reviews existing data pertaining to the biochemistry, mechanism of action, pharmacokinetics/pharmacodynamics, in vitro activity, and curre...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2185
更新日期:2018-12-01 00:00:00
abstract::Meropenem-vaborbactam is a new β-lactam/β-lactamase inhibitor combination designed to target Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae. Meropenem-vaborbactam was United States Food and Drug Administration-approved for complicated urinary tract infections in patients 18 years of age or olde...
journal_title:Pharmacotherapy
pub_type:
doi:10.1002/phar.2187
更新日期:2018-12-01 00:00:00
abstract::Methicillin-resistant Staphylococcus aureus (MRSA) has become the most prevalent cause of acute hematogenous osteomyelitis (AHO) in pediatric patients. This increase in MRSA is due to the rise in community-acquired MRSA. Therefore, it is important that clinicians are aware of the various and upcoming therapies that co...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2164
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:Neurocritically ill patients have clinically significant alterations in pharmacokinetic parameters of renally eliminated medications that may result in subtherapeutic plasma and cerebrospinal fluid antibiotic concentrations. METHODS:We conducted a prospective randomized open-label study of adult neurocriticall...
journal_title:Pharmacotherapy
pub_type: 杂志文章,随机对照试验
doi:10.1002/phar.2156
更新日期:2018-09-01 00:00:00
abstract::Skilled nursing facilities and nursing homes are care settings that offer increasing opportunities for pharmacists to take the lead when addressing the new updated Centers for Medicare and Medicaid Services (CMS) requirements coupled with enhanced quality measures reporting. In addition, the complexity of the medicati...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2155
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVES:To identify the impact of penicillin versus alternative β-lactams on clinical outcomes in patients with penicillin-susceptible Staphylococcus aureus (PSSA) bacteremia. DESIGN:Retrospective cohort study. SETTING:Academic medical center. PATIENTS:Adult patients with PSSA bacteremia treated with a β-lactam a...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2124
更新日期:2018-07-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the clinical course and long-term impact of high-dose acyclovir (HD-A, 800 mg 4 times/day) cytomegalovirus (CMV) prophylaxis failure in a CMV-seropositive abdominal solid organ transplant population. DESIGN:Retrospective cohort study. SETTING:Tertiary academic medical center. PATIENTS:A t...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2126
更新日期:2018-07-01 00:00:00
abstract::Cytochrome P450 3A5 (CYP3A5) and cytochrome P450 3A4 (CYP3A4) are the predominate enzymes responsible for tacrolimus metabolism. The presence of CYP3A4 and CYP3A5 genetic variants significantly affects tacrolimus clearance and dose requirements. CYP3A5*3 is a loss-of-function variant resulting in no CYP3A5 enzyme prod...
journal_title:Pharmacotherapy
pub_type:
doi:10.1002/phar.2131
更新日期:2018-07-01 00:00:00
abstract::The National Academies of Sciences, Engineering, and Medicine has found substantial evidence that cannabis (plant) is effective for the treatment of chronic pain in adults, and moderate evidence that oromucosal cannabinoids (extracts, especially nabiximols) improve short-term sleep disturbances in chronic pain. The pa...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2115
更新日期:2018-06-01 00:00:00
abstract::Obesity is a worldwide epidemic often complicated by multiple comorbidities, including type 2 diabetes mellitus (T2DM). Bariatric surgery is an increasingly common and effective weight-loss strategy for obese patients that may result in resolution of metabolic-related disease states, such as T2DM. Although bariatric s...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2120
更新日期:2018-06-01 00:00:00
abstract::Tobacco use continues to be a major cause of morbidity and mortality. Even with behavioral and pharmacologic treatment, long-term tobacco cessation rates are low. Electronic nicotine delivery systems, commonly referred to as electronic cigarettes or e-cigarettes, are increasingly used for tobacco cessation. Because e-...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2103
更新日期:2018-05-01 00:00:00
abstract::Acute respiratory distress syndrome (ARDS) is an acute inflammatory process that impairs the ability of the lungs to oxygenate and ultimately leads to respiratory failure. Patients who develop ARDS often have prolonged and complicated hospital courses putting them at risk for intensive care unit (ICU) delirium. Patien...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2093
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Modification of guideline-directed medical therapy (GDMT) in hospitalized patients with heart failure (HF) has not been extensively evaluated. METHODS:The community surveillance arm of the Atherosclerosis Risk in Communities Study identified 6959 HF hospitalizations from 2005-2011. Predictors of GDMT modifi...
journal_title:Pharmacotherapy
pub_type: 杂志文章,多中心研究
doi:10.1002/phar.2091
更新日期:2018-04-01 00:00:00
abstract::Cabozantinib is an oral small-molecule multitargeted tyrosine kinase inhibitor (TKI) that may confer an advantage over other TKIs that target a single receptor. It was approved by the U.S. Food and Drug Administration for the treatment of both advanced renal cell carcinoma and progressive metastatic medullary thyroid ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2076
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:To examine the knowledge, attitudes, and interest of an inner-city population toward pharmacogenetic testing, with the primary objective of identifying facilitators and barriers toward pharmacogenetic testing; and secondary objectives of determining predictors of patient interest in pharmacogenetic testing a...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2077
更新日期:2018-02-01 00:00:00