Metabolism of tenofovir and didanosine in quiescent or stimulated human peripheral blood mononuclear cells.

abstract：STUDY OBJECTIVES:To determine the incidence of hepatotoxicity in critically ill patients who were treated with voriconazole and to identify potential risk factors for voriconazole-associated hepatotoxicity in these patients. DESIGN:Single-center prospective observational study. SETTING:Intensive care unit (ICU) in a ...

journal_title：Pharmacotherapy

authors： Wang Y,Wang T,Xie J,Yang Q,Zheng X,Dong W,Xing J,Wang X,Dong Y

更新日期：2016-07-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the level of agreement between two sets of criteria, the Thrombolysis in Myocardial Infarction (TIMI) criteria and investigator-developed criteria, for identifying bleeding events in patients who had undergone a percutaneous coronary intervention (PCI) and to measure length of hospital stay ...

journal_title：Pharmacotherapy

authors： McCollum M,Stringer KA,Wittkowsky AK,Young S,Spinler SA

更新日期：2007-01-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the impact of a hospital-acquired pneumonia (HAP) protocol on appropriateness of empiric antibiotic therapy, antibiotic deescalation, antibiotic duration, patient mortality, and length of stay. DESIGN:Before- and after-study of protocol implementation. SETTING:A 450-bed, academic medical c...

journal_title：Pharmacotherapy

authors： Lancaster JW,Lawrence KR,Fong JJ,Doron SI,Garpestad E,Nasraway SA,Devlin JW

更新日期：2008-07-01 00:00:00

abstract：:The appropriate level of sedation in patients with an open abdomen following damage control laparotomy (DCL) is debated. Chemical paralysis with neuromuscular blocking agents (NMBAs) has been used to decrease time to abdominal closure. We sought to evaluate the effect of NMBA use on sedation requirements in patients w...

journal_title：Pharmacotherapy

authors： Smith SE,Hamblin SE,Dennis BM

更新日期：2019-03-01 00:00:00

abstract：:Fentanyl iontophoretic transdermal system (ITS) is a novel, patient-activated drug delivery device used for the management of acute postoperative pain in the hospital setting. This credit-card-sized device uses an imperceptible current of 170 milliampere to actively deliver a fentanyl hydrochloride 40-microg dose into...

journal_title：Pharmacotherapy

authors： Herndon CM

更新日期：2007-05-01 00:00:00

abstract：STUDY OBJECTIVE:Bevacizumab is used in the treatment of recurrent glioblastoma, but evidence is limited on the incidence of thromboembolic complications regarding the use of this drug in real-world settings. We evaluated the risk of arterial thromboembolism (ATE) and venous thromboembolism (VTE) associated with the use...

journal_title：Pharmacotherapy

authors： Lee I,Adimadhyam S,Nutescu EA,Zhou J,Asfaw AA,Sweiss KI,Patel PR,Calip GS

更新日期：2019-09-01 00:00:00

abstract：:Atorvastatin calcium is an HMG-coenzyme A (CoA) reductase inhibitor that was approved by the Food and Drug Administration on December 17, 1996. Like other such agents, it inhibits the action of HMG-CoA reductase and thereby decreases endogenous cholesterol synthesis, leading to a decrease in circulating low-density li...

journal_title：Pharmacotherapy

authors： Chong PH,Seeger JD

更新日期：1997-11-01 00:00:00

abstract：:Patients undergoing cardiopulmonary bypass may develop clinically significant physiologic alterations in the perioperative period, including alteration of thyroid hormone concentrations. Alterations in the concentration of thyroid hormones are of concern due to the effects of these hormones on cardiac function. Hypoth...

journal_title：Pharmacotherapy

authors： Reichert MG,Verzino KC

更新日期：2001-11-01 00:00:00

abstract：:We reviewed the spectrum of activity, pharmacokinetics, clinical efficacy, adverse effects, and relative advantages of piperacillin-tazobactam, a new beta-lactam-beta-lactamase inhibitor. Piperacillin-tazobactam has a wide spectrum of activity that includes gram-positive organisms such as staphylococci and streptococc...

journal_title：Pharmacotherapy

authors： Daniel KP,Krop LC

更新日期：1996-03-01 00:00:00

abstract：STUDY OBJECTIVE:To determine clinical and microbiologic success in patients receiving adjunctive aerosolized antibiotics for the treatment of ventilator-associated pneumonia (VAP). DESIGN:Retrospective medical record review. SETTING:Level I trauma intensive care unit of a large academic medical center. PATIENTS:Fort...

journal_title：Pharmacotherapy

authors： Czosnowski QA,Wood GC,Magnotti LJ,Croce MA,Swanson JM,Boucher BA,Fabian TC

更新日期：2009-09-01 00:00:00

abstract：:Paclitaxel is a novel antineoplastic that effects cytotoxicity by promoting intracellular tubulin polymerization and stabilizes abnormal microtubule structures against depolymerization. Although its clinical development had been hampered by misconceptions about its pharmacology, its scarcity, difficulties extracting i...

journal_title：Pharmacotherapy

authors： Kohler DR,Goldspiel BR

更新日期：1994-01-01 00:00:00

abstract：:Contrast medium-induced nephrotoxicity (CMN) is a common form of iatrogenic acute renal failure. Typically, patients experience changes in serum creatinine or creatinine clearance between 1 and 5 days after exposure to a contrast medium, but they rarely require dialysis. The mechanism for CMN is not understood, but re...

journal_title：Pharmacotherapy

authors： Gerlach AT,Pickworth KK

更新日期：2000-05-01 00:00:00

abstract：:Infections caused by yeasts and molds continue to be associated with high rates of morbidity and mortality in both immunocompromised and immunocompetent patients. Many antifungal drugs have been developed over the past 15 years to aid in the management of these infections. However, treatment is still not optimal, as t...

journal_title：Pharmacotherapy

authors： Mohr J,Johnson M,Cooper T,Lewis JS,Ostrosky-Zeichner L

更新日期：2008-05-01 00:00:00

abstract：:Death is the ultimate adverse drug event. Despite its importance, the frequency of fatal adverse drug events is unknown. Estimates in the United States are as high as 140,000/year, although this number is heavily disputed. Potential reasons and risks for fatal adverse drug events, as well as epidemiologic designs for ...

journal_title：Pharmacotherapy

authors： Kelly WN

更新日期：2001-05-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate claims-related treatment adherence, health care resource utilization, and associated costs of therapy conversion from an insulin vial and syringe to a premixed biphasic insulin analog pen device among privately insured patients with type 2 diabetes mellitus. DESIGN:Retrospective, longitudin...

journal_title：Pharmacotherapy

authors： Cobden D,Lee WC,Balu S,Joshi AV,Pashos CL

更新日期：2007-07-01 00:00:00

abstract：:Recent evidence suggests that periodontal disease may predispose to atherosclerotic cardiovascular disease. Data support mechanisms of host-derived local and systemic proinflammatory responses similar to atherosclerosis, consisting of monocytic-derived cytokines and other inflammatory mediators, which are induced by p...

journal_title：Pharmacotherapy

authors： Chong PH,Kezele B

更新日期：2000-07-01 00:00:00

abstract：STUDY OBJECTIVE:To compare adverse events related to anticoagulation in patients assigned to a pharmacist-managed anticoagulation service versus those receiving usual care. DESIGN:Retrospective cohort analysis. SETTING:Three hundred-bed community hospital. PATIENTS:Four hundred twenty patients referred for anticoagu...

journal_title：Pharmacotherapy

authors： Locke C,Ravnan SL,Patel R,Uchizono JA

更新日期：2005-05-01 00:00:00

abstract：:A 71-year-old Caucasian woman was admitted to the hospital with right-sided weakness and slurred speech. Glioblastoma multiforme was diagnosed, and resection of the tumor was performed. During the patient's hospitalization, blood and urine cultures were obtained after her temperature rose to 103.3 degrees F. Four bloo...

journal_title：Pharmacotherapy

authors： Pound MW,Fulton KB,Chima CO

更新日期：2007-01-01 00:00:00

abstract：:Personalized medicine has been a mainstay and in practice in transplant pharmacotherapy since the advent of the field. Decisions pertaining to the diagnosis, selection, and monitoring of transplant pharmacotherapy are aimed toward the individual, the allograft, and the overall immunologic needs of the patient. Recent ...

journal_title：Pharmacotherapy

authors： Maldonado AQ,West-Thielke P,Joyal K,Marks CR

更新日期：2020-11-06 00:00:00

abstract：:A hiccup is a myoclonic jerk of the diaphragm, and cases of hiccups may last for more than 48 hours (persistent hiccups) or even more than 2 months (intractable hiccups). Current pharmacologic treatment of persistent or intractable hiccups mainly includes antidopaminergic drugs. We describe the case of a 60-year-old m...

journal_title：Pharmacotherapy

authors： Naro A,Bramanti P,Calabrò RS

更新日期：2014-12-01 00:00:00

abstract：:Bedaquiline is a diarylquinoline antitubercular drug with a novel mechanism of action against Mycobacterium tuberculosis. Bedaquiline works by inhibiting bacterial adenosine triphosphate (ATP) synthase and represents the first novel class of antituberculosis agents in more than 40 years. Bedaquiline is indicated for t...

journal_title：Pharmacotherapy

authors： Worley MV,Estrada SJ

更新日期：2014-11-01 00:00:00

abstract：STUDY OBJECTIVES:To determine changes in bone mineral density (BMD) and T scores of patients after 2 years of teriparatide therapy, and to determine the number of fractures that occurred during therapy. DESIGN:Prospective, observational study. SETTING:Pharmacist-run teriparatide clinic in a private-practice endocrino...

journal_title：Pharmacotherapy

authors： Stroup JS,Rivers SM,Abu-Baker AM,Kane MP

更新日期：2007-06-01 00:00:00

abstract：STUDY OBJECTIVE:To compare the effectiveness of darbepoetin alfa with epoetin alfa (recombinant human erythropoietin [rHuEPO]) for achieving transfusion independence and increasing hemoglobin concentrations in critically ill patients. DESIGN:Retrospective, descriptive study. SETTING:Level I trauma center intensive ca...

journal_title：Pharmacotherapy

authors： Voils SA,Harpe SH,Brophy GM

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVES:To identify the impact of penicillin versus alternative β-lactams on clinical outcomes in patients with penicillin-susceptible Staphylococcus aureus (PSSA) bacteremia. DESIGN:Retrospective cohort study. SETTING:Academic medical center. PATIENTS:Adult patients with PSSA bacteremia treated with a β-lactam a...

journal_title：Pharmacotherapy

authors： Shah MD,Wardlow LC,Stevenson KB,Coe KE,Reed EE

更新日期：2018-07-01 00:00:00

abstract：:Genotype-guided warfarin dosing algorithms are a rational approach to optimize warfarin dosing and potentially reduce adverse drug events. Diverse populations, such as African Americans and Latinos, have greater variability in warfarin dose requirements and are at greater risk for experiencing warfarin-related adverse...

journal_title：Pharmacotherapy

authors： Kaye JB,Schultz LE,Steiner HE,Kittles RA,Cavallari LH,Karnes JH

更新日期：2017-09-01 00:00:00

abstract：:With the emergence of new anticoagulants, clinicians need a thorough understanding of coagulation assays. Various laboratory assays exist to measure the effectiveness of anticoagulants. Coagulation assays are the primary method for measuring the effectiveness of anticoagulants; therefore, a comprehensive understanding...

journal_title：Pharmacotherapy

authors： Peters GL,Erwin PB,Pitlick MK,Stacy ZA

更新日期：2013-11-01 00:00:00

abstract：:Health care-associated infections, especially those caused by multidrug-resistant gram-positive organisms, such as methicillin-resistant Staphylococcus aureus (MRSA), are a growing public health threat. In 2014, the U.S. Food and Drug Administration approved two new lipoglycopeptides, oritavancin and dalbavancin, for ...

journal_title：Pharmacotherapy

authors： Roberts KD,Sulaiman RM,Rybak MJ

更新日期：2015-10-01 00:00:00

abstract：:Data obtained from 23 critically ill patients treated with intravenous ciprofloxacin in two clinical trials were used to validate prospectively a previously developed maximum a posteriori (MAP)-Bayesian estimator and optimal plasma-sampling strategy (OSS). Dosages ranged from 200 mg every 12 hours to 400 mg every 8 ho...

journal_title：Pharmacotherapy

authors： Amsden GW,Ballow CH

更新日期：1996-09-01 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GMCSF) is a hematopoietic protein that has been studied both in vitro and in vivo in human immunodeficiency virus (HIV) infection. Since both HIV infection primarily and zidovudine (formerly AZT) treatment secondarily may result in neutropenia, administration of GMCSF ...

journal_title：Pharmacotherapy

authors： Hewitt RG,Morse GD

更新日期：1992-01-01 00:00:00

abstract：:Decades of overuse and misuse of antibiotics have turned the resistance problem into a crisis. Preventive and corrective measures are urgently needed. This article presents a broad overview of the status of antimicrobial resistance. Resistance in key bacterial pathogens such as enterococci, staphylococci, pneumococci,...

journal_title：Pharmacotherapy

authors： Rybak MJ

更新日期：2004-12-01 00:00:00