Abstract:
STUDY OBJECTIVE:To evaluate the accuracy of four equations based on serum creatinine concentration-the original Schwartz equation and the Leger, Bedside Chronic Kidney Disease in Children (CKiD), and Counahan-Barratt equations-for determining glomerular filtration rate (GFR) in pediatric patients with chronic kidney disease. DESIGN:Retrospective, observational, cross-sectional study. SETTING:Single-center, academic, outpatient pediatric nephrology clinic. PATIENTS:Fifty-three pediatric patients with stages 2-5 chronic kidney disease who completed GFR assessment with (125) I-iothalamate between January 2002 and January 2005. MEASUREMENT AND MAIN RESULTS:Data were collected from each patient's medical record. Glomerular filtration rate data were analyzed using 59 evaluations from the 53 pediatric patients. (125) I-iothalamate clearance was used as the index GFR. The Bedside CKiD and Counahan-Barratt equations outperformed the Schwartz and Leger equations when the index GFR was less than 60 ml/minute/1.73 m(2) ; the Schwartz and Counahan-Barratt equations performed best for index GFRs of 60 ml/minute/1.73 m(2) or greater. Overestimation was highest with the Schwartz and Leger equations (> 20% index GFR in 57.6% and 62.7% of patients, respectively). Underestimation was highest with the Bedside CKiD and Counahan-Barratt equations (> 20% index GFR in 30.5% and 28.8%, respectively). CONCLUSION:The new Bedside CKiD equation performed well for pediatric patients with moderate-to-severe chronic kidney disease, but less well for pediatric patients with mild disease. Additional studies are needed to develop more precise GFR equations using serum creatinine concentration.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Lee CK,Swinford RD,Cerda RD,Portman RJ,Hwang W,Furth SLdoi
10.1002/j.1875-9114.2012.01095.xsubject
Has Abstractpub_date
2012-07-01 00:00:00pages
642-8issue
7eissn
0277-0008issn
1875-9114journal_volume
32pub_type
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