Abstract:
:Two patients with chronic kidney disease experienced a major bleeding event, retroperitoneal hematoma, requiring a blood transfusion after the administration of enoxaparin. The first patient was a 61-year-old Caucasian woman with multiple comorbidities, including chronic kidney disease stage 4. She received subcutaneous enoxaparin 45 mg every 12 hours, along with antiplatelet agents. On the seventh day, she developed a large retroperitoneal hematoma and her hematocrit had decreased, requiring a transfusion of packed red blood cells. The second patient was a 74-year-old, obese Caucasian woman with multiple comorbidities, including chronic kidney disease stage 2-3 and atrial fibrillation. She was given enoxaparin 120 mg every 12 hours, along with warfarin and aspirin to prevent embolization. She developed a large retroperitoneal hematoma and died despite vigorous supportive care. Enoxaparin should be administered with great caution in patients with chronic kidney disease, especially if antiplatelet agents or other anticoagulants are administered concomitantly.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Malik A,Capling R,Bastani Bdoi
10.1592/phco.25.5.769.63596subject
Has Abstractpub_date
2005-05-01 00:00:00pages
769-72issue
5eissn
0277-0008issn
1875-9114journal_volume
25pub_type
杂志文章相关文献
PHARMACOTHERAPY文献大全abstract:STUDY OBJECTIVE:A safe alternative to erythropoiesis-stimulating agents to treat anemia is warranted in patients with cancer and anemia; thus the objective of this trial was to compare the efficacy and safety of intravenous (IV) iron isomaltoside with oral iron in patients with cancer and anemia by testing the noninfer...
journal_title:Pharmacotherapy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/phar.1729
更新日期:2016-04-01 00:00:00
abstract::Methicillin-resistant Staphylococcus aureus (MRSA) has become the most prevalent cause of acute hematogenous osteomyelitis (AHO) in pediatric patients. This increase in MRSA is due to the rise in community-acquired MRSA. Therefore, it is important that clinicians are aware of the various and upcoming therapies that co...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2164
更新日期:2018-10-01 00:00:00
abstract:STUDY OBJECTIVE:To describe the pharmacokinetic disposition of tobramycin in children undergoing stem cell transplantation (SCT) after intravenous administration either every 24 hours or every 8 hours, and to use this information to create initial dosing guidelines for administration every 24 hours in this patient popu...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1592/phco.24.6.564.34743
更新日期:2004-05-01 00:00:00
abstract::Infections caused by multidrug-resistant Acinetobacter baumannii have become a therapeutic challenge for clinicians worldwide. Although colistin and tigecycline have been successful in treating patients with these infections, these agents are not available on a worldwide basis. We describe four critically ill patients...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.27.11.1506
更新日期:2007-11-01 00:00:00
abstract::Patients undergoing cardiopulmonary bypass may develop clinically significant physiologic alterations in the perioperative period, including alteration of thyroid hormone concentrations. Alterations in the concentration of thyroid hormones are of concern due to the effects of these hormones on cardiac function. Hypoth...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.21.17.1368.34425
更新日期:2001-11-01 00:00:00
abstract::Cancer therapeutics is undergoing a revolution with the advent of new drugs that can selectively target molecules responsible for carcinogenesis and tumor growth. The type and mechanism of these targeting drugs vary. Some are small molecules that specifically target a binding site on a receptor or signal transduction ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.31.1.62
更新日期:2011-01-01 00:00:00
abstract::Limitations of traditional anticoagulants have led to the need for structured services to provide anticoagulation monitoring. Anticoagulation management services have historically filled this role. Novel antithrombotic agents currently in development have the potential to improve on the limitations of vitamin K antago...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.24.15.199s.43159
更新日期:2004-10-01 00:00:00
abstract::Neuroleptic malignant syndrome (NMS) is an idiosyncratic and uncommon but serious adverse effect that has been reported with both typical and atypical antipsychotic agents. We describe a 58-year-old man with Down syndrome and dementia who was receiving low-dose olanzapine and rivastigmine therapy; he developed NMS 4 m...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.28.3.403
更新日期:2008-03-01 00:00:00
abstract::Warfarin is a commonly used oral anticoagulant that is usually initiated after the definitive diagnosis of a certain thromboembolic disorder or disease. Warfarin therapy will usually be prescribed for 6-12 weeks or more, and some patients may continue therapy throughout life, depending on the type of thromboembolic di...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章
doi:
更新日期:1996-11-01 00:00:00
abstract:STUDY OBJECTIVE:To categorize institutional review board (IRB) challenges and solutions encountered in a multicenter practice-based research network (PBRN) study and to assess the impact of IRB requirements on the willingness of individual principal investigators (PIs) to participate in future PBRN studies. DESIGN:Des...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1276
更新日期:2013-09-01 00:00:00
abstract::Abstract Cetuximab and panitumumab, monoclonal antibodies used to target the epidermal growth factor receptor (EGFR), were recently approved by the United States Food and Drug Administration for use as single agents or in combination with other chemotherapy drugs in the treatment of metastatic colorectal cancer. The a...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.28.11-supp.31S
更新日期:2008-11-01 00:00:00
abstract::In a 10-year (1979-1988) follow-up study of young insulin-dependent diabetics carried out at Group Health Cooperative of Puget Sound, the frequency of hospitalization for hypoglycemia remained constant. During the early years only animal insulins were available; during the latter years, human insulins were used in a m...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::The death rate from coronary heart disease (CHD) declined by 25% in the United States during 1987-1997, but the actual number of deaths fell by only 9%. Modifiable risk factors for CHD include hypertension, elevated low-density lipoprotein cholesterol, reduced high-density lipoprotein cholesterol, cigarette smoking, a...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.21.14.195s.34602
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVE:In an era of increasing polypharmacy, adverse drug effects such as ototoxicity have significant public health implications. Despite the availability of evidence, many health care professionals may not know the risk of ototoxicity in common medications. Therefore, the aim of this review is to provide a compreh...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2478
更新日期:2020-12-01 00:00:00
abstract::Venous thromboembolism (VTE) is an important medical problem that affects millions of patients each year. With appropriate prophylaxis, many of these thromboembolic events can be prevented. Although strong evidence supporting VTE prophylaxis spans several decades, several large American and global registries have docu...
journal_title:Pharmacotherapy
pub_type:
doi:10.1592/phco.29.4.410
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVES:To examine the knowledge, attitudes, and interest of an inner-city population toward pharmacogenetic testing, with the primary objective of identifying facilitators and barriers toward pharmacogenetic testing; and secondary objectives of determining predictors of patient interest in pharmacogenetic testing a...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2077
更新日期:2018-02-01 00:00:00
abstract:INTRODUCTION:Vancomycin (VAN) is associated with an increased risk of acute kidney injury (AKI). Evidence is conflicting regarding the risk of AKI when VAN is combined with an antipseudomonal β-lactam. OBJECTIVES:To determine the comparative incidence of AKI when VAN is combined with piperacillin-tazobactam (PTZ) or m...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2179
更新日期:2018-12-01 00:00:00
abstract::Olanzapine has been associated with insulin resistance and new-onset diabetes mellitus. A 27-year-old African-American man developed new-onset severe hyperglycemia-glucose 1240 mg/dl, with ketonuria and acidosis, but no weight gain-2 years after starting olanzapine. Although his diabetes was stabilized with insulin, h...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.21.17.1448.34421
更新日期:2001-11-01 00:00:00
abstract::A hiccup is a myoclonic jerk of the diaphragm, and cases of hiccups may last for more than 48 hours (persistent hiccups) or even more than 2 months (intractable hiccups). Current pharmacologic treatment of persistent or intractable hiccups mainly includes antidopaminergic drugs. We describe the case of a 60-year-old m...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1523
更新日期:2014-12-01 00:00:00
abstract::After the introduction of penicillin G into therapeutics, bacteria became increasingly resistant to this penicillin and subsequent beta-lactam antibiotics. The major cause of this resistance is beta-lactamase, an enzyme produced by the bacterium, that destroys the antibiotic before it reaches its target within the bac...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::A 12-year-old girl with cystic fibrosis was diagnosed with a high-grade glioma after radiographic and biopsy results confirmed the primary intracranial lesion. She was treated with single-agent erlotinib during and after daily localized radiation therapy. Pharmacokinetic studies were conducted to assess the effect of ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.29.7.858
更新日期:2009-07-01 00:00:00
abstract:STUDY OBJECTIVE:To contrast the characteristics of two groups of anabolic-androgenic steroid (AAS) users-those with versus those without AAS dependence. DESIGN:Subanalysis of data from the Anabolic 500, a cross-sectional survey. PARTICIPANTS:One hundred twelve male AAS-dependent users and 367 AAS-nondependent users w...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/j.1875-9114.2012.01123
更新日期:2012-10-01 00:00:00
abstract::Fluconazole is a commonly prescribed antifungal agent with a favorable safety profile. A patient experienced agranulocytosis and eosinophilia associated with the drug. Similar bone marrow-suppressive effect due to the azoles is rarely described in the English-language literature. ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.20.5.484.35058
更新日期:2000-04-01 00:00:00
abstract::Weight-adjusted nomograms have been a significant advance in the use of unfractionated heparin (UFH). Clinical trials have demonstrated the ability of weight-adjusted nomograms to achieve a therapeutic activated partial thromboplastin time (aPTT) more rapidly than with standard UFH dosing. Despite this advantage, a si...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.24.12.142s.36113
更新日期:2004-08-01 00:00:00
abstract::Abstract Therapeutic hypothermia has emerged as an effective means of improving neurologic outcomes among cardiac arrest survivors. To achieve optimal results, clinicians must understand and anticipate potential adverse effects of cooling and provide rigorous monitoring and/or pharmacologic interventions as appropriat...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.28.1.102
更新日期:2008-01-01 00:00:00
abstract::Levodopa is one of the principal agents administered to treat patients with Parkinson's disease (PD). Several pharmacologic strategies can limit its side effects and enhance its activity. Although certain exceptions apply, dosage adjustments and drug changes should be instituted slowly. Levodopa is typically introduce...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.20.2.33s.34632
更新日期:2000-01-01 00:00:00
abstract::Children warrant access to care from clinical pharmacists trained in pediatrics. The American College of Clinical Pharmacy Pediatrics Practice and Research Network (ACCP Pediatrics PRN) released an opinion paper in 2005 with recommendations for improving the quality and quantity of pediatric pharmacy education in coll...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1246
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:Allopurinol is a drug indicated for the treatment and prevention of gout. Through various theorized mechanisms, there has been an observed benefit in reducing aggression in patients with dementia who are refractory to traditional interventions. This case series of eight patients reports the use of allopurinol...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1943
更新日期:2017-06-01 00:00:00
abstract::The incidence and severity of Clostridium difficile infection (CDI) remain high across intensive care units in the United States despite national efforts to decrease this escalating health care burden. Most published literature and guidelines address treatment rather than prevention, yet this approach may be too downs...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2200
更新日期:2019-03-01 00:00:00
abstract::The National Academies of Sciences, Engineering, and Medicine has found substantial evidence that cannabis (plant) is effective for the treatment of chronic pain in adults, and moderate evidence that oromucosal cannabinoids (extracts, especially nabiximols) improve short-term sleep disturbances in chronic pain. The pa...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2115
更新日期:2018-06-01 00:00:00