Abstract：
:Cancer therapeutics is undergoing a revolution with the advent of new drugs that can selectively target molecules responsible for carcinogenesis and tumor growth. The type and mechanism of these targeting drugs vary. Some are small molecules that specifically target a binding site on a receptor or signal transduction molecule. Antibodies have been engineered to bind to the receptors or the corresponding ligands that mediate a critical cancer activity. In almost all cases, the intent is to inhibit or shut down a specific molecular pathway. Unprecedented activity against the cancer is seen without overt traditional toxicities such as alopecia, nausea and/or vomiting, and cytopenias. Unfortunately, an increase in toxicity has now become evident as more experience accumulates with the use of these drugs. In some cases, unexpected cardiotoxicities have arisen when these new drugs have been added to more conventional chemotherapies. Heart failure is the unfortunate manifestation for many of these toxicities. We outline the scope of this problem and examine the mechanisms of drug-induced heart failure. The distinctive signs and symptoms specific to each drug are described, and the diagnosis and treatment of the condition are discussed. Our aim is to allow the practitioner to recognize the unusual manifestations of heart failure in this setting in order to make a timely diagnosis and begin appropriate treatment measures.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Jarkowski A 3rd,Glode AE,Spangenthal EJ,Wong MKdoi
10.1592/phco.31.1.62subject
Has Abstractpub_date
2011-01-01 00:00:00pages
62-75issue
1eissn
0277-0008issn
1875-9114pii
10.1592/phco.31.1.62journal_volume
31pub_type
杂志文章,评审相关文献
PHARMACOTHERAPY文献大全abstract：:A popular garlic preparation containing 1.3% allicin at a large dose (2400 mg) was evaluated in this open-label study in nine patients with rather severe hypertension (diastolic blood pressure > or = 115 mm Hg). Sitting blood pressure fell 7/16 (+/- 3/2 SD) mm Hg at peak effect approximately 5 hours after the dose, wi...
journal_title：Pharmacotherapy
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：:Concerns about cross-allergenicity between sulfonamide antibiotics and nonantibiotic, sulfonamide-containing drugs persist and can complicate patients' drug therapy unnecessarily. No interaction between the human immune system and the sulfonamide functional group has been demonstrated. The immunologic determinant of t...
journal_title：Pharmacotherapy
pub_type： 杂志文章,评审
doi：10.1592/phco.24.9.856.36106
更新日期：2004-07-01 00:00:00
abstract：STUDY OBJECTIVE:To investigate the relationship between two widely used, generic health-related quality of life (HRQOL) measures, Short Form-12 (SF-12) and EuroQol's EQ-5D, and potentially inappropriate drug use in an elderly cohort. DESIGN:Longitudinal retrospective cohort study. DATA SOURCE:Medical Expenditure Pane...
journal_title：Pharmacotherapy
pub_type： 杂志文章
doi：10.1592/phco.26.6.768
更新日期：2006-06-01 00:00:00
abstract：:Therapeutic goals for atrial fibrillation (AF) include ventricular rate control, stroke prevention, conversion to normal sinus rhythm, and maintenance of normal sinus rhythm. The optimal strategy of rate versus rhythm control for acute management of patients with AF is a continuing debate. However, selected patients m...
journal_title：Pharmacotherapy
pub_type： 杂志文章,评审
doi：10.1592/phco.24.8.792.36065
更新日期：2004-06-01 00:00:00
abstract：:Meropenem-vaborbactam is a new β-lactam/β-lactamase inhibitor combination designed to target Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae. Meropenem-vaborbactam was United States Food and Drug Administration-approved for complicated urinary tract infections in patients 18 years of age or olde...
journal_title：Pharmacotherapy
pub_type：
doi：10.1002/phar.2187
更新日期：2018-12-01 00:00:00
abstract：:Although heparin-dependent antibodies (HDAs) typically manifest with thrombocytopenia as in heparin-induced thrombocytopenia (HIT), they may also manifest with preserved platelet counts. We describe a 35-year-old woman who developed severe thrombotic complications due to heparinization and unrecognized HDAs. She had r...
journal_title：Pharmacotherapy
pub_type： 杂志文章
doi：10.1592/phco.28.11.1401
更新日期：2008-11-01 00:00:00
abstract：STUDY OBJECTIVES:To evaluate the effect of a standard meal on bioavailability of bromfenac, and on the relative analgesic efficacy and adverse effect liability of bromfenac 25 mg, naproxen sodium 550 mg, and acetaminophen 325 mg in the treatment of pain after orthopedic surgery. DESIGN:Randomized, double-blind, single...
journal_title：Pharmacotherapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1998-05-01 00:00:00
abstract：:A 63-year-old man with ventricular tachycardia (VT) refractory to drug therapy was admitted for surgical ablation of the VT with coronary artery bypass graft surgery. He developed increased theophylline concentrations with decreased calculated theophylline clearance after propafenone therapy for recurrent VT was initi...
journal_title：Pharmacotherapy
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Venous thromboembolism (VTE) is an important medical problem that affects millions of patients each year. With appropriate prophylaxis, many of these thromboembolic events can be prevented. Although strong evidence supporting VTE prophylaxis spans several decades, several large American and global registries have docu...
journal_title：Pharmacotherapy
pub_type：
doi：10.1592/phco.29.4.410
更新日期：2009-04-01 00:00:00
abstract：:Widespread anecdotal use of sublingual tacrolimus administration has arisen, although little literature exists to guide practice. Given the paucity of data, we conducted a survey to evaluate the practice of sublingual tacrolimus administration at transplant centers across the United States and evaluated the literature...
journal_title：Pharmacotherapy
pub_type： 杂志文章,评审
doi：10.1002/phar.1492
更新日期：2014-11-01 00:00:00
abstract：STUDY OBJECTIVE:To describe the pharmacokinetics and pharmacodynamics of fludarabine in patients with rheumatoid arthritis (RA). DESIGN:Open-label, staggered trial conducted in conjunction with a phase I-II clinical trial. SETTING:Government research hospital. PATIENTS:Twenty-six patients with refractory RA. INTERV...
journal_title：Pharmacotherapy
pub_type： 临床试验,杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：:Substantial error occurs when individual saliva theophylline concentrations are used to predict serum theophylline concentrations. However, the use of saliva theophylline concentrations to determine product bioavailability has never been evaluated. Subjects in this study were 18 stable patients (20-51 yr) with a histo...
journal_title：Pharmacotherapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1002/j.1875-9114.1983.tb03263.x
更新日期：1983-07-01 00:00:00
abstract：:Exenatide is an incretin mimetic indicated for the treatment of type 2 diabetes mellitus in combination with a sulfonylurea, a thiazolidinedione, metformin, or metformin plus a sulfonylurea or thiazolidinedione. Exenatide lowers postprandial blood glucose levels by stimulating glucose-dependent insulin secretion, inhi...
journal_title：Pharmacotherapy
pub_type： 杂志文章
doi：10.1592/phco.27.10.1449
更新日期：2007-10-01 00:00:00
abstract：OBJECTIVE:Allopurinol is a drug indicated for the treatment and prevention of gout. Through various theorized mechanisms, there has been an observed benefit in reducing aggression in patients with dementia who are refractory to traditional interventions. This case series of eight patients reports the use of allopurinol...
journal_title：Pharmacotherapy
pub_type： 杂志文章
doi：10.1002/phar.1943
更新日期：2017-06-01 00:00:00
abstract：:Major depression afflicts a significant percentage of the population, and optimum therapy is often limited by the poor tolerability and lethality in overdose of the tricyclic antidepressants. The selective serotonin reuptake inhibitors (SSRIs) fluoxetine, sertraline, and, more recently, paroxetine are viewed as welcom...
journal_title：Pharmacotherapy
pub_type： 杂志文章,评审
doi：
更新日期：1994-03-01 00:00:00
abstract：:A literature search was conducted to examine the safety and effectiveness of low-dosage methotrexate for treatment and maintenance of remission in patients with inflammatory bowel disease. Nine published articles indicated that for patients with Crohn's disease, oral or intramuscular methotrexate 20-25 mg/week is safe...
journal_title：Pharmacotherapy
pub_type： 杂志文章,评审
doi：10.1592/phco.22.8.613.33208
更新日期：2002-05-01 00:00:00
abstract：:We evaluated the efficacy and tolerability of amphotericin B triglyceride emulsion in 16 patients with acquired immunodeficiency syndrome-related candidal esophagitis and cryptococcosis, compared with standard amphotericin B in 24 patients. Compared with the conventional formulation, the fat emulsion was administered ...
journal_title：Pharmacotherapy
pub_type： 临床试验,杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：:Aspirin has been used for the prevention and treatment of cardiovascular disease (CVD) for several decades. The efficacy of aspirin for secondary prevention of cardiovascular disease is well established, but the clinical benefit of aspirin for primary prevention of CVD is less clear. The primary literature suggests th...
journal_title：Pharmacotherapy
pub_type： 杂志文章,评审
doi：10.1002/phar.1127
更新日期：2012-11-01 00:00:00
abstract：:Abstract Outbreaks of extensively drug-resistant tuberculosis (XDR-TB) in developing countries and recent headlines of an American traveling with a resistant variant of tuberculosis have brought XDR-TB into the spotlight. The World Health Organization and the United States Centers for Disease Control and Prevention ha...
journal_title：Pharmacotherapy
pub_type： 杂志文章,评审
doi：10.1592/phco.28.10.1243
更新日期：2008-10-01 00:00:00
abstract：:Patients with atrial fibrillation (AF) who suffer an acute ischemic stroke are at risk for both hemorrhagic transformation and recurrent ischemic stroke in the acute post-stroke period. Oral anticoagulants are recommended for secondary stroke prevention in patients with AF. The optimal time to initiate anticoagulant t...
journal_title：Pharmacotherapy
pub_type： 杂志文章,评审
doi：10.1002/phar.2345
更新日期：2020-01-01 00:00:00
abstract：STUDY OBJECTIVES:To evaluate hepatic cytochrome P450 (CYP) 3A4 activity in patients infected with the human immunodeficiency virus (HIV) using the erythromycin breath test (ERMBT), and to examine the relationship of the ERMBT to plasma concentrations of indinavir and nelfinavir. DESIGN:Prospective observational study....
journal_title：Pharmacotherapy
pub_type： 临床试验,杂志文章
doi：10.1592/phco.20.11.898.35262
更新日期：2000-08-01 00:00:00
abstract：:A 32-year-old woman with a history of deep vein thrombosis (DVT), steroid-dependent ulcerative colitis, and osteoporosis was prescribed azathioprine for a steroid-sparing effect. Stable, therapeutic international normalized ratios (INRs) were obtained with warfarin 35 mg/week during a 6-week postpartum course to treat...
journal_title：Pharmacotherapy
pub_type： 杂志文章
doi：10.1592/phco.21.3.355.34208
更新日期：2001-03-01 00:00:00
abstract：:The pharmacokinetic characteristics of levofloxacin, moxifloxacin, and gatifloxacin include excellent oral bioavailability (90-99%), extensive penetration into tissues and body fluids, and an elimination half-life (6-12 hrs) that allows for once-daily dosing in patients with normal renal function. Levofloxacin and gat...
journal_title：Pharmacotherapy
pub_type： 杂志文章,评审
doi：10.1592/phco.21.16.233s.33992
更新日期：2001-10-01 00:00:00
abstract：:This study documents a pharmacokinetic interaction between carbamazepine and cyclosporine (CsA) in pediatric renal transplant recipients. Noncompartmental steady-state CsA pharmacokinetics were determined in three pediatric renal transplant recipients who were receiving both CsA and carbamazepine as long-term therapy ...
journal_title：Pharmacotherapy
pub_type： 临床试验,杂志文章
doi：
更新日期：1995-05-01 00:00:00
abstract：:Cephalosporins are often administered to prevent infections that can follow total joint replacements (TJR) and other arthroplastic procedures. However, recommendations contained within published guidelines and review articles vary greatly from those given by the manufacturer in product information circulars. Similarly...
journal_title：Pharmacotherapy
pub_type： 杂志文章,评审
doi：
更新日期：1991-01-01 00:00:00
abstract：STUDY OBJECTIVE:To evaluate the effect of a potent experimental leukotriene receptor antagonist, MK-571, on airway responses to inhaled allergen. DESIGN:Randomized, double-blind, placebo-controlled, crossover trial. SETTING:Clinical research center. SUBJECTS:Eight male volunteers with allergic asthma. INTERVENTIONS...
journal_title：Pharmacotherapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1592/phco.19.16.1243.30878
更新日期：1999-11-01 00:00:00
abstract：STUDY OBJECTIVES:To determine if low-dose lovastatin in combination with niacin causes a greater percentage reduction in low-density lipoprotein (LDL) cholesterol than lovastatin alone, and to determine if the combination increases the risk of serious adverse effects. design. Prospective, randomized, open-label, clinic...
journal_title：Pharmacotherapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-05-01 00:00:00
abstract：STUDY OBJECTIVE:To evaluate the clinical course and long-term impact of high-dose acyclovir (HD-A, 800 mg 4 times/day) cytomegalovirus (CMV) prophylaxis failure in a CMV-seropositive abdominal solid organ transplant population. DESIGN:Retrospective cohort study. SETTING:Tertiary academic medical center. PATIENTS:A t...
journal_title：Pharmacotherapy
pub_type： 杂志文章
doi：10.1002/phar.2126
更新日期：2018-07-01 00:00:00
abstract：:A 40-month-old child was sedated with a fentanyl and midazolam infusion for 7 days. After the drugs were discontinued he became unresponsive and globally aphasic, and had marked thrombocytosis. He was hospitalized for 4 weeks, during which time his motor and cognitive status slowly improved, and had almost returned to...
journal_title：Pharmacotherapy
pub_type： 杂志文章
doi：10.1002/j.1875-9114.1995.tb02877.x
更新日期：1995-09-01 00:00:00
abstract：:Hypertension remains a major risk factor for cardiovascular disease. The optimal choice of pharmacologic and nonpharmacologic treatment regimens is based on a plethora of published literature. This compilation is the initial update to the Key Articles and Guidelines in the Management of Hypertension authored by member...
journal_title：Pharmacotherapy
pub_type： 杂志文章
doi：10.1592/phco.28.8.1041
更新日期：2008-08-01 00:00:00
