Case-control study of amphotericin B in a triglyceride fat emulsion versus conventional amphotericin B in patients with AIDS.

Abstract:

:We evaluated the efficacy and tolerability of amphotericin B triglyceride emulsion in 16 patients with acquired immunodeficiency syndrome-related candidal esophagitis and cryptococcosis, compared with standard amphotericin B in 24 patients. Compared with the conventional formulation, the fat emulsion was administered in a significantly greater daily dose, and required shorter induction period and infusion time (p<0.001-<0.03). Although the two drugs had similar clinical and microbiologic efficacy, the fat emulsion had a better safety profile with respect to frequency of flu-like symptoms, other local and systemic adverse events, and treatment discontinuation (p<0.02-<0.05). Because it is easily available and inexpensive, it may have a number of advantages over the conventional formulation. Further similar comparisons are warranted, in addition to investigations to assess whether reduced toxicity can be obtained with fat emulsion without impairing (or possibly improving) the efficacy of this key antifungal agent.

journal_name

Pharmacotherapy

journal_title

Pharmacotherapy

authors

Manfredi R,Chiodo F

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

1087-92

issue

5

eissn

0277-0008

issn

1875-9114

journal_volume

18

pub_type

临床试验,杂志文章
  • Atracurium resistance in a critically Ill patient.

    abstract::A previously healthy 25-year-old man with metastatic testicular teratocarcinoma became resistant to atracurium-induced neuromuscular blockade as evidenced by train-of-four (TOF) monitoring combined with clinical assessment. Subsequently he had an adequate response with a standard dosage of pancuronium. During the firs...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:

    authors: Tschida SJ,Hoey LL,Nahum A,Vance-Bryan K

    更新日期:1995-07-01 00:00:00

  • Alfuzosin treatment improves the rate and time for stone expulsion in patients with distal uretral stones: a prospective randomized controlled study.

    abstract:OBJECTIVE:To evaluate the safety and efficacy of alfuzosin treatment on rate and time of stone expulsion in patients with uncomplicated distal ureteral stones. PATIENTS AND METHODS:Prospective, randomized, open-label, controlled study. Patients > 18 years of age presenting to the outpatient urology clinic with uncompl...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/phar.1593

    authors: El Said NO,El Wakeel L,Kamal KM,Morad Ael R

    更新日期:2015-05-01 00:00:00

  • Pharmacokinetics of the Meropenem Component of Meropenem-Vaborbactam in the Treatment of KPC-Producing Klebsiella pneumoniae Bloodstream Infection in a Pediatric Patient.

    abstract::Meropenem-vaborbactam is a new β-lactam/β-lactamase inhibitor combination designed to target Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae. Meropenem-vaborbactam was United States Food and Drug Administration-approved for complicated urinary tract infections in patients 18 years of age or olde...

    journal_title:Pharmacotherapy

    pub_type:

    doi:10.1002/phar.2187

    authors: Hanretty AM,Kaur I,Evangelista AT,Moore WS 2nd,Enache A,Chopra A,Cies JJ

    更新日期:2018-12-01 00:00:00

  • Strategies in the management of acute myocardial infarction.

    abstract::Clinical trials continue to evaluate the pharmacologic management of myocardial infarction for benefits in mortality, degree of infarct artery patency, and frequency of reocclusion. The discovery of thrombus formation in the development of the myocardial infarction renewed interest in thrombolytic therapy. In appropri...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:

    authors: Talbert RL

    更新日期:1996-09-01 00:00:00

  • Randomized, multicenter comparison of oral granisetron and oral ondansetron for emetogenic chemotherapy.

    abstract:STUDY OBJECTIVES:To compare the antiemetic effectiveness and safety of oral granisetron plus dexamethasone with those of oral ondansetron plus dexamethasone administered before emetogenic chemotherapy. DESIGN:Randomized, prospective, multicenter, open-label study. SETTINGS:University-teaching hospital and veterans he...

    journal_title:Pharmacotherapy

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1592/phco.20.17.1318.34894

    authors: Herrington JD,Kwan P,Young RR,Lagow E,Lagrone L,Riggs MW

    更新日期:2000-11-01 00:00:00

  • Warfarin Pharmacogenomics in Diverse Populations.

    abstract::Genotype-guided warfarin dosing algorithms are a rational approach to optimize warfarin dosing and potentially reduce adverse drug events. Diverse populations, such as African Americans and Latinos, have greater variability in warfarin dose requirements and are at greater risk for experiencing warfarin-related adverse...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1002/phar.1982

    authors: Kaye JB,Schultz LE,Steiner HE,Kittles RA,Cavallari LH,Karnes JH

    更新日期:2017-09-01 00:00:00

  • Pharmacotherapy specialty certification examination. IV. 1992 results and process modifications, including recertification. The 1992 Specialty Council on Pharmacotherapy, Board of Pharmaceutical Specialties.

    abstract::Certification of pharmacotherapy specialists is proceeding smoothly. Modifications to the examination process, which include reapportioning domains, offering the examination at several sites, and establishing the recertification process, have occurred. The guidelines for petitioners and structure of specialization con...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:

    authors: Zarowitz BJ,Vlasses PH,Dukes GE,Gal P,Miller WA,Porter WC,Rush DR,Schneider P,Talbert RL

    更新日期:1993-05-01 00:00:00

  • Genetic causes of clopidogrel nonresponsiveness: which ones really count?

    abstract::Clopidogrel decreases the morbidity and mortality associated with several cardiovascular diseases. However, clopidogrel is a prodrug that needs to be metabolized to the active thiol metabolite by the cytochrome P450 (CYP) system. This activation is a source of significant interindividual variability in clopidogrel res...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1592/phco.30.3.265

    authors: Momary KM,Dorsch MP,Bates ER

    更新日期:2010-03-01 00:00:00

  • Clinical Outcomes with Penicillin Versus Alternative β-Lactams in the Treatment of Penicillin-Susceptible Staphylococcus aureus Bacteremia.

    abstract:OBJECTIVES:To identify the impact of penicillin versus alternative β-lactams on clinical outcomes in patients with penicillin-susceptible Staphylococcus aureus (PSSA) bacteremia. DESIGN:Retrospective cohort study. SETTING:Academic medical center. PATIENTS:Adult patients with PSSA bacteremia treated with a β-lactam a...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.2124

    authors: Shah MD,Wardlow LC,Stevenson KB,Coe KE,Reed EE

    更新日期:2018-07-01 00:00:00

  • Effects of buprenorphine on cardiac repolarization in a patient with methadone-related torsade de pointes.

    abstract::Torsade de pointes is a rare but potentially fatal ventricular arrhythmia that is often triggered by drugs that prolong the rate-corrected QT (QTc) interval. This arrhythmia has been attributed to levacetylmethadol and methadone, synthetic opioids used to treat heroin addiction. Levacetylmethadol, a derivative of meth...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1592/phco.25.4.611.61020

    authors: Krantz MJ,Garcia JA,Mehler PS

    更新日期:2005-04-01 00:00:00

  • Therapy with macrolides in patients with cystic fibrosis.

    abstract::Cystic fibrosis affects 1/2500 individuals and is the most common lethal autosomal recessive disease in people of northern European descent. It is characterized by chronic infections with mucoid Pseudomonas aeruginosa and progressive deterioration of respiratory function. Much research has focused on the inflammatory ...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1592/phco.22.3.227.33544

    authors: Gaylor AS,Reilly JC

    更新日期:2002-02-01 00:00:00

  • Pharmacokinetics and pharmacodynamics of fluoroquinolones.

    abstract::The pharmacokinetic characteristics of levofloxacin, moxifloxacin, and gatifloxacin include excellent oral bioavailability (90-99%), extensive penetration into tissues and body fluids, and an elimination half-life (6-12 hrs) that allows for once-daily dosing in patients with normal renal function. Levofloxacin and gat...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1592/phco.21.16.233s.33992

    authors: Rodvold KA,Neuhauser M

    更新日期:2001-10-01 00:00:00

  • Suspected carbamazepine-induced hepatotoxicity.

    abstract::Carbamazepine is a potent anticonvulsant agent with proven efficacy in the treatment of partial and tonic-clonic seizures. An epileptic child treated with therapeutic dosages of carbamazepine developed severe hepatitis and hepatic insufficiency. She had a positive response to withdrawal of the drug and administration ...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1592/phco.19.3.252.30918

    authors: Morales-Diaz M,Pinilla-Roa E,Ruiz I

    更新日期:1999-02-01 00:00:00

  • Postoperative atrial fibrillation: role of inflammatory biomarkers and use of colchicine for its prevention.

    abstract::Postoperative atrial fibrillation (POAF) is the most common complication following cardiac surgery, occurring in up to 65% of cardiac surgical patients. It is a condition associated with increased morbidity, increased length of hospital stay, and increased health care costs. One of the many potential causes of POAF is...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1002/phar.1485

    authors: Worden JC,Asare K

    更新日期:2014-11-01 00:00:00

  • Effects of acetaminophen, naproxen, and acetylsalicylic acid on tapentadol pharmacokinetics: results of two randomized, open-label, crossover, drug-drug interaction studies.

    abstract:STUDY OBJECTIVE:To evaluate the effects of acetaminophen, naproxen, and acetylsalicylic acid on the pharmacokinetics of the centrally acting analgesic tapentadol in healthy subjects. DESIGN:Two randomized, open-label, crossover, drug-drug interaction studies. SETTING:Clinical research facilities in the United States ...

    journal_title:Pharmacotherapy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1592/phco.30.1.25

    authors: Smit JW,Oh C,Rengelshausen J,Terlinden R,Ravenstijn PG,Wang SS,Upmalis D,Mangold B

    更新日期:2010-01-01 00:00:00

  • Methodology and safety considerations in the production of an intravenous immunoglobulin preparation.

    abstract::Intravenous immunoglobulins are biologic substances and differ in many respects from chemical pharmaceuticals. To produce a safe and efficacious preparation, special points must be considered. Careful screening procedures and excluding high-risk donor populations reduce the risk of transmitting viral disease from the ...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1002/j.1875-9114.1987.tb03512.x

    authors: Friedli HR

    更新日期:1987-01-01 00:00:00

  • Hepatic drug metabolism in critical illness.

    abstract::Hepatic drug metabolism is altered in critically ill patients. The etiology and mechanisms of the alterations are not clearly understood and are difficult to address in clinical studies. For this reason, in vitro and animal models were developed to investigate the effects of critical illness on hepatic drug metabolism...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:

    authors: McKindley DS,Hanes S,Boucher BA

    更新日期:1998-07-01 00:00:00

  • Illicit use of specific prescription stimulants among college students: prevalence, motives, and routes of administration.

    abstract:OBJECTIVES:To explore the illicit use of specific prescription stimulants among college students and add to our understanding of reasons (motives) and routes of administration associated with illicit use of these drugs. METHODS:A random sample of 4580 college students self-administered a Web-based survey. The survey c...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1592/phco.26.10.1501

    authors: Teter CJ,McCabe SE,LaGrange K,Cranford JA,Boyd CJ

    更新日期:2006-10-01 00:00:00

  • Predicting Interactions between Rifampin and Antihypertensive Drugs Using the Biopharmaceutics Drug Disposition Classification System.

    abstract:STUDY OBJECTIVE:Lack of blood pressure control is often seen in hypertensive patients concomitantly taking antituberculosis medications due to the complex drug-drug interactions between rifampin and antihypertensive drugs. Therefore, it is of clinical importance to understand the underlying mechanisms of these interact...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.2380

    authors: Liu W,Yan T,Chen K,Yang L,Benet LZ,Zhai S

    更新日期:2020-04-01 00:00:00

  • Tacrolimus Elimination in Four Patients With a CYP3A5*3/*3 CYP3A4*22/*22 Genotype Combination.

    abstract::Cytochrome P450 3A5 (CYP3A5) and cytochrome P450 3A4 (CYP3A4) are the predominate enzymes responsible for tacrolimus metabolism. The presence of CYP3A4 and CYP3A5 genetic variants significantly affects tacrolimus clearance and dose requirements. CYP3A5*3 is a loss-of-function variant resulting in no CYP3A5 enzyme prod...

    journal_title:Pharmacotherapy

    pub_type:

    doi:10.1002/phar.2131

    authors: Scheibner A,Remmel R,Schladt D,Oetting WS,Guan W,Wu B,Dorr C,Israni A,Jacobson PA

    更新日期:2018-07-01 00:00:00

  • Recommendations for meeting the pediatric patient's need for a clinical pharmacist: a joint opinion of the Pediatrics Practice and Research Network of the American College of Clinical Pharmacy and the Pediatric Pharmacy Advocacy Group.

    abstract::Children warrant access to care from clinical pharmacists trained in pediatrics. The American College of Clinical Pharmacy Pediatrics Practice and Research Network (ACCP Pediatrics PRN) released an opinion paper in 2005 with recommendations for improving the quality and quantity of pediatric pharmacy education in coll...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.1246

    authors: Bhatt-Mehta V,Buck ML,Chung AM,Farrington EA,Hagemann TM,Hoff DS,LaRochelle JM,Pettit RS,Phan H,Potts AL,Smith KP,Parrish RH 2nd

    更新日期:2013-02-01 00:00:00

  • Off-label use of exenatide for the management of insulin-resistant type 1 diabetes mellitus in an obese patient with human immunodeficiency virus infection.

    abstract::Exenatide is an incretin mimetic indicated for the treatment of type 2 diabetes mellitus in combination with a sulfonylurea, a thiazolidinedione, metformin, or metformin plus a sulfonylurea or thiazolidinedione. Exenatide lowers postprandial blood glucose levels by stimulating glucose-dependent insulin secretion, inhi...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1592/phco.27.10.1449

    authors: Sheffield CA,Kane MP,Busch RS

    更新日期:2007-10-01 00:00:00

  • Benzalkonium Chloride: A Bronchoconstricting Preservative in Continuous Albuterol Nebulizer Solutions.

    abstract::For convenience, many pediatric hospitals are preparing solutions for continuous nebulized albuterol using the 0.5% 20-ml multidose albuterol dropper bottle. This product contains benzalkonium chloride (BAC) that, by itself, produces bronchospasm that is dose dependent and cumulative. The bronchoconstrictive effects o...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1002/phar.1929

    authors: Prabhakaran S,Abu-Hasan M,Hendeles L

    更新日期:2017-05-01 00:00:00

  • Decreased serum linezolid levels in a critically ill patient receiving concomitant linezolid and rifampin.

    abstract::Serious gram-positive infections present an increasingly common therapeutic dilemma. Combination antimicrobial regimens (e.g., linezolid with rifampin) aimed at improving bacterial eradication and preventing resistance are often used; however, most data supporting this treatment strategy are not from randomized contro...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1592/phco.27.3.476

    authors: Gebhart BC,Barker BC,Markewitz BA

    更新日期:2007-03-01 00:00:00

  • 1992 National Clinical Pharmacy Services Study.

    abstract:STUDY OBJECTIVE:To determine the extent of hospital-based clinical pharmacy services in 1992. DESIGN:National survey with trend comparison to 1989. SETTING:All 1597 United States acute care, general medical-surgical and pediatric hospitals with 50 or more licensed beds and one or more full-time pharmacists (43% of al...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:

    authors: Bond CA,Raehl CL,Pitterle ME

    更新日期:1994-05-01 00:00:00

  • Intravenous amiodarone for conversion of atrial fibrillation: misled by meta-analysis?

    abstract::Therapeutic goals for atrial fibrillation (AF) include ventricular rate control, stroke prevention, conversion to normal sinus rhythm, and maintenance of normal sinus rhythm. The optimal strategy of rate versus rhythm control for acute management of patients with AF is a continuing debate. However, selected patients m...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1592/phco.24.8.792.36065

    authors: Slavik RS,Zed PJ

    更新日期:2004-06-01 00:00:00

  • Granulocyte-macrophage colony-stimulating factor and zidovudine in the treatment of neutropenia and human immunodeficiency virus infection.

    abstract::Granulocyte-macrophage colony-stimulating factor (GMCSF) is a hematopoietic protein that has been studied both in vitro and in vivo in human immunodeficiency virus (HIV) infection. Since both HIV infection primarily and zidovudine (formerly AZT) treatment secondarily may result in neutropenia, administration of GMCSF ...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:

    authors: Hewitt RG,Morse GD

    更新日期:1992-01-01 00:00:00

  • Decreased antimicrobial resistance after changes in antibiotic use.

    abstract::Vancomycin-resistant enterococci (VRE) and methicillin-oxacillin-resistant Staphylococcus aureus (MRSA) originally predominated in large medical centers; however, these isolates are now common in community hospitals and community clinics. No simple answer is available regarding control of antimicrobial-resistant bacte...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1592/phco.19.12.129s.31702

    authors: Smith DW

    更新日期:1999-08-01 00:00:00

  • Cost-effectiveness analysis of antithrombotic therapy in nonurgent percutaneous coronary intervention.

    abstract:STUDY OBJECTIVE:To perform a cost-effectiveness analysis comparing three treatment approaches during nonurgent percutaneous coronary intervention (PCI): bivalirudin with provisional glycoprotein (GP) IIb-IIIa inhibitor therapy, unfractionated heparin (UFH) with eptifibatide, and UFH with abciximab. DESIGN:Literature-b...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1592/phco.26.5.609

    authors: Summers KM,Holdford DA,Crouch MA

    更新日期:2006-05-01 00:00:00

  • Salary survey of ambulatory care clinical pharmacists.

    abstract::To determine salary and selected fringe benefits of members of the Ambulatory Care Practice and Research Network of the American College of Clinical Pharmacy, we developed a self-administered questionnaire that surveyed demographic information, schooling and training, academic appointments, yearly salary (as of Februa...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:

    authors: Anastasio GD,Shaughnessy AF

    更新日期:1997-05-01 00:00:00