A case report of warfarin resistance due to azathioprine and review of the literature.

abstract：:The death rate from coronary heart disease (CHD) declined by 25% in the United States during 1987-1997, but the actual number of deaths fell by only 9%. Modifiable risk factors for CHD include hypertension, elevated low-density lipoprotein cholesterol, reduced high-density lipoprotein cholesterol, cigarette smoking, a...

journal_title：Pharmacotherapy

authors： Pieper JA

更新日期：2001-09-01 00:00:00

abstract：:Genotype-guided warfarin dosing algorithms are a rational approach to optimize warfarin dosing and potentially reduce adverse drug events. Diverse populations, such as African Americans and Latinos, have greater variability in warfarin dose requirements and are at greater risk for experiencing warfarin-related adverse...

journal_title：Pharmacotherapy

authors： Kaye JB,Schultz LE,Steiner HE,Kittles RA,Cavallari LH,Karnes JH

更新日期：2017-09-01 00:00:00

abstract：:The U.S. population continues to experience an alarmingly high rate of unintended pregnancies that have an impact on individual families and society alike. Lack of effective contraception accounts for most unintended pregnancies, along with incorrect use of contraceptives. The most common reversible contraceptive meth...

journal_title：Pharmacotherapy

authors： Rafie S,McIntosh J,Shealy KM,Borgelt LM,Forinash A,Shrader SP,Koepf ER,McClendon KS,Griffin BL,Horlen C,Karaoui LR,Rowe EL,Lodise NM,Wigle PR

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:To identify and describe the scope of practice that characterizes the critical care pharmacist and critical care pharmacy services. Specifically, the goals were to define the level of clinical practice and specialized skills characterizing the critical care pharmacist as clinician, educator, researcher, and m...

journal_title：Pharmacotherapy

authors：

更新日期：2000-11-01 00:00:00

abstract：:Buspirone is the first of a new class of anxioselective agents, the azaspirodecanediones. It achieves peak serum concentrations within one hour and has a serum half-life of 2 to 5 hours. Animal studies have suggested antianxiety activity and the absence of abuse potential. Buspirone is both a dopamine agonist and anta...

journal_title：Pharmacotherapy

authors： Goldberg HL

更新日期：1984-11-01 00:00:00

abstract：:Several pivotal clinical trials have generated new knowledge regarding drug therapy for heart failure. Thus, the Heart Failure Society of America (HFSA) and the American College of Cardiology-American Heart Association (ACC-AHA) guidelines were updated in 2006 and 2005, respectively. We review the evidence from these ...

journal_title：Pharmacotherapy

authors： Uddin N,Patterson JH

更新日期：2007-04-01 00:00:00

abstract：:A 12-year-old girl with cystic fibrosis was diagnosed with a high-grade glioma after radiographic and biopsy results confirmed the primary intracranial lesion. She was treated with single-agent erlotinib during and after daily localized radiation therapy. Pharmacokinetic studies were conducted to assess the effect of ...

journal_title：Pharmacotherapy

authors： Christiansen SR,Broniscer A,Panetta JC,Stewart CF

更新日期：2009-07-01 00:00:00

abstract：:Treating elderly debilitated patients with symptomatic bradyarrhythmia may be difficult. Traditional therapy includes use of limited resources (intensive care unit monitoring) and expensive interventions (permanent pacemaker insertion). When a pacemaker is not ideal or appropriate, yet intervention is desired to impro...

journal_title：Pharmacotherapy

authors： Kragie L,Sekovski B

更新日期：1992-01-01 00:00:00

abstract：:Graves' disease is an autoimmune disorder in which inappropriate stimulation of the thyroid gland results in unregulated secretion of thyroid hormones resulting in hyperthyroidism. Graves' disease is the most common cause of autoimmune hyperthyroidism during pregnancy. Treatment options for Graves' disease include thi...

journal_title：Pharmacotherapy

authors： Prunty JJ,Heise CD,Chaffin DG

更新日期：2016-01-01 00:00:00

abstract：:Aztreonam is the first monobactam available for use in this country. A parenteral antibiotic, its antibacterial spectrum is limited to gram-negative aerobic pathogens. The drug's pharmacologic, pharmacokinetic, and toxicologic properties are reviewed. Based on early experience in pediatric patients, certain recommenda...

journal_title：Pharmacotherapy

authors： Bosso JA,Black PG

更新日期：1991-01-01 00:00:00

abstract：:Torsade de pointes is a rare but potentially fatal ventricular arrhythmia that is often triggered by drugs that prolong the rate-corrected QT (QTc) interval. This arrhythmia has been attributed to levacetylmethadol and methadone, synthetic opioids used to treat heroin addiction. Levacetylmethadol, a derivative of meth...

journal_title：Pharmacotherapy

authors： Krantz MJ,Garcia JA,Mehler PS

更新日期：2005-04-01 00:00:00

abstract：:Abstract Therapeutic hypothermia has emerged as an effective means of improving neurologic outcomes among cardiac arrest survivors. To achieve optimal results, clinicians must understand and anticipate potential adverse effects of cooling and provide rigorous monitoring and/or pharmacologic interventions as appropriat...

journal_title：Pharmacotherapy

authors： Arpino PA,Greer DM

更新日期：2008-01-01 00:00:00

abstract：:A 58-year-old man experienced an asthma exacerbation after administration of nicotine nasal spray for smoking cessation. His medical history was significant for asthma, chronic obstructive pulmonary disease, hypertension, and tobacco use when he was prescribed nicotine nasal spray for smoking cessation in an outpatien...

journal_title：Pharmacotherapy

authors： Roth MT,Westman EC

更新日期：2002-06-01 00:00:00

abstract：STUDY OBJECTIVE:To compare clinical and safety outcomes of warfarin therapy before and after implementation of a novel patient self-management (PSM) program in which patients received their venipuncture-derived international normalized ratio (INR) results through a secure online messaging system and adjusted their warf...

journal_title：Pharmacotherapy

authors： Simmons BJ,Jenner KM,Delate T,Clark NP,Kurz D,Witt DM

更新日期：2012-12-01 00:00:00

abstract：:A literature search was conducted to examine the safety and effectiveness of low-dosage methotrexate for treatment and maintenance of remission in patients with inflammatory bowel disease. Nine published articles indicated that for patients with Crohn's disease, oral or intramuscular methotrexate 20-25 mg/week is safe...

journal_title：Pharmacotherapy

authors： Vandell AG,DiPiro JT

更新日期：2002-05-01 00:00:00

abstract：:Currently available anesthetic induction agents provide adequate hypnosis but are not ideal, particularly in the high risk patient (ASA class III-V), because most cause myocardial and/or respiratory depression and some have other important side effects. Etomidate was recently marketed as an intravenous anesthetic indu...

journal_title：Pharmacotherapy

authors： Giese JL,Stanley TH

更新日期：1983-09-01 00:00:00

abstract：:Although in the last few years new antidepressants have become available in the United States, responses in many patients differ, from none, to partial, to delayed therapeutic response to the agents. If the antidepressant properties of these drugs could be enhanced or accelerated, it might be possible to improve patie...

journal_title：Pharmacotherapy

authors： Puzantian T,Kawase K

更新日期：1999-02-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the clinical course and long-term impact of high-dose acyclovir (HD-A, 800 mg 4 times/day) cytomegalovirus (CMV) prophylaxis failure in a CMV-seropositive abdominal solid organ transplant population. DESIGN:Retrospective cohort study. SETTING:Tertiary academic medical center. PATIENTS:A t...

journal_title：Pharmacotherapy

authors： Siodlak M,Jorgenson MR,Descourouez JL,Leverson GE,Mandelbrot DA,Smith JA,Redfield RR

更新日期：2018-07-01 00:00:00

abstract：:Recent literature has demonstrated significant improvements in neurologic outcomes in patients who have received induced hypothermia in the setting of out-of-hospital cardiac arrest. Through multiple metabolic mechanisms, the induction of hypothermia slows the progression and devastation of transient cerebral hypoxia....

journal_title：Pharmacotherapy

authors： Weant KA,Martin JE,Humphries RL,Cook AM

更新日期：2010-08-01 00:00:00

abstract：:Erectile dysfunction, a problem estimated to affect up to 30 million American men, is associated with a number of systemic illnesses and drugs. Age is not thought to be an independent risk factor for the disorder, but accompanying illnesses and their treatments may contribute to its onset. Newer classes of antihyperte...

journal_title：Pharmacotherapy

authors： Barksdale JD,Gardner SF

更新日期：1999-05-01 00:00:00

abstract：STUDY OBJECTIVES:To determine the incidence of Clostridium difficile infection (CDI) at one community hospital by identifying patients with stool samples positive for C. difficile toxin A or B, and to compare the incidence with a 2008 national estimate; and to determine which patient characteristics and concomitant ant...

journal_title：Pharmacotherapy

authors： King RN,Lager SL

更新日期：2011-07-01 00:00:00

abstract：:Hyponatremia is the most common electrolyte disorder encountered in clinical practice and is associated with significant morbidity and mortality. Clinical consequences of hyponatremia include neurologic dysfunction, decreased mental function, cerebral edema, gait disturbances and falls, osteoporosis, and fractures. Hy...

journal_title：Pharmacotherapy

authors： Patterson JH

更新日期：2011-05-01 00:00:00

abstract：:Limitations of traditional anticoagulants have led to the need for structured services to provide anticoagulation monitoring. Anticoagulation management services have historically filled this role. Novel antithrombotic agents currently in development have the potential to improve on the limitations of vitamin K antago...

journal_title：Pharmacotherapy

authors： Nutescu EA,Spinler SA,Dager WE,Bussey HI

更新日期：2004-10-01 00:00:00

abstract：:High-performance capillary electrophoresis (HPCE) is a new separation technique that is applied in the pharmaceutical sciences. Separations by HPCE occur in a narrow-bore capillary under the influence of an applied electrical field. Components of the sample matrix are separated and migrate at different rates based on ...

journal_title：Pharmacotherapy

authors： Brunner LJ,DiPiro JT,Feldman S

更新日期：1995-01-01 00:00:00

abstract：:A popular garlic preparation containing 1.3% allicin at a large dose (2400 mg) was evaluated in this open-label study in nine patients with rather severe hypertension (diastolic blood pressure > or = 115 mm Hg). Sitting blood pressure fell 7/16 (+/- 3/2 SD) mm Hg at peak effect approximately 5 hours after the dose, wi...

journal_title：Pharmacotherapy

authors： McMahon FG,Vargas R

更新日期：1993-07-01 00:00:00

abstract：:Ondansetron hydrochloride dihydrate is a 5-hydroxytryptamine (5-HT3) antagonist that was recently approved by the Food and Drug Administration for the treatment of chemotherapy-induced emesis. The mechanism of action is thought to be due to competitive inhibition of specific serotonin receptors in the central nervous ...

journal_title：Pharmacotherapy

authors： Burnette PK,Perkins J

更新日期：1992-01-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effect of fluoxetine on the pharmacokinetics and cardiovascular safety of cisapride at steady state in healthy men. DESIGN:Open-label, three-phase, sequential study. SETTING:Clinical research center. SUBJECTS:Twelve healthy male volunteers. INTERVENTIONS:Each subject was treated acco...

journal_title：Pharmacotherapy

authors： Zhao Q,Wojcik MA,Parier JL,Pesco-Koplowitz L

更新日期：2001-02-01 00:00:00

abstract：:Staphylococcus aureus (S. aureus) has proven to be a major pathogen with the emergence of methicillin-resistant S. aureus (MRSA) infections and recently with heteroresistant vancomycin-intermediate S. aureus (hVISA) and vancomycin-intermediate S. aureus (VISA) infections. Although vancomycin is traditionally a first-l...

journal_title：Pharmacotherapy

authors： Gomes DM,Ward KE,LaPlante KL

更新日期：2015-04-01 00:00:00

abstract：:For many years, a regimen of fluorouracil and cisplatin has been the standard of care for the treatment of patients with metastatic gastric cancer. More recently, triplet regimens that incorporate fluorouracil and cisplatin with epirubicin (ECF) or docetaxel are being used in the management of patients with metastatic...

journal_title：Pharmacotherapy

authors： Comella P,Franco L,Casaretti R,de Portu S,Menditto E

更新日期：2009-03-01 00:00:00

abstract：:This study compared limited sampling methods (LSM) of estimating area under the plasma concentration versus time curve (AUC) based on a Bayesian regularized neural network, the Bayesian approach, and multiple forward stepwise regression models from selected concentration-time points. Plasma concentration versus time d...

journal_title：Pharmacotherapy

authors： Ng CM

更新日期：2003-08-01 00:00:00