Abstract:
:A literature search was conducted to examine the safety and effectiveness of low-dosage methotrexate for treatment and maintenance of remission in patients with inflammatory bowel disease. Nine published articles indicated that for patients with Crohn's disease, oral or intramuscular methotrexate 20-25 mg/week is safe and effective to induce remission, followed by a lower dosage to maintain remission. In addition, methotrexate allows for corticosteroid dosage reduction. Therapy may be continued until the disease flares or adverse events occur. Evidence is insufficient to support methotrexate as treatment for ulcerative colitis.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Vandell AG,DiPiro JTdoi
10.1592/phco.22.8.613.33208subject
Has Abstractpub_date
2002-05-01 00:00:00pages
613-20issue
5eissn
0277-0008issn
1875-9114journal_volume
22pub_type
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