Abstract:
STUDY OBJECTIVE:To evaluate the effect of a potent experimental leukotriene receptor antagonist, MK-571, on airway responses to inhaled allergen. DESIGN:Randomized, double-blind, placebo-controlled, crossover trial. SETTING:Clinical research center. SUBJECTS:Eight male volunteers with allergic asthma. INTERVENTIONS:An intravenous loading dose was followed by an 8-hour infusion of MK-571 or placebo, with a 7- to 14-day washout between treatments. Allergen challenge was performed after the loading dose and a histamine challenge was performed before and 24 hours after allergen. MEASUREMENTS AND MAIN RESULTS:Forced expiratory volume in 1 second was measured serially. MK-571 provided about 50% protection during maximum early and late responses compared with placebo (p=0.005), but airway obstruction persisted 8-24 hours after allergen on both treatment days. Airway responsiveness to histamine was not significantly attenuated at 24 hours. CONCLUSION:Blocking Cys LT1 receptors for 8 hours attenuated the early and late responses but did not interrupt the cascade of events leading to subsequent allergen-induced airway obstruction and hyperreactivity.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Hendeles L,Davison D,Harman E,Sherman JMdoi
10.1592/phco.19.16.1243.30878subject
Has Abstractpub_date
1999-11-01 00:00:00pages
1243-51issue
11eissn
0277-0008issn
1875-9114journal_volume
19pub_type
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