Emerging role of capecitabine in gastric cancer.

abstract：:A 32-year-old woman with a history of deep vein thrombosis (DVT), steroid-dependent ulcerative colitis, and osteoporosis was prescribed azathioprine for a steroid-sparing effect. Stable, therapeutic international normalized ratios (INRs) were obtained with warfarin 35 mg/week during a 6-week postpartum course to treat...

journal_title：Pharmacotherapy

authors： Havrda DE,Rathbun S,Scheid D

更新日期：2001-03-01 00:00:00

abstract：:The clinical and economic impacts of bacterial resistance are substantial. The development of bacterial resistance during a course of therapy often leads to clinical failure, prolonged hospitalization, increased morbidity, mortality, and increased health care costs. Resistance has been reported to occur most frequentl...

journal_title：Pharmacotherapy

authors： Barriere SL

更新日期：1992-01-01 00:00:00

abstract：STUDY OBJECTIVE:To quantify Asian and Asian-American college students' knowledge of osteoporosis and preventive health behaviors. DESIGN:Sixty-four-question survey SETTING:University of Minnesota. SUBJECTS:One hundred sixty-eight male and female Asian and Asian-American students, mean age 21 +/- 3.4 years. MAIN RES...

journal_title：Pharmacotherapy

authors： Nguyen DN,O'Connell MB

更新日期：2002-08-01 00:00:00

abstract：STUDY OBJECTIVES:To determine if low-dose lovastatin in combination with niacin causes a greater percentage reduction in low-density lipoprotein (LDL) cholesterol than lovastatin alone, and to determine if the combination increases the risk of serious adverse effects. design. Prospective, randomized, open-label, clinic...

journal_title：Pharmacotherapy

authors： Gardner SF,Schneider EF,Granberry MC,Carter IR

更新日期：1996-05-01 00:00:00

abstract：:Colistin, the most widely used polymyxin antibiotic, was originally introduced in the late 1950s before the establishment of the present-day drug approval process. Originally shelved due to toxicity concerns, colistin, in the form of its inactive prodrug colistin methanesulfonate, has undergone a renaissance in the pa...

journal_title：Pharmacotherapy

authors： Ortwine JK,Kaye KS,Li J,Pogue JM

更新日期：2015-01-01 00:00:00

abstract：:A 58-year-old man experienced an asthma exacerbation after administration of nicotine nasal spray for smoking cessation. His medical history was significant for asthma, chronic obstructive pulmonary disease, hypertension, and tobacco use when he was prescribed nicotine nasal spray for smoking cessation in an outpatien...

journal_title：Pharmacotherapy

authors： Roth MT,Westman EC

更新日期：2002-06-01 00:00:00

abstract：STUDY OBJECTIVES:To examine potential threats to internal and external study validity caused by differential patient withdrawal from a randomized controlled trial evaluating pharmacist management of hypertension, to compare the characteristics of patients who withdrew with those of patients who completed the study, and...

journal_title：Pharmacotherapy

authors： Rozenfeld Y,Hunt JS

更新日期：2006-11-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the hemodynamic and electrocardiographic effects of a single dose of commercially available bitter-orange dried-fruit extract, which is increasingly being used in dietary supplements. DESIGN:Randomized, double-blind, placebo-controlled, crossover study. SETTING:University of Connecticut, S...

journal_title：Pharmacotherapy

authors： Min B,Cios D,Kluger J,White CM

更新日期：2005-12-01 00:00:00

abstract：:Patients who experienced pain after surgery were administered a single dose of 1 of 3 treatments: acetaminophen 1000 mg, codeine phosphate 60 mg, or a combination of these. Patients rated their pain intensity on ordinal and visual analog scales just prior to medication and at intervals thereafter for up to 5 hours. Th...

journal_title：Pharmacotherapy

authors： Gertzbein SD,Tile M,McMurty RY,Kellam JF,Hunter GA,Keith RG,Harsanyi Z,Luffman J

更新日期：1986-05-01 00:00:00

abstract：:A hiccup is a myoclonic jerk of the diaphragm, and cases of hiccups may last for more than 48 hours (persistent hiccups) or even more than 2 months (intractable hiccups). Current pharmacologic treatment of persistent or intractable hiccups mainly includes antidopaminergic drugs. We describe the case of a 60-year-old m...

journal_title：Pharmacotherapy

authors： Naro A,Bramanti P,Calabrò RS

更新日期：2014-12-01 00:00:00

abstract：STUDY OBJECTIVE:To compare the safety and efficacy of rabbit antithymocyte globulin (r-ATG) with basiliximab in renal transplant recipients for whom an early steroid withdrawal (ESW) regimen was planned. DESIGN:Single-center, retrospective, cohort study. SETTING:Tertiary care medical center, including inpatient hospi...

journal_title：Pharmacotherapy

authors： Martin ST,Roberts KL,Malek SK,Tullius SG,Vadivel N,De Serres S,Grafals M,Elsanjak A,Filkins BA,Chandraker A,Gabardi S

更新日期：2011-06-01 00:00:00

abstract：:The frequency of type 2 diabetes mellitus is increasing at an alarming rate. Prediabetes, also referred to as impaired glucose tolerance (IGT) and/or impaired fasting glucose, is a major risk factor for development of type 2 diabetes mellitus. In addition, IGT has been associated with an increased risk of cardiovascul...

journal_title：Pharmacotherapy

authors： Irons BK,Mazzolini TA,Greene RS

更新日期：2004-03-01 00:00:00

abstract：STUDY OBJECTIVE:To compare the absorption profile of cyclosporine after preprandial administration with that after postprandial administration, and to determine which administration time resulted in a more stable absorption profile and the timing of the drug concentration that was the most reliable marker for monitorin...

journal_title：Pharmacotherapy

authors： Kusaba T,Konno Y,Hatta S,Fujino T,Yasuda T,Miura H,Sasaki H,Okabayashi J,Murao M,Sakurada T,Imai G,Shirai S,Kuboshima S,Shima Y,Ogimoto G,Sato T,Masuhara K,Kimura K

更新日期：2005-01-01 00:00:00

abstract：:Original research, reviews, and case reports discussing viral infectivity of blood- and plasma-derived products were reviewed to determine the potential viral infectivity of human serum albumin (HSA) and plasma protein fraction (PPF). Data concerning viral infectivity viral screening and inactivation procedures, and v...

journal_title：Pharmacotherapy

authors： Erstad BL

更新日期：1996-11-01 00:00:00

abstract：:Patients undergoing cardiopulmonary bypass may develop clinically significant physiologic alterations in the perioperative period, including alteration of thyroid hormone concentrations. Alterations in the concentration of thyroid hormones are of concern due to the effects of these hormones on cardiac function. Hypoth...

journal_title：Pharmacotherapy

authors： Reichert MG,Verzino KC

更新日期：2001-11-01 00:00:00

abstract：:This study documents a pharmacokinetic interaction between carbamazepine and cyclosporine (CsA) in pediatric renal transplant recipients. Noncompartmental steady-state CsA pharmacokinetics were determined in three pediatric renal transplant recipients who were receiving both CsA and carbamazepine as long-term therapy ...

journal_title：Pharmacotherapy

authors： Cooney GF,Mochon M,Kaiser B,Dunn SP,Goldsmith B

更新日期：1995-05-01 00:00:00

abstract：:We reviewed the spectrum of activity, pharmacokinetics, clinical efficacy, adverse effects, and relative advantages of piperacillin-tazobactam, a new beta-lactam-beta-lactamase inhibitor. Piperacillin-tazobactam has a wide spectrum of activity that includes gram-positive organisms such as staphylococci and streptococc...

journal_title：Pharmacotherapy

authors： Daniel KP,Krop LC

更新日期：1996-03-01 00:00:00

abstract：:The pharmacokinetics of methylprednisolone sodium succinate (MPHS) and methylprednisolone (MP) were determined in six patients undergoing open heart surgery with cardiopulmonary bypass. Plasma concentrations of both compounds were measured by high-performance liquid chromatography after doses of MPHS of 1.7-2.4 g. The...

journal_title：Pharmacotherapy

authors： Kong AN,Jungbluth GL,Pasko MT,Beam TR,Jusko WJ

更新日期：1990-01-01 00:00:00

abstract：STUDY OBJECTIVES:To determine the prevalence of hyperlipidemia and the effectiveness of hyperlipidemia management in a large population of transplant recipients. A secondary objective was to assess the effect of the National Cholesterol Education Program (NCEP) Adult Treatment Panel III guidelines on hyperlipidemia man...

journal_title：Pharmacotherapy

authors： Schonder KS,McKaveney TP,Lynch KJ

更新日期：2005-07-01 00:00:00

abstract：:A retrospective study evaluated the success of dosages of simvastatin lower than the 10-20 mg/day recommended by the manufacturer in patients with hypercholesterolemia. Records of 95 patients enrolled in a pharmacist-managed lipid clinic receiving stable dosages of simvastatin were reviewed. Data collected were demogr...

journal_title：Pharmacotherapy

authors： Rindone JP

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVE:Twice/day dosing of insulin glargine has been used to treat hyperglycemia in clinical practice; however, data supporting its use in the critically ill population are lacking. This study was designed to evaluate the safety and efficacy of twice/day insulin glargine in critically ill patients. METHODS:A retros...

journal_title：Pharmacotherapy

authors： Fox MA,Perry MC,Liu-DeRyke X

更新日期：2020-03-01 00:00:00

abstract：:Use of the Molecular Adsorbent Recirculating System (MARS) as a liver support device continues to grow worldwide. Various components of the MARS circuit remove both protein-bound and water-soluble molecules. Little is known about the extent of the enhanced clearance mechanisms used in MARS therapy on drug elimination....

journal_title：Pharmacotherapy

authors： Personett HA,Larson SL,Frazee EN,Nyberg SL,El-Zoghby ZM

更新日期：2015-08-01 00:00:00

abstract：:Widespread anecdotal use of sublingual tacrolimus administration has arisen, although little literature exists to guide practice. Given the paucity of data, we conducted a survey to evaluate the practice of sublingual tacrolimus administration at transplant centers across the United States and evaluated the literature...

journal_title：Pharmacotherapy

authors： Doligalski CT,Liu EC,Sammons CM,Silverman A,Logan AT

更新日期：2014-11-01 00:00:00

abstract：STUDY OBJECTIVE:To investigate potential associations between the histamine N-methyltransferase (HNMT) gene, HNMT, C314T (Thr105Ile) polymorphism and atopic dermatitis in a cohort of Caucasian children. DESIGN:Prospective, multicenter, genotype-association study. SETTING:Four academic, tertiary care medical centers w...

journal_title：Pharmacotherapy

authors： Kennedy MJ,Loehle JA,Griffin AR,Doll MA,Kearns GL,Sullivan JE,Hein DW

更新日期：2008-12-01 00:00:00

abstract：STUDY OBJECTIVE:To investigate the adverse drug reactions (ADRs) from peginterferon alfa-2b plus ribavirin in patients infected with the hepatitis C virus (HCV). DESIGN:Prospective, observational, pharmacovigilance study. SETTING:Gastroenterology department of a French university hospital. PATIENTS:A cohort of conse...

journal_title：Pharmacotherapy

authors： Bagheri H,Fouladi A,Barange K,Lapeyre-Mestre M,Payen JL,Montastruc JL,Vinel JP

更新日期：2004-11-01 00:00:00

abstract：:Nabilone, a synthetic cannabinoid, is approved in many countries including, but not limited to, Canada, the United States, Mexico, and the United Kingdom for the treatment of severe nausea and vomiting associated with chemotherapy. Clinical evidence is emerging for its use in managing pain conditions with different et...

journal_title：Pharmacotherapy

authors： Tsang CC,Giudice MG

更新日期：2016-03-01 00:00:00

abstract：:Intravenous unfractionated heparin (UFH) remains an important therapeutic agent, particularly in the inpatient setting, for anticoagulation. Historically, the activated partial thromboplastin time (aPTT) has been the primary laboratory test used to monitor and adjust UFH. The aPTT test has evolved since the 1950s, and...

journal_title：Pharmacotherapy

authors： Vandiver JW,Vondracek TG

更新日期：2012-06-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the efficacy and safety of a new combination product, enalapril-diltiazem ER, when administered over the long term. DESIGN:Open-label, titration to response, with treatment lasting 46 weeks after a 6-week, double-blind phase. SETTING:Medical clinics in the private and academic sectors. PA...

journal_title：Pharmacotherapy

authors： Applegate W,Cohen JD,Wolfson P,Davis A,Green S

更新日期：1997-01-01 00:00:00

abstract：:Outpatient transesophageal echocardiography was performed in a 69-year-old man with a history of aortic valve repair. During the procedure the patient became markedly cyanotic and hypotensive. Oxygen saturation measured by pulse oximetry decreased from 97% to the mid-80s. The man's condition continued to deteriorate. ...

journal_title：Pharmacotherapy

authors： Wurdeman RL,Mohiuddin SM,Holmberg MJ,Shalaby A

更新日期：2000-06-01 00:00:00

abstract：:The incidence and severity of Clostridium difficile infection (CDI) remain high across intensive care units in the United States despite national efforts to decrease this escalating health care burden. Most published literature and guidelines address treatment rather than prevention, yet this approach may be too downs...

journal_title：Pharmacotherapy

authors： Leedahl DD,Personett HA,Nagpal A,Barreto EF

更新日期：2019-03-01 00:00:00