Colistin: understanding and applying recent pharmacokinetic advances.

abstract：:Many physiologic differences between children and adults can result in age-related differences in pharmacokinetics. Understanding the effects of age on bioavailability, volume of distribution, protein binding, hepatic metabolic isoenzymes, and renal elimination can provide insight into optimizing doses for pediatric p...

journal_title：Pharmacotherapy

authors： Anderson GD,Lynn AM

更新日期：2009-06-01 00:00:00

abstract：STUDY OBJECTIVE:To assess patients' perception of care delivery by anticoagulation clinics (ACs) throughout Alberta, Canada. DESIGN:Prospective postal survey. SETTING:Therapy provision by an AC to ambulatory-based patients for a minimum of 3 months across the province. PATIENTS:A total of 1687 patients (67.9%) recei...

journal_title：Pharmacotherapy

authors： Bungard TJ,Barry AR,Jones C,Brocklebank C

更新日期：2013-11-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the extent of hospital-based clinical pharmacy services in 1992. DESIGN:National survey with trend comparison to 1989. SETTING:All 1597 United States acute care, general medical-surgical and pediatric hospitals with 50 or more licensed beds and one or more full-time pharmacists (43% of al...

journal_title：Pharmacotherapy

authors： Bond CA,Raehl CL,Pitterle ME

更新日期：1994-05-01 00:00:00

abstract：:Meropenem-vaborbactam is a new β-lactam/β-lactamase inhibitor combination designed to target Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae. Meropenem-vaborbactam was United States Food and Drug Administration-approved for complicated urinary tract infections in patients 18 years of age or olde...

journal_title：Pharmacotherapy

authors： Hanretty AM,Kaur I,Evangelista AT,Moore WS 2nd,Enache A,Chopra A,Cies JJ

更新日期：2018-12-01 00:00:00

abstract：:Cabozantinib is an oral small-molecule multitargeted tyrosine kinase inhibitor (TKI) that may confer an advantage over other TKIs that target a single receptor. It was approved by the U.S. Food and Drug Administration for the treatment of both advanced renal cell carcinoma and progressive metastatic medullary thyroid ...

journal_title：Pharmacotherapy

authors： Markowitz JN,Fancher KM

更新日期：2018-03-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effect of a potent experimental leukotriene receptor antagonist, MK-571, on airway responses to inhaled allergen. DESIGN:Randomized, double-blind, placebo-controlled, crossover trial. SETTING:Clinical research center. SUBJECTS:Eight male volunteers with allergic asthma. INTERVENTIONS...

journal_title：Pharmacotherapy

authors： Hendeles L,Davison D,Harman E,Sherman JM

更新日期：1999-11-01 00:00:00

abstract：:Endothelin (ET)-1 is an endothelium-derived peptide with potent vasoconstrictor and proliferative properties. The ET system is activated in several cardiovascular disease states associated with functional and structural vascular changes, including hypertension and heart failure. The two ET receptor subtypes are known ...

journal_title：Pharmacotherapy

authors： Ergul A

更新日期：2002-01-01 00:00:00

abstract：:Aneurysmal subarachnoid hemorrhage (SAH) accounts for a significant percentage of morbidity and mortality among patients admitted to neurosurgical centers throughout the world. Even for individuals surviving beyond the initial presentation and intervention for aneurysmal SAH, the occurrence of cerebral vasospasm has t...

journal_title：Pharmacotherapy

authors： Weant KA,Ramsey CN 3rd,Cook AM

更新日期：2010-04-01 00:00:00

abstract：:A literature search was conducted to examine the safety and effectiveness of low-dosage methotrexate for treatment and maintenance of remission in patients with inflammatory bowel disease. Nine published articles indicated that for patients with Crohn's disease, oral or intramuscular methotrexate 20-25 mg/week is safe...

journal_title：Pharmacotherapy

authors： Vandell AG,DiPiro JT

更新日期：2002-05-01 00:00:00

abstract：STUDY OBJECTIVE:To compare the effectiveness of darbepoetin alfa with epoetin alfa (recombinant human erythropoietin [rHuEPO]) for achieving transfusion independence and increasing hemoglobin concentrations in critically ill patients. DESIGN:Retrospective, descriptive study. SETTING:Level I trauma center intensive ca...

journal_title：Pharmacotherapy

authors： Voils SA,Harpe SH,Brophy GM

更新日期：2007-04-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the appropriate compartmental and noncompartmental pharmacokinetic parameters for intravenous piperacillin and tazobactam. DESIGN:Sequential selection of patients entered into a randomized, open-label clinical efficacy trial. SETTING:Los Angeles County-University of Southern California Me...

journal_title：Pharmacotherapy

authors： Jhee SS,Kern JW,Burm JP,Yellin AE,Gill MA

更新日期：1995-07-01 00:00:00

abstract：:During the past decade, patient safety issues during care transitions have gained greater attention at both the local and national level. Readmission rates to U.S. hospitals are high, often because of poor care transitions. Serious adverse drug events (ADEs) caused by an incomplete understanding of changes in complex ...

journal_title：Pharmacotherapy

authors： American College of Clinical Pharmacy.,Hume AL,Kirwin J,Bieber HL,Couchenour RL,Hall DL,Kennedy AK,LaPointe NM,Burkhardt CD,Schilli K,Seaton T,Trujillo J,Wiggins B

更新日期：2012-11-01 00:00:00

abstract：:Currently available anesthetic induction agents provide adequate hypnosis but are not ideal, particularly in the high risk patient (ASA class III-V), because most cause myocardial and/or respiratory depression and some have other important side effects. Etomidate was recently marketed as an intravenous anesthetic indu...

journal_title：Pharmacotherapy

authors： Giese JL,Stanley TH

更新日期：1983-09-01 00:00:00

abstract：:A new transdermal drug-delivery system that administers the synthetic opioid fentanyl through intact skin was evaluated for 24 hours postoperatively in eight patients who had undergone orthopedic surgery. Plasma samples were obtained over a 72-hour period for pharmacokinetic analysis in five patients. The patients wer...

journal_title：Pharmacotherapy

authors： Plezia PM,Kramer TH,Linford J,Hameroff SR

更新日期：1989-01-01 00:00:00

abstract：:Use of oral N-acetylcysteine for preventing radiographic contrast material-induced nephropathy (RCIN) has become widespread, despite conflicting results from clinical trials and meta-analyses. The variability in study results may reflect differences in baseline risks in study patients, hydration regimens, choice of co...

journal_title：Pharmacotherapy

authors： Shalansky SJ,Vu T,Pate GE,Levin A,Humphries KH,Webb JG

更新日期：2005-08-01 00:00:00

abstract：:Human herpesvirus infections continue to be a concern in immunocompetent as well as immunocompromised hosts. They are often life threatening in the immunocompromised patient. In the healthy immunocompetent person the infections tend to be self-limited, although they can directly or indirectly cause periods of severe d...

journal_title：Pharmacotherapy

authors： Dudley MN

更新日期：1995-09-01 00:00:00

abstract：PURPOSE:Neurocritically ill patients have clinically significant alterations in pharmacokinetic parameters of renally eliminated medications that may result in subtherapeutic plasma and cerebrospinal fluid antibiotic concentrations. METHODS:We conducted a prospective randomized open-label study of adult neurocriticall...

journal_title：Pharmacotherapy

authors： Kassel LE,Van Matre ET,Foster CJ,Fish DN,Mueller SW,Sherman DS,Wempe MF,MacLaren R,Neumann RT,Kiser TH

更新日期：2018-09-01 00:00:00

abstract：STUDY OBJECTIVES:To determine whether glomerular filtration rate (GFR) changes during induction chemotherapy in children with leukemia, and to examine GFR as a determinant of pharmacokinetic variability of methotrexate clearance. DESIGN:Prospective, unblinded observational study in consecutive patients. SETTING:A res...

journal_title：Pharmacotherapy

authors： Murry DJ,Synold TW,Pui CH,Rodman JH

更新日期：1995-03-01 00:00:00

abstract：:Weight-adjusted nomograms have been a significant advance in the use of unfractionated heparin (UFH). Clinical trials have demonstrated the ability of weight-adjusted nomograms to achieve a therapeutic activated partial thromboplastin time (aPTT) more rapidly than with standard UFH dosing. Despite this advantage, a si...

journal_title：Pharmacotherapy

authors： Dobesh PP,Heparin Consensus Group.

更新日期：2004-08-01 00:00:00

abstract：:Midazolam is a commonly used sedative in critically ill, mechanically ventilated patients in intensive care unit (ICU) settings worldwide. We used a nine-step decision-making algorithm to determine whether therapeutic monitoring of midazolam in the ICU is warranted. Midazolam has a higher clearance and shorter half-li...

journal_title：Pharmacotherapy

authors： Spina SP,Ensom MH

更新日期：2007-03-01 00:00:00

abstract：:Subtherapeutic tacrolimus trough concentrations were noted in a 52-year-old woman who had undergone liver transplantation. Her tacrolimus dosage was increased from 7 to 28 mg twice/day, and ketoconazole therapy was added; however, her tacrolimus concentration remained undetectable. Metoclopramide 10 mg 4 times/day was...

journal_title：Pharmacotherapy

authors： Prescott WA Jr,Callahan BL,Park JM

更新日期：2004-04-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effects of topical atorvastatin on the healing process of pressure ulcers in critically ill patients. DESIGN:Randomized, double-blind, placebo-controlled clinical trial. SETTING:Medical-surgical intensive care unit of a university-affiliated teaching hospital in Tehran, Iran. PATIENTS...

journal_title：Pharmacotherapy

authors： Farsaei S,Khalili H,Farboud ES,Karimzadeh I,Beigmohammadi MT

更新日期：2014-01-01 00:00:00

abstract：:A 58-year-old man experienced an asthma exacerbation after administration of nicotine nasal spray for smoking cessation. His medical history was significant for asthma, chronic obstructive pulmonary disease, hypertension, and tobacco use when he was prescribed nicotine nasal spray for smoking cessation in an outpatien...

journal_title：Pharmacotherapy

authors： Roth MT,Westman EC

更新日期：2002-06-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the prevalence, over 40 years, of using the last-observation-carried-forward (LOCF) imputation method in clinical trials, the association between use of LOCF and how the trials were conducted, and the extent of information about attrition and LOCF use in published reports. DESIGN:Retrospec...

journal_title：Pharmacotherapy

authors： Woolley SB,Cardoni AA,Goethe JW

更新日期：2009-12-01 00:00:00

abstract：:Abstract Outbreaks of extensively drug-resistant tuberculosis (XDR-TB) in developing countries and recent headlines of an American traveling with a resistant variant of tuberculosis have brought XDR-TB into the spotlight. The World Health Organization and the United States Centers for Disease Control and Prevention ha...

journal_title：Pharmacotherapy

authors： Mitrzyk BM

更新日期：2008-10-01 00:00:00

abstract：:We have developed a method for measuring the efficacy of a single dose of an analgesic for 12 hours after administration to outpatients with postoperative oral surgery pain. Using a self-rating record, patients evaluate their pain and its relief for 12 hours after medication. We have used this method successfully in a...

journal_title：Pharmacotherapy

authors： Beaver WT,Forbes JA,Shackleford RW

更新日期：1983-03-01 00:00:00

abstract：:Buspirone is the first of a new class of anxioselective agents, the azaspirodecanediones. It achieves peak serum concentrations within one hour and has a serum half-life of 2 to 5 hours. Animal studies have suggested antianxiety activity and the absence of abuse potential. Buspirone is both a dopamine agonist and anta...

journal_title：Pharmacotherapy

authors： Goldberg HL

更新日期：1984-11-01 00:00:00

abstract：:Major depression afflicts a significant percentage of the population, and optimum therapy is often limited by the poor tolerability and lethality in overdose of the tricyclic antidepressants. The selective serotonin reuptake inhibitors (SSRIs) fluoxetine, sertraline, and, more recently, paroxetine are viewed as welcom...

journal_title：Pharmacotherapy

authors： Nemeroff CB

更新日期：1994-03-01 00:00:00

abstract：STUDY OBJECTIVE:To contrast the characteristics of two groups of anabolic-androgenic steroid (AAS) users-those with versus those without AAS dependence. DESIGN:Subanalysis of data from the Anabolic 500, a cross-sectional survey. PARTICIPANTS:One hundred twelve male AAS-dependent users and 367 AAS-nondependent users w...

journal_title：Pharmacotherapy

authors： Ip EJ,Lu DH,Barnett MJ,Tenerowicz MJ,Vo JC,Perry PJ

更新日期：2012-10-01 00:00:00

abstract：:Addressing the issue of unintended pregnancy is a national priority. One proposed strategy to reduce unintended pregnancy is to improve access to oral contraceptives by changing them to over-the-counter (OTC) status. Existing data indicate that oral contraceptives meet safety criteria required of OTC products. Availab...

journal_title：Pharmacotherapy

authors： McIntosh J,Rafie S,Wasik M,McBane S,Lodise NM,El-Ibiary SY,Forinash A,Kachlic MD,Rowe E,Besinque K

更新日期：2011-04-01 00:00:00