Abstract:
:Cabozantinib is an oral small-molecule multitargeted tyrosine kinase inhibitor (TKI) that may confer an advantage over other TKIs that target a single receptor. It was approved by the U.S. Food and Drug Administration for the treatment of both advanced renal cell carcinoma and progressive metastatic medullary thyroid cancer, and it is being investigated for a wide array of other malignancies. Rationale for use, clinical trial data, and current recommendations for cabozantinib in renal cell cancer, thyroid cancer, prostate cancer, hepatocellular cancer, and lung cancer are detailed in this article. Common adverse events are reviewed, and management strategies for select adverse events are discussed. Implications for contemporary practitioners are also provided because use of this novel agent is likely to increase as more studies are completed.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Markowitz JN,Fancher KMdoi
10.1002/phar.2076subject
Has Abstractpub_date
2018-03-01 00:00:00pages
357-369issue
3eissn
0277-0008issn
1875-9114journal_volume
38pub_type
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