Efficacy of topical atorvastatin for the treatment of pressure ulcers: a randomized clinical trial.

Abstract:

STUDY OBJECTIVE:To evaluate the effects of topical atorvastatin on the healing process of pressure ulcers in critically ill patients. DESIGN:Randomized, double-blind, placebo-controlled clinical trial. SETTING:Medical-surgical intensive care unit of a university-affiliated teaching hospital in Tehran, Iran. PATIENTS:One hundred four patients with stage I or II pressure ulcers, graded according to the 2-digit Stirling Pressure Sore Severity Scale. INTERVENTION:Patients were randomized to receive topical atorvastatin 1% ointment (51 patients [atorvastatin group]) or placebo ointment (53 patients [control group]) applied once/day to pressure ulcers for 14 days in addition to standard care for pressure ulcers. MEASUREMENTS AND MAIN RESULTS:The efficacy of each treatment was assessed on days 7 and 14. Efficacy was determined based on the degree of healing of the existing pressure ulcer by using the 2-digit Stirling scale. The baseline stage of the pressure ulcers did not differ significantly between the control and atorvastatin groups. However, the mean ± SD stage of pressure ulcers significantly decreased in the atorvastatin group compared with the control group on day 7 (0.97 ± 0.76 vs 1.74 ± 0.75, p<0.01) and day 14 (0.42 ± 0.67 vs 1.71 ± 0.78, p<0.01) of treatment. In addition, the mean ± SD surface areas of ulcers in the atorvastatin group were significantly declined compared with the control group after 7 days (5.55 ± 4.55 vs 9.41 ± 5.03 cm², p<0.01) and 14 days (3.72 ± 4.45 vs 10.41 ± 6.41 cm², p<0.01) of treatment. CONCLUSION:Topical application of atorvastatin ointment 1% for 14 days in addition to standard care significantly accelerated the healing of stage I or II pressure ulcers in critically ill patients.

journal_name

Pharmacotherapy

journal_title

Pharmacotherapy

authors

Farsaei S,Khalili H,Farboud ES,Karimzadeh I,Beigmohammadi MT

doi

10.1002/phar.1339

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

19-27

issue

1

eissn

0277-0008

issn

1875-9114

journal_volume

34

pub_type

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