The antioxidant vitamins: impact on atherosclerosis.

abstract：STUDY OBJECTIVE:To determine if transitioning patients from a pharmacist- managed anticoagulation clinic after stabilization of warfarin therapy to physician-managed care alters the quality of anticoagulation care. DESIGN:Retrospective medical record review. SETTING:Pharmacist-managed, urban academic medical center-b...

journal_title：Pharmacotherapy

authors： Garwood CL,Dumo P,Baringhaus SN,Laban KM

更新日期：2008-01-01 00:00:00

abstract：:Opioid-related adverse drug events (ORADEs) can have a significant impact on patient recovery after surgery. This review investigates the impact of two ORADEs, respiratory depression and postoperative ileus (POI), on clinical and economic outcomes. Opioid-induced ventilatory impairment is a potentially serious ORADE t...

journal_title：Pharmacotherapy

authors： Barletta JF

更新日期：2012-09-01 00:00:00

abstract：:Diazepam is frequently the subject of review by various agencies and institutions charged with determining whether or not to substitute another, more economical drug--in most instances, chlordiazepoxide. A review of the comparative literature has shown that, on clinical and pharmacokinetic grounds, chlordiazepoxide is...

journal_title：Pharmacotherapy

authors： Baskin SI,Esdale A

更新日期：1982-03-01 00:00:00

abstract：:Midazolam is a commonly used sedative in critically ill, mechanically ventilated patients in intensive care unit (ICU) settings worldwide. We used a nine-step decision-making algorithm to determine whether therapeutic monitoring of midazolam in the ICU is warranted. Midazolam has a higher clearance and shorter half-li...

journal_title：Pharmacotherapy

authors： Spina SP,Ensom MH

更新日期：2007-03-01 00:00:00

abstract：:The objective of this study was to describe the postinduction clearance of carbamazepine (CBZ) in adult psychiatric patients by population pharmacokinetic analysis using the NONMEM program. Specifically, an estimate of CBZ clearance and insight into the effect of common patient characteristics on clearance were sought...

journal_title：Pharmacotherapy

authors： Martin ES 3rd,Crismon ML,Godley PJ

更新日期：1991-01-01 00:00:00

abstract：:Meta-analyses are key components of evidence-based decision making. The numbers of meta-analyses published in different areas of health care increased dramatically during the past 10 years. Many of them covered different pharmacologic interventions, making them useful resources to clinical pharmacists. Although a well...

journal_title：Pharmacotherapy

authors： Etminan M,Levine M

更新日期：1999-06-01 00:00:00

abstract：STUDY OBJECTIVE:To contrast the characteristics of two groups of anabolic-androgenic steroid (AAS) users-those with versus those without AAS dependence. DESIGN:Subanalysis of data from the Anabolic 500, a cross-sectional survey. PARTICIPANTS:One hundred twelve male AAS-dependent users and 367 AAS-nondependent users w...

journal_title：Pharmacotherapy

authors： Ip EJ,Lu DH,Barnett MJ,Tenerowicz MJ,Vo JC,Perry PJ

更新日期：2012-10-01 00:00:00

abstract：:Ischemic stroke is a prevalent disease with a large burden on the health system. Preventive strategies, therefore, are paramount. Primary prevention is aimed at reducing the risk of stroke in asymptomatic people. The most effective prevention is through control of modifiable risk factors. Due to the large amount of li...

journal_title：Pharmacotherapy

authors： Baker WL,Marrs JC,Davis LE,Nutescu EA,Rowe AS,Ryan M,Splinter MY,Vardeny O,Fagan SC

更新日期：2013-06-01 00:00:00

abstract：:Hypoactive sexual desire disorder (HSDD) affects nearly 1 in 10 women. Thus, it is essential for pharmacists and other health care providers to be comfortable when discussing a patient's sexual health to ensure appropriate triage so that the specific causes of HSDD can be identified and potential recommendations provi...

journal_title：Pharmacotherapy

authors： Lodise NM

更新日期：2013-04-01 00:00:00

abstract：:Neuroleptic malignant syndrome (NMS) is an idiosyncratic and uncommon but serious adverse effect that has been reported with both typical and atypical antipsychotic agents. We describe a 58-year-old man with Down syndrome and dementia who was receiving low-dose olanzapine and rivastigmine therapy; he developed NMS 4 m...

journal_title：Pharmacotherapy

authors： Stevens DL,Lee MR,Padua Y

更新日期：2008-03-01 00:00:00

abstract：:Low-molecular-weight heparins (LMWHs) are safe and effective in the treatment of venous thromboembolic disease. Since they require less therapeutic monitoring than unfractionated heparin and may be administered to outpatients, it is possible to decrease overall health care costs of patients diagnosed with deep vein th...

journal_title：Pharmacotherapy

authors： Yurkowski P

更新日期：1998-11-01 00:00:00

abstract：STUDY OBJECTIVES:To evaluate hepatic cytochrome P450 (CYP) 3A4 activity in patients infected with the human immunodeficiency virus (HIV) using the erythromycin breath test (ERMBT), and to examine the relationship of the ERMBT to plasma concentrations of indinavir and nelfinavir. DESIGN:Prospective observational study....

journal_title：Pharmacotherapy

authors： Slain D,Pakyz A,Israel DS,Monroe S,Polk RE

更新日期：2000-08-01 00:00:00

abstract：:A 32-year-old woman with a history of deep vein thrombosis (DVT), steroid-dependent ulcerative colitis, and osteoporosis was prescribed azathioprine for a steroid-sparing effect. Stable, therapeutic international normalized ratios (INRs) were obtained with warfarin 35 mg/week during a 6-week postpartum course to treat...

journal_title：Pharmacotherapy

authors： Havrda DE,Rathbun S,Scheid D

更新日期：2001-03-01 00:00:00

abstract：STUDY OBJECTIVE:To assess the level of agreement between one subjective definition of major bleeding (criteria A) and two objective definitions: the International Society on Thrombosis and Haemostasis ([ISTH] criteria B) and the Italian Study of Complications of Anticoagulant Therapy ([ISCOAT] criteria C). DESIGN:Retr...

journal_title：Pharmacotherapy

authors： Seto AC,Kenyon K,Wittkowsky AK

更新日期：2008-09-01 00:00:00

abstract：:Limited data are available on ceftolozane/tazobactam dosing in patients receiving continuous renal replacement therapy (CRRT). Thus we performed a pharmacokinetic analysis of intravenous ceftolozane/tazobactam in a critically ill patient receiving CRRT at our medical center. A 47-year-old critically ill man with multi...

journal_title：Pharmacotherapy

authors： Bremmer DN,Nicolau DP,Burcham P,Chunduri A,Shidham G,Bauer KA

更新日期：2016-05-01 00:00:00

abstract：:The management of heart failure is complex. Initiating and maintaining drug therapy in patients with heart failure can be challenging. Many factors influence the heart failure syndrome and are important to account for when evaluating these patients. Concomitant diseases such as ischemic heart disease and hypertension ...

journal_title：Pharmacotherapy

authors： Gattis WA

更新日期：2000-11-01 00:00:00

abstract：STUDY OBJECTIVE:To compare adverse events related to anticoagulation in patients assigned to a pharmacist-managed anticoagulation service versus those receiving usual care. DESIGN:Retrospective cohort analysis. SETTING:Three hundred-bed community hospital. PATIENTS:Four hundred twenty patients referred for anticoagu...

journal_title：Pharmacotherapy

authors： Locke C,Ravnan SL,Patel R,Uchizono JA

更新日期：2005-05-01 00:00:00

abstract：:The authors sought to evaluate the impact on length of hospital stay and treatment duration of morphine after implementation of a change in the institutional protocol for managing neonatal abstinence syndrome (NAS) in an effort to improve patient outcomes. A single-center, retrospective chart review was conducted at a...

journal_title：Pharmacotherapy

authors： DeAtley HN,Burton A,Fraley MD,Haltom J

更新日期：2017-07-01 00:00:00

abstract：:Hodgkin lymphoma (HL) and systemic anaplastic large cell lymphoma (sALCL), which is a subtype of non-Hodgkin lymphoma, are relatively uncommon lymphoproliferative types of cancer. These malignancies are highly curable with initial treatment. Nonetheless, some patients are refractory to or relapse after first- and seco...

journal_title：Pharmacotherapy

authors： Newland AM,Li JX,Wasco LE,Aziz MT,Lowe DK

更新日期：2013-01-01 00:00:00

abstract：:The risk of venous thromboembolism (VTE) in patients with cancer is 6-12-fold higher than in the general population, and VTE is the second leading cause of death in this population, after cancer itself. The etiology underlying the increased risk of VTE is multifactorial and complex, involving patient-, tumor-, and tre...

journal_title：Pharmacotherapy

authors： Saraiya B,Goodin S

更新日期：2009-11-01 00:00:00

abstract：:Colistin, the most widely used polymyxin antibiotic, was originally introduced in the late 1950s before the establishment of the present-day drug approval process. Originally shelved due to toxicity concerns, colistin, in the form of its inactive prodrug colistin methanesulfonate, has undergone a renaissance in the pa...

journal_title：Pharmacotherapy

authors： Ortwine JK,Kaye KS,Li J,Pogue JM

更新日期：2015-01-01 00:00:00

abstract：:The era of the integrase strand transfer inhibitors (INSTIs) for the treatment of human immunodeficiency virus (HIV) infection began with raltegravir in 2007. Since that time, several other INSTIs have been introduced including elvitegravir, dolutegravir, and, most recently, bictegravir, that have shown great utility ...

journal_title：Pharmacotherapy

authors： Brooks KM,Sherman EM,Egelund EF,Brotherton A,Durham S,Badowski ME,Cluck DB

更新日期：2019-05-01 00:00:00

abstract：:Obesity is a worldwide epidemic often complicated by multiple comorbidities, including type 2 diabetes mellitus (T2DM). Bariatric surgery is an increasingly common and effective weight-loss strategy for obese patients that may result in resolution of metabolic-related disease states, such as T2DM. Although bariatric s...

journal_title：Pharmacotherapy

authors： Howard ML,Steuber TD,Nisly SA

更新日期：2018-06-01 00:00:00

abstract：:Rituximab has been approved by the United States Food and Drug Administration in combination with methotrexate for the treatment of rheumatoid arthritis in patients who failed to achieve adequate benefit from tumor necrosis factor-alpha inhibitors. Rituximab is a biologic agent that depletes peripheral B cells--an act...

journal_title：Pharmacotherapy

authors： Schuna AA

更新日期：2007-12-01 00:00:00

abstract：:A formerly infrequently isolated strain of Clostridium difficile known as BI/NAP1 has resulted in geographically diverse outbreaks of C. difficile-associated disease. Such rapid dissemination and distribution of an outbreak strain of C. difficile are unprecedented, with many regions across North America, as well as se...

journal_title：Pharmacotherapy

authors： Owens RC

更新日期：2006-03-01 00:00:00

abstract：:Buspirone is the first of a new class of anxioselective agents, the azaspirodecanediones. It achieves peak serum concentrations within one hour and has a serum half-life of 2 to 5 hours. Animal studies have suggested antianxiety activity and the absence of abuse potential. Buspirone is both a dopamine agonist and anta...

journal_title：Pharmacotherapy

authors： Goldberg HL

更新日期：1984-11-01 00:00:00

abstract：:Methamphetamine is a highly potent and addictive drug that is abused in the United States and around the world. The drug is inexpensive and easily manufactured from simple chemicals such as pseudoephedrine. These features, coupled with its long half-life and highly addictive nature, contribute to the increasing proble...

journal_title：Pharmacotherapy

authors： Romanelli F,Smith KM

更新日期：2006-08-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effectiveness, safety, and costs associated with a formulary conversion from amlodipine to alternative calcium channel blockers. DESIGN:Retrospective study. SETTING:Veterans Affairs Medical Center. PATIENTS:One hundred patients with hypertension who were receiving amlodipine. INTERVE...

journal_title：Pharmacotherapy

authors： Parra D,Beckey NP,Korman L

更新日期：2000-09-01 00:00:00

abstract：STUDY OBJECTIVE:To assess the influence of withholding continuous enteral nutrition for 1 hour before and after warfarin administration compared with the coadministration of warfarin with continuous enteral nutrition on changes in international normalized ratios (INRs). DESIGN:Retrospective, crossover case series. SE...

journal_title：Pharmacotherapy

authors： Dickerson RN,Garmon WM,Kuhl DA,Minard G,Brown RO

更新日期：2008-03-01 00:00:00

abstract：STUDY OBJECTIVE:To compare the efficacy of amlodipine and valsartan in African-American patients with hypertension using ambulatory blood pressure monitoring (ABPM). DESIGN:Prospective, randomized, double-blind, crossover comparison study. SETTING:University-affiliated cardiac center clinic. PATIENTS:Twenty African-...

journal_title：Pharmacotherapy

authors： Maciejewski S,Mohiuddin SM,Packard KA,Mooss AN,Reyes AP,Aryana A,Hilleman DE

更新日期：2006-07-01 00:00:00