Vitamin K-independent warfarin resistance after concurrent administration of warfarin and continuous enteral nutrition.

abstract：:A 58-year-old man went to his physician with complaints of midepigastric pain, flatulence, belching, and shortness of breath. During a physical examination, the patient was in no acute distress. The patient underwent an ultrasound examination, which revealed cholelithiasis, a laparoscopic cholecystectomy, which reveal...

journal_title：Pharmacotherapy

authors： Baker EL,Baker WL,Cloney DJ

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVE:In an era of increasing polypharmacy, adverse drug effects such as ototoxicity have significant public health implications. Despite the availability of evidence, many health care professionals may not know the risk of ototoxicity in common medications. Therefore, the aim of this review is to provide a compreh...

journal_title：Pharmacotherapy

authors： Rizk HG,Lee JA,Liu YF,Endriukaitis L,Isaac JL,Bullington WM

更新日期：2020-12-01 00:00:00

abstract：:A 38-year-old woman with type 1 diabetes underwent kidney-pancreas transplantation. Her postoperative course was complicated due to recurrent acute graft rejections and pancreatitis. After initial immunosuppression with microemulsion cyclosporine, mycophenolate mofetil, and prednisone with muromonab-CD3 induction, cyc...

journal_title：Pharmacotherapy

authors： Min DI,Ku YM,Rayhill S,Corwin C,Wu YM,Hunsicker LG

更新日期：1999-07-01 00:00:00

abstract：:Serious gram-positive infections present an increasingly common therapeutic dilemma. Combination antimicrobial regimens (e.g., linezolid with rifampin) aimed at improving bacterial eradication and preventing resistance are often used; however, most data supporting this treatment strategy are not from randomized contro...

journal_title：Pharmacotherapy

authors： Gebhart BC,Barker BC,Markewitz BA

更新日期：2007-03-01 00:00:00

abstract：:Atrial fibrillation is the most common sustained cardiac arrhythmia and is associated with thromboembolic events and hemodynamic impairment that results in considerable morbidity, mortality, and cost. Cardioversion to sinus rhythm is a common approach to the treatment of these patients. However, cardioversion is assoc...

journal_title：Pharmacotherapy

authors： Wodlinger AM,Pieper JA

更新日期：2003-01-01 00:00:00

abstract：:The pharmacokinetic characteristics of levofloxacin, moxifloxacin, and gatifloxacin include excellent oral bioavailability (90-99%), extensive penetration into tissues and body fluids, and an elimination half-life (6-12 hrs) that allows for once-daily dosing in patients with normal renal function. Levofloxacin and gat...

journal_title：Pharmacotherapy

authors： Rodvold KA,Neuhauser M

更新日期：2001-10-01 00:00:00

abstract：:During the past decade, the incidence and severity of Clostridium difficile infection (CDI) have significantly increased, leading to a rise in CDI-associated hospitalizations, health care costs, and mortality. Although treatment options exist for CDI, recurrence is frequent following treatment. Furthermore, patients w...

journal_title：Pharmacotherapy

authors： Kufel WD,Devanathan AS,Marx AH,Weber DJ,Daniels LM

更新日期：2017-10-01 00:00:00

abstract：:Recombinant human erythropoietin reverses the severe anemia associated with end-stage renal disease. Mean half-life values after a single intravenous bolus dose range from 4-13 hours. Renal clearance is not a significant route of elimination. Dosing schedules in chronic renal failure involve a single intravenous bolus...

journal_title：Pharmacotherapy

authors： Flaharty KK

更新日期：1990-03-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the usage patterns of the lipid-based amphotericin B formulations at our institution and to compare the observed nephrotoxicity and efficacy of these formulations. DESIGN:Prospective and retrospective observational study SETTING:Urban 350-bed teaching hospital. PATIENTS:Sixty-seven nonhe...

journal_title：Pharmacotherapy

authors： Cannon JP,Garey KW,Danziger LH

更新日期：2001-09-01 00:00:00

abstract：:The statins are widely used to treat dyslipidemias. They are generally associated with mild adverse effects, but rarely, more serious reactions may occur. A 51-year-old man experienced delayed-onset, progressive memory loss while receiving simvastatin for hypercholesterolemia. His therapy was switched to pravastatin, ...

journal_title：Pharmacotherapy

authors： Orsi A,Sherman O,Woldeselassie Z

更新日期：2001-06-01 00:00:00

abstract：:The Institute of Medicine has identified adverse drug events as factors that significantly contribute to increased patient morbidity and mortality. As critically ill patients receive numerous drugs to treat a multitude of complicated health problems, they are at high risk for adverse drug events. Sedation is often a k...

journal_title：Pharmacotherapy

authors： Corbett SM,Montoya ID,Moore FA

更新日期：2008-02-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effects of acetaminophen, naproxen, and acetylsalicylic acid on the pharmacokinetics of the centrally acting analgesic tapentadol in healthy subjects. DESIGN:Two randomized, open-label, crossover, drug-drug interaction studies. SETTING:Clinical research facilities in the United States ...

journal_title：Pharmacotherapy

authors： Smit JW,Oh C,Rengelshausen J,Terlinden R,Ravenstijn PG,Wang SS,Upmalis D,Mangold B

更新日期：2010-01-01 00:00:00

abstract：:The effect of treatment for hepatitis C viral infection on hemoglobin A(1c) (A1C) levels is not well described in the literature. We describe a 59-year-old man with type 2 diabetes mellitus whose A1C level became falsely low when ribavirin and peginterferon alfa-2b therapy were started for treatment of hepatitis C. Af...

journal_title：Pharmacotherapy

authors： Gross BN,Cross LB,Foard JC,Wood YA

更新日期：2009-01-01 00:00:00

abstract：:A 37-year-old Hispanic man with advanced acquired immunodeficiency syndrome developed extensive pulmonary disease with persistent cough, fever, night sweats, worsening dyspnea, and weight loss. Sputum samples showed scant growth of acid-fast bacilli. He failed to respond to the standard tuberculosis regimen of isoniaz...

journal_title：Pharmacotherapy

authors： Kang-Birken SL,Prichard JG

更新日期：2006-11-01 00:00:00

abstract：:Decades of overuse and misuse of antibiotics have turned the resistance problem into a crisis. Preventive and corrective measures are urgently needed. This article presents a broad overview of the status of antimicrobial resistance. Resistance in key bacterial pathogens such as enterococci, staphylococci, pneumococci,...

journal_title：Pharmacotherapy

authors： Rybak MJ

更新日期：2004-12-01 00:00:00

abstract：:The clinical and economic impacts of bacterial resistance are substantial. The development of bacterial resistance during a course of therapy often leads to clinical failure, prolonged hospitalization, increased morbidity, mortality, and increased health care costs. Resistance has been reported to occur most frequentl...

journal_title：Pharmacotherapy

authors： Barriere SL

更新日期：1992-01-01 00:00:00

abstract：:Weight-adjusted nomograms have been a significant advance in the use of unfractionated heparin (UFH). Clinical trials have demonstrated the ability of weight-adjusted nomograms to achieve a therapeutic activated partial thromboplastin time (aPTT) more rapidly than with standard UFH dosing. Despite this advantage, a si...

journal_title：Pharmacotherapy

authors： Dobesh PP,Heparin Consensus Group.

更新日期：2004-08-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the activity of CYP2D6, N-acetylation, and xanthine oxidase, three drug-metabolizing enzyme systems, in patients with cystic fibrosis and compare the findings with those in individuals without the disease. DESIGN:Prospective cohort study. SETTING:General pediatrics service. PATIENTS:Fift...

journal_title：Pharmacotherapy

authors： Bosso JA,Liu Q,Evans WE,Relling MV

更新日期：1996-09-01 00:00:00

abstract：:Addressing the issue of unintended pregnancy is a national priority. One proposed strategy to reduce unintended pregnancy is to improve access to oral contraceptives by changing them to over-the-counter (OTC) status. Existing data indicate that oral contraceptives meet safety criteria required of OTC products. Availab...

journal_title：Pharmacotherapy

authors： McIntosh J,Rafie S,Wasik M,McBane S,Lodise NM,El-Ibiary SY,Forinash A,Kachlic MD,Rowe E,Besinque K

更新日期：2011-04-01 00:00:00

abstract：STUDY OBJECTIVES:To develop and validate an improved unfractionated heparin (UFH) dosage protocol, using antifactor Xa levels as the outcome variable. DESIGN:Prospective case series. SETTING:A 625-bed, adults-only private, tertiary care teaching hospital. PATIENTS:Three hundred seventy-two patients receiving UFH for...

journal_title：Pharmacotherapy

authors： Rosborough TK,Shepherd MF

更新日期：2004-06-01 00:00:00

abstract：:Verapamil and diltiazem are effective in terminating paroxysmal supraventricular tachycardias and slowing ventricular response during atrial fibrillation or flutter. Results from clinical trials for each individual drug demonstrate comparative efficacy rates, and both drugs share the same contraindications and relativ...

journal_title：Pharmacotherapy

authors： Cheiman DM,Shea BF,Kelly RA

更新日期：1996-09-01 00:00:00

abstract：:Drug-induced thrombocytopenia is a rare but serious adverse event that has been associated with multiple drugs including β-lactams. Although it mostly occurs with prolonged medication use, some cases of rapid-onset thrombocytopenia have been reported. We describe the case of a 69-year-old man who developed severe and ...

journal_title：Pharmacotherapy

authors： Nguyen VD,Tourigny JF,Roy R,Brouillette D

更新日期：2015-12-01 00:00:00

abstract：STUDY OBJECTIVE:To determine if milk thistle (silymarin) alters the pharmacokinetics of indinavir. DESIGN:Sequential crossover trial. SETTING:General clinical research center. SUBJECTS:Ten healthy subjects. INTERVENTION:Indinavir 800 mg 3 times/day was given for four doses on days 1 and 2. Silymarin 160 mg 3 times/...

journal_title：Pharmacotherapy

authors： DiCenzo R,Shelton M,Jordan K,Koval C,Forrest A,Reichman R,Morse G

更新日期：2003-07-01 00:00:00

abstract：:After the introduction of penicillin G into therapeutics, bacteria became increasingly resistant to this penicillin and subsequent beta-lactam antibiotics. The major cause of this resistance is beta-lactamase, an enzyme produced by the bacterium, that destroys the antibiotic before it reaches its target within the bac...

journal_title：Pharmacotherapy

authors： Jackson D

更新日期：1991-01-01 00:00:00

abstract：STUDY OBJECTIVE:To determine whether a relationship exists between medication adherence to angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) and distance to dispensing pharmacies and prescribers among an urban public aid population with diabetes mellitus. DESIGN:Retrospective...

journal_title：Pharmacotherapy

authors： Syed ST,Sharp LK,Kim Y,Jentleson A,Lora CM,Touchette DR,Berbaum ML,Suda KJ,Gerber BS

更新日期：2016-06-01 00:00:00

abstract：STUDY OBJECTIVES:To determine the prevalence of hyperlipidemia and the effectiveness of hyperlipidemia management in a large population of transplant recipients. A secondary objective was to assess the effect of the National Cholesterol Education Program (NCEP) Adult Treatment Panel III guidelines on hyperlipidemia man...

journal_title：Pharmacotherapy

authors： Schonder KS,McKaveney TP,Lynch KJ

更新日期：2005-07-01 00:00:00

abstract：:Central nervous system stimulants are a commonly used first-line treatment option for attention-deficit/hyperactivity disorder (ADHD). Stimulants are generally well tolerated, with anorexia and insomnia the most common adverse effects. However, there are some concerns with long-term use of stimulants, such as potentia...

journal_title：Pharmacotherapy

authors： Troksa K,Kovacich N,Moro M,Chavez B

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:To estimate the effect of a triplicate prescription policy on administration of benzodiazepines and possible substitute drugs in nursing home residents during 1994-1995. DESIGN:Retrospective cross-sectional study SETTING:Medicare- and Medicaid-certified nursing homes in five states: New York, which has a po...

journal_title：Pharmacotherapy

authors： VanHaaren AM,Lapane KL,Hughes CM

更新日期：2001-10-01 00:00:00

abstract：STUDY OBJECTIVE:To characterize a time-dependent disposition of oral tacrolimus and its relationship with plasma endothelin-1 concentrations. DESIGN:Randomized, crossover study. SETTING:Clinical research center of a university-affiliated hospital. PATIENTS:Twelve stable liver transplant recipients. INTERVENTIONS:In...

journal_title：Pharmacotherapy

authors： Min DI,Chen HY,Lee MK,Ashton K,Martin MF

更新日期：1997-05-01 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GMCSF) is a hematopoietic protein that has been studied both in vitro and in vivo in human immunodeficiency virus (HIV) infection. Since both HIV infection primarily and zidovudine (formerly AZT) treatment secondarily may result in neutropenia, administration of GMCSF ...

journal_title：Pharmacotherapy

authors： Hewitt RG,Morse GD

更新日期：1992-01-01 00:00:00