Decreased serum linezolid levels in a critically ill patient receiving concomitant linezolid and rifampin.

abstract：:A 67-year-old woman with iron deficiency anemia required parenteral iron therapy and was treated with intravenous ferric gluconate. She tolerated the first dose, but after the second dose, she developed a tingling feeling all over her body, along with swelling in her hands and feet, and a rash with hives over most of ...

journal_title：Pharmacotherapy

authors： Sane R,Baribeault D,Rosenberg CL

更新日期：2007-04-01 00:00:00

abstract：:Recombinant tissue plasminogen activator (t-PA) is a synthetic fibrinolytic protein which activates plasminogen or converts plasminogen to plasmin specifically in the presence of fibrin. With its "clot-selectivity", t-PA is capable of lysing clots without having a significant effect on circulating plasminogen. In cont...

journal_title：Pharmacotherapy

authors： Rogers SD,Riemersma LB,Clements SD

更新日期：1987-01-01 00:00:00

abstract：:Although in the last few years new antidepressants have become available in the United States, responses in many patients differ, from none, to partial, to delayed therapeutic response to the agents. If the antidepressant properties of these drugs could be enhanced or accelerated, it might be possible to improve patie...

journal_title：Pharmacotherapy

authors： Puzantian T,Kawase K

更新日期：1999-02-01 00:00:00

abstract：:A 63-year-old man with ventricular tachycardia (VT) refractory to drug therapy was admitted for surgical ablation of the VT with coronary artery bypass graft surgery. He developed increased theophylline concentrations with decreased calculated theophylline clearance after propafenone therapy for recurrent VT was initi...

journal_title：Pharmacotherapy

authors： Spinler SA,Gammaitoni A,Charland SL,Hurwitz J

更新日期：1993-01-01 00:00:00

abstract：:During the past decade, the incidence and severity of Clostridium difficile infection (CDI) have significantly increased, leading to a rise in CDI-associated hospitalizations, health care costs, and mortality. Although treatment options exist for CDI, recurrence is frequent following treatment. Furthermore, patients w...

journal_title：Pharmacotherapy

authors： Kufel WD,Devanathan AS,Marx AH,Weber DJ,Daniels LM

更新日期：2017-10-01 00:00:00

abstract：:Erectile dysfunction, a problem estimated to affect up to 30 million American men, is associated with a number of systemic illnesses and drugs. Age is not thought to be an independent risk factor for the disorder, but accompanying illnesses and their treatments may contribute to its onset. Newer classes of antihyperte...

journal_title：Pharmacotherapy

authors： Barksdale JD,Gardner SF

更新日期：1999-05-01 00:00:00

abstract：:3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are a frequently prescribed class of drugs that are generally well tolerated by most patients. A rare, yet serious side effect associated with these drugs is rhabdomyolysis. Although all HMG-CoA reductase inhibitors can cause this adverse effect, pre...

journal_title：Pharmacotherapy

authors： Ravnan SL,Locke C,Yee WP,Haase K

更新日期：2002-04-01 00:00:00

abstract：:Pseudomonas aeruginosa is one of the leading gram-negative organisms associated with nosocomial infections. The increasing frequency of multi-drug-resistant Pseudomonas aeruginosa (MDRPA) strains is concerning as efficacious antimicrobial options are severely limited. By searching MEDLINE from January 1966-February 20...

journal_title：Pharmacotherapy

authors： Obritsch MD,Fish DN,MacLaren R,Jung R

更新日期：2005-10-01 00:00:00

abstract：:In 2006, the American College of Clinical Pharmacy (ACCP) charged the Task Force on Residency Equivalency to define the professional experience expected of a clinically mature practitioner that would meet or exceed the knowledge and skills of an accredited postgraduate year one residency-trained pharmacist. In this co...

journal_title：Pharmacotherapy

authors： American College of Clinical Pharmacy.,Jordan CJ,Wall GC,Lobo B,Wilkinson J,Creekmore FM,Sorrells K,Hartis C,Miller S,Uchal L

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:The bispectral index (BIS), a processed variable derived from the raw electroencephalogram (EEG) used to guide sedation in the intensive care unit (ICU), has not been tested during barbiturate therapy for elevated intracranial pressure. We determined the BIS and suppression ratio (SR) values during traditiona...

journal_title：Pharmacotherapy

authors： Riker RR,Fraser GL,Wilkins ML

更新日期：2003-09-01 00:00:00

abstract：:Struvite calculi result from urinary tract infections secondary to urease-producing bacteria. To prevent recurrent infection and stone formation complete removal of struvite calculi is recommended. Two illustrative reports of patients with renal struvite calculi are presented in which 10% hemiacidrin (Renacidin) irrig...

journal_title：Pharmacotherapy

authors： Massaro FJ,Weiner B,Sant GR,Meares EM Jr

更新日期：1983-11-01 00:00:00

abstract：:Personalized medicine has been a mainstay and in practice in transplant pharmacotherapy since the advent of the field. Decisions pertaining to the diagnosis, selection, and monitoring of transplant pharmacotherapy are aimed toward the individual, the allograft, and the overall immunologic needs of the patient. Recent ...

journal_title：Pharmacotherapy

authors： Maldonado AQ,West-Thielke P,Joyal K,Marks CR

更新日期：2020-11-06 00:00:00

abstract：:Infections in the cerebrospinal fluid (CSF) occur in an area of impaired host defenses; therefore, bactericidal antibiotics that reach adequate concentrations in the CSF are necessary for treatment. Measurements of antibiotic penetration into the CSF include CSF inhibitory and bactericidal titers, the absolute antibio...

journal_title：Pharmacotherapy

authors： Friedrich LV,White RL,Reboli AC

更新日期：1990-01-01 00:00:00

abstract：:Cardiotoxicity due to tacrolimus is documented infrequently in the medical literature. Sinus bradycardia associated with intravenous tacrolimus occurred in a 15-year-old orthotopic liver transplant recipient. The mechanism of this adverse effect is unknown; however, it does not appear to be concentration dependent, an...

journal_title：Pharmacotherapy

authors： Cox TH,Baillie GM,Baliga P

更新日期：1997-11-01 00:00:00

abstract：:Patients with ST-segment elevation acute myocardial infarction require immediate reperfusion therapy. Reperfusion therapy can be provided by either pharmacologic or mechanical means. Pharmacologic reperfusion therapy consists of administering fibrinolytics, whereas mechanical reperfusion consists of performing percuta...

journal_title：Pharmacotherapy

authors： Dobesh PP,Kasiar JB

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:There is a high prevalence of HIV infection in Newark, New Jersey, with University Hospital admitting approximately 600 HIV-infected patients per year. Medication errors involving antiretroviral therapy (ART) could significantly affect treatment outcomes. The goal of this study was to evaluate the effectiven...

journal_title：Pharmacotherapy

authors： Zucker J,Mittal J,Jen SP,Cheng L,Cennimo D

更新日期：2016-03-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the appropriate compartmental and noncompartmental pharmacokinetic parameters for intravenous piperacillin and tazobactam. DESIGN:Sequential selection of patients entered into a randomized, open-label clinical efficacy trial. SETTING:Los Angeles County-University of Southern California Me...

journal_title：Pharmacotherapy

authors： Jhee SS,Kern JW,Burm JP,Yellin AE,Gill MA

更新日期：1995-07-01 00:00:00

abstract：:Levonorgestrel implants (Norplant) are an alternative to oral contraceptives and medroxyprogesterone acetate intramuscular injections. An interaction may exist between levonorgestrel and agents that induce the hepatic microsomal enzyme system. A 21-year-old woman with a history of a seizure disorder, treated with phen...

journal_title：Pharmacotherapy

authors： Shane-McWhorter L,Cerveny JD,MacFarlane LL,Osborn C

更新日期：1998-11-01 00:00:00

abstract：:Meclofenamate sodium was compared, double-blind, with codeine and placebo for the treatment of acute episiotomy pain. One hundred sixty-eight women with moderate or severe episiotomy pain after normal delivery were assigned randomly to one of four treatment groups: one received meclofenamate sodium 200 mg at dose 1 an...

journal_title：Pharmacotherapy

authors： Hebertson RM,Storey N,Turner JL

更新日期：1986-09-01 00:00:00

abstract：:The clinical and economic impacts of bacterial resistance are substantial. The development of bacterial resistance during a course of therapy often leads to clinical failure, prolonged hospitalization, increased morbidity, mortality, and increased health care costs. Resistance has been reported to occur most frequentl...

journal_title：Pharmacotherapy

authors： Barriere SL

更新日期：1992-01-01 00:00:00

abstract：:A hiccup is a myoclonic jerk of the diaphragm, and cases of hiccups may last for more than 48 hours (persistent hiccups) or even more than 2 months (intractable hiccups). Current pharmacologic treatment of persistent or intractable hiccups mainly includes antidopaminergic drugs. We describe the case of a 60-year-old m...

journal_title：Pharmacotherapy

authors： Naro A,Bramanti P,Calabrò RS

更新日期：2014-12-01 00:00:00

abstract：:Hodgkin lymphoma (HL) and systemic anaplastic large cell lymphoma (sALCL), which is a subtype of non-Hodgkin lymphoma, are relatively uncommon lymphoproliferative types of cancer. These malignancies are highly curable with initial treatment. Nonetheless, some patients are refractory to or relapse after first- and seco...

journal_title：Pharmacotherapy

authors： Newland AM,Li JX,Wasco LE,Aziz MT,Lowe DK

更新日期：2013-01-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the relationship between impaired renal function and antifactor Xa activity in patients receiving dalteparin. DESIGN:Open-label prospective study. SETTING:Inpatient and outpatient units of a large teaching hospital. SUBJECTS:Eleven patients with renal impairment and 11 control subjects wi...

journal_title：Pharmacotherapy

authors： Shprecher AR,Cheng-Lai A,Madsen EM,Cohen HW,Sinnett MJ,Wong ST,Billett HH

更新日期：2005-06-01 00:00:00

abstract：:Use of the Molecular Adsorbent Recirculating System (MARS) as a liver support device continues to grow worldwide. Various components of the MARS circuit remove both protein-bound and water-soluble molecules. Little is known about the extent of the enhanced clearance mechanisms used in MARS therapy on drug elimination....

journal_title：Pharmacotherapy

authors： Personett HA,Larson SL,Frazee EN,Nyberg SL,El-Zoghby ZM

更新日期：2015-08-01 00:00:00

abstract：:Vancomycin-resistant enterococci (VRE) and methicillin-oxacillin-resistant Staphylococcus aureus (MRSA) originally predominated in large medical centers; however, these isolates are now common in community hospitals and community clinics. No simple answer is available regarding control of antimicrobial-resistant bacte...

journal_title：Pharmacotherapy

authors： Smith DW

更新日期：1999-08-01 00:00:00

abstract：:Advances in the care of critically ill patients and in diagnostic techniques, such as fiberoptic endoscopy, have enabled greater recognition of stress-related mucosal damage (SRMD). This condition is distinguished from chronic peptic ulcer disease by its greater number of lesions, proximal location in the acid-produci...

journal_title：Pharmacotherapy

authors： Peura DA

更新日期：1987-01-01 00:00:00

abstract：:Clinical trials continue to evaluate the pharmacologic management of myocardial infarction for benefits in mortality, degree of infarct artery patency, and frequency of reocclusion. The discovery of thrombus formation in the development of the myocardial infarction renewed interest in thrombolytic therapy. In appropri...

journal_title：Pharmacotherapy

authors： Talbert RL

更新日期：1996-09-01 00:00:00

abstract：:Ceftazidime, a beta-lactamase-stable, third-generation cephalosporin, is widely used for the treatment of serious gram-negative infections. Neurotoxicity has rarely been associated with the drug; however, two of our patients developed ceftazidime-induced neurotoxicity that produced confusion, disorientation, agitation...

journal_title：Pharmacotherapy

authors： Slaker RA,Danielson B

更新日期：1991-01-01 00:00:00

abstract：:This study compared limited sampling methods (LSM) of estimating area under the plasma concentration versus time curve (AUC) based on a Bayesian regularized neural network, the Bayesian approach, and multiple forward stepwise regression models from selected concentration-time points. Plasma concentration versus time d...

journal_title：Pharmacotherapy

authors： Ng CM

更新日期：2003-08-01 00:00:00

abstract：:Antithrombin deficiency is a hypercoagulable state that can increase the risk for thrombosis, especially in the presence of other procoagulant triggers. Unfractionated heparin and low-molecular-weight heparins may not provide effective anticoagulation since they require antithrombin for activity. Direct thrombin inhib...

journal_title：Pharmacotherapy

authors： Dager WE,Gosselin RC,Owings JT

更新日期：2004-05-01 00:00:00