Successful use of tetrabenazine in a patient with intractable hiccups after stroke.

abstract：:In patients infected with chronic hepatitis B virus (HBV) that goes untreated, therapeutic options are limited once the disease decompensates, and orthotopic liver transplantation is often the only treatment available to save the patient's life. After liver transplantation, combined therapy with hepatitis B immune glo...

journal_title：Pharmacotherapy

authors： McGonigal KH,Bajjoka IE,Abouljoud MS

更新日期：2013-09-01 00:00:00

abstract：:Omadacycline is a novel aminomethylcycline approved for the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections. This article reviews existing data pertaining to the biochemistry, mechanism of action, pharmacokinetics/pharmacodynamics, in vitro activity, and curre...

journal_title：Pharmacotherapy

authors： Barber KE,Bell AM,Wingler MJB,Wagner JL,Stover KR

更新日期：2018-12-01 00:00:00

abstract：STUDY OBJECTIVE:To compare the efficacy of amlodipine and valsartan in African-American patients with hypertension using ambulatory blood pressure monitoring (ABPM). DESIGN:Prospective, randomized, double-blind, crossover comparison study. SETTING:University-affiliated cardiac center clinic. PATIENTS:Twenty African-...

journal_title：Pharmacotherapy

authors： Maciejewski S,Mohiuddin SM,Packard KA,Mooss AN,Reyes AP,Aryana A,Hilleman DE

更新日期：2006-07-01 00:00:00

abstract：:Cystic fibrosis affects 1/2500 individuals and is the most common lethal autosomal recessive disease in people of northern European descent. It is characterized by chronic infections with mucoid Pseudomonas aeruginosa and progressive deterioration of respiratory function. Much research has focused on the inflammatory ...

journal_title：Pharmacotherapy

authors： Gaylor AS,Reilly JC

更新日期：2002-02-01 00:00:00

abstract：:Antimicrobial resistance among gram-positive organisms such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) continues to limit therapeutic options. The oxazolidinones are a synthetic class of agents now commonly relied on for the treatment of serious MRSA and VRE infect...

journal_title：Pharmacotherapy

authors： Rybak JM,Marx K,Martin CA

更新日期：2014-11-01 00:00:00

abstract：:Patient-controlled analgesia is a relatively new method of administering intravenous narcotics for postoperative pain relief. The technique involves the self-administration of a given analgesic in a bolus dose with the aid of a timed infusion and sequencing device. Ten morbidity obese patients undergoing elective gast...

journal_title：Pharmacotherapy

authors： Bennett R,Batenhorst R,Graves DA,Foster TS,Griffen WO,Wright BD

更新日期：1982-01-01 00:00:00

abstract：:Studies that demonstrate the clinical and economic burden of drug misadventures have been published. The economic burden of drug misadventures likely exceeds $100 billion annually in the United States alone. Clinical pharmacy services (CPS) have been shown to reduce negative clinical outcomes and costs of drug therapy...

journal_title：Pharmacotherapy

authors： Schumock GT

更新日期：2000-10-01 00:00:00

abstract：:The antiretroviral combination of emtricitabine-tenofovir disoproxil fumarate (FTC/TDF) was approved by the U.S. Food and Drug Administration for use as pre-exposure prophylaxis (PrEP) in individuals at high risk for acquiring human immunodeficiency virus (HIV) in July 2012. Since then, Centers for Disease Control and...

journal_title：Pharmacotherapy

authors： Adams JL,Shelley K,Nicol MR

更新日期：2019-04-01 00:00:00

abstract：:Fluoxetine hydrochloride is the sixth most prescribed drug in the United States and is administered to treat major depression. A cadaveric skin donation was obtained from a 46-year-old woman who died as a result of a fluoxetine overdose. Due to the potential penetration of the drug and its major metabolite, norfluoxet...

journal_title：Pharmacotherapy

authors： Neudeck BL,Taddonio TE,Garner WL,Welage LS

更新日期：1998-07-01 00:00:00

abstract：:Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a rare neurodegenerative disease caused by the decreased ability of cells to produce sufficient energy in the form of adenosine 5'-triphosphate. Although it is one of the most common maternally inherited mitochondrial...

journal_title：Pharmacotherapy

authors： Santa KM

更新日期：2010-11-01 00:00:00

abstract：STUDY OBJECTIVES:To develop and validate a self-assessment adherence tool for imatinib in patients with chronic myeloid leukemia (CML), and to correlate the use of this tool with response to treatment and adverse effects. DESIGN:Retrospective cohort study. SETTING:Regional cancer center in France. PATIENTS:Forty-six...

journal_title：Pharmacotherapy

authors： Daouphars M,Ouvry M,Lenain P,Rouvet J,Jardin F,Bubenheim M,Varin R

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVES:To examine the knowledge, attitudes, and interest of an inner-city population toward pharmacogenetic testing, with the primary objective of identifying facilitators and barriers toward pharmacogenetic testing; and secondary objectives of determining predictors of patient interest in pharmacogenetic testing a...

journal_title：Pharmacotherapy

authors： Lee YM,Manzoor BS,Cavallari LH,Nutescu EA

更新日期：2018-02-01 00:00:00

abstract：:For convenience, many pediatric hospitals are preparing solutions for continuous nebulized albuterol using the 0.5% 20-ml multidose albuterol dropper bottle. This product contains benzalkonium chloride (BAC) that, by itself, produces bronchospasm that is dose dependent and cumulative. The bronchoconstrictive effects o...

journal_title：Pharmacotherapy

authors： Prabhakaran S,Abu-Hasan M,Hendeles L

更新日期：2017-05-01 00:00:00

abstract：STUDY OBJECTIVES:To assess the use and safety of concurrent administration of voriconazole and sirolimus-which is contraindicated-and to determine approaches for appropriately managing patients who receive both drugs. DESIGN:Retrospective medical record review. SETTING:University-affiliated medical center. PATIENTS:...

journal_title：Pharmacotherapy

authors： Surowiec D,DePestel DD,Carver PL

更新日期：2008-06-01 00:00:00

abstract：:Surgical hemostasis may be achieved by using a number of physical, chemical, or biologic methods. One such method is with topical thrombin; however, one member of that class of drugs, bovine-derived thrombin, is associated with potentially serious consequences such as development of immune-mediated coagulopathy. This ...

journal_title：Pharmacotherapy

authors： Naoum JJ

更新日期：2009-07-01 00:00:00

abstract：:Ischemic stroke is a prevalent disease with a large burden on the health system. Preventive strategies, therefore, are paramount. Primary prevention is aimed at reducing the risk of stroke in asymptomatic people. The most effective prevention is through control of modifiable risk factors. Due to the large amount of li...

journal_title：Pharmacotherapy

authors： Baker WL,Marrs JC,Davis LE,Nutescu EA,Rowe AS,Ryan M,Splinter MY,Vardeny O,Fagan SC

更新日期：2013-06-01 00:00:00

abstract：:Combination antiretroviral therapy including protease inhibitors such as ritonavir has added significant potency to therapy for human immunodeficiency viral (HIV) infection as well as substantial drug-drug interactions. Methadone metabolism is affected by cytochrome P450 (CYP) 3A4 inhibitors or inducers. Because riton...

journal_title：Pharmacotherapy

authors： Geletko SM,Erickson AD

更新日期：2000-01-01 00:00:00

abstract：:Nabilone, a synthetic cannabinoid, is approved in many countries including, but not limited to, Canada, the United States, Mexico, and the United Kingdom for the treatment of severe nausea and vomiting associated with chemotherapy. Clinical evidence is emerging for its use in managing pain conditions with different et...

journal_title：Pharmacotherapy

authors： Tsang CC,Giudice MG

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:Assess the effects of linezolid on hematologic outcomes in newly diagnosed patients with acute myeloid leukemia (AML) following induction chemotherapy. DESIGN:Single-center, retrospective, observational, cohort study. SETTING:Large, tertiary care academic medical center. PATIENTS:A total of 225 patients ≥ ...

journal_title：Pharmacotherapy

authors： Nedved AN,DeFrates SR,Hladnik LM,Stockerl-Goldstein KE

更新日期：2016-10-01 00:00:00

abstract：:Calcium channel blockers are extensively used for their beneficial effects on the cardiovascular system. Solid organ transplant recipients commonly have cardiovascular disease and are often treated with these agents. Research demonstrates that calcium antagonists may have beneficial effects in this population that are...

journal_title：Pharmacotherapy

authors： Chitwood KK,Heim-Duthoy KL

更新日期：1993-09-01 00:00:00

abstract：:Death is the ultimate adverse drug event. Despite its importance, the frequency of fatal adverse drug events is unknown. Estimates in the United States are as high as 140,000/year, although this number is heavily disputed. Potential reasons and risks for fatal adverse drug events, as well as epidemiologic designs for ...

journal_title：Pharmacotherapy

authors： Kelly WN

更新日期：2001-05-01 00:00:00

abstract：:The complexities of oral anticoagulation with warfarin have led to the search for more practical alternative agents. Novel direct factor IIa inhibitors and direct factor Xa inhibitors currently in development can be administered at a fixed dose and do not require routine coagulation monitoring and ongoing dosage adjus...

journal_title：Pharmacotherapy

authors： Wittkowsky AK

更新日期：2011-12-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effect of a potent experimental leukotriene receptor antagonist, MK-571, on airway responses to inhaled allergen. DESIGN:Randomized, double-blind, placebo-controlled, crossover trial. SETTING:Clinical research center. SUBJECTS:Eight male volunteers with allergic asthma. INTERVENTIONS...

journal_title：Pharmacotherapy

authors： Hendeles L,Davison D,Harman E,Sherman JM

更新日期：1999-11-01 00:00:00

abstract：:Bar code technology has been used for 5 years to improve the efficiency of identifying and documenting clinical pharmacy services at our institution. Data for an entire year (1993) were analyzed to quantify the nature and magnitude of pharmacy services provided for critically ill patients in intensive care units (ICU)...

journal_title：Pharmacotherapy

authors： Zarowitz BJ,Petitta A,Rudis MI,Horst HM,Hyzy R

更新日期：1996-03-01 00:00:00

abstract：:A 76-year-old man developed akinetic mutism after 3 days of receiving low-dosage baclofen. Electroencephalography showed a diffusely slow background with intermittent generalized sharp wave discharges. The condition resolved after discontinuing baclofen. To our knowledge, this is the first reported case of baclofen-in...

journal_title：Pharmacotherapy

authors： Rubin DI,So EL

更新日期：1999-04-01 00:00:00

abstract：:Venous thromboembolism (VTE) is an important medical problem that affects millions of patients each year. With appropriate prophylaxis, many of these thromboembolic events can be prevented. Although strong evidence supporting VTE prophylaxis spans several decades, several large American and global registries have docu...

journal_title：Pharmacotherapy

authors： Dobesh PP,Wittkowsky AK,Stacy Z,Dager WE,Haines ST,Lopez LM,Nutescu E,Phillips KW,Trujillo TC,Vondracek T

更新日期：2009-04-01 00:00:00

abstract：:Atherosclerosis, the great killer of Western society, probably is initiated when the balance of subendothelial lipoproteins and oxidation potential is upset. Oxidation products, especially oxidized low-density lipoprotein, set into motion the cascading of numerous pathways, culminating in the fibrous atherosclerotic p...

journal_title：Pharmacotherapy

authors： Meyers DG,Maloley PA

更新日期：1993-11-01 00:00:00

abstract：:We conducted a retrospective analysis to evaluate the relationship between anxiolytic or hypnotic therapy and maintenance of therapy with selective serotonin reuptake inhibitors (SSRIs). Subjects were 654 patients who received anxiolytics or hypnotics early in SSRI therapy (study group ) and 15,172 patients who did no...

journal_title：Pharmacotherapy

authors： Shields SA,Gregor KJ,Young CH,James SP

更新日期：1998-11-01 00:00:00

abstract：:Certain demographic, practice, staffing, and pharmacist satisfaction variables may contribute to dispensing errors. A survey was randomly mailed to 7298 (50%) Texas pharmacists, of which 2862 were returned (39% response rate). Responders were 2437 pharmacists who indicated that they were in practice. Of these, 535 (23...

journal_title：Pharmacotherapy

authors： Bond CA,Raehl CL

更新日期：2001-05-01 00:00:00

abstract：STUDY OBJECTIVE:To describe the population pharmacokinetics and pharmacodynamic target attainment of ampicillin in neonates with hypoxic-ischemic encephalopathy (HIE) undergoing controlled hypothermia (CH). DESIGN:Prospective, open-label pharmacokinetic study. SETTING:A 189-bed, freestanding children's tertiary care ...

journal_title：Pharmacotherapy

authors： Cies JJ,Fugarolas KN,Moore WS 2nd,Mason RW,Menkiti OR

更新日期：2017-04-01 00:00:00